Clobetasol

Last updated
Clobetasol
Clobetasol.svg
Clinical data
Other names9α-Fluoro-11β,17α-dihydroxy-16β-methyl-21-chloropregna-1,4-diene-3,20-dione
Pregnancy
category
Drug class Corticosteroid; Glucocorticoid
Identifiers
  • (8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-Chloroacetyl)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
ECHA InfoCard 100.042.379 OOjs UI icon edit-ltr-progressive.svg
Chemical and physical data
Formula C22H28ClFO4
Molar mass 410.91 g·mol−1
3D model (JSmol)
  • C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CCl)O)C)O)F)C
  • InChI=1S/C22H28ClFO4/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,24)17(26)10-20(16,3)22(12,28)18(27)11-23/h6-7,9,12,15-17,26,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,17-,19-,20-,21-,22-/m0/s1
  • Key:FCSHDIVRCWTZOX-DVTGEIKXSA-N

Clobetasol is a synthetic glucocorticoid corticosteroid. A propionate ester of clobetasol, clobetasol propionate, has also been marketed, and is far more widely used in comparison. [2] [3]

Related Research Articles

<span class="mw-page-title-main">Fluticasone</span> Chemical compound

Fluticasone is a manufactured glucocorticoid used to treat nasal symptoms. Both the esters, fluticasone propionate and fluticasone furoate, are also used as topical anti-inflammatories and inhaled corticosteroids, and are used much more commonly in comparison.

<span class="mw-page-title-main">Methylprednisolone aceponate</span> Chemical compound

Methylprednisolone aceponate, or methylprednisolone acetate propionate, sold under the brand names Advantan and Avancort, is a glucocorticoid and a corticosteroid ester—specifically the C17α propionate and C21 acetate diester of methylprednisolone.

<span class="mw-page-title-main">Propetandrol</span> Chemical compound

Propetandrol, or propethandrol, also known as 17α-ethyl-19-nortestosterone 3β-propionate or 17α-ethyl-19-nor-4-androstenediol 3β-propionate, as well as 17α-ethylestr-4-en-3β,17β-diol 3β-propionate, is a synthetic and orally active anabolic–androgenic steroid (AAS) and progestogen and a 17α-alkylated derivative of 19-nortestosterone. It is an androgen ester – specifically, the 3β-propionate ester of norethandrolone (17α-ethyl-19-nortestosterone).

<span class="mw-page-title-main">Testosterone ketolaurate</span> Chemical compound

Testosterone ketolaurate, also known as testosterone caprinoylacetate, is an androgen and anabolic steroid medication and a testosterone ester. It was introduced in 1956. It was marketed both as an oil solution and as a crystalline aqueous suspension.

<span class="mw-page-title-main">Testosterone caproate</span> Chemical compound

Testosterone caproate (TCa), also known as testosterone hexanoate, is an androgen and anabolic steroid and a testosterone ester that is no longer marketed. It was formerly available as a component of Omnadren 250, along with testosterone isocaproate, testosterone phenylpropionate, and testosterone propionate, but this formulation has since been discontinued.

<span class="mw-page-title-main">Estrapronicate</span> Chemical compound

Estrapronicate, also known as estradiol nicotinate propionate is an estrogen medication and estrogen ester which was never marketed. It was studied as a component of the experimental tristeroid combination drug Trophobolene, which contained nandrolone decanoate, estrapronicate, and hydroxyprogesterone heptanoate.

<span class="mw-page-title-main">Orestrate</span> Chemical compound

Orestrate, also known as estradiol 3-propionate 17β-(1-cyclohexenyl) ether, is an estrogen medication and estrogen ester which was never marketed. It is the C3 propionate ester and C17β-(1-cyclohexenyl) ether of estradiol.

<span class="mw-page-title-main">Testosterone nicotinate</span> Chemical compound

Testosterone nicotinate is an androgen and anabolic steroid medication made by esterifying nicotinic acid and testosterone It was formulated as a 50 mg/mL aqueous suspension provided in ampoules. The medication was manufactured and sold by Lannacher Heilmittel GmbH in Austria. It is no longer marketed.

<span class="mw-page-title-main">Androstanolone propionate</span> Synthetic androgen and anabolic steroid

Androstanolone propionate, also known as stanolone propionate or dihydrotestosterone propionate (DHTP), as well as 5α-androstan-17β-ol-3-one 17β-propionate, is a synthetic androgen and anabolic steroid and a dihydrotestosterone ester that is marketed in Italy. It is used as an injectable and acts as a prodrug of androstanolone.

<span class="mw-page-title-main">Nandrolone cyclohexylpropionate</span> Chemical compound

Nandrolone cyclohexylpropionate, or nandrolone cyclohexanepropionate, also known as 19-nortestosterone 17β-(3-cyclohexyl)propionate (NTHCP), is a synthetic androgen and anabolic steroid and a nandrolone ester that is or has been marketed in Spain, Austria, and Israel.

<span class="mw-page-title-main">Nandrolone hydrogen succinate</span> Chemical compound

Nandrolone hydrogen succinate, or nandrolone hemisuccinate, also known as 19-nortestosterone 17β-(3-carboxy)propionate, is a synthetic androgen and anabolic steroid and a nandrolone ester that is or has been marketed in Italy.

<span class="mw-page-title-main">Nandrolone propionate</span> Chemical compound

Nandrolone propionate, or nandrolone propanoate, also known as 19-nortestosterone 17β-propionate, is a synthetic androgen and anabolic steroid and nandrolone ester that is or has been marketed in Spain.

<span class="mw-page-title-main">Bolandiol dipropionate</span> Chemical compound

Bolandiol dipropionate (USAN), or bolandiol propionate (JAN), also known as norpropandrolate or 19-nor-4-androstenediol dipropionate, as well as estr-4-ene-3β,17β-diol 3,17-dipropionate, is a synthetic anabolic-androgenic steroid (AAS) and derivative of 19-nortestosterone (nandrolone). It is an androgen ester – specifically, the 3,17-dipropionate ester of bolandiol (19-nor-4-androstenediol).

<span class="mw-page-title-main">Clostebol acetate</span> Chemical compound

Clostebol acetate is a synthetic, injected anabolic-androgenic steroid (AAS) and a derivative of testosterone that is marketed in Germany and Italy. It is an androgen ester – specifically, the C17β acetate ester of clostebol (4-chlorotestosterone) – and acts as a prodrug of clostebol in the body. Clostebol acetate is administered via intramuscular injection.

<span class="mw-page-title-main">Clostebol caproate</span> Chemical compound

Clostebol caproate, also known as clostebol hexanoate or chlorotestosterone caproate (JAN), as well as 4-chlorotestosterone 17β-caproate or as 4-chloroandrost-4-en-17β-ol-3-one 17β-caproate, is a synthetic, injected anabolic-androgenic steroid (AAS) and a derivative of testosterone. It is an androgen ester – specifically, the C17β caproate ester of clostebol (4-chlorotestosterone) – and acts as a prodrug of clostebol in the body. Clostebol acetate is administered via intramuscular injection.

<span class="mw-page-title-main">Clostebol propionate</span> Chemical compound

Clostebol propionate, also known as 4-chlorotestosterone 17β-propionate or as 4-chloroandrost-4-en-17β-ol-3-one 17β-propionate, is a synthetic, injected anabolic-androgenic steroid (AAS) and a derivative of testosterone. It is an androgen ester – specifically, the C17β propionate ester of clostebol (4-chlorotestosterone) – and acts as a prodrug of clostebol in the body. Clostebol acetate is administered via intramuscular injection.

<span class="mw-page-title-main">Methandriol diacetate</span> Chemical compound

Methandriol diacetate, or methylandrostenediol diacetate, also known as 17α-methylandrost-5-ene-3β,17β-diol 3β,17β-diacetate, is a synthetic, injected anabolic–androgenic steroid (AAS) and a 17α-alkylated derivative of 5-androstenediol that was never marketed. It is an androgen ester – specifically, the C3,17β diacetate ester of methandriol (17α-methyl-5-androstenediol) – and acts as a prodrug of methandriol in the body.

<span class="mw-page-title-main">Procinonide</span> Chemical compound

Procinonide is a synthetic glucocorticoid corticosteroid which was never marketed.

References

  1. "Updates to the Prescribing Medicines in Pregnancy database". Therapeutic Goods Administration (TGA). 21 December 2022. Archived from the original on 3 April 2022. Retrieved 2 January 2023.
  2. Elks J, Ganellin CR, eds. (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 292–. doi:10.1007/978-1-4757-2085-3. ISBN   978-1-4757-2085-3.
  3. Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. pp. 252–. ISBN   978-3-88763-075-1.