Madurella grisea

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Madurella grisea
Madurella grisea PHIL 4158 lores.jpg
Scientific classification
Kingdom: Fungi
Phylum: Ascomycota
Class: Sordariomycetes
Order: Sordariales
Family: Incertae sedis
Genus: Madurella
Species:M. grisea
Binomial name
Madurella grisea

Madurella grisea is a fungal species of the genus Madurella . [1] Along with Exophiala jeanselmei , Madurella grisea is one of the most common pathogenic agents associated with eumycetoma. [2]

<i>Madurella</i> genus of fungi

Madurella is a genus of fungus of the Hyphomycetes class.

Exophiala jeanselmei is a saprotrophic fungus in the family Herpotrichiellaceae. Four varieties have been discovered: Exophiala jeanselmei var. heteromorpha, E. jeanselmei var. lecanii-corni, E. jeanselmei var. jeanselmei, and E. jeanselmei var. castellanii. Other species in the genus Exophiala such as E. dermatitidis and E. spinifera have been reported to have similar annellidic conidiogenesis and may therefore be difficult to differentiate.

Eumycetoma chronic granulomatous[1] fungal disease[2] of humans, affecting mainly the limbs, and sometimes the abdominal and chest walls or the head

Eumycetoma is a chronic granulomatous fungal disease of humans, affecting mainly the limbs, and sometimes the abdominal and chest walls or the head. Mycetoma pedis, the most common form of mycetoma, is known widely as the Madura foot. The infection is endemic in Africa, India and Central and South America.

Contents

Laboratory characteristics

Colonies of Madurella grisea are slow growing, dark, leathery, and folded with radial grooves and with a light brown to greyish surface mycelium. With age, colonies become dark- to reddish-brown and acquire a brownish-black reverse. Microscopically, cultures are sterile, although hyphae of two widths have been described: thin at 1 to 3 um in width, and broad at 3 to 5 um in width. The optimum temperature of growth for M. grisea is 30C, it does not grow at 37C. RG-2 organism.

Grains of Madurella grisea (tissue microcolonies) are black, round to lobed, soft to firm, up to 1.0 mm, with two distinctive zones, a hyaline to weakly pigmented central zone and a deeply pigmented periphery.

M. grisea can be distinguished from Madurella mycetomatis by the inability to grow at 37C or assimilate lactose.

MIC data for Madurella grisea is limited. Antifungal susceptibility testing of individual strains is recommended.

Antifungal MIC ug/mL Antifungal MIC ug/mL Antifungal MIC ug/mL Range Range Range Amphotericin B 0.25 Itraconazole 0.5 Voriconazole 0.5

Clinical significance

The genus Madurella is based on tissue morphology (mycetoma with black grains) and the formation of sterile cultures on mycological media and is in need of revision. Both M. mycetomatis and M. grisea have been isolated from soil and are one of the major causative agents of mycetoma.

Mycosis: Mycetoma

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References

  1. Vilela R, Duarte OM, Rosa CA, et al. (November 2004). "A case of eumycetoma due to Madurella grisea in northern Brazil" (PDF). Mycopathologia. 158 (4): 415–8. doi:10.1007/s11046-004-2844-y. PMID   15630550.
  2. Cynthia Nau Cornelissen; Bruce D. Fisher; Richard A. Harvey (eds.). Lippincott's Illustrated Reviews: Microbiologyy (3 ed.). Wolters Kluwer. p. 209.

Kwon-Chung, K.J. and J.E. Bennett. 1992. Medical Mycology. Lea & Febiger, Philadelphia and London. http://www.mycology.adelaide.edu.au/Fungal_Descriptions/Hyphomycetes_(hyaline)/Madurella/grisea.html