Michael M. Gottesman

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Michael M. Gottesman
Michael Gottesman (41871897991).jpg
Born (1946-10-07) October 7, 1946 (age 78)
Jersey City, New Jersey, U.S.
Education Harvard University
Known forImpact of silent polymorphisms on tertiary structure and function
Scientific career
FieldsBiochemistry
Institutions Peter Dent Brigham Hospital, Boston; Harvard University; National Institutes of Health

Michael M. Gottesman (born October 7, 1946, in Jersey City, New Jersey [1] ) is an American biochemist and physician-scientist. He was the deputy director (Intramural) of the National Institutes of Health (NIH) in the United States and also Chief of the Laboratory of Cell Biology at the National Cancer Institute (NCI) within the NIH. [2]

Contents

Early life and education

He graduated summa cum laude in biochemical sciences in 1966 from Harvard College, and received his M.D. magna cum laude from Harvard Medical School in 1970. [1]

Gottesman completed his internship and residency at the Peter Bent Brigham Hospital in Boston, Massachusetts. [3]

Career

Gottesman was an assistant professor at Harvard for one year before taking a permanent position at the NIH in 1976. [3]

He served as deputy director of the NIH Intramural Research Program from 1994-2022. [4] On August 1, 2022, Gottesman was succeeded as director of the NIH Intramural Research Program by pediatric neurologist Nina F. Schor. [5] As of 2023, he serves as the deputy director of intramural research and is chief of the Laboratory of Cell Biology. [3]

Research

His areas of expertise includes a major contribution to the discovery of P-glycoprotein (MDR1, ABCB1), the multidrug resistance efflux transporter associated with clinical resistance to anti-cancer agents. [6] [7] In 2007, he reported for the first time in Science magazine that silent polymorphisms can impact the tertiary structure and function of a protein. [8]

Awards and distinctions

Gottesman is an elected member of the American Association for the Advancement of Science (1988), the National Academy of Medicine (2003), the Association of American Physicians (2006), the American Academy of Arts and Sciences (2010), and the National Academy of Sciences (2018).

Gottesman received the 2013 Paul A. Volcker Career Achievement Award [9] , and in 2018, the American Medical Association (AMA) awarded Gottesman the Dr. Nathan Davis Award for Outstanding Government Service. [10]

References

  1. 1 2 Pharmacology Conference Speakers Archived January 16, 2009, at the Wayback Machine , Office of Research on Women's Health. Accessed April 20, 2023. "Michael Marc Gottesman was born on October 7, 1946 in Jersey City, New Jersey, and grew up in Flushing, New York."
  2. ↑ Staff profile Archived 2010-05-27 at the Wayback Machine , NCI, retrieved 2010-02-28.
  3. 1 2 3 "Michael M. Gottesman, M.D. | Principal Investigators | NIH Intramural Research Program". irp.nih.gov. Retrieved 2025-03-06.
  4. ↑ "Michael Gottesman, M.D." National Institutes of Health (NIH). 2015-08-07. Retrieved 2025-03-06.
  5. ↑ "Dr. Nina Schor appointed as the NIH Acting Deputy Director for Intramural Research". National Institutes of Health (NIH). 2022-07-13. Retrieved 2022-07-29.
  6. ↑ Chen, Chang-jie; Chin, Janice E.; Ueda, Kazumitsu; Clark, Douglas P.; Pastan, Ira; Gottesman, Michael M.; Roninson, Igor B. (1986), "Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells", Cell , 47 (3): 381–389, doi:10.1016/0092-8674(86)90595-7, PMID   2876781, S2CID   20431107 .
  7. ↑ Thiebaut, F.; Tsuruo, T.; Hamada, H.; Gottesman, M. M.; Pastan, I.; Willingham, M. C. (1987), "Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues", Proceedings of the National Academy of Sciences , 84 (21): 7735–7738, Bibcode:1987PNAS...84.7735T, doi: 10.1073/pnas.84.21.7735 , PMC   299375 , PMID   2444983 .
  8. ↑ Kimchi-Sarfaty, Chava; Oh, Jung Mi; Kim, In-Wha; Sauna, Zuben E.; Calcagno, Anna Maria; Ambudkar, Suresh V.; Gottesman, Michael M. (2007), "A "silent" polymorphism in the MDR1 gene changes substrate specificity", Science , 315 (5811): 525–528, Bibcode:2007Sci...315..525K, doi: 10.1126/science.1135308 , PMID   17185560, S2CID   15146955 .
  9. ↑ Medals, Samuel J. Heyman Service to America. "Michael Gottesman". Samuel J. Heyman Service to America Medals. Retrieved 2025-03-11.
  10. ↑ "Past Recipients of the Nathan Davis Awards" (PDF). 2019. Retrieved March 11, 2025.


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