List of side effects of estradiol

Last updated May 30, 2025

List of side effects of estradiol which may occur as a result of its use or have been associated with estrogen and/or progestogen therapy includes:^[1]^[2]

Gynecological: changes in vaginal bleeding, dysmenorrhea, increase in size of uterine leiomyomata, vaginitis including vaginal candidiasis, changes in cervical secretion and cervical ectropion, ovarian cancer, endometrial hyperplasia, endometrial cancer, nipple discharge, galactorrhea, fibrocystic breast changes and breast cancer.
Cardiovascular: chest pain, deep and superficial venous thrombosis, pulmonary embolism, thrombophlebitis, myocardial infarction, stroke, and increased blood pressure.
Gastrointestinal: nausea and vomiting, abdominal cramps, bloating, diarrhea, dyspepsia, dysuria, gastritis, cholestatic jaundice, increased incidence of gallbladder disease, pancreatitis, or enlargement of hepatic hemangiomas.
Cutaneous: chloasma or melasma (which may continue despite discontinuation of the drug), erythema multiforme, erythema nodosum, otitis media, hemorrhagic eruption, loss of scalp hair, pruritus, or rash.
Ocular: retinal vascular thrombosis, steepening of corneal curvature or intolerance to contact lenses.
Central: headache, migraine, dizziness, chorea, nervousness/anxiety, mood disturbances, irritability, changes in libido, worsening of epilepsy, and increased risk of dementia.
Others: changes in weight, reduced carbohydrate tolerance, worsening of porphyria, edema, arthralgias, bronchitis, leg cramps, hemorrhoids, urticaria, angioedema, anaphylactic reactions, syncope, toothache, tooth disorder, urinary incontinence, hypocalcemia, exacerbation of asthma, and increased triglycerides.

References

↑ Warner Chilcott (March 2005). "ESTRACE TABLETS, (estradiol tablets, USP)" (PDF). fda.gov. Archived from the original (PDF) on November 28, 2016. Retrieved 27 November 2016.
↑ Pfizer (August 2008). "ESTRING (estradiol vaginal ring)" (PDF). Archived from the original (PDF) on 2010-01-17. Retrieved 2018-06-29.

External links

All Side Effects Archived 2020-07-05 at the Wayback Machine

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[EstraceLabel-1] Warner Chilcott (March 2005). "ESTRACE TABLETS, (estradiol tablets, USP)" (PDF). fda.gov. Archived from the original (PDF) on November 28, 2016. Retrieved 27 November 2016.

[EstringLabel-2] Pfizer (August 2008). "ESTRING (estradiol vaginal ring)" (PDF). Archived from the original (PDF) on 2010-01-17. Retrieved 2018-06-29.

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