Triclonide

Triclonide
Clinical data
Synonyms	RS-4464; 6α-Fluoro-9α,11β,21-trichloro-16α,17α-dihydroxypregna-1,4-diene-3,20-dione cyclic acetal with acetone; 6α-Fluoro-9α,11β,21-trichloro-16α,17α-((1-methylethylidene)bis(oxy))-pregna-1,4-diene-3,20-dione
Drug class	Corticosteroid; Glucocorticoid
Identifiers
	IUPAC name (4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS,12S)-4b,5-Dichloro-6b-(chloroacetyl)-12-fluoro-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one;
CAS Number	26849-57-0 ;
PubChem CID	10323902 ;
ChemSpider	8499365 ;
UNII	PSM3RT117Z ;
KEGG	D06225 ;
ChEMBL	CHEMBL2107225 ;
Chemical and physical data
Formula	C24H28Cl3FO4
Molar mass	505.83 g·mol−1
3D model (JSmol)	Interactive image ;
	SMILES C[C@]12C[C@@H]([C@]3([C@H]([C@@H]1C[C@@H]4[C@]2(OC(O4)(C)C)C(=O)CCl)C[C@@H](C5=CC(=O)C=C[C@@]53C)F)Cl)Cl;
	InChI InChI=1S/C24H28Cl3FO4/c1-20(2)31-19-9-13-14-8-16(28)15-7-12(29)5-6-21(15,3)23(14,27)17(26)10-22(13,4)24(19,32-20)18(30)11-25/h5-7,13-14,16-17,19H,8-11H2,1-4H3/t13-,14-,16-,17-,19+,21-,22-,23-,24+/m0/s1; Key:VSVSLEMVVAYTQW-VSXGLTOVSA-N;

Last updated March 16, 2019

Triclonide (developmental code name RS-4464) is a synthetic glucocorticoid corticosteroid which was never marketed.^[1]^[2]

Glucocorticoids are a class of corticosteroids, which are a class of steroid hormones. Glucocorticoids are corticosteroids that bind to the glucocorticoid receptor that is present in almost every vertebrate animal cell. The name "glucocorticoid" is a portmanteau and is composed from its role in regulation of glucose metabolism, synthesis in the adrenal cortex, and its steroidal structure. A less common synonym is glucocorticosteroid.

Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, as well as the synthetic analogues of these hormones. Two main classes of corticosteroids, glucocorticoids and mineralocorticoids, are involved in a wide range of physiological processes, including stress response, immune response, and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior.

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References

↑ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 282,486. ISBN 978-1-4757-2085-3.
↑ Cynthia A. Challener (1 December 2001). Chiral Drugs. Wiley. p. 312. ISBN 978-0-566-08411-9.

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[Elks2014-1] J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 282,486. ISBN 978-1-4757-2085-3.

[Challener2001-2] Cynthia A. Challener (1 December 2001). Chiral Drugs. Wiley. p. 312. ISBN 978-0-566-08411-9.