Nexin is a proteinous inter-doublet linkage that prevents microtubules in the outer layer of axonemes from moving with respect to one another; otherwise, vesicular transport proteins such as dynein would dissolve the whole structure. [1]
Nexin is a proteinous inter-doublet linkage that prevents microtubules in the outer layer of axonemes from moving with respect to one another; otherwise, vesicular transport proteins such as dynein would dissolve the whole structure. [1]
An axoneme, also called an axial filament is the microtubule-based cytoskeletal structure that forms the core of a cilium or flagellum. Cilia and flagella are found on many cells, organisms, and microorganisms, to provide motility. The axoneme serves as the "skeleton" of these organelles, both giving support to the structure and, in some cases, the ability to bend. Though distinctions of function and length may be made between cilia and flagella, the internal structure of the axoneme is common to both.
The PX domain is a phosphoinositide-binding structural domain involved in targeting of proteins to cell membranes.
Sorting nexin-1 is a protein that in humans is encoded by the SNX1 gene. The protein encoded by this gene is a sorting nexin. SNX1 is a component of the retromer complex.
A vesicular transport protein, or vesicular transporter, is a membrane protein that regulates or facilitates the movement of specific molecules across a vesicle's membrane. As a result, vesicular transporters govern the concentration of molecules within a vesicle.
Glia-derived nexin is a protein that in humans is encoded by the SERPINE2 gene.
Sorting nexin-9 is a protein that in humans is encoded by the SNX9 gene.
Sorting nexin-2 is a protein that in humans is encoded by the SNX2 gene.
Sorting nexin-17 is a protein that in humans is encoded by the SNX17 gene.
Sorting nexin-5 is a protein that in humans is encoded by the SNX5 gene.
TC10/CDC42 GTPase-activating protein is an enzyme that in humans is encoded by the SNX26 gene.
Sorting nexin-3 is a protein that in humans is encoded by the SNX3 gene.
Sorting nexin family member 27, also known as SNX27, is a human gene.
Sorting nexin-13 is a protein that in humans is encoded by the SNX13 gene.
Sorting nexin-15 is a protein that in humans is encoded by the SNX15 gene.
Sorting nexin-4 is a protein that in humans is encoded by the SNX4 gene.
Sorting nexin-21 is a protein that in humans is encoded by the SNX21 gene.
Sorting nexin-18 is a protein that in humans is encoded by the SNX18 gene.
Sorting nexins are a large group of proteins that are localized in the cytoplasm and have the potential for membrane association either through their lipid-binding PX domain or through protein–protein interactions with membrane-associated protein complexes Some members of this family have been shown to facilitate protein sorting.
Sorting Nexin 6 also known as SNX6 is a well-conserved membrane-associated protein belonging to the sorting nexin family that is a component of the retromer complex. The protein contains a coiled-coil domain at its C terminus and a PX domain at its N terminus. Binding to PIM1 causes translocation to the nucleus. SNX6 has been shown to associate with TRAF4.
Sorting nexin 10 is a protein that in humans is encoded by the SNX10 gene.
