Cortobenzolone

Cortobenzolone
Clinical data
Trade names	Tuplix
Synonyms	Betamethasone salicylate; 9α-Fluoro-11β,16α,17α-trihydroxy-21-((2-hydroxybenzoyl)oxy)pregna-1,4-diene-3,20-dione
Drug class	Corticosteroid; Glucocorticoid
Identifiers
	IUPAC name [2-[(8S,10S,11S,13S,14S,16R,17S)-9-Fluoro-11,16,17-trihydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] 2-hydroxybenzoate;
CAS Number	52619-32-6 ; 65849-38-9;
PubChem CID	191783 ;
ChemSpider	166511 ;
Chemical and physical data
Formula	C28H31FO8
Molar mass	514.546 g·mol−1
3D model (JSmol)	Interactive image ;
	SMILES C[C@]12C[C@@H](C3([C@H]([C@@H]1C[C@H]([C@@]2(C(=O)COC(=O)C4=CC=CC=C4O)O)O)CCC5=CC(=O)C=C[C@@]53C)F)O;
	InChI InChI=1S/C28H31FO8/c1-25-10-9-16(30)11-15(25)7-8-18-19-12-21(32)28(36,26(19,2)13-22(33)27(18,25)29)23(34)14-37-24(35)17-5-3-4-6-20(17)31/h3-6,9-11,18-19,21-22,31-33,36H,7-8,12-14H2,1-2H3/t18-,19-,21+,22-,25-,26-,27?,28-/m0/s1; Key:FVUHHROTFPGTFL-OHKAWVANSA-N;

Last updated June 04, 2019

Cortobenzolone (brand name Tuplix), also known as betamethasone salicylate, is a synthetic glucocorticoid corticosteroid and corticosteroid ester which is marketed in Spain.^[1]^[2]^[3]

Glucocorticoids are a class of corticosteroids, which are a class of steroid hormones. Glucocorticoids are corticosteroids that bind to the glucocorticoid receptor that is present in almost every vertebrate animal cell. The name "glucocorticoid" is a portmanteau and is composed from its role in regulation of glucose metabolism, synthesis in the adrenal cortex, and its steroidal structure. A less common synonym is glucocorticosteroid.

Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, as well as the synthetic analogues of these hormones. Two main classes of corticosteroids, glucocorticoids and mineralocorticoids, are involved in a wide range of physiological processes, including stress response, immune response, and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior.

Spain, officially the Kingdom of Spain, is a country mostly located in Europe. Its continental European territory is situated on the Iberian Peninsula. Its territory also includes two archipelagoes: the Canary Islands off the coast of Africa, and the Balearic Islands in the Mediterranean Sea. The African enclaves of Ceuta, Melilla, and Peñón de Vélez de la Gomera make Spain the only European country to have a physical border with an African country (Morocco). Several small islands in the Alboran Sea are also part of Spanish territory. The country's mainland is bordered to the south and east by the Mediterranean Sea except for a small land boundary with Gibraltar; to the north and northeast by France, Andorra, and the Bay of Biscay; and to the west and northwest by Portugal and the Atlantic Ocean.

Related Research Articles

Fluticasone are two manufactured steroids used to treat nasal symptoms. Both the esters, fluticasone furoate and fluticasone propionate, are also used as topical anti-inflammatories and inhaled corticosteroids, and are used much more commonly in comparison.

Clobetasol is a synthetic glucocorticoid corticosteroid which is marketed in Denmark. A propionate ester of clobetasol, clobetasol propionate, has also been marketed, and is far more widely used in comparison.

Cortisone acetate is a synthetic glucocorticoid corticosteroid and corticosteroid ester which is marketed in many countries throughout the world, including in the United States, the United Kingdom, and various other European countries. It is the C21 acetate ester of cortisone, and acts as a prodrug of cortisone in the body.

Fluorometholone acetate, also known as oxylone acetate and sold under the brand names Flarex, Florate, and Omnitrol, is a synthetic glucocorticoid corticosteroid and a corticosteroid ester, as well as a progestogen and progestogen ester. It is the C17α acetate ester of fluorometholone.

Fluocinolone is a synthetic glucocorticoid corticosteroid which was never marketed. The acetonide cyclic ketal of fluocinolone, fluocinolone acetonide, in contrast, has been marketed.

Fluprednidene, also known as fluprednylidene, is a synthetic glucocorticoid corticosteroid which was never marketed. An acetate ester of fluprednidene, fluprednidene acetate, in contrast, has been marketed.

Hydrocortamate is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive properties. It is used topically to treat inflammation due to corticosteroid-responsive dermatoses.

Fluclorolone is a synthetic glucocorticoid corticosteroid which was never marketed. The acetonide cyclic ketal of fluclorolone, fluclorolone acetonide, in contrast, has been marketed.

Diflorasone is a synthetic glucocorticoid corticosteroid which was never marketed. A diacetate ester of diflorasone, diflorasone diacetate, in contrast, has been marketed.

Dichlorisone is a synthetic glucocorticoid corticosteroid which was never marketed.

Halopredone is a synthetic glucocorticoid corticosteroid which was never marketed.

Isoflupredone, also known as deltafludrocortisone and 9α-fluoroprednisolone, is a synthetic glucocorticoid corticosteroid which was never marketed.

Mazipredone, also known as depersolone, is a synthetic glucocorticoid corticosteroid which is or has been marketed in the Czech Republic and Hungary.

Prednazoline, a compound of prednisolone phosphate with fenoxazoline, is a synthetic corticosteroid as well as vasoconstrictor and α-adrenergic sympathomimetic.

Prednisolamate, also known as prednisolone 21-diethylaminoacetate, is a synthetic corticosteroid. It is or was a component of Etaproctene, which contains lidocaine, prednisolamate hydrochloride, and tetryzoline.

Ciclometasone is a synthetic glucocorticoid corticosteroid which is marketed in Italy.

Fluocortin butyl, or fluocortin 21-butylate, is a synthetic glucocorticoid corticosteroid which is marketed in Germany, Belgium, Luxembourg, Spain, and Italy. Chemically, it is the butyl ester derivative of fluocortin.

Fluazacort is a synthetic glucocorticoid corticosteroid which is marketed in Italy.

Flupamesone, also known as triamcinolone acetonide metembonate, is a synthetic glucocorticoid corticosteroid which is marketed in Spain. It is a dimer of a C21 ester of triamcinolone acetonide.

Hydrocortisone hemisuccinate (USAN), also known as hydrocortisone hydrogen succinate (BANM) or simply hydrocortisone succinate and sold under the brand name Solu-Cortel among many others, is a synthetic glucocorticoid corticosteroid and a corticosteroid ester which is used for antiinflammatory and antiallergic indications.

References

↑ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 147–. ISBN 978-1-4757-2085-3.
↑ Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. pp. 119–. ISBN 978-3-88763-075-1.
↑ Martin Negwer; Hans-Georg Scharnow (2001). Organic-chemical drugs and their synonyms: (an international survey). Wiley-VCH. p. 3523. ISBN 978-3-527-30247-5.

This article about a steroid is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[Elks2014-1] J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 147–. ISBN 978-1-4757-2085-3.

[IndexNominum2000-2] Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. pp. 119–. ISBN 978-3-88763-075-1.

[NegwerScharnow2001-3] Martin Negwer; Hans-Georg Scharnow (2001). Organic-chemical drugs and their synonyms: (an international survey). Wiley-VCH. p. 3523. ISBN 978-3-527-30247-5.