Interstate 59 (I-59) is an Interstate Highway located in the southeastern United States. It is a north–south route that spans 445.23 miles (716.53 km) from a junction with I-10 and I-12 at Slidell, Louisiana, to a junction with I-24 near Wildwood, Georgia.
Picayune is the largest city in Pearl River County, Mississippi, United States. The population was 11,885 at the 2020 census. The city is located approximately 45 miles (72 km) from New Orleans, Hattiesburg, and Gulfport–Biloxi. The Stennis Space Center is 10 miles (16 km) away. Picayune is part of the New Orleans–Metairie–Hammond combined statistical area.
Mississippi Highway 2 is a designation for two highways in northern Mississippi. The westernmost segment starts at MS 5 in Hickory Flat, and ends at MS 15 and MS 368 in Blue Mountain. The eastern segment starts at MS 4 near Ripley and it travels northeastwards towards Corinth. The route becomes concurrent with U.S. Route 72 and US 45 in Corinth, and ends at the Tennessee state line. The road continues as Tennessee State Route 22. The route was designated around 1932, from the state line near Mount Pleasant to the state line near Corinth. The section west of Corinth became a part of US 72 by 1935, and the route was extended southwestwards to Hickory Flat by 1958.
Mississippi Highway 5 is a state highway in Benton County, Mississippi, United States. It runs 24.3 mi (39.107 km) from MS 178 in Hickory Flat north to U.S. Route 72 to the south of Michigan City. The route runs through the Holly Springs National Forest for much of its length and passes through Ashland. To the south of Ashland, MS 5 has a concurrency with MS 4. The MS 5 designation was first used by 1932 for an unpaved road between Hickory Flat and the Tennessee border in Michigan City. In 1943, the northern terminus was cut back to US 72. MS 5 was completely paved by 1951 and has retained its current alignment since then.
Mississippi Highway 43 is a state highway in Mississippi that generally runs north–south in three segments: the first from US 90 near Bay St. Louis to MS 13 south of Columbia, resuming at MS 13 in southern Jefferson Davis County to end near Mendenhall, and finally starting again at MS 18 near Puckett to end at Attala Road 3122 in northern Attala County. It traverses approximately 235 miles (378 km), serving Hancock, Pearl River, Marion, Jefferson Davis, Lawrence, Simpson, Rankin, Madison, Leake, and Attala counties.
Interstate 10 (I-10), a major east–west Interstate Highway in the southern areas of the United States, has a section of about 77 miles (124 km) in Mississippi.
Mississippi Highway 53 is a state highway in Mississippi. The highway starts at U.S. Highway 49 in Gulfport and travels northwestward to MS 603 in Hancock County. The road then travels north to Poplarville, meeting Interstate 59 (I-59). MS 53 ends at MS 26 and US 11 in southwestern Poplarville. The road that became MS 53 has existed since 1928, and the highway was designated in 1950. The highway was completely paved by 1957, and an interchange was created at I-59 in 1967.
U.S. Highway 11 (US 11) is a part of the United States Numbered Highway System that spans 1,645 miles (2,647 km) from New Orleans, Louisiana, to Rouses Point, New York. Within the state of Louisiana, the highway travels 31 miles (50 km) from the national southern terminus at US 90 in New Orleans to the Mississippi state line south of Picayune.
Mississippi Highway 450 is a highway in western Mississippi. Its western terminus is at MS 1 south of Benoit. The route travels east to its eastern terminus at U.S. Route 61 and US 278. It was designated in 1956, starting at MS 1 south of Scott, and ending at Choctaw. Starting in 1962, the section near Stringtown was rerouted significantly. The last realignment was in 1974, where the section near Stringtown was straightened, and US 61 moved east of Choctaw.
Mississippi Highway 465 is a highway in the southern region of the Mississippi Delta. The highway starts at U.S. Route 61 near Redwood. It travels westward towards the Mississippi River, and then northwards to the village of Eagle Bend. The highway then traverses on the Mississippi River levee on a one-lane road. Later, MS 465 leaves the levee, continues northward, and soon ends at MS 1.
Mississippi Highway 607 is a state highway in the Mississippi Gulf Coast region. The route starts at U.S. Route 90, and it travels westward to Interstate 10 (I-10). The route has a gap as the road travels through the Stennis Space Center, but resumes north of the center to end at I-59 and US 11 south of Picayune. The road was part of US 11 and US 90, before MS 43 was designated in 1948. MS 607 was created in 1967, after MS 43 was rerouted, and Stennis Space Center was built.
Mississippi Highway 604 (MS 604) is a 5.071-mile-long (8.161 km) state highway on the Mississippi Gulf Coast. Its southern terminus is at U.S. Route 90 (US 90). MS 604 travels northward through Pearlington to its northern terminus at MS 607. The route was designated in 1950, after US 90 was realigned off of it in 1939 onto a new road built in 1936.
Mississippi Highway 332 is a highway in central Mississippi. Its western terminus is at U.S. Route 51 in Grenada. The route travels northeastward through farmland to Grenada Municipal Airport. The road continues to its eastern terminus at Toe Road, southwest of the Grenada Lake. The designation was created in 1958 for a former segment of MS 7, which was rerouted north of the lake.
Mississippi Highway 603 is a 25.0-mile-long (40.2 km) state highway in Hancock County, Mississippi. The highway generally runs north–south from its southern terminus at U.S. Route 90 (US 90) in Waveland through Bay St. Louis and Kiln to its northern terminus at MS 53 near Necaise. The road is maintained by the Mississippi Department of Transportation (MDOT). MDOT and Mississippi's law code define MS 603's southern terminus as its intersection with MS 43 in Kiln. However, many maps such as Google Maps and MapQuest, and local signage show the highway continuing farther south to Waveland.' The road that became MS 603 has existed since 1927, and the highway was designated in 1950. The highway was also partially paved, from Waveland to Kiln, in 1950 and was completely paved in 1957. An interchange was created at Interstate 10 (I-10) in 1960.
Mississippi Highway 569 is a state highway in southwestern Mississippi. The route starts at the Mississippi–Louisiana state line, and it travels northeastward from that point. It intersects MS 48 southwest of Liberty, and MS 569 becomes concurrent with it. Inside Liberty, MS 569 is also concurrent with MS 24 briefly before travelling northeastward out of the city. It continues through Amite County and it ends at U.S. Route 98 in extreme southwestern Lincoln County.
Mississippi Highway 600 was a state highway in southern Mississippi. The route started at U.S. Route 11 in Carriere and traveled eastward. The road crossed from Pearl River County to Hancock County and continued east until it reached MS 603 in Necaise. MS 600 was designated around 1958 from the Pearl River–Hancock county line to MS 603, and it was extended to US 11 by 1960. The route was removed from the state highway system by 1967.
Mississippi Highway 397 (MS 397) is a 33+1⁄2-mile-long (53.9 km) state highway in eastern Mississippi. Running generally in a southeast to northwest direction, it is signed north--south traveling from the De Kalb vicinity at MS 16 to Louisville at MS 14.
Mississippi Highway 407 (MS 407) is a two-lane wide state highway in central Mississippi consisting of two separate segments. The first segment connects the towns of McCool and Weir with MS 12 and is signed a north-south route. The second segment runs from French Camp at MS 413 west to Winona at U.S. Route 51 (US 51). Most of the road is state maintained, however, a 5.5-mile-long (8.9 km) segment between McCool and Weir are maintained as county roads.
Mississippi Highway 590 (MS 590) is a state highway that runs for 22 miles (35 km) from the Seminary area at U.S. Route 49 (US 49) to just outside of Ellisville at MS 29 in the southern portion of Mississippi.
MS 43 near Logtown 
