Fluocinolone

Last updated
Fluocinolone
Fluocinolone.svg
Clinical data
Other names6α-Fluorotriamcinolone; 6α,9α-Difluoro-11β,16α,17α,21-tetrahydroxypregna-1,4-diene-3,20-dione
Drug class Corticosteroid; Glucocorticoid
Identifiers
  • (6S,8S,9R,10S,11S,13S,14S,16R,17S)-6,9-Difluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
CAS Number
PubChem CID
ChemSpider
UNII
ECHA InfoCard 100.011.239 OOjs UI icon edit-ltr-progressive.svg
Chemical and physical data
Formula C21H26F2O6
Molar mass 412.430 g·mol−1
3D model (JSmol)
  • C[C@]12C[C@@H]([C@]3([C@H]([C@@H]1C[C@H]([C@@]2(C(=O)CO)O)O)C[C@@H](C4=CC(=O)C=C[C@@]43C)F)F)O
  • InChI=1S/C21H26F2O6/c1-18-4-3-10(25)5-13(18)14(22)6-12-11-7-15(26)21(29,17(28)9-24)19(11,2)8-16(27)20(12,18)23/h3-5,11-12,14-16,24,26-27,29H,6-9H2,1-2H3/t11-,12-,14-,15+,16-,18-,19-,20-,21-/m0/s1
  • Key:UUOUOERPONYGOS-CLCRDYEYSA-N

Fluocinolone is a synthetic glucocorticoid corticosteroid which was never marketed. [1] [2] The acetonide cyclic ketal of fluocinolone, fluocinolone acetonide, in contrast, has been marketed. [1] [2]

Related Research Articles

ATC code D07Corticosteroids, dermatological preparations is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products. Subgroup D07 is part of the anatomical group D Dermatologicals.

ATC code S02Otologicals is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products. Subgroup S02 is part of the anatomical group S Sensory organs.

Triamcinolone Steroid medication

Triamcinolone is a glucocorticoid used to treat certain skin diseases, allergies, and rheumatic disorders among others. It is also used to prevent worsening of asthma and COPD. It can be taken in various ways including by mouth, injection into a muscle, and inhalation.

Triamcinolone acetonide Medicinal chemical compound, steroid

Triamcinolone acetonide is a synthetic corticosteroid medication used topically to treat various skin conditions, to relieve the discomfort of mouth sores, and intra-articularly by proceduralists to treat various joint conditions. It is also injected intralesionally to treat inflammation in some parts of the body, particularly the skin. In nasal spray form, it is used to treat allergic rhinitis. It is a more potent derivative of triamcinolone, and is about eight times as potent as prednisone.

Triamcinolone hexacetonide

Triamcinolone hexacetonide is a synthetic glucocorticoid corticosteroid.

Fluocinolone acetonide Corticosteroid anti-inflammatory drug

Fluocinolone acetonide is a corticosteroid primarily used in dermatology to reduce skin inflammation and relieve itching. It is a synthetic hydrocortisone derivative. The fluorine substitution at position 9 in the steroid nucleus greatly enhances its activity. It was first synthesized in 1959 in the Research Department of Syntex Laboratories S.A. Mexico City. Preparations containing it were first marketed under the name Synalar. A typical dosage strength used in dermatology is 0.01–0.025%. One such cream is sold under the brand name Flucort-N and includes the antibiotic neomycin.

Triamcinolone furetonide

Triamcinolone furetonide is a synthetic glucocorticoid corticosteroid which was never marketed.

Triamcinolone benetonide

Triamcinolone benetonide is a synthetic glucocorticoid corticosteroid.

Topical steroids are the topical forms of corticosteroids. Topical steroids are the most commonly prescribed topical medications for the treatment of rash, eczema, and dermatitis. Topical steroids have anti-inflammatory properties, and are classified based on their skin vasoconstrictive abilities. There are numerous topical steroid products. All the preparations in each class have the same anti-inflammatory properties, but essentially differ in base and price.

Fluclorolone

Fluclorolone is a synthetic glucocorticoid corticosteroid which was never marketed. The acetonide cyclic ketal of fluclorolone, fluclorolone acetonide, in contrast, has been marketed.

Algestone acetonide

Algestone acetonide, also known as algestone 16α,17α-acetonide or 16α,17α-isopropylidenedioxyprogesterone, is a progestin which was never marketed. It is the acetonide cyclic ketal of algestone. Another progestin, algestone acetophenide, in contrast, has been marketed.

Ciprocinonide

Ciprocinonide, also known as fluocinolone acetonide cyclopropylcarboxylate, is a synthetic glucocorticoid corticosteroid which was never marketed.

Descinolone acetonide

Descinolone acetonide, also known as desoxytriamcinolone acetonide, is a synthetic glucocorticoid corticosteroid which was never marketed.

Procinonide

Procinonide is a synthetic glucocorticoid corticosteroid which was never marketed.

Flupamesone

Flupamesone, also known as triamcinolone acetonide metembonate, is a synthetic glucocorticoid corticosteroid which is marketed in Spain. It is a dimer of a C21 ester of triamcinolone acetonide.

In organic chemistry, pentanonide is a functional group which is composed of a cyclic ketal of a diol with 3-pentanone. It is seen in amcinafal.

In organic chemistry, aminobenzal is a functional group which is composed of a cyclic ketal of a diol with 4-dimethylaminobenzylidene. It is seen in triamcinolone aminobenzal benzamidoisobutyrate.

References

  1. 1 2 Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 282–. ISBN   978-1-4757-2085-3.
  2. 1 2 Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. pp. 455–456. ISBN   978-3-88763-075-1.