Tixocortol pivalate

Last updated
Tixocortol pivalate
Tixocortol pivalate.svg
Names
IUPAC name
S-(11β,17-Dihydroxy-3,20-dioxopregn-4-en-21-yl) 2,2-dimethylpropanethioate
Systematic IUPAC name
S-{2-[(1R,3aS,3bS,9aR,9bS,10S,11aS)-1,10-Dihydroxy-9a,11a-dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[a]phenanthren-1-yl]-2-oxoethyl} 2,2-dimethylpropanethioate
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard 100.054.261 OOjs UI icon edit-ltr-progressive.svg
EC Number
  • 259-706-4
KEGG
PubChem CID
UNII
  • InChI=1S/C26H38O5S/c1-23(2,3)22(30)32-14-20(29)26(31)11-9-18-17-7-6-15-12-16(27)8-10-24(15,4)21(17)19(28)13-25(18,26)5/h12,17-19,21,28,31H,6-11,13-14H2,1-5H3/t17-,18-,19-,21+,24-,25-,26-/m0/s1
    Key: BISFDZNIUZIKJD-XDANTLIUSA-N
  • CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4(C(=O)CSC(=O)C(C)(C)C)O)C)O
Properties
C26H38O5S
Molar mass 462.64
Hazards
GHS labelling:
GHS-pictogram-exclam.svg
Warning
H317, H413
P261, P272, P273, P280, P302+P352, P321, P333+P317, P362+P364, P501
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Tixocortol pivalate is a corticosteroid. It has anti-inflammatory properties similar to hydrocortisone. [1] It is marketed under the brand name Pivalone. [2]

It is sometimes used in patch testing in atopic dermatitis. [3]

See also

References

  1. ↑ P Larochelle MD, PhD; P Du Souich MD, PhD; E Bolte MD; J Lelorier MD, PhD & R Goyer PhD (1983). "Tixocortol pivalate, a corticosteroid with no systemic glucocorticoid effect after oral, intrarectal, and intranasal application" . Clinical Pharmacology and Therapeutics. 33 (3): 343–350. doi:10.1038/clpt.1983.43. PMID   6402333. S2CID   29876079 . Retrieved 2011-03-29.
  2. ↑ "Tixocortol Pivalate". Drugs.com. Retrieved 2011-03-29.
  3. ↑ Nedorost ST, Babineau D (October 2010). "Patch testing in atopic dermatitis" . Dermatitis. 21 (5): 251–4. doi:10.2310/6620.2010.10036. PMID   20920410. S2CID   25026888.


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