U.S. Route 400 is a 481.306-mile-long (774.587 km) mostly east–west U.S. Highway, commissioned in 1994. The highway's western terminus is in Granada, Colorado, at an intersection with US 385. The highway's eastern terminus is southwest of Joplin, Missouri, near Loma Linda, at an interchange with Interstate 44, with which it shares with US 166. It originally ended in Garden City, Kansas; in 1996 it was extended to its current western terminus.
U.S. Route 412 is an east–west United States highway, first commissioned in 1982. U.S. 412 overlaps expressway-grade Cimarron Turnpike from Tulsa west to Interstate 35 and the Cherokee Turnpike from 5 miles (8.0 km) east of Chouteau, Oklahoma, to 8 miles (13 km) west of the Arkansas state line. It runs the entire length of the Oklahoma Panhandle and traverses the Missouri Bootheel.
U.S. Route 54 is an east–west United States Highway that runs northeast–southwest for 1,197 miles (1,926 km) from El Paso, Texas, to Griggsville, Illinois. The Union Pacific Railroad's Tucumcari Line runs parallel to US 54 from El Paso to Pratt, Kansas, which comprises about two-thirds of the route.
Route 14 is a state highway traveling through the southern part of the U.S. state of Missouri. Its western terminus is at U.S. Route 60 (US 60) in Marionville, and its eastern terminus is at US 63 on the northern edge of West Plains. Route 14 is a two-lane highway for its entire length, however, there are plans to widen Route 14 in some spots.
Missouri Route 5 is the longest state highway in Missouri and the only Missouri state highway to traverse the entire state. To the north, it continues into Iowa as Iowa Highway 5 and to the south it enters Arkansas as Arkansas Highway 5 as part of a three state 650 mile highway 5. With only a few exceptions, it is mostly a two-lane for its entire length.
Route 13 is a highway in Missouri which runs almost the entire north–south length of the state. Its northern terminus is at U.S. Route 69/136 in Bethany. Its southern terminus is at the Arkansas state line in downtown Blue Eye, Missouri–Arkansas where it continues as Highway 21. It is one of the original state highways of Missouri.
Route 76 is a highway in the west half of southern Missouri running between U.S. Route 60 and U.S. Route 63 at Willow Springs and the Oklahoma state line near Tiff City where it continues as a county road. It bypasses Branson on the Ozark Mountain High Road and is the namesake of the Branson strip, 76 Country Blvd. The road runs for its entirety through the Missouri Ozarks, and is at times very hilly and curvy.
Route 7 is a state highway with its northern terminus at U.S. Route 24 in northeast Independence and its southern terminus at Interstate 44 southeast of Richland. The section between Harrisonville and Clinton provides an important link for traffic between Springfield and Kansas City.
Route 265 is a highway in southwestern Missouri. Its northern terminus is at Interstate 44 in Mount Vernon; its southern terminus is at U.S. Route 65 south of Branson. Much of the highway is concurrent with other routes. It is also known as the Ozark Mountain Parkway.
Route 95 is a highway in southern Missouri. Its northern terminus is at Route 32 at Lynchburg in Laclede County. Its southern terminus is at U.S. Route 160 at Lutie about 2.5 miles west of the Theodosia arm of Bull Shoals Lake in Ozark County.
Route 181 is a highway in southern Missouri. Its southern terminus is at US 160 in Gainesville in Ozark County. It passes through eastern Douglas County and reaches its northern terminus at Business U.S. Route 60 in Cabool in Texas County.
Route 19 is a long state highway in Missouri. Its northern terminus is at U.S. Route 61 in New London and its southern terminus is at U.S. Route 63 on the north side of Thayer. Route 19 is one of Missouri's original 1922 highways, though it initially had a northern terminus at Route 14 in Cuba and was later extended north.
Route 248 is a highway in southwestern Missouri. Its eastern terminus is at U.S. Route 65 in Branson. Its western terminus is at Route 76/Route 86/Route 112 in Cassville.
Route 42 is a highway in central Missouri. Its eastern terminus is at Route 28 south of Belle; its western terminus is at US 54 in Osage Beach.
Route 47 is a highway in eastern Missouri. Its northern terminus is at Route 79 near Winfield; its southern terminus is at U.S. Route 67 in Bonne Terre.
Route 176 is a highway in southwestern Missouri. The eastern terminus is at U.S. Route 160 north of Forsyth; its western terminus is at Route 248/Route 265/Route 413 in Galena.
Route 165 and County Road 165 (CR 165) form a loop around the west side of Branson, Missouri, in Taney and Stone counties. The highway's southern terminus is at U.S. Route 65 (US 65) south of Branson, in Hollister. Even though the county road designation belongs to Taney County, it briefly enters Stone County at Table Rock State Park. Upon re-entering Taney County, it crosses the Table Rock Lake Dam, along with Route 265, at Table Rock Lake. Its northern terminus is at US 65 along the Red Route in north Branson.
Arkansas Highway 23 is a north–south state highway in north Arkansas. The route runs 129.88 miles (209.02 km) from US 71 near Elm Park north to the Missouri state line through Ozark and Eureka Springs. Between AR 16 at Brashears and Interstate 40 north of Ozark, Highway 23 winds through the Ozark National Forest and is designated as the Pig Trail Scenic Byway due to its steep hills and hairpin turns. The route has a strong connection with the University of Arkansas Razorbacks, connecting fans in Central Arkansas with the Northwest Arkansas area.
Highway 21 is a north–south state highway in north central Arkansas. The route of 99.14 miles (159.55 km) runs from US Route 64 (US 64) in Clarksville north across US 62 to Missouri Route 13 at the Missouri state line The route is a two-lane highway with the exception of a brief concurrency with US 62, a four-lane highway, in Berryville.
U.S. Route 54 in Missouri is a west-east highway that runs between the Kansas state line in Nevada, Missouri and the Illinois state line in Louisiana, Missouri.
Route 5 northwest of Sunrise Beach 
US 50 near Smithton 
I-70 / US 40 / Route 41 west of Boonville 
