Names | |
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Preferred IUPAC name 1,3,6-Trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one | |
Other names alpha-mangostin | |
Identifiers | |
3D model (JSmol) | |
ChEBI | |
ChEMBL | |
ChemSpider | |
ECHA InfoCard | 100.208.637 |
PubChem CID | |
UNII | |
CompTox Dashboard (EPA) | |
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Properties | |
C24H26O6 | |
Molar mass | 410.466 g·mol−1 |
Appearance | Yellow crystalline solid |
Density | 1.265 g/ml |
Melting point | 182 °C (360 °F; 455 K) |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). |
Mangostin is a natural xanthonoid, a type of organic compound isolated from various parts of the mangosteen tree (Garcinia mangostana). It is a yellow crystalline solid with a xanthone core structure.
The rind of partially ripe mangosteen fruit yields mangostin and also the related compound β-mangostin. Researchers conducted the optimization steps in order to increase the yield of α-mangostin extraction from the pericarp of the mangosteen and was able to achieve 9.2 g/kg DW. [1] The rind of fully ripe fruits also contains the xanthonoids gartanin, 8-disoxygartanin, and normangostin.[ citation needed ]
Mangostin and a variety of other xanthonoids from mangosteen have been investigated for biological properties including antioxidant, anti-bacterial, anti-inflammatory, and anticancer activities. [2]
In animal studies, mangostin has been found to be a central nervous system depressant which causes sedation, decreased motor activity, and ptosis. [3] [ better source needed ]
A derivative of mangostin, mangostin-3,6-di-O-glucoside, is a central nervous system depressant and causes a rise in blood pressure.[ citation needed ]
Methcathinone is a monoamine alkaloid and psychoactive stimulant, a substituted cathinone. It is used as a recreational drug due to its potent stimulant and euphoric effects and is considered to be addictive, with both physical and psychological withdrawal occurring if its use is discontinued after prolonged or high-dosage administration. It is usually snorted, but can be smoked, injected, or taken orally.
Mangosteen, also known as the purple mangosteen, is a tropical evergreen tree with edible fruit tree native to Island Southeast Asia, from the Malay Peninsula to Borneo. It has been cultivated extensively in tropical Asia since ancient times. It is grown mainly in Southeast Asia, southwest India and other tropical areas such as Colombia, Puerto Rico and Florida, where the tree has been introduced. The tree grows from 6 to 25 m tall.
Garcinia is a genus of flowering plants in the family Clusiaceae native to Asia, America, Australia, tropical and southern Africa, and Polynesia. The number of species is disputed; Plants of the World Online (POWO) recognise up to 400. Commonly, the plants in this genus are called saptrees, mangosteens, or garcinias, and is one of several plants known as by the name "monkey fruit".
Xango, LLC, was a privately owned Lehi, Utah-based multi-level marketing company founded in 2002. It was acquired by Zija International in May 2017.
Garcinia gummi-gutta is a tropical species of Garcinia native to South Asia and Southeast Asia. Common names include Garcinia cambogia, as well as brindle berry, and Malabar tamarind. The fruit looks like a small pumpkin and is green to pale yellow in color.
Xanthone is an organic compound with the molecular formula O[C6H4]2CO. It is a white solid.
In botany, a berry is a fleshy fruit without a stone (pit) produced from a single flower containing one ovary. Berries so defined include grapes, currants, and tomatoes, as well as cucumbers, eggplants (aubergines), persimmons and bananas, but exclude certain fruits that meet the culinary definition of berries, such as strawberries and raspberries. The berry is the most common type of fleshy fruit in which the entire outer layer of the ovary wall ripens into a potentially edible "pericarp". Berries may be formed from one or more carpels from the same flower. The seeds are usually embedded in the fleshy interior of the ovary, but there are some non-fleshy exceptions, such as Capsicum species, with air rather than pulp around their seeds.
Etaqualone is a quinazolinone-class GABAergic and is an analogue of methaqualone that was developed in the 1960s and marketed mainly in France and some other European countries. It has sedative, hypnotic, muscle relaxant and central nervous system depressant properties resulting from its agonist activity at the β-subtype of the GABAA receptor, and was used for the treatment of insomnia.
A serotonin antagonist, or serotonin receptor antagonist, is a drug used to inhibit the action of serotonin and serotonergic drugs at serotonin (5-HT) receptors.
Apamin is an 18 amino acid globular peptide neurotoxin found in apitoxin (bee venom). Dry bee venom consists of 2–3% of apamin. Apamin selectively blocks SK channels, a type of Ca2+-activated K+ channel expressed in the central nervous system. Toxicity is caused by only a few amino acids, in particular cysteine1, lysine4, arginine13, arginine14 and histidine18. These amino acids are involved in the binding of apamin to the Ca2+-activated K+ channel. Due to its specificity for SK channels, apamin is used as a drug in biomedical research to study the electrical properties of SK channels and their role in the afterhyperpolarizations occurring immediately following an action potential.
Garcinia morella is a species of tree in the family Clusiaceae found in India, and Sri Lanka.
Mangiferin is a glucosylxanthone (xanthonoid). This molecule is a glucoside of norathyriol.
A xanthonoid is a chemical natural phenolic compound formed from the xanthone backbone. Many members of the Clusiaceae contain xanthonoids.
Gambogic acid is a xanthonoid that is derived from the brownish or orange resin from Garcinia hanburyi. Garcinia hanburyi is a small to medium-sized evergreen tree with smooth grey bark. It is native to Cambodia, southern Vietnam, and Thailand and has been successfully introduced in Singapore.
The pomegranate ellagitannins, which include punicalagin isomers, are ellagitannins found in the sarcotestas, rind (peel), bark or heartwood of the pomegranate fruit.
In pharmacology, GABAA receptor positive allosteric modulators, also known as GABAkines or GABAA receptor potentiators, are positive allosteric modulator (PAM) molecules that increase the activity of the GABAA receptor protein in the vertebrate central nervous system.
Garcinia pedunculata is an evergreen tree related to the purple mangosteen. The tree is endemic to the south-eastern regions of Asia such as parts of Myanmar, Bangladesh and north-eastern parts of India. It is popularly known in India as Amlavetasa, in Bangladesh as Thoikor or Taikor and in Assam as Bor Thekera(বৰ থেকেৰা ).
Garcinia cowa, commonly known as cowa fruit or cowa mangosteen is an evergreen plant with edible fruit native to Asia, India, Bangladesh, Myanmar, Malaysia, Vietnam, Laos, Cambodia, and southwest China. The tree is harvested from the wild for its edible fruits and leaves, which are used locally. Flowers are yellow, male & female flowers are separated.
Garcinia forbesii, commonly known as the rose kandis or kandis, is a small to medium-sized tree in the family Clusiaceae (Guttiferae). The specific epithet (forbesii) honors Scottish naturalist Henry Ogg Forbes.
Lichexanthone is an organic compound in the structural class of chemicals known as xanthones. Lichexanthone was first isolated and identified by Japanese chemists from a species of leafy lichen in the 1940s. The compound is known to occur in many lichens, and it is important in the taxonomy of species in several genera, such as Pertusaria and Pyxine. More than a dozen lichen species have a variation of the word lichexanthone incorporated as part of their binomial name. The presence of lichexanthone in lichens causes them to fluoresce a greenish-yellow colour under long-wavelength UV light; this feature is used to help identify some species. Lichexanthone is also found in several plants, and some species of fungi that do not form lichens.