| Rank | Building | Image | City | Height ft (m) | Floors | Year built | Notes |
|---|---|---|---|---|---|---|---|
| 1 | Beau Rivage Casino Hotel | | Biloxi | 346 feet (105 m) | 32 | 1999 | Tallest building in Biloxi, and all of Mississippi. Like many on this list, damaged by both Hurricane Katrina and Hurricane Georges. [1] |
| 2 | IP Casino Hotel | | Biloxi | 335 feet (102 m) | 32 | 1997 | Tallest building in Mississippi from 1997 to 1999. [2] |
| 3 | Regions Plaza | | Jackson | 318 feet (97 m) | 22 | 1975 | Tallest building in Jackson since its completion in 1975. [3] |
| 4 | Gold Strike Casino Hotel | Tunica Resorts | 317 feet (97 m) | 31 | 1998 | [4] | |
| 5 | Golden Moon Hotel Casino | Philadelphia | 310 feet (94 m) | 22 | 2000 | [5] |