MST4

STK26
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3GGF, 3W8I, 4FZA, 4FZD, 4FZF, 4GEH
Identifiers
Aliases	STK26 , MASK, MST4, serine/threonine protein kinase 26, serine/threonine kinase 26
External IDs	OMIM: 300547 MGI: 1917665 HomoloGene: 84402 GeneCards: STK26
Gene location (Human) Chr. X chromosome (human) [1] Band Xq26.2 Start 132,023,302 bp [1] End 132,075,943 bp [1]
Gene location (Mouse) Chr. X chromosome (mouse) [2] Band X|X A5 Start 49,929,924 bp [2] End 49,981,974 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in germinal epithelium tibia palpebral conjunctiva seminal vesicula bone marrow spongy bone amniotic fluid parietal pleura corpus epididymis placenta Top expressed in abdominal wall condyle endocardial cushion superior cervical ganglion parotid gland blood pineal gland maxillary prominence thymus hair follicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity protein kinase activity nucleotide binding protein homodimerization activity metal ion binding kinase activity protein binding identical protein binding ATP binding magnesium ion binding protein serine/threonine kinase activity MAP kinase kinase kinase kinase activity Cellular component cytoplasm cytosol Golgi apparatus Golgi membrane Golgi-associated vesicle apical plasma membrane perinuclear region of cytoplasm extracellular exosome cell periphery vesicle membrane membrane Biological process regulation of apoptotic process microvillus assembly phosphorylation regulation of hydrogen peroxide-induced cell death protein phosphorylation protein autophosphorylation response to hydrogen peroxide apoptotic process execution phase of apoptosis cellular response to starvation negative regulation of cell migration MAPK cascade regulation of mitotic cell cycle stress-activated protein kinase signaling cascade neuron projection morphogenesis signal transduction activation of protein kinase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51765 70415 Ensembl ENSG00000134602 ENSMUSG00000031112 UniProt Q9P289 Q99JT2 RefSeq (mRNA) NM_001042452 NM_001042453 NM_016542 NM_133729 NM_001313744 RefSeq (protein) NP_001035917 NP_001035918 NP_057626 NP_001300673 NP_598490 Location (UCSC) Chr X: 132.02 – 132.08 Mb Chr X: 49.93 – 49.98 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Serine/threonine protein kinase MST4, also known as mammalian STE20-like protein kinase 4 (MST-4), is a protein that in humans is encoded by the MST4 gene. ^[5]

Function

The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. ^[5]

Interactions

RP6-213H19.1 has been shown to interact with:

• CTTNBP2NL, ^[6]
• CTTNBP2, ^[6]
• FAM40A, ^[6]
• MOBKL3, ^[6]
• PDCD10, ^[6]
• STRN3, ^[6] and
• STRN. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000134602 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031112 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: RP6-213H19.1 serine/threonine protein kinase MST4".
6. Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (January 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Mol. Cell. Proteomics. 8 (1): 157–71. doi: 10.1074/mcp.M800266-MCP200 . PMC   2621004 . PMID   18782753.

Further reading

• Liu KC, Wang D (1975). "[Synthesis of n-substituted beta-methyl DL-aspartates as potential hypocholesteremics (author's transl)]". Archiv der Pharmazie. 308 (7): 564–70. doi:10.1002/ardp.19753080712. PMID   1164178. S2CID   82913379.
• Qian Z, Lin C, Espinosa R, LeBeau M, Rosner MR (2001). "Cloning and characterization of MST4, a novel Ste20-like kinase". J. Biol. Chem. 276 (25): 22439–45. doi: 10.1074/jbc.M009323200 . PMID   11306563.
• Dan I, Watanabe NM, Kusumi A (2001). "The Ste20 group kinases as regulators of MAP kinase cascades". Trends Cell Biol. 11 (5): 220–30. doi:10.1016/S0962-8924(01)01980-8. PMID   11316611.
• Lin JL, Chen HC, Fang HI, Robinson D, Kung HJ, Shih HM (2001). "MST4, a new Ste20-related kinase that mediates cell growth and transformation via modulating ERK pathway". Oncogene. 20 (45): 6559–69. doi:10.1038/sj.onc.1204818. PMID   11641781. S2CID   27885152.
• Dan I, Ong SE, Watanabe NM, Blagoev B, Nielsen MM, Kajikawa E, Kristiansen TZ, Mann M, Pandey A (2002). "Cloning of MASK, a novel member of the mammalian germinal center kinase III subfamily, with apoptosis-inducing properties". J. Biol. Chem. 277 (8): 5929–39. doi: 10.1074/jbc.M110882200 . PMID   11741893.
• Sung V, Luo W, Qian D, Lee I, Jallal B, Gishizky M (2003). "The Ste20 kinase MST4 plays a role in prostate cancer progression". Cancer Res. 63 (12): 3356–63. PMID   12810671.
• Preisinger C, Short B, De Corte V, Bruyneel E, Haas A, Kopajtich R, Gettemans J, Barr FA (2004). "YSK1 is activated by the Golgi matrix protein GM130 and plays a role in cell migration through its substrate 14-3-3zeta". J. Cell Biol. 164 (7): 1009–20. doi:10.1083/jcb.200310061. PMC   2172068 . PMID   15037601.
• Chan EH, Nousiainen M, Chalamalasetty RB, Schäfer A, Nigg EA, Silljé HH (2005). "The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1". Oncogene. 24 (12): 2076–86. doi:10.1038/sj.onc.1208445. PMID   15688006. S2CID   27285160.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Ma X, Zhao H, Shan J, Long F, Chen Y, Chen Y, Zhang Y, Han X, Ma D (2007). "PDCD10 interacts with Ste20-related kinase MST4 to promote cell growth and transformation via modulation of the ERK pathway". Mol. Biol. Cell. 18 (6): 1965–78. doi:10.1091/mbc.E06-07-0608. PMC   1877091 . PMID   17360971.