Sir Melvyn Greaves | |
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Born | 12 September 1941 |
Alma mater | University College London |
Scientific career | |
Institutions | |
Website | www |
Sir Melvyn Francis Greaves (born 12 September 1941) is a British cancer biologist, and Professor of Cell Biology at the Institute of Cancer Research (ICR) in London. [1] He is noted for his research into childhood leukaemia and the roles of evolution in cancer, including important discoveries in the genetics and molecular biology underpinning leukaemia. [2] [3]
Greaves initially trained in zoology and immunology, earning a PhD degree in 1968 from University College London.[ citation needed ]
In the mid-1970s his research turned to leukaemia, an interest he attributes to a tour of Great Ormond Street Hospital. He worked at the Imperial Cancer Research Fund laboratories at Lincoln's Inn Fields (now part of the Francis Crick Institute) before moving to the ICR in 1984. [4] At the ICR he served as Director of the Leukaemia Research Fund's Centre for Cell and Molecular Biology of Leukaemia from 1984-2003, and launched the Centre for Cancer Evolution in 2013. [5]
Greaves awards and honours include:
Angela Vincent is a British neurosurgeon who is emeritus professor at the University of Oxford and a Fellow of Somerville College, Oxford.
Sir Alan Roy Fersht is a British chemist at the MRC Laboratory of Molecular Biology, Cambridge, and an Emeritus Professor in the Department of Chemistry at the University of Cambridge. He was Master of Gonville and Caius College, Cambridge from 2012 to 2018. He works on protein folding, and is sometimes described as a founder of protein engineering.
Sir Gregory Paul Winter is a Nobel Prize-winning English molecular biologist best known for his work on the therapeutic use of monoclonal antibodies. His research career has been based almost entirely at the MRC Laboratory of Molecular Biology and the MRC Centre for Protein Engineering, in Cambridge, England.
Tak Wah Mak, is a Canadian medical researcher, geneticist, oncologist, and biochemist. He first became widely known for his discovery of the T-cell receptor in 1983 and pioneering work in the genetics of immunology. In 1995, Mak published a landmark paper on the discovery of the function of the immune checkpoint protein CTLA-4, thus opening the path for immunotherapy/checkpoint inhibitors as a means of cancer treatment. Mak is also the founder of Agios Pharmaceuticals, whose lead compound, IDHIFA®, was approved by the FDA for acute myeloid leukemia in August 2017, becoming the first drug specifically targeting cancer metabolism to be used for cancer treatment. He has worked in a variety of areas including biochemistry, immunology, and cancer genetics.
Richard Henderson is a British molecular biologist and biophysicist and pioneer in the field of electron microscopy of biological molecules. Henderson shared the Nobel Prize in Chemistry in 2017 with Jacques Dubochet and Joachim Frank. "Thanks to his work, we can look at individual atoms of living nature, thanks to cryo-electron microscopes we can see details without destroying samples, and for this he won the Nobel Prize in Chemistry."
Dame Carol Vivien Robinson, is a British chemist and former president of the Royal Society of Chemistry (2018–2020). She was a Royal Society Research Professor and is the Dr Lee's Professor of Physical and Theoretical Chemistry, and a professorial fellow at Exeter College, University of Oxford. She is the founding director of the Kavli Institute for Nanoscience Discovery, University of Oxford, and she was previously professor of mass spectrometry at the chemistry department of the University of Cambridge.
Christopher John Marshall FRS FMedSci was a British scientist who worked as director of the Division for Cancer Biology at the Institute of Cancer Research. Marshall was distinguished for research in the field of tumour cell signalling. His track record includes the discovery of the N-Ras oncogene , the identification of farnesylation of Ras proteins, and the discovery that Ras signals through the MAPK/ERK pathway. These findings have led to therapeutic development of inhibitors of Ras farnesylation, MEK and B-Raf.
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Sir Tony Kouzarides, FMedSci, FRS is a senior group leader Gurdon Institute, a founding non-executive director of Abcam and a Professor of Cancer Biology at the University of Cambridge.
Terence Howard Rabbitts FRS FMedSci is currently Professor of Molecular Immunology at the Institute of Cancer Research, London.
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Edith Yvonne Jones is a British molecular biologist who is director of the Cancer Research UK Receptor Structure Research Group at the University of Oxford and a Fellow of Jesus College, Oxford. She is widely known for her research on the molecular biology of cell surface receptors and signalling complexes.
Tessa Laurie Holyoake, was a Scottish haematology-oncology physician. She specialised in chronic myeloid leukaemia (CML), and discovered its stem cell. She was considered a world leading expert in leukaemia research.
Richard Malcolm Marais a British researcher who is Director of the Cancer Research UK (CRUK) Manchester Institute and Professor of Molecular Oncology at the University of Manchester.
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Freda Kathryn Stevenson is a British immunologist and Professor at the University of Southampton. She was elected a Fellow of the Academy of Medical Sciences in 2000, and was the first British researcher to be awarded the American Society of Hematology Henry M. Stratton Medal.
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