CORT-108297

Last updated

CORT-108297
CORT-108297.svg
Clinical data
Other namesCORT108297; ADS-108297; ADS108297
Routes of
administration
Oral [1]
Drug class Antiglucocorticoid; Selective glucocorticoid receptor modulator
ATC code
  • None
Identifiers
  • (4aR)-4a-(ethoxymethyl)-1-(4-fluorophenyl)-6-[4-(trifluoromethyl)phenyl]sulfonyl-4,5,7,8-tetrahydropyrazolo[5,4-g]isoquinoline
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
Chemical and physical data
Formula C26H25F4N3O3S
Molar mass 535.56 g·mol−1
3D model (JSmol)
  • CCOC[C@]12CC3=C(C=C1CCN(C2)S(=O)(=O)C4=CC=C(C=C4)C(F)(F)F)N(N=C3)C5=CC=C(C=C5)F
  • InChI=1S/C26H25F4N3O3S/c1-2-36-17-25-14-18-15-31-33(22-7-5-21(27)6-8-22)24(18)13-20(25)11-12-32(16-25)37(34,35)23-9-3-19(4-10-23)26(28,29)30/h3-10,13,15H,2,11-12,14,16-17H2,1H3/t25-/m1/s1
  • Key:SLKURXRZHJOZOD-RUZDIDTESA-N

CORT-108297, also known as ADS-108297, is a nonsteroidal selective glucocorticoid receptor modulator (SEGRM) with mixed glucocorticoid and antiglucocorticoid actions which is under development for the treatment of Alzheimer's disease, cognition disorders, memory disorders, and post-traumatic stress disorder (PTSD). [1] [2] [3] [4] It was also being developed for treatment of other psychiatric disorders and weight gain, but development for these indications was discontinued. [1] The drug is taken by mouth. [1] As of November 2022, CORT-108297 is in phase 2 clinical trials for the aforementioned active indications. [1] [2]

See also

References

  1. 1 2 3 4 5 "CORT 108297". AdisInsight. 29 November 2022. Retrieved 28 September 2025.
  2. 1 2 "Delving into the Latest Updates on CORT-108297 with Synapse". Synapse. 27 September 2025. Retrieved 28 September 2025.
  3. Viho EM, Buurstede JC, Mahfouz A, Koorneef LL, van Weert LT, Houtman R, et al. (2019). "Corticosteroid Action in the Brain: The Potential of Selective Receptor Modulation". Neuroendocrinology. 109 (3): 266–276. doi:10.1159/000499659. PMC   6878852 . PMID   30884490.
  4. Lucafò M, Franzin M, Decorti G, Stocco G (May 2020). "A patent review of anticancer glucocorticoid receptor modulators (2014-present)". Expert Opinion on Therapeutic Patents. 30 (5): 313–324. doi:10.1080/13543776.2020.1740206. PMID   32148111.