Modes of mechanical ventilation

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Modes of mechanical ventilation are one of the most important aspects of the usage of mechanical ventilation. The mode refers to the method of inspiratory support. In general, mode selection is based on clinician familiarity and institutional preferences, since there is a paucity of evidence indicating that the mode affects clinical outcome. The most frequently used forms of volume-limited mechanical ventilation are intermittent mandatory ventilation (IMV) and continuous mandatory ventilation (CMV). [1] There have been substantial changes in the nomenclature of mechanical ventilation over the years, but more recently it has become standardized by many respirology and pulmonology groups. [2] [3] Writing a mode is most proper in all capital letters with a dash between the control variable and the strategy (i.e. PC-IMV, or VC-MMV etc.).

Contents

Taxonomy for mechanical ventilation

The taxonomy is a logical classification system based on 10 maxims of ventilator design [4]

10 maxims

  1. A breath is one cycle of positive flow (inspiration) and negative flow (expiration) defined in terms of the flow-time curve. Inspiratory time is defined as the period from the start of positive flow to the start of negative flow. Expiratory time is defined as the period from the start of expiratory flow to the start of inspiratory flow. The flow-time curve is the basis for many variables related to ventilator settings.
  2. A breath is assisted if the ventilator does work on the patient. An assisted breath is one for which the ventilator does some portion of the work of breathing. For constant flow inflation, work is defined as inspiratory pressure multiplied by tidal volume. Therefore, an assisted breath is identified as a breath for which airway pressure (displayed on the ventilator) rises above baseline during inspiration. An unassisted breath is one for which the ventilator simply provides the inspiratory flow demanded by the patient and pressure stays constant throughout the breath.
  3. A ventilator assists breathing using either pressure control or volume control based on the equation of motion for the respiratory system. Providing assistance means doing work on the patient, which is accomplished by controlling either pressure or volume. A simple mathematical model describing this fact is known as the equation of motion for the passive respiratory system:

    Pressure = (Elastance × Volume) + (Resistance × Flow)

    In this equation, pressure, volume, and flow are all continuous functions of time. Pressure is actually a pressure difference across the system (e.g., transrespiratory pressure defined as pressure at the airway opening minus pressure on the body surface). Elastance (defined as the change in pressure divided by the associated change in volume; the reciprocal of compliance) and resistance (defined as a change in pressure divided by the associated change in flow) are parameters assumed to remain constant during a breath.

    Volume control (VC) means that both volume and flow are preset prior to inspiration. In other words, the right hand side of the equation of motion remains constant while pressure changes with changes in elastance and resistance.
    Pressure control (PC) means that inspiratory pressure is preset as either a constant value or it is proportional to the patient's inspiratory effort. In other words, the left-hand side of the equation of motion remains constant while volume and flow change with changes in elastance and resistance.
    Time control (TC) means that, in some rare situations, none of the main variables (pressure, volume, or flow) are preset. In this case only the inspiratory and expiratory times are preset.

  4. Breaths are classified by the criteria that trigger (start) and cycle (stop) inspiration. The start of inspiration is called the trigger event. The end of inspiration is called the cycle event.
  5. Trigger and cycle events can be initiated by the patient or the machine. Inspiration can be patient triggered or patient cycled by a signal representing inspiratory effort. Inspiration may also be machine triggered or machine cycled by preset ventilator thresholds.

    Patient triggering means starting inspiration based on a patient signal independent of a machine trigger signal. Machine triggering means starting inspiratory flow based on a signal from the ventilator, independent of a patient trigger signal. Patient cycling means ending inspiratory time based on signals representing the patient determined components of the equation of motion, (ie, elastance or resistance and including effects due to inspiratory effort). Flow cycling is a form of patient cycling because the rate of flow decay to the cycle threshold is determined by patient mechanics. Machine cycling means ending inspiratory time independent of signals representing the patient determined components of the equation of motion.

  6. Breaths are classified as spontaneous or mandatory based on both the trigger and cycle events. A spontaneous breath is a breath for which the patient both triggers and cycles the breath. A spontaneous breath may occur during a mandatory breath (e.g. Airway Pressure Release Ventilation). A spontaneous breath may be assisted or unassisted. A mandatory breath is a breath for which the machine triggers and/or cycles the breath. A mandatory breath can occur during a spontaneous breath (e.g., High Frequency Jet Ventilation). A mandatory breath is, by definition, assisted.
  7. There are 3 breath sequences: Continuous mandatory ventilation (CMV), Intermittent Mandatory Ventilation (IMV), and Continuous Spontaneous Ventilation (CSV). A breath sequence is a particular pattern of spontaneous and/or mandatory breaths. The 3 possible breath sequences are: continuous mandatory ventilation, (CMV, spontaneous breaths are not allowed between mandatory breaths), intermittent mandatory ventilation (IMV, spontaneous breaths may occur between mandatory breaths), and continuous spontaneous ventilation (CSV, all breaths are spontaneous).
  8. There are 5 basic ventilatory patterns: VC-CMV, VC-IMV, PC-CMV, PC-IMV, and PC-CSV. The combination VC-CSV is not possible because volume control implies machine cycling and machine cycling makes every breath mandatory, not spontaneous. A sixth pattern, TC-IMV is possible but rare.
  9. Within each ventilatory pattern there are several variations that can be distinguished by their targeting scheme(s). A targeting scheme is a description of how the ventilator achieves preset targets. A target is a predetermined goal of ventilator output. Examples of within-breath targets include inspiratory flow or pressure and rise time (set-point targeting), tidal volume (dual targeting) and constant of proportionality between inspiratory pressure and patient effort (servo targeting). Examples of between-breath targets and targeting schemes include average tidal volume (for adaptive targeting), percent minute ventilation (for optimal targeting) and combined PCO2, volume, and frequency values describing a "zone of comfort" (for intelligent targeting, e.g., SmartCarePS or IntelliVent-ASV). The targeting scheme (or combination of targeting schemes) is what distinguishes one ventilatory pattern from another. There are 7 basic targeting schemes that comprise the wide variety seen in different modes of ventilation:

    Set-point: A targeting scheme for which the operator sets all the parameters of the pressure waveform (pressure control modes) or volume and flow waveforms (volume control modes).
    Dual: A targeting scheme that allows the ventilator to switch between volume control and pressure control during a single inspiration.
    Bio-variable: A targeting scheme that allows the ventilator to automatically set the inspiratory pressure or tidal volume randomly to mimic the variability observed during normal breathing.
    Servo: A targeting scheme for which inspiratory pressure is proportional to inspiratory effort.
    Adaptive: A targeting scheme that allows the ventilator to automatically set one target (eg, pressure within a breath) to achieve another target (eg, average tidal volume over several breaths).
    Optimal: A targeting scheme that automatically adjusts the targets of the ventilatory pattern to either minimize or maximize some overall performance characteristic (eg, minimize the work rate done by the ventilatory pattern).
    Intelligent: A targeting scheme that uses artificial intelligence programs such as fuzzy logic, rule based expert systems, and artificial neural networks.

  10. A mode of ventilation is classified according to its control variable, breath sequence, and targeting scheme(s). The preceding 9 maxims create a theoretical foundation for a taxonomy of mechanical ventilation. The taxonomy is based on these theoretical constructs and has 4 hierarchical levels:

The "primary breath" is either the only breath there is (mandatory for CMV and spontaneous for CSV) or it is the mandatory breath in IMV. The targeting schemes can be represented by single, lower case letters: set-point = s, dual = d, servo = r, bio-variable = b, adaptive = a, optimal = o, intelligent = i. A tag is an abbreviation for a mode classification, such as PC-IMVs,s. Compound tags are possible, eg, PC-IMVoi,oi.

How modes are classified

Step 1: Identify the primary breath control variable. If inspiration starts with a preset inspiratory pressure, or if pressure is proportional to inspiratory effort, then the control variable is pressure. If inspiration starts with a preset tidal volume and inspiratory flow, then the control variable is volume. If neither is true, the control variable is time.

Step 2: Identify the breath sequence. Determine whether trigger and cycle events are patient or machine determined. Then, use this information to determine the breath sequence.

Step 3: Identify the targeting schemes for the primary breaths and (if applicable) secondary breaths.

Example mode classification is given below

Mode Name: A/C Volume Control (Covidien PB 840):[ citation needed ]

  1. Inspiratory volume and flow are preset, so the control variable is volume.
  2. Every breath is volume cycled, which is a form of machine cycling. Any breath for which inspiration is machine cycled is classified as a mandatory breath. Hence, the breath sequence is continuous mandatory ventilation.
  3. The operator sets all the parameters of the volume and flow waveforms so the targeting scheme is set-point. Thus, the mode is classified as volume control continuous mandatory ventilation with set-point targeting (VC-CMVs).

Mode Name: SIMV Volume Control Plus (Covidien PB 840):[ citation needed ]

  1. The operator sets the tidal volume but not the inspiratory flow. Because setting volume alone (like setting flow alone) is a necessary but not sufficient criterion for volume control, the control variable is pressure.
  2. Spontaneous breaths are allowed between mandatory breaths so the breath sequence is IMV[ clarification needed ].
  3. The ventilator adjusts inspiratory pressure between breaths to achieve an average preset tidal volume, so the targeting scheme is adaptive. The mode tag is PC-IMVa,s.

Descriptions of common modes

Mechanical ventilation machines are available with both invasive modes (such as intubation) and non-invasive modes (such as BPAP). Invasive has to do with the insertion of medical devices or tubes internal to the patient, while non-invasive is completely external to the patient, as for example in using a tightly fitting mask or other device that covers the patient's nose and mouth.

Assist mode, control mode, and assist-control mode

A basic distinction in mechanical ventilation is whether each breath is initiated by the patient (assist mode) or by the machine (control mode). Dynamic hybrids of the two (assist-control modes) are also possible, and control mode without assist is now mostly obsolete.

Airway pressure release ventilation

Airway pressure release ventilation graph Airway pressure release ventilation graph.png
Airway pressure release ventilation graph

Airway pressure release ventilation is a time-cycled alternant between two levels of positive airway pressure, with the main time on the high level and a brief expiratory release to facilitate ventilation. [5]

Airway pressure release ventilation is usually utilized as a type of inverse ratio ventilation. The exhalation time (Tlow) is shortened to usually less than one second to maintain alveoli inflation. In the basic sense, this is a continuous pressure with a brief release. APRV currently the most efficient conventional mode for lung protective ventilation. [6]

Different perceptions of this mode may exist around the globe. While 'APRV' is common to users in North America, a very similar mode, biphasic positive airway pressure (BIPAP), was introduced in Europe. [7] The term APRV has also been used in American journals where, from the ventilation characteristics, BIPAP would have been perfectly good terminology. [8] But BiPAP(tm) is a trademark for a noninvasive ventilation mode in a specific ventilator (Respironics Inc.).

Other manufacturers have followed with their own brand names (BILEVEL, DUOPAP, BIVENT). Although similar in modality, these terms describe how a mode is intended to inflate the lung, rather than defining the characteristics of synchronization or the way spontaneous breathing efforts are supported.

Intermittent mandatory ventilation has not always had the synchronized feature, so the division of modes were understood to be SIMV (synchronized) vs IMV (not-synchronized). Since the American Association for Respiratory Care established a nomenclature of mechanical ventilation the "synchronized" part of the title has been dropped and now there is only IMV.

Mandatory minute ventilation

Mandatory minute ventilation (MMV) allows spontaneous breathing with automatic adjustments of mandatory ventilation to the meet the patient's preset minimum minute volume requirement. If the patient maintains the minute volume settings for VT x f, no mandatory breaths are delivered.[ citation needed ]

If the patient's minute volume is insufficient, mandatory delivery of the preset tidal volume will occur until the minute volume is achieved. The method for monitoring whether or not the patient is meeting the required minute ventilation (VE) differs by ventilator brand and model, but, in general, there is a window of monitored time, and a smaller window checked against the larger window (i.e., in the Dräger Evita® line of mechanical ventilators there is a moving 20-second window, and every 7 seconds the current tidal volume and rate are measured) to decide whether a mechanical breath is needed to maintain the minute ventilation.[ citation needed ]

MMV is an optimal mode for weaning in neonatal and pediatric populations and has been shown to reduce long-term complications related to mechanical ventilation. [9]

Pressure-regulated volume control

Pressure-regulated volume control is an Assist Controlled Ventilation (ACV) based mode. Pressure-regulated volume control utilizes pressure-limited, volume-targeted, time-cycled breaths that can be either ventilator- or patient-initiated.

The peak inspiratory pressure delivered by the ventilator is varied on a breath-to-breath basis to achieve a target tidal volume that is set by the clinician.

For example, if a target tidal volume of 500 mL is set but the ventilator delivers 600 mL, the next breath will be delivered with a lower inspiratory pressure to achieve a lower tidal volume. Though PRVC is regarded as a hybrid mode because of its tidal-volume (VC) settings and pressure-limiting (PC) settings fundamentally PRVC is a pressure-control mode with adaptive targeting.

Continuous positive airway pressure

Continuous positive airway pressure (CPAP) is a non-invasive positive pressure mode of respiratory support. CPAP is a continuous pressure applied to keep the alveoli open and not fully deflate. This mechanism for maintaining inflated alveoli helps increase partial pressure of oxygen in arterial blood, an appropriate increase in CPAP increases the PaO2.

Automatic positive airway pressure

Automatic positive airway pressure (APAP) is a form of CPAP that automatically tunes the amount of pressure delivered to the patient to the minimum required to maintain an unobstructed airway on a breath-by-breath basis by measuring the resistance in the patient's breathing.

Bilevel positive airway pressure

Bilevel positive airway pressure (BPAP) is a mode used during non-invasive ventilation (NIV). First used in 1988 by Professor Benzer in Austria, [10] it delivers a preset inspiratory positive airway pressure (IPAP) and expiratory positive airway pressure (EPAP). BPAP can be described as a Continuous Positive Airway Pressure system with a time-cycle change of the applied CPAP level. [11]

CPAP/APAP, BPAP, and other non-invasive ventilation modes have been shown to be effective management tools for chronic obstructive pulmonary disease, acute respiratory failure, sleep apnea, etc. [12]

Often BPAP is incorrectly referred to as "BiPAP". BiPAP is the name of a portable ventilator manufactured by Respironics Corporation; it is just one of many ventilators that can deliver BPAP.

Medical uses

BPAP has been shown to be useful in reducing mortality and reducing the need for endotracheal intubation when used in people with chronic obstructive pulmonary disease (COPD). [13] [14]

High-frequency ventilation (Active)

The term active refers to the ventilator's forced expiratory system. In a HFV-A scenario, the ventilator uses pressure to apply an inspiratory breath and then applies an opposite pressure to force an expiratory breath. In high-frequency oscillatory ventilation (sometimes abbreviated HFOV) the oscillation bellows and piston force positive pressure in and apply negative pressure to force an expiration. [15]

High-frequency ventilation (Passive)

The term passive refers to the ventilator's non-forced expiratory system. In a HFV-P scenario, the ventilator uses pressure to apply an inspiratory breath and then returns to atmospheric pressure to allow for a passive expiration. This is seen in High-Frequency Jet Ventilation, sometimes abbreviated HFJV. Also categorized under High Frequency Ventilation is High Frequency Percussive Ventilation, sometimes abbreviated HFPV. With HFPV it utilizes an open circuit to deliver its subtidal volumes by way of the patient interface known as the Phasitron.

Volume guarantee

Volume guarantee an additional parameter available in many types of ventilators that allows the ventilator to change its inspiratory pressure setting to achieve a minimum tidal volume. This is utilized most often in neonatal patients who need a pressure controlled mode with a consideration for volume control to minimize volutrauma.

Spontaneous breathing and support settings

Positive end-expiratory pressure

Positive end expiratory pressure (PEEP) is pressure applied upon expiration. PEEP is applied using either a valve that is connected to the expiratory port and set manually or a valve managed internally by a mechanical ventilator.

PEEP is a pressure that an exhalation has to bypass, in effect causing alveoli to remain open and not fully deflate. This mechanism for maintaining inflated alveoli helps increase partial pressure of oxygen in arterial blood, and an increase in PEEP increases the PaO2. [16]

Pressure support

Pressure support is a spontaneous mode of ventilation also named Pressure Support Ventilation (PSV). The patient initiates every breath and the ventilator delivers support with the preset pressure value. With support from the ventilator, the patient also regulates their own respiratory rate and their tidal volume.

In Pressure Support, the set inspiratory pressure support level is kept constant and there is a decelerating flow. The patient triggers all breaths. If there is a change in the mechanical properties of the lung/thorax and patient effort, the delivered tidal volume will be affected. The user must then regulate the pressure support level to obtain desired ventilation. [17] [18]

Pressure support improves oxygenation, [19] ventilation and decreases work of breathing.

Also see adaptive support ventilation.

Other ventilation modes and strategies

Flow-controlled ventilation

Flow-controlled ventilation (FCV) is an entirely dynamic ventilation mode, without pauses, with continuous and stable gas flows during both inspiration and expiration, aiming for linear changes in both volume and pressure. [20] FCV is an invasive ventilation mode but, unlike Volume- and pressure controlled modes, it does not rely on a passive expiration created by collapse of the thoracic wall and elastic recoil of the lungs. A high resistant breathing circuit inhibits a passive expiration and therewith allows to fully control and stabilize the expiration flow. FCV creates an inspiration by generating a stable flow from a set End-expiratory pressure (EEP) to a set Peak pressure. Then a stable expiratory flow is created by suctioning. [21] This expiratory flow rate is preferably similar to the inspiratory flow, aiming for an I:E ratio of 1:1.0, to minimize energy dissipation in the lungs. [22] [23] FCV® is a more efficient ventilation as compared to conventional modes, [24] [25] [26] [27] [28] allows ventilation through even small lumens (~2 – 10 mm ID) [29] [30] and results in less applied mechanical power. [31] [32] FCV was invented by Professor Dr. med. Dietmar Enk. [20]

Negative pressure ventilation

Main article: Negative pressure ventilator

Negative-pressure ventilation stimulates (or forces) breathing by periodic application of partial vacuum (air pressure reduced below ambient pressure), applied externally to the patient's torso—specifically, chest and abdomen—to assist (or force) the chest to expand, expanding the lungs, resulting in voluntary (or involuntary) inhalation through the patient's airway. [33] [34] [35] [36] [37]

Various "negative pressure ventilators" (NPVs) have been developed to serve this function—most famously the "Iron lung," a tank in which the patient lays, with only their head exposed to ambient air, while air pressure on the remainder of their body, inside the tank, is varied by pumping, to stimulate chest and lung expansion and contraction. Though not in wide use today, NPVs were the principal forms of hospital and long-term mechanical ventilation in the first half of the 20th century, and remain in limited use today. [33] [34] [35] [36] [37]

Closed loop systems

Adaptive Support Ventilation

Adaptive Support Ventilation (ASV) is the only commercially available mode that uses optimal targeting. This ventilation mode was invented and subsequently patented in 1991 by Tehrani [38] [39] [40] In this positive pressure mode of ventilation, the frequency and tidal volume of breaths of a patient on the ventilator are automatically adjusted and optimized to mimic natural breathing, stimulate spontaneous breathing, and reduce weaning time. In the ASV mode, every breath is synchronized with patient effort if such an effort exists, and otherwise, full mechanical ventilation is provided to the patient. [41] [42]

Automatic Tube Compensation

Automatic Tube Compensation (ATC) is the simplest example of a computer-controlled targeting system on a ventilator. It is a form of servo targeting.

The goal of ATC is to support the resistive work of breathing through the artificial airway

Neurally Adjusted Ventilatory Assist

Neurally Adjusted Ventilatory Assist (NAVA) is adjusted by a computer (servo) and is similar to ATC but with more complex requirements for implementation.

In terms of patient-ventilator synchrony, NAVA supports both resistive and elastic work of breathing in proportion to the patient's inspiratory effort

Proportional Assist Ventilation

Proportional assist ventilation (PAV) is another servo targeting based mode in which the ventilator guarantees the percentage of work regardless of changes in pulmonary compliance and resistance. [43]

The ventilator varies the tidal volume and pressure based on the patient's work of breathing. The amount it delivers is proportional to the percentage of assistance it is set to give.

PAV, like NAVA, supports both restrictive and elastic work of breathing in proportion to the patient's inspiratory effort.

Liquid ventilation

Liquid ventilation is a technique of mechanical ventilation in which the lungs are insufflated with an oxygenated perfluorochemical liquid rather than an oxygen-containing gas mixture. The use of perfluorochemicals, rather than nitrogen, as the inert carrier of oxygen and carbon dioxide offers a number of theoretical advantages for the treatment of acute lung injury, including:

Despite its theoretical advantages, efficacy studies have been disappointing and the optimal clinical use of LV has yet to be defined. [44]

Total liquid ventilation

In total liquid ventilation (TLV), the entire lung is filled with an oxygenated PFC liquid, and a liquid tidal volume of PFC is actively pumped into and out of the lungs. A specialized apparatus is required to deliver and remove the relatively dense, viscous PFC tidal volumes, and to extracorporeally oxygenate and remove carbon dioxide from the liquid. [45] [46] [47]

Partial liquid ventilation

In partial liquid ventilation (PLV), the lungs are slowly filled with a volume of PFC equivalent or close to the FRC during gas ventilation. The PFC within the lungs is oxygenated and carbon dioxide is removed by means of gas breaths cycling in the lungs by a conventional gas ventilator. [48]

See also

Related Research Articles

<span class="mw-page-title-main">Mechanical ventilation</span> Method to mechanically assist or replace spontaneous breathing

Mechanical ventilation or assisted ventilation is the medical term for using a machine called a ventilator to fully or partially provide artificial ventilation. Mechanical ventilation helps move air into and out of the lungs, with the main goal of helping the delivery of oxygen and removal of carbon dioxide. Mechanical ventilation is used for many reasons, including to protect the airway due to mechanical or neurologic cause, to ensure adequate oxygenation, or to remove excess carbon dioxide from the lungs. Various healthcare providers are involved with the use of mechanical ventilation and people who require ventilators are typically monitored in an intensive care unit.

<span class="mw-page-title-main">Spirometry</span> Pulmonary function test

Spirometry is the most common of the pulmonary function tests (PFTs). It measures lung function, specifically the amount (volume) and/or speed (flow) of air that can be inhaled and exhaled. Spirometry is helpful in assessing breathing patterns that identify conditions such as asthma, pulmonary fibrosis, cystic fibrosis, and COPD. It is also helpful as part of a system of health surveillance, in which breathing patterns are measured over time.

<span class="mw-page-title-main">Respiratory arrest</span> Medical condition

Respiratory arrest is a serious medical condition caused by apnea or respiratory dysfunction severe enough that it will not sustain the body. Prolonged apnea refers to a patient who has stopped breathing for a long period of time. If the heart muscle contraction is intact, the condition is known as respiratory arrest. An abrupt stop of pulmonary gas exchange lasting for more than five minutes may permanently damage vital organs, especially the brain. Lack of oxygen to the brain causes loss of consciousness. Brain injury is likely if respiratory arrest goes untreated for more than three minutes, and death is almost certain if more than five minutes.

<span class="mw-page-title-main">Bag valve mask</span> Hand-held device to provide positive pressure ventilation

A bag valve mask (BVM), sometimes known by the proprietary name Ambu bag or generically as a manual resuscitator or "self-inflating bag", is a hand-held device commonly used to provide positive pressure ventilation to patients who are not breathing or not breathing adequately. The device is a required part of resuscitation kits for trained professionals in out-of-hospital settings (such as ambulance crews) and is also frequently used in hospitals as part of standard equipment found on a crash cart, in emergency rooms or other critical care settings. Underscoring the frequency and prominence of BVM use in the United States, the American Heart Association (AHA) Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiac Care recommend that "all healthcare providers should be familiar with the use of the bag-mask device." Manual resuscitators are also used within the hospital for temporary ventilation of patients dependent on mechanical ventilators when the mechanical ventilator needs to be examined for possible malfunction or when ventilator-dependent patients are transported within the hospital. Two principal types of manual resuscitators exist; one version is self-filling with air, although additional oxygen (O2) can be added but is not necessary for the device to function. The other principal type of manual resuscitator (flow-inflation) is heavily used in non-emergency applications in the operating room to ventilate patients during anesthesia induction and recovery.

<span class="mw-page-title-main">Dual-control modes of ventilation</span>

Dual-control modes of ventilation are auto-regulated pressure-controlled modes of mechanical ventilation with a user-selected tidal volume target. The ventilator adjusts the pressure limit of the next breath as necessary according to the previous breath's measured exhaled tidal volume. Peak airway pressure varies from breath to breath according to changes in the patient's airway resistance and lung compliance.

Permissive hypercapnia is hypercapnia in respiratory insufficient patients in which oxygenation has become so difficult that the optimal mode of mechanical ventilation is not capable of exchanging enough carbon dioxide. Carbon dioxide is a gaseous product of the body's metabolism and is normally expelled through the lungs.

Positive end-expiratory pressure (PEEP) is the pressure in the lungs above atmospheric pressure that exists at the end of expiration. The two types of PEEP are extrinsic PEEP and intrinsic PEEP. Pressure that is applied or increased during an inspiration is termed pressure support.PEEP is a therapeutic parameter set in the ventilator, or a complication of mechanical ventilation with air trapping (auto-PEEP).

High-frequency ventilation is a type of mechanical ventilation which utilizes a respiratory rate greater than four times the normal value and very small tidal volumes. High frequency ventilation is thought to reduce ventilator-associated lung injury (VALI), especially in the context of ARDS and acute lung injury. This is commonly referred to as lung protective ventilation. There are different types of high-frequency ventilation. Each type has its own unique advantages and disadvantages. The types of HFV are characterized by the delivery system and the type of exhalation phase.

Neurally adjusted ventilatory assist (NAVA) is a mode of mechanical ventilation. NAVA delivers assistance in proportion to and in synchrony with the patient's respiratory efforts, as reflected by an electrical signal. This signal represents the electrical activity of the diaphragm, the body's principal breathing muscle.

Pressure support ventilation (PSV), also known as pressure support, is a spontaneous mode of ventilation. The patient initiates every breath and the ventilator delivers support with the preset pressure value. With support from the ventilator, the patient also regulates their own respiratory rate and tidal volume.

Pressure control (PC) is a mode of mechanical ventilation alone and a variable within other modes of mechanical ventilation. Pressure control is used to regulate pressures applied during mechanical ventilation. Air delivered into the patients lungs (breaths) are currently regulated by Volume Control or Pressure Control. In pressure controlled breaths a tidal volume achieved is based on how much volume can be delivered before the pressure control limit is reached.

<span class="mw-page-title-main">Airway pressure release ventilation</span> Pressure control mode of mechanical ventilation

Airway pressure release ventilation (APRV) is a pressure control mode of mechanical ventilation that utilizes an inverse ratio ventilation strategy. APRV is an applied continuous positive airway pressure (CPAP) that at a set timed interval releases the applied pressure. Depending on the ventilator manufacturer, it may be referred to as BiVent. This is just as appropriate to use, since the only difference is that the term APRV is copyrighted.

<span class="mw-page-title-main">Liquid ventilator</span> Medical device

A liquid ventilator is similar to a medical ventilator except that it should be able to ensure reliable total liquid ventilation with a breatheable liquid ·. Liquid ventilators are prototypes that may have been used for animal experimentations but experts recommend continued development of a liquid ventilator toward clinical applications.

Continuous mandatory ventilation (CMV) is a mode of mechanical ventilation in which breaths are delivered based on set variables. Still used in the operating room, in previous nomenclature, CMV referred to "controlled mechanical ventilation", a mode of ventilation characterized by a ventilator that makes no effort to sense patient breathing effort. In continuous mandatory ventilation, the ventilator can be triggered either by the patient or mechanically by the ventilator. The ventilator is set to deliver a breath according to parameters selected by the operator. "Controlled mechanical ventilation" is an outdated expansion for "CMV"; "continuous mandatory ventilation" is now accepted standard nomenclature for mechanical ventilation. CMV today can assist or control itself dynamically, depending on the transient presence or absence of spontaneous breathing effort. Thus, today's CMV would have been called ACV in older nomenclature, and the original form of CMV is a thing of the past. But despite continual technological improvement over the past half century, CMV may still be uncomfortable for the patient.

Many terms are used in mechanical ventilation, some are specific to brand, model, trademark and mode of mechanical ventilation. There is a standardized nomenclature of mechanical ventilation that is specific about nomenclature related to modes, but not settings and variables.

Mandatory minute ventilation (MMV) is a mode of mechanical ventilation which requires the operator to determine what the appropriate minute ventilation for the patient should be and the ventilator then monitors the patient's ability to generate this volume. If the calculation suggests the volume target will not be met, supplemental breaths are delivered at the targeted volume to achieve the desired minute ventilation.

Intermittent Mandatory Ventilation (IMV) refers to any mode of mechanical ventilation where a regular series of breaths are scheduled but the ventilator senses patient effort and reschedules mandatory breaths based on the calculated need of the patient. Similar to continuous mandatory ventilation in parameters set for the patients pressures and volumes but distinct in its ability to support a patient by either supporting their own effort or providing support when patient effort is not sensed. IMV is frequently paired with additional strategies to improve weaning from ventilator support or to improve cardiovascular stability in patients who may need full life support.

Dynamic hyperinflation is a phenomenon that occurs when a new breath begins before the lung has reached the static equilibrium volume. In simpler terms, this means that a new breath starts before the usual amount of air has been breathed out, leading to a build-up of air in the lungs, and causing breathing in and out to take place when the lung is nearly full.

<span class="mw-page-title-main">Pathophysiology of acute respiratory distress syndrome</span>

The pathophysiology of acute respiratory distress syndrome involves fluid accumulation in the lungs not explained by heart failure. It is typically provoked by an acute injury to the lungs that results in flooding of the lungs' microscopic air sacs responsible for the exchange of gases such as oxygen and carbon dioxide with capillaries in the lungs. Additional common findings in ARDS include partial collapse of the lungs (atelectasis) and low levels of oxygen in the blood (hypoxemia). The clinical syndrome is associated with pathological findings including pneumonia, eosinophilic pneumonia, cryptogenic organizing pneumonia, acute fibrinous organizing pneumonia, and diffuse alveolar damage (DAD). Of these, the pathology most commonly associated with ARDS is DAD, which is characterized by a diffuse inflammation of lung tissue. The triggering insult to the tissue usually results in an initial release of chemical signals and other inflammatory mediators secreted by local epithelial and endothelial cells.

<span class="mw-page-title-main">Pendelluft</span>

Pendelluft refers to the movement of gas between two regions of the lung, usually between regions of differing compliance or airway resistance. Pendelluft is an important physiological concept to take into account during mechanical ventilation, particularly in patients with an open thorax, severe bronchospasm, or with heterogeneous lung compliance. It was first published as a physiological concept in 1956.

References

  1. ↑ Esteban A, Anzueto A, Alía I, Gordo F, Apezteguía C, Pálizas F, Cide D, Goldwaser R, Soto L, Bugedo G, Rodrigo C, Pimentel J, Raimondi G, Tobin MJ (2000). "How is mechanical ventilation employed in the intensive care unit? An international utilization review". Am J Respir Crit Care Med. 161 (5): 1450–8. doi:10.1164/ajrccm.161.5.9902018. PMID   10806138.
  2. ↑ Donn SM (2009). "Neonatal ventilators: how do they differ?". J Perinatol. 29 (Suppl 2): S73-8. doi: 10.1038/jp.2009.23 . PMID   19399015.
  3. ↑ Chatburn RL, Volsko TA, Hazy J, Harris LN, Sanders S (2011). "Determining the Basis for a Taxonomy of Mechanical Ventilation". Respir Care . 57 (4): 514–24. doi:10.4187/respcare.01327. PMID   22004898. S2CID   27417478.
  4. ↑ Chatburn RL, El-Khatib M, Mireles-Cabodevila E (2014). "A taxonomy for mechanical ventilation: 10 fundamental maxims". Respir Care. 59 (11): 1747–63. doi: 10.4187/respcare.03057 . PMID   25118309.
  5. ↑ Dietrich Henzler (2011). "What on earth is APRV?". Critical Care . 15 (1). London, England: 115. doi: 10.1186/cc9419 . PMC   3222047 . PMID   21345265.
  6. ↑ Adrian A. Maung & Lewis J. Kaplan (July 2011). "Airway pressure release ventilation in acute respiratory distress syndrome". Critical Care Clinics . 27 (3): 501–509. doi:10.1016/j.ccc.2011.05.003. PMID   21742214.
  7. ↑ M. Baum, H. Benzer, C. Putensen, W. Koller & G. Putz (September 1989). "[Biphasic positive airway pressure (BIPAP)--a new form of augmented ventilation]". Der Anaesthesist . 38 (9): 452–458. PMID   2686487.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  8. ↑ C. Putensen, S. Zech, H. Wrigge, J. Zinserling, F. Stuber, T. Von Spiegel & N. Mutz (July 2001). "Long-term effects of spontaneous breathing during ventilatory support in patients with acute lung injury". American Journal of Respiratory and Critical Care Medicine . 164 (1): 43–49. doi:10.1164/ajrccm.164.1.2001078. PMID   11435237.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  9. ↑ Scott O. Guthrie, Chris Lynn, Bonnie J. Lafleur, Steven M. Donn & William F. Walsh (October 2005). "A crossover analysis of mandatory minute ventilation compared to synchronized intermittent mandatory ventilation in neonates". Journal of Perinatology . 25 (10): 643–646. doi: 10.1038/sj.jp.7211371 . PMID   16079905.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  10. ↑ Benzer H (1988) Ventilatory support by intermittent changes in PEEP levels. 4th European Congress on Intensive Care Medicine. Baveno-Stresa
  11. ↑ C. Hormann, M. Baum, C. Putensen, N. J. Mutz & H. Benzer (January 1994). "Biphasic positive airway pressure (BIPAP)—a new mode of ventilatory support". European Journal of Anaesthesiology . 11 (1): 37–42. PMID   8143712.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  12. ↑ M. A. Levitt (November 2001). "A prospective, randomized trial of BiPAP in severe acute congestive heart failure". The Journal of Emergency Medicine . 21 (4): 363–9. doi:10.1016/s0736-4679(01)00385-7. PMID   11728761.
  13. ↑ Osadnik, CR; Tee, VS; Carson-Chahhoud, KV; Picot, J; Wedzicha, JA; Smith, BJ (13 July 2017). "Non-invasive ventilation for the management of acute hypercapnic respiratory failure due to exacerbation of chronic obstructive pulmonary disease" (PDF). The Cochrane Database of Systematic Reviews. 2017 (7): CD004104. doi:10.1002/14651858.CD004104.pub4. hdl:10044/1/53458. PMC   6483555 . PMID   28702957.
  14. ↑ Yañez, LJ; Yunge, M; Emilfork, M; Lapadula, M; Alcántara, A; Fernández, C; Lozano, J; Contreras, M; Conto, L; Arevalo, C; Gayan, A; Hernández, F; Pedraza, M; Feddersen, M; Bejares, M; Morales, M; Mallea, F; Glasinovic, M; Cavada, G (September 2008). "A prospective, randomized, controlled trial of noninvasive ventilation in pediatric acute respiratory failure". Pediatric Critical Care Medicine. 9 (5): 484–9. doi:10.1097/PCC.0b013e318184989f. PMID   18679148. S2CID   20821767.
  15. ↑ Allardet-Servent J (2011). "High-frequency oscillatory ventilation in adult patients with acute respiratory distress syndrome: Where do we stand and where should we go?". Crit Care Med. 39 (12): 2761–2. doi:10.1097/CCM.0b013e31822a5c35. PMID   22094505.
  16. ↑ D. P. Schuster, M. Klain & J. V. Snyder (October 1982). "Comparison of high frequency jet ventilation to conventional ventilation during severe acute respiratory failure in humans". Critical Care Medicine . 10 (10): 625–630. doi:10.1097/00003246-198210000-00001. PMID   6749433.
  17. ↑ MAQUET, "Modes of ventilation in SERVO-i, invasive and non-invasive", 2008 MAQUET Critical Care AB, Order No 66 14 692
  18. ↑ MAQUET, "Modes of ventilation in SERVO-s, invasive and non-invasive", 2009 MAQUET Critical Care AB, Order No 66 61 131
  19. ↑ Spieth PM, Carvalho AR, Güldner A, et al. (April 2011). "Pressure support improves oxygenation and lung protection compared to pressure-controlled ventilation and is further improved by random variation of pressure support". Critical Care Medicine . 39 (4): 746–55. doi:10.1097/CCM.0b013e318206bda6. PMID   21263322. S2CID   35876431.
  20. 1 2 Enk D. Verfahren und Vorrichtung zur Beatmung eines Patienten (method and device for ventilating a patient). (2017) Available at: https://depatisnet.dpma.de/DepatisNet/depatisnet?window=1&space=menu&content=treffer&action=pdf&docid=DE102016109528A1&xxxfull=1
  21. ↑ Enk D: Gasstromumkehrelement (gas flow reversing element). Patent application (DE 10 2007 013 385 A1). German Patent Office, 16.03.2007
  22. ↑ Barnes T, van Asseldonk D, Enk D. Minimisation of dissipated energy in the airways during mechanical ventilation by using constant inspiratory and expiratory flows - flow-controlled ventilation (FCV). Med Hypotheses 2018; 121:167–176.
  23. ↑ Barnes T, Enk D. Ventilation for low dissipated energy achieved using flow control during both inspiration and expiration. Trends Anaesth Crit Care. 2019;24:5–12.
  24. ↑ Weber J, Schmidt J, Straka L, Wirth S, Schumann S. Flow-controlled ventilation improves gas exchange in lung-healthy patients – a randomized interventional cross-over study. Acta Anaesthesiol Scand 2020; 64: 481-488. doi: 10.1111/aas.13526.
  25. ↑ Sebrechts T, Morrison SG, Schepens T, Saldien V. Flow-controlled ventilation with the Evone ventilator and Tritube versus volume-controlled ventilation: a clinical cross-over pilot study describing oxygenation, ventilation and haemodynamic variables. Eur J Anaesthesiol 2021; 38: 209-211. doi: 10.1097/EJA.0000000000001326.
  26. ↑ Schmidt J, Wenzel C, Mahn M, et al. Improved lung recruitment and oxygenation during mandatory ventilation with a new expiratory ventilation assistance device: A controlled interventional trial in healthy pigs. Eur J Anaesthesiol 2018; 35: 736-744. doi: 10.1097/ EJA.0000000000000819.
  27. ↑ Schmidt J, Wenzel C, Spassov S, et al. Flow-controlled ventilation attenuates lung injury in a porcine model of acute respiratory distress syndrome: a preclinical randomized controlled study. Crit Care Med 2020; 48: e241-e248. doi: 10.1097/CCM.0000000000004209.
  28. ↑ Spraider, P, Martini J, Abram J, et al. Individualized flow-controlled ventilation compared to best clinical practice pressure-controlled ventilation: a prospective randomized porcine study. Crit Care 2020: 24: 662. doi: 10.1186/s13054-020-03325-3.
  29. ↑ Schmidt J, Günther F, Weber J, et al. Glottic visibility for laryngeal surgery: tritube vs. microlaryngeal tube: a randomised controlled trial. Eur J Anaesthesiol 2019; 36: 963-971. doi: 10.1097/EJA. 0000000000001110.
  30. ↑ Meulemans J, Jans A, Vermeulen K, et al. Evone® flow-controlled ventilation during upper airway surgery: a clinical feasibility study and safety assessment. Front Surg 2020; 7: 6. doi: 10.3389/fsurg. 2020.00006.
  31. ↑ Spraider, P. et al. Individualisedflow-controlled ventilation versus pressure-controlled ventilation in a porcine model of thoracic surgery requiring one-lung ventilation: A laboratory study. EurJ Anaesthesiol39, 885–894 (2022).
  32. ↑ Grassetto, A. et al. Flow-controlled ventilation may reduce mechanical power and increase ventilatory efficiency in severe coronavirus disease-19 acute respiratory distress syndrome. Pulmonology S2531-0437(22)00126-X (2022)
  33. 1 2 Shneerson, Dr. John M., Newmarket General Hospital, (Newmarket, Suffolk, U.K.), "Non-invasive and domiciliary ventilation: negative pressure techniques," #5 of series "Assisted ventilation" in Thorax, 1991;46: pp.131-135, retrieved April 12, 2020
  34. 1 2 Matioc, Adrian A., M.D., University of Wisconsin School of Medicine & Public Health, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin, "Early Positive and Alternate Pressure Machines" in "An Anesthesiologist's Perspective on the History of Basic Airway Management: The 'Progressive' Era, 1904 to 1960," submitted May 27, 2017, published February 2018, Anesthesiology, Vol. 128, No 2.
  35. 1 2 Grum, Cyril M., MD, and Melvin L. Morganroth, MD, "Initiating Mechanical Ventilation," in Intensive Care Medicine 1988;3:6-20, retrieved April 12, 2020
  36. 1 2 Rockoff, Mark, M.D., "The Iron Lung and Polio,", video (8 minutes), January 11, 2016, OPENPediatrics and Boston Children's Hospital on YouTube, retrieved April 11, 2020 (historical background and images, explanatory diagrams, and live demonstrations)
  37. 1 2 Walkey, Allan M.D. and Ross Summer M.D., "Negative pressure" in "E. Noninvasive Mechanical Ventilation," in Boston Medical Center ICU Manual 2008, 2008, Boston University, p.17, retrieved April 12, 2020.
  38. ↑ Tehrani FT. Method and apparatus for controlling an artificial respiratory. US patent 4,986,268, issued January 22, 1991.
  39. ↑ Tehrani FT (1991). "Automatic control of an artificial respirator". Proc IEEE EMBS Conf. Vol. 13. pp. 1738–9. doi:10.1109/IEMBS.1991.684729. ISBN   0-7803-0216-8. S2CID   63221714.
  40. ↑ Chatburn, Robert L., Mireles-Cabodevila E., "Closed-loop control of mechanical ventilation: description and classification of targeting schemes", Respiratory Care, 56(1), 85-102, 2011.
  41. ↑ Tehrani, Fleur T., Automatic control of mechanical ventilation. Part 1: theory and history of the technology, Journal of Clinical Monitoring and Computing 22 (2008) 409–415.
  42. ↑ Tehrani, Fleur T., Automatic control of mechanical ventilation. Part 2: the existing techniques and future trends, Journal of Clinical Monitoring and Computing 22 (2008) 417–424.
  43. ↑ Younes M (1992). "Proportional assist ventilation, a new approach to ventilatory support. Theory". Am Rev Respir Dis. 145 (1): 114–120. doi:10.1164/ajrccm/145.1.114. PMID   1731573.
  44. ↑ Degraeuwe PL, Vos GD, Blanco CE (1995). "Perfluorochemical liquid ventilation: from the animal laboratory to the intensive care unit". Int J Artif Organs. 18 (10): 674–83. doi:10.1177/039139889501801020. PMID   8647601. S2CID   13038566.
  45. ↑ Norris MK, Fuhrman BP, Leach CL (1994). "Liquid ventilation: it's not science fiction anymore". AACN Clin Issues Crit Care Nurs. 5 (3): 246–54. doi:10.4037/15597768-1994-3004. PMID   7780839.
  46. ↑ Greenspan JS (1996). "Physiology and clinical role of liquid ventilation therapy". J Perinatol. 16 (2 Pt 2 Su): S47-52. PMID   8732549.
  47. ↑ Dirkes S (1996). "Liquid ventilation: new frontiers in the treatment of ARDS". Crit Care Nurse. 16 (3): 53–8. doi:10.4037/ccn1996.16.3.53. PMID   8852261.
  48. ↑ Cox CA, Wolfson MR, Shaffer TH (1996). "Liquid ventilation: a comprehensive overview". Neonatal Netw. 15 (3): 31–43. PMID   8715647.
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