Proligestone

Last updated
Proligestone
Proligestone.svg
Clinical data
Trade names Covinan, Delvosteron
Other names14α,17α-Propylidenedioxyprogesterone; 14α,17α-Dihydroxyprogesterone cyclic acetal with propionaldehyde; 14α,17α-Dihydroxypregn-4-ene-3,20-dione cyclic acetal with propionaldehyde
Drug class Progestogen; Progestin
ATC code
Identifiers
  • 14α,17α-(propylidenebis(oxy))pregn-4-ene-3,20-dione
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
ECHA InfoCard 100.041.733 OOjs UI icon edit-ltr-progressive.svg
Chemical and physical data
Formula C24H34O4
Molar mass 386.532 g·mol−1
3D model (JSmol)
  • CCC1O[C@@]23CC[C@]([C@]2(CC[C@H]4[C@H]3CCC5=CC(=O)CC[C@]45C)C)(O1)C(=O)C
  • InChI=1S/C24H34O4/c1-5-20-27-23(15(2)25)12-13-24(28-20)19-7-6-16-14-17(26)8-10-21(16,3)18(19)9-11-22(23,24)4/h14,18-20H,5-13H2,1-4H3/t18-,19+,20?,21-,22+,23-,24+/m0/s1
  • Key:MQSDUYIXZDSLSZ-QSDCUGRSSA-N

Proligestone, sold under the brand names Covinan and Delvosteron, is a progestin medication which is used in veterinary medicine. [1] [2] [3]

Contents

Uses

Veterinary

Proligestone is used to control estrus in dogs and cats and has also been used to treat hypersexuality in dogs and cats. [4]

Pharmacology

Pharmacodynamics

Proligestone is a progestogen, or an agonist of the progesterone receptor (PR).

Chemistry

Proligestone, also known as 14α,17α-propylidenedioxyprogesterone or as 14α,17α-dihydroxyprogesterone cyclic acetal with propionaldehyde, as well as 14α,17α-propylidenedioxypregn-4-ene-3,20-dione, is a synthetic pregnane steroid and a derivative of progesterone and 17α-hydroxyprogesterone. [1] [2] It is a C14α,17α cyclic ketal of 14α,17α-dihydroxyprogesterone. [5] [6] [7]

History

Proligestone was described as early as 1968 and was introduced for veterinary use in 1975. [1] [8] [9]

Society and culture

Generic names

Proligestone is the generic name of the drug and its INN and BAN. [1] [2] [3]

Brand names

Proligestone is marketed under the brand names Covinan and Delvosteron. [1] [2] [3]

Availability

Proligestone is or has been available for veterinary use in Argentina, Australia, Austria, Belgium, Czechoslovakia, France, Germany, Ireland, Italy, the Netherlands, New Zealand, Poland, South Africa, Switzerland, and the United Kingdom. [2] [3]

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References

  1. 1 2 3 4 5 J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 1025–. ISBN   978-1-4757-2085-3.
  2. 1 2 3 4 5 Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 882–. ISBN   978-3-88763-075-1.
  3. 1 2 3 4 "List of Progestins".
  4. ↑ Mundt, S. (22 April 1981). "Indications for proligestone (Delvosteron) in dogs and cats". Praktische Tierarzt. 62 (12).
  5. ↑ E. E. J. Marler (1976). Pharmacological and Chemical Synonyms: A Collection of Names of Drugs, Pesticides and Other Compounds Drawn from the Medical Literature of the World. Excerpta Medica. p. 376. ISBN   978-90-219-0298-2.
  6. ↑ Martin Negwer; Hans-Georg Scharnow (4 October 2001). Organic-chemical drugs and their synonyms: (an international survey). Wiley-VCH. p. 2569. ISBN   978-3-527-30247-5.
  7. ↑ Medical Subject Headings: Supplementary chemical records. The Library. 1993. p. 965.
  8. ↑ Official Gazette of the United States Patent and Trademark Office: Trademarks. U.S. Department of Commerce, Patent and Trademark Office. 1984. p. 30.
  9. ↑ Vanos JL, Oldenkamp EP (1978). "Oestrus control in bitches with proligestone, a new progestational steroid". J Small Anim Pract. 19 (9): 521–9. doi:10.1111/j.1748-5827.1978.tb05534.x. PMID   567718.


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