Neamine transaminase

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Neamine transaminase
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EC no. 2.6.1.93
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Neamine transaminase (EC 2.6.1.93, glutamate---6'-dehydroparomamine aminotransferase, btrB (gene), neoN (gene), kacL (gene)) is an enzyme with systematic name neamine:2-oxoglutarate aminotransferase. [1] [2] [3] This enzyme catalyses the following chemical reaction

neamine + 2-oxoglutarate 6'-dehydroparomamine + L-glutamate

The reaction occurs in vivo in the opposite direction.

Related Research Articles

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<span class="mw-page-title-main">Succinylornithine transaminase</span>

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Paromamine 6'-oxidase (EC 1.1.3.43, btrQ (gene), neoG (gene), kanI (gene), tacB (gene)) is an enzyme with systematic name paromamine:oxygen 6'-oxidoreductase. This enzyme catalyses the following chemical reaction

2-deoxystreptamine N-acetyl-D-glucosaminyltransferase is an enzyme with systematic name UDP-N-acetyl-alpha-D-glucosamine:2-deoxystreptamine N-acetyl-D-glucosaminyltransferase. This enzyme catalyses the following chemical reaction

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2'-Deamino-2'-hydroxyneamine transaminase is an enzyme with systematic name 2'-deamino-2'-hydroxyneamine:2-oxoglutarate aminotransferase. This enzyme catalyses the following chemical reaction

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References

  1. ↑ Huang F, Spiteller D, Koorbanally NA, Li Y, Llewellyn NM, Spencer JB (February 2007). "Elaboration of neosamine rings in the biosynthesis of neomycin and butirosin". ChemBioChem. 8 (3): 283–8. doi:10.1002/cbic.200600371. PMID   17206729.
  2. ↑ Clausnitzer D, Piepersberg W, Wehmeier UF (September 2011). "The oxidoreductases LivQ and NeoQ are responsible for the different 6'-modifications in the aminoglycosides lividomycin and neomycin". Journal of Applied Microbiology. 111 (3): 642–51. doi: 10.1111/j.1365-2672.2011.05082.x . PMID   21689223.
  3. ↑ Park JW, Park SR, Nepal KK, Han AR, Ban YH, Yoo YJ, Kim EJ, Kim EM, Kim D, Sohng JK, Yoon YJ (October 2011). "Discovery of parallel pathways of kanamycin biosynthesis allows antibiotic manipulation". Nature Chemical Biology. 7 (11): 843–52. doi:10.1038/nchembio.671. PMID   21983602.
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