Obesogen

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Bisphenol A found in food and beverage packaging is an obesogen showing up in the bodies of about 95% of the human population. Bisphenol A.svg
Bisphenol A found in food and beverage packaging is an obesogen showing up in the bodies of about 95% of the human population.

Obesogens are certain chemical compounds that are hypothesised to disrupt normal development and balance of lipid metabolism, which in some cases, can lead to obesity. [2] [3] [4] Obesogens may be functionally defined as chemicals that inappropriately alter lipid homeostasis and fat storage, change metabolic setpoints, disrupt energy balance or modify the regulation of appetite and satiety to promote fat accumulation and obesity. [5]

Contents

There are many different proposed mechanisms through which obesogens can interfere with the body's adipose tissue biology. These mechanisms include alterations in the action of metabolic sensors; dysregulation of sex steroid synthesis, action or breakdown; changes in the central integration of energy balance including the regulation of appetite and satiety; and reprogramming of metabolic setpoints. [6] [7] Some of these proposed pathways include inappropriate modulation of nuclear receptor function which therefore allows the compounds to be classified as endocrine disrupting chemicals that act to mimic hormones in the body, altering the normal homeostasis maintained by the endocrine system. [8]

Obesogens have been detected in the body both as a result of intentional administration of obesogenic chemicals in the form of pharmaceutical drugs such as diethylstilbestrol, selective serotonin reuptake inhibitors, and thiazolidinedione and as a result of unintentional exposure to environmental obesogens such as tributyltin, bisphenol A, diethylhexylphthalate, and perfluorooctanoate. [6] [7]

The term obesogen was coined in 2006 by Felix Grün and Bruce Blumberg of the University of California, Irvine. [3]

Mechanisms of action

There are many ways in which obesogenic drugs and chemicals can disrupt the body's adipose tissue biology. The three main mechanisms of action include

Metabolic sensors

Obesogenic drugs and chemicals have been shown to target transcription regulators found in gene networks that function to control intracellular lipid homeostasis and proliferation and differentiation on adipocytes. The major group of regulators that is targeted is a group of nuclear hormone receptors known as peroxisome proliferator activated receptors (PPARα, δ, and γ). These hormone receptors sense a variety of metabolic ligands including lipophilic hormones, dietary fatty acids and their metabolites, and, depending on the varying levels of these ligands, control transcription of genes involved in balancing the changes in lipid balance in the body. [6] [7] To become active and properly function as metabolic sensors and transcription regulators, the PPAR receptors must heterodimerize with another receptor known as the 9-cis retinoic acid receptor (RXR). The RXR receptor itself is the second major target of obesogens next to the PPAR receptors. [6] [7]

The PPARα receptor, when complexed with RXR and activated by the binding of a lipid, promotes peroxisome proliferation leading to increased fatty acid β-oxidation. [9] Substances, such a xenobiotics that target and act as agonists of PPARα, typically act to reduce overall serum concentrations of lipids. In contrast, the PPARγ receptor, when complexed with RXR and activated by the binding of fatty acids or their derivatives, promotes lipid biosynthesis and storage of lipids is favored over fatty acid oxidation. In addition, activation promotes differentiation of preadipocytes and the conversion of mesenchymal progenitor cells to preadipocytes in adipose tissues. Substances that target and act as agonists of PPARγ/RXR complex typically act to increase overall serum concentrations of lipids. [10]

Obesogens that target the PPARγ/RXR complex mimic the metabolic ligands and activate the receptor leading to upregulation of lipid accumulation which explains their obesogenic effects. However, in the case of obesogens that target the PPARα/RXR complex, which when stimulated reduces adipose mass and body weight, there are a few explanations as to how they promote obesity. [6] [7]

The ligand binding pockets of PPARs are very large and unspecified, allowing for different isoforms of the receptor (PPARα, δ, and γ) to be activated by the same agonist ligands or their metabolites. In addition, fatty acid oxidation stimulated by PPARα requires continuous stimulation while only a single activation event of PPARγ is required to permanently increase adipocyte differentiation and number. [6] [7] Therefore, it may be the case that metabolites of PPARα targeting obesogens are also activating PPARγ, providing the single activation event needed to potentially lead to a pro-adipogenic response. [11] [12]

A second explanation points to specific PPARα targeters that have been shown to additionally cause abnormal transcriptional regulation of testicular steroidogenesis when introduced during fetal development. This abnormal regulation leads to a decreased level of androgen in the body which, itself, is obesogenic. [13] [14] [15]

Finally, if PPARα activation occurs during critical periods of development, the resulting decrease in lipid concentration in the developing fetus is recognized by the fetal brain as undernourishment. In this case, the developing brain makes what will become permanent changes to the body's metabolic control, leading to long-term upregulation of lipid storage and maintenance. [16]

Sex steroid dysregulation

Sex steroids normally play a significant role in lipid balance in the body. Aided by other peptide hormones such as growth hormone, they act against the lipid accumulation mediated by insulin and cortisol by mobilizing lipid stores that are present. Exposure to obesogens often leads to a deficiency or change in the ratio between androgen and estrogen sex steroid levels, which modifies this method of lipid balance resulting in lowered growth hormone secretion, hypocortisolemia (low levels of circulating cortisol), and increased resistance to insulin effects. [17]

This alteration in sex steroid levels due to obesogens can vary enormously according to both the sex of the exposed individual as well as the timing of the exposure. [6] [7] If the chemicals are introduced at critical windows of development, the vulnerability of an individual to their effects is much higher than if exposure occurs later in adulthood. It has been shown that obesogenic effects are apparent in female mice exposed to both phytoestrogens and DES during their neonatal periods of development, as they, though born with a lower birth weight, almost always developed obesity, high leptin levels, and altered glucose response pathways. [18] [19] [20] Both phytoestrogen and DES exposed male mice did not develop obesity and, rather, showed decreased body weights with increased exposure confirming the role of gender differences in exposure response. [19] [20] [21] Further studies have shown positive correlations for serum BPA levels with obese females in the human population, along with other xenoestrogen compounds suggesting the parallel roles that these effects may be having on humans. [22]

Central balance of energy

While hormone receptors tend to be the most obvious candidates for targets of obesogens, central mechanisms that balance and regulate the body's nutritional changes on a day-to-day basis as a whole cannot be overlooked. The HPA axis (hypothalamic-pituitary-adrenal) is involved in controlling appetite and energy homeostasis circuits which are mediated by a large number of monoaminoergic, peptidergic (use of hormones as neurotransmitters), and endocannabinoid signals that come from the digestive tract, adipose tissues, and from within the brain. It is these types of signals that provide a likely target for obesogens that have shown to have weight altering effects. [6] [7]

Neuroendocrine effects

Neurological disorders may enhance the susceptibility to develop the metabolic syndrome that includes obesity. [23] Many neuropharmaceuticals used to alter behavioral pathways in patients with neurological disorders have shown to have metabolic altering side-effects leading to obesogenic phenotypes as well. These findings give evidence to conclude that an increase in lipid accumulation can result from the targeting of neurotransmitter receptors by foreign chemicals. [6] [7] [24]

Peptidergic hormones

Several peptidergic hormone pathways controlling appetite and energy balance —such as those involving ghrelin, neuropeptide Y, and agouti-related peptide — are particularly sensitive to changes in nuclear receptor signaling pathways and can therefore be easily altered by the introduction of endocrine disruptors. Such an alteration can lead to induced feelings of hunger and decreased feelings of fullness causing an increase in food intake and inability to feel satisfied, both characteristic of obesity. [6] [7]

Some xenoestrogens such as BPA, nonylphenol, and DEHP have all shown to act is this way, altering NPY expression and significantly shifting the feeding behaviors of exposed mice. [25] [26] In addition, organotins such as trimethyltin (TMT), triethyltin (TET), and tributyltin (TBT) compounds can exert their effects through similar pathways. TBT can locally disrupt aromatase regulation in the hypothalamus causing the responses of the HPA axis to hormones to become abnormal. TMT works in a similar but unique way, inducing NPY and NPY2 receptor expression initially which later is counteracted by neuronal degeneration in lesions causing decrease in signaling ability. [27] [28]

While an increase in food intake is often the case after exposure, weight gain involves the body's maintenance of its metabolic setpoint as well. Given this information, it is particularly important to note that exposure during development and initial programming of these setpoints can be extremely significant throughout the remainder of life. [6] [7]

Endocannabinoid signaling

A wide range of environmental organotins that mimic petidergic hormones in the HPA axis as mentioned before, additionally mimic lipid activators of the cannabinoid system and inhibit AMPK activity. [6] [7] Endocannaboid levels are high in those suffering from obesity due to hyperactivity of cannaboid signalling pathways. It is these high levels that have been found to be closely associated with increased fat stores linking the lipid activator mimics to the actual disease. [29]

Programming of metabolic set points

Regions in the hypothalamus control the responses that establish an individual’s metabolic setpoint and metabolic efficiency. These responses are adaptive in that they vary according to the individual's needs, always working to restore the metabolic setpoint through the increase or decrease of metabolic functions depending on varying energy needs. Since it is adapted, it is expected that it would be able to achieve equilibrium if the lipid balance was altered by hormones via the mechanisms mentioned above. However, since obesogenic phenotypes persist, it can be concluded that adaptive response components of the hypothalamus may be a target of obesogens as well. [6] [7]

Body composition is very much predetermined before birth and changes rarely occur in adulthood. Adipocyte numbers increase during development and come to a plateau, after which adipocytes are restricted to mostly hypertrophic growth and don't seem to change much in cell number. This is demonstrated by the difficulty in altering somatotypes or more simply by the difficulty that goes along with trying to lose weight past a certain point. [30] [ better source needed ]

A particular study on polybrominated diphenyl ethers (PBDE), a commonly used chemical in flame retardants, made its role in altering the functions of the thyroid hormone axis apparent. [31] [32] This finding leads to increased concern as neonatal thyroid status plays a large role in the integration of maternal environmental signals during development in the womb that is used for long-term body weight programming. [6] [7]

Pharmaceutical obesogens

Obesogens detection in the body and resulting obesogenic effects can result as side effects from intentional administration of obesogenic chemicals in the form of pharmaceutical drugs. These pharmaceutical obesogens can show their effects through a variety of targets.

Metabolic sensors

Thiazolidinediones (TZD), rosiglitazone, and pioglitazone are all used to treat diabetes. These drugs act as agonists of the PPAR-γ receptor leading to insulin sensitizing effects that can improve glycemic control and serum triglyceride levels. [33] Despite the positive effects these chemicals can have in treating diabetes patients, administration also lead to unwanted PPAR-γ mediated side effects such as peripheral edema which can be followed by persistent weight gain if the drug is used over a long period of time. These side effects are particularly prominent in diabetes 2 patients, a disease that tends to result from an overabundance of adipose tissue. [34] [35]

Sex steroid dysregulation

Diethylstilbestrol (DES) is a synthetic estrogen that was once prescribed to women to decrease the risk of miscarriage until it was found to be causing abnormalities in exposed offspring. This same chemical has been shown to cause weight gain in female mice when exposed during neonatal development. While exposure didn't lead to an abnormal birth weight, significant weight gain occurred much later in adulthood. [19] [20]

Central integration of energy balance

Selective serotonin reuptake inhibitors (SSRI) (e.g. paroxetine), tricyclic antidepressants (e.g. amitriptyline), tetracyclic antidepressants (e.g. mirtazapine) and atypical antipsychotics (e.g. clozapine) are all neuropharmaceuticals that target neurotransmitter receptors that are involved with brain circuits that regulate behavior. Often the function of these receptors overlaps with metabolism regulation, such as that of the H1 receptor which when activated decreases AMPK activity. [36] As a result, the administration of these drugs can have side effects including increased lipid accumulation that can result in obesity.

Metabolic setpoints

The mechanisms behind SSRI, tricyclic antidepressants, and atypical antipsychotics function allow them all to have potential roles in the alteration of metabolic setpoints. TZD, in particular has been linked to regulatory function in the HPT axis, however, no conclusive evidence has been determined thus far and further research is required to confirm these hypotheses. [6] [7]

Environmental obesogens

While obesogens can be introduced to the body intentionally via administration of obesogenic pharmaceuticals, exposure can also occur through chemical exposure to obesogens found in the environment such as organotins and xenobiotics.

Organotins

Particular members of the organotin class of persistent organic pollutants (POPs), namely tributyltin (TBT) and triphenyltin (TPT) are highly selective and act as very potent agonists of both the retinoid X receptors (RXR α,β, and γ) and PPARγ. [37] [38] This ability to target both receptors at the same time, is more effective than single receptor activation, as adopogenic signaling can be mediated through both components of the heterodimer complex. This highly effective activation mechanism can pose detrimental, long-term adipogenic effects especially if exposure occurs during development and early life.

Organotins (tin-based chemicals), used in marine anti-fouling paints, wood catalysts, plasticizers, slimicides, in industrial water systems, and fungicides on food have recently been linked to obesogenic properties when introduced in the body. [39] Human exposure to these major environmental sources most commonly occurs through ingestion of contaminated seafood, agricultural products, and drinking water as well as from exposure to leaching from plastics. [40] [41] [42]

Although studies that have directly measured organotin levels in human tissue and blood are limited, it has been determined that vulnerability of a portion of the general population to organotin exposure at levels high enough to activate RXRs and PPARγ receptors is very probable. The high usage of organotins in both plastics and agricultural maintenance as well as the high affinity of the chemicals further confirms this conclusion. [6] [7]

Liver samples from the late 1990s in Europe and Asia contained on average 6 and 84 ng/g wet wt respectively for total organotin levels, while later studies found levels of total organotins in US blood samples averaged around 21 ng/mL with TBT comprising around 8 ng/mL (~ 27 nM). [43] Even more recent analyses of European blood samples found the predominant species to be TPT rather than TBT at 0.09 and 0.67 ng/mL (~0.5-2 nM). Only occasional trace amounts of TBT were found. [44] [45] These results indicate that organtin exposure to humans, while found to be present among many different populations, can vary in terms of type of organatin and level of exposure from region to region.

Other xenobiotics

Other common xenobiotics found in the environment have been shown to have PPAR activity, posing even further threats to dysregulated metabolic balance. BPA from polycarbonate plastics, phthalate plasticizers used to soften PVC plastics, and various perfluoroalkyll compounds (PFCs) that are widely used surfactants and surface repellents in consumer products are all potentially obesogenic when introduced in the body. [6] [7] Phthalates and PFCs in particular have been found to function as agonists for one or more of the PPARs [46] Additionally, metabolites of DHEP such as MEHP also activate PPARγ leading to a proadipogenic response. [11] [12]

Public health implications

Although research on endocrine disruptors or "obesogens" is still emerging, the public health implications so far have mainly surrounded obesity, diabetes, and cardiovascular disease. Obesity has become a pandemic, increasing for all population groups. From 1980 to 2008, the rates of obesity have doubled for adults and tripled for children. [47] In the U.S. alone, it has been estimated that almost 100 million individuals in are obese [48] Traditional thinking suggested that diet and exercise alone were the main contributors to obesity; however, current experimental evidence shows that obesogens might be part of the cause.[ medical citation needed ]

Obesity may lead to potentially debilitating chronic diseases such as diabetes, and certain environmental exposures, or obesogens, have been directly linked to Type II diabetes mellitus (T2DM). [49]

Potential obesogens in everyday life

Obesogens can be found in many things, from water bottles to microwaveable popcorn, and from nonstick pans to shower curtains. People interact with them on a daily basis,[ citation needed ] both intentionally and unintentionally, at work, school and home. They are an unnecessary and mostly preventable potential hazard to health,[ medical citation needed ] which can have a large impact on how individuals gain and lose weight.[ medical citation needed ]

Bisphenol-A (BPA) is an industrial chemical and organic compound that has been used in the production of plastics and resins for over a half-century. It is used in products such as toys, medical devices, plastic food and beverage containers, shower curtains, dental sealants and compounds, and register receipts. [50] BPA has been shown to seep into food sources from containers or into the body just by handling products made from it. Certain researchers suggest that BPA actually decreases the fat cell count in the body, but at the same time increasing the size of the ones remaining; therefore, no difference in weight is shown, and an individual is even likely to gain more. [51]

Nicotine is a chemical found in tobacco products and certain insecticides. As an obesogen, nicotine mostly acts on prenatal development after maternal smoking occurs. A strong association has been made between maternal smoking and childhood overweight/obesity, with nicotine as the single causal agent. [49]

Arsenic is a metalloid (i.e., an element with some metallic properties) found in and on most naturally occurring substances on Earth. It can be found in the soil, ground water, air, and in small concentrations in food. Arsenic has many applications such as in the production of insecticides, herbicides, pesticides and electronic devices. [52] [53] The development of diabetes has been linked to arsenic exposure from drinking water and occupational contact.

Pesticides are substances used to prevent, destroy, repel or mitigate pests, and they have been used throughout all of recorded history. Some pesticides persist for short periods of time and some for long periods of time which are considered persistent organic pollutants (POPs). Several cross-sectional studies have shown pesticides as obesogens, linking them to obesity, diabetes and other morbidities. [49] [54]

Some pharmaceutical drugs are also potentially obesogens. From 2005–2008, 11% of Americans aged 12 and over took antidepressant medications. [55] Certain antidepressants, known as selective serotonin reuptake inhibitors (SSRIs), are potentially adding to the almost 100 million obese individuals in the U.S. [48] A key function of SSRI antidepressants is to regulate the serotonin reuptake transporter (SERT) which can affect food intake and lipid accumulation leading to obesity. [56]

Organotins such as tributyltin (TBT) and triphenyltin (TPT) are endocrine disruptors that have been shown to increase triglyceride storage in adipocytes. Although they have been widely used in the marine industry since the 1960s, other common sources of human exposure include contaminated seafood and shellfish, fungicides on crops and as antifungal agents used in wood treatments, industrial water systems and textiles. Organotins are also being used in the manufacture of PVC plastics and have been identified in drinking water and food supplies. [3]

Perfluorooctanoic acid (PFOA) is a surfactant used for reduction of friction, and it is also used in nonstick cookware. PFOA has been detected in the blood of more than 98% of the general US population. [57] It is a potential endocrine disruptor. [58] Animal studies have shown that prenatal exposure to PFOA is linked to obesity when reaching adulthood. [59]

Future research

Most of the environmental obesogens currently identified are either classified into the category of chemical mimics of metabolic hormones throughout the body or of neurotransmitters within the brain. Because they fall into these two categories, extensive opportunities for complex interactions and varied sites of action as well as multiple molecular targets are open for consideration. Changing dose ranges tend to result in varying phenotypes and timing of exposure, gender, and gender predisposition introduce even more levels of complexity in how these substances effect the human body. [6] [7]

Because the mechanisms behind the different effects of obesogens are so complex and not well understood, the extent to which they play in the current obesity epidemic may be greater than once thought. Epigenetic changes due to obesogen exposure must also be considered as a possibility, as they open up the potential for misregulated metabolic functions to be passed on from generation to generation. Epigenetic processes via hypermethylation of regulatory regions could lead to overexpression of different proteins, and therefore, amplification of acquired environmental effects. Research will be required in order to gain a better understanding of the mechanism of action these chemicals are involved in before the extent of the risk of exposure can be determined and methods of prevention and removal from the environment can be established. [6] [7]

Natural occurring obesogens

Fructose is a natural occurring obesogen found in several of our food products. It increases the development of diabetes as well as increasing the amount of fat stored in the liver which results in weight gain. It is found in sweets and sweetened beverages. [60]

Genistein is a naturally occurring obesogen found in soy bean and soy products. Genestein has been found to decrease mammary tumors in animal models. Genestein belongs to a family of phytoestrogens. Phytoestrogens are used to help humans with menopausal relief and the prevention of hormonal cancers. [61]

Obesogen prevention

Preventing the effects of obesogen in the human body is crucial for maintaining healthy body weights. A few ways individuals can proactively reverse the effects would be regularly exercising, maintaining a healthy diet, ensuring quality sleep, and managing stress levels. These few options that allow individuals to practice healthy habits will in turn reduce the effects of obesogen within the body. [62]

See also

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References

  1. Calafat AM, Kuklenyik Z, Reidy JA, Caudill SP, Ekong J, Needham LL (Apr 2005). "Urinary concentrations of bisphenol A and 4-nonylphenol in a human reference population". Environmental Health Perspectives. 113 (4): 391–5. doi:10.1289/ehp.7534. PMC   1278476 . PMID   15811827.
  2. Grün F, Blumberg B (June 2007). "Perturbed nuclear receptor signaling by environmental obesogens as emerging factors in the obesity crisis". Rev Endocr Metab Disord. 8 (2): 161–71. doi:10.1007/s11154-007-9049-x. PMID   17657605. S2CID   7677454.
  3. 1 2 3 Grün F, Blumberg B (June 2006). "Environmental obesogens: organotins and endocrine disruption via nuclear receptor signaling". Endocrinology. 147 (6 Suppl): S50–5. doi: 10.1210/en.2005-1129 . PMID   16690801.
  4. Sharon B (2009-09-21). "Why Chemicals Called Obesogens May Make You Fat". Newsweek. Retrieved 2010-04-29.
  5. Kirchner S, Kieu T, Chow C, Casey S, Blumberg B (March 2010). "Prenatal exposure to the environmental obesogen tributyltin predisposes multipotent stem cells to become adipocytes". Mol. Endocrinol. 24 (3): 526–39. doi:10.1210/me.2009-0261. PMC   2840805 . PMID   20160124.
  6. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 Grün F, Blumberg B (May 2009). "Endocrine disrupters as obesogens". Mol. Cell. Endocrinol. 304 (1–2): 19–29. doi:10.1016/j.mce.2009.02.018. PMC   2713042 . PMID   19433244.
  7. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 Grün F, Blumberg B (August 2009). "Minireview: the case for obesogens". Mol. Endocrinol. 23 (8): 1127–34. doi:10.1210/me.2008-0485. PMC   2718750 . PMID   19372238.
  8. Diamanti-Kandarakis E, Bourguignon JP, Giudice LC, Hauser R, Prins GS, Soto AM, et al. (June 2009). "Endocrine-disrupting chemicals: an Endocrine Society scientific statement". Endocr. Rev. 30 (4): 293–342. doi:10.1210/er.2009-0002. PMC   2726844 . PMID   19502515.
  9. Ferré P (February 2004). "The biology of peroxisome proliferator-activated receptors: relationship with lipid metabolism and insulin sensitivity". Diabetes. 53 (Suppl 1): S43–50. doi: 10.2337/diabetes.53.2007.s43 . PMID   14749265.
  10. Rosen ED, Sarraf P, Troy AE, Bradwin G, Moore K, Milstone DS, et al. (October 1999). "PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro". Mol. Cell. 4 (4): 611–7. doi: 10.1016/S1097-2765(00)80211-7 . PMID   10549292.
  11. 1 2 Hurst CH, Waxman DJ (August 2003). "Activation of PPARalpha and PPARgamma by environmental phthalate monoesters". Toxicol. Sci. 74 (2): 297–308. doi:10.1093/toxsci/kfg145. PMID   12805656.
  12. 1 2 Feige JN, Gelman L, Rossi D, Zoete V, Metivier R, Tudor C, et al. (June 2007). "The Endocrine Disruptor Monoethyl-hexyl-phthalate Is a Selective Peroxisome Proliferator-activated Receptor γ Modulator That Promotes Adipogenesis". J. Biol. Chem. 282 (26): 19152–19166. doi: 10.1074/jbc.M702724200 . PMID   17468099.
  13. Parks LG, Ostby JS, Lambright CR, Abbott BD, Klinefelter GR, Barlow NJ, et al. (December 2000). "The plasticizer diethylhexyl phthalate induces malformations by decreasing fetal testosterone synthesis during sexual differentiation in the male rat". Toxicol. Sci. 58 (2): 339–49. doi: 10.1093/toxsci/58.2.339 . PMID   11099646.
  14. Jarfelt K, Dalgaard, Hass U, Borch J, Jacobsen H, Ladefoged O (March–April 2008). "Antiandrogenic effects in male rats perinatally exposed to a mixture of di(2-ethylhexyl) phthalate and di(2-ethylhexyl) adipate". Reprod. Toxicol. 19 (4): 505–515. doi:10.1016/j.reprotox.2004.11.005. PMID   15749265.
  15. Braga-Basaria M, Dobs AS, Muller DC, Carducci MA, John M, Egan J, et al. (August 2006). "Metabolic syndrome in men with prostate cancer undergoing long-term androgen-deprivation therapy". J. Clin. Oncol. 24 (24): 3979–83. doi: 10.1200/JCO.2006.05.9741 . PMID   16921050.
  16. Levin BE (July 2006). "Metabolic imprinting: critical impact of the perinatal environment on the regulation of energy homeostasis". Philos. Trans. R. Soc. Lond. B Biol. Sci. 361 (1471): 1107–21. doi:10.1098/rstb.2006.1851. PMC   1642705 . PMID   16815795.
  17. Björntorp P (September 1997). "Body fat distribution, insulin resistance, and metabolic diseases". Nutrition. 13 (9): 795–803. doi:10.1016/s0899-9007(97)00191-3. PMID   9290093.
  18. Ruhlen RL, Howdeshell KL, Mao J, Taylor JA, Bronson FH, Newbold RR, et al. (March 2008). "Low phytoestrogen levels in feed increase fetal serum estradiol resulting in the "fetal estrogenization syndrome" and obesity in CD-1 mice". Environ. Health Perspect. 116 (3): 322–8. doi:10.1289/ehp.10448. PMC   2265041 . PMID   18335098.
  19. 1 2 3 Newbold RR, Padilla-Banks E, Snyder RJ, Jefferson WN (July 2007). "Perinatal exposure to environmental estrogens and the development of obesity". Mol Nutr Food Res. 51 (7): 912–7. doi:10.1002/mnfr.200600259. PMID   17604389.
  20. 1 2 3 Newbold RR, Padilla-Banks E, Snyder RJ, Phillips TM, Jefferson WN (2007). "Developmental exposure to endocrine disruptors and the obesity epidemic". Reprod. Toxicol. 23 (3): 290–6. Bibcode:2007RepTx..23..290N. doi:10.1016/j.reprotox.2006.12.010. PMC   1931509 . PMID   17321108.
  21. Penza M, Montani C, Romani A, Vignolini P, Pampaloni B, Tanini A, et al. (December 2006). "Genistein affects adipose tissue deposition in a dose-dependent and gender-specific manner". Endocrinology. 147 (12): 5740–51. doi: 10.1210/en.2006-0365 . PMID   16959845.
  22. Takeuchi T, Tsutsumi O, Ikezuki Y, Takai Y, Taketani Y (April 2004). "Positive relationship between androgen and the endocrine disruptor, bisphenol A, in normal women and women with ovarian dysfunction". Endocr. J. 51 (2): 165–9. doi: 10.1507/endocrj.51.165 . PMID   15118266.
  23. Casey DE (April 2005). "Metabolic issues and cardiovascular disease in patients with psychiatric disorders". Am. J. Med. 118 (Suppl 2): 15S–22S. doi:10.1016/j.amjmed.2005.01.046. PMID   15903291.
  24. See also: #Central integration of energy balance
  25. Masuo Y, Morita M, Oka S, Ishido M (December 2004). "Motor hyperactivity caused by a deficit in dopaminergic neurons and the effects of endocrine disruptors: a study inspired by the physiological roles of PACAP in the brain". Regul. Pept. 123 (1–3): 225–34. doi: 10.1016/j.regpep.2004.05.010 . PMID   15518916. S2CID   9419249.
  26. Masuo Y, Ishido M, Morita M, Oka S (2004). "Effects of neonatal treatment with 6-hydroxydopamine and endocrine disruptors on motor activity and gene expression in rats". Neural Plast. 11 (1–2): 59–76. doi: 10.1155/NP.2004.59 . PMC   2565434 . PMID   15303306.
  27. Ishikura N, Tsunashima K, Watanabe K, Nishimura T, Minabe Y, Kato N (2002). "Neuropeptide Y and somatostatin participate differently in the seizure-generating mechanisms following trimethyltin-induced hippocampal damage". Neurosci Res. 44 (3): 237–248. doi:10.1016/S0168-0102(02)00132-3. PMID   12413652. S2CID   29090185.
  28. Sadamatsu M, Tsunashima K, Schwarzer C, Takahashi Y, Kato N, Sperk G (1998). "Trimethyltin-induced expression of neuropeptide Y Y2 receptors in rat dentate gyrus". Neurotoxicol Teratol. 20 (6): 607–10. doi:10.1016/S0892-0362(98)00022-1. PMID   9831121.
  29. Engeli S, Böhnke J, Feldpausch M, Gorzelniak K, Janke J, Bátkai S, et al. (October 2005). "Activation of the peripheral endocannabinoid system in human obesity". Diabetes. 54 (10): 2838–43. doi:10.2337/diabetes.54.10.2838. PMC   2228268 . PMID   16186383.
  30. Janesick A, Blumberg B (March 2011). "Endocrine disrupting chemicals and the developmental programming of adipogenesis and obesity". Birth Defects Res. C. 93 (1): 34–50. doi:10.1002/bdrc.20197. PMC   4919125 . PMID   21425440.
  31. Ellis-Hutchings RG, Cherr GN, Hanna LA, Keen CL (September 2006). "Polybrominated diphenyl ether (PBDE)-induced alterations in vitamin A and thyroid hormone concentrations in the rat during lactation and early postnatal development". Toxicol. Appl. Pharmacol. 215 (2): 135–45. Bibcode:2006ToxAP.215..135E. doi:10.1016/j.taap.2006.02.008. PMID   16580039.
  32. Kuriyama SN, Wanner A, Fidalgo-Neto AA, Talsness CE, Koerner W, Chahoud I (December 2007). "Developmental exposure to low-dose PBDE-99: tissue distribution and thyroid hormone levels". Toxicology. 242 (1–3): 80–90. Bibcode:2007Toxgy.242...80K. doi:10.1016/j.tox.2007.09.011. PMID   17964054.
  33. Goldberg RB (August 2007). "The new clinical trials with thiazolidinediones--DREAM, ADOPT, and CHICAGO: promises fulfilled?". Curr. Opin. Lipidol. 18 (4): 435–42. doi:10.1097/MOL.0b013e32821f604c. PMID   17620861. S2CID   25296886.
  34. Larsen MO, Rolin B, Ribel U, Wilken M, Deacon CF, Svendsen O, et al. (2003). "Valine pyrrolidide preserves intact glucose-dependent insulinotropic peptide and improves abnormal glucose tolerance in minipigs with reduced beta-cell mass". Exp. Diabetes Res. 4 (2): 93–105. doi: 10.1155/EDR.2003.93 . PMC   2478600 . PMID   14630571.
  35. Rubenstrunk A, Hanf R, Hum DW, Fruchart JC, Staels B (August 2007). "Safety issues and prospects for future generations of PPAR modulators". Biochim. Biophys. Acta. 1771 (8): 1065–81. doi:10.1016/j.bbalip.2007.02.003. PMID   17428730.
  36. Kim SF, Huang AS, Snowman AM, Teuscher C, Snyder SH (February 2007). "From the Cover: Antipsychotic drug-induced weight gain mediated by histamine H1 receptor-linked activation of hypothalamic AMP-kinase". Proc. Natl. Acad. Sci. U.S.A. 104 (9): 3456–9. Bibcode:2007PNAS..104.3456K. doi: 10.1073/pnas.0611417104 . PMC   1805549 . PMID   17360666.
  37. Kanayama T, Kobayashi N, Mamiya S, Nakanishi T, Nishikawa J (March 2005). "Organotin compounds promote adipocyte differentiation as agonists of the peroxisome proliferator-activated receptor gamma/retinoid X receptor pathway". Mol. Pharmacol. 67 (3): 766–74. doi:10.1124/mol.104.008409. PMID   15611480. S2CID   20588515.
  38. Grün F, Watanabe H, Zamanian Z, Maeda L, Arima K, Cubacha R, et al. (September 2006). "Endocrine-disrupting organotin compounds are potent inducers of adipogenesis in vertebrates" (PDF). Mol. Endocrinol. 20 (9): 2141–55. doi: 10.1210/me.2005-0367 . PMID   16613991.
  39. Nath M (2008). "Toxicity and the cardiovascular activity of organotin compounds: a review". Applied Organometallic Chemistry. 22 (10): 598–612. doi:10.1002/aoc.1436.
  40. Tsuda T, Inoue T, Kojima M, Aoki S (1995). "Daily intakes of tributyltin and triphenyltin compounds from meals". J AOAC Int. 78 (4): 941–3. doi: 10.1093/jaoac/78.4.941 . PMID   7580332.
  41. Guérin T, Sirot V, Volatier JL, Leblanc JC (December 2007). "Organotin levels in seafood and its implications for health risk in high-seafood consumers". Sci. Total Environ. 388 (1–3): 66–77. Bibcode:2007ScTEn.388...66G. doi:10.1016/j.scitotenv.2007.08.027. PMID   17889928.
  42. Ohno H, Suzuki M, Nakashima S, Aoyama T, Mitani K (August 2002). "[Determination of organotin compounds in plastic products by GC/MS after ethyl derivatization with sodium tetraethylborate]". Shokuhin Eiseigaku Zasshi (in Japanese). 43 (4): 208–14. doi: 10.3358/shokueishi.43.208 . PMID   12436712.
  43. Kanaan K, Sethilkumar K, Giesy J (1999). "Occurrence of butyltin compounds in human blood". Environmental Science & Technology. 33 (10): 1776–9. Bibcode:1999EnST...33.1776K. doi:10.1021/es990011w.
  44. Rantakokko P, Turunen A, Verkasalo PK, Kiviranta H, Männistö S, Vartiainen T (July 2008). "Blood levels of organotin compounds and their relation to fish consumption in Finland". Sci. Total Environ. 399 (1–3): 90–5. Bibcode:2008ScTEn.399...90R. doi:10.1016/j.scitotenv.2008.03.017. PMID   18436279.
  45. Lo S, Alléra A, Albers P, Heimbrecht J, Jantzen E, Klingmüller D, et al. (April 2003). "Dithioerythritol (DTE) prevents inhibitory effects of triphenyltin (TPT) on the key enzymes of the human sex steroid hormone metabolism". J. Steroid Biochem. Mol. Biol. 84 (5): 569–76. doi:10.1016/S0960-0760(03)00074-8. PMID   12767282. S2CID   21495365.
  46. Bell FP (November 1982). "Effects of phthalate esters on lipid metabolism in various tissues, cells and organelles in mammals". Environ. Health Perspect. 45: 41–50. doi:10.1289/ehp.824541. PMC   1568983 . PMID   7140695.
  47. Centers for Disease Control and Prevention. "Obesity and Overweight for Professionals: Data and Statistics: Facts - DNPAO - CDC". U.S. Department of Health and human Services.
  48. 1 2 "Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults--The Evidence Report. National Institutes of Health" (PDF). Obesity Research. 6 (Suppl 2): 51S–209S. Sep 1998. PMID   9813653.
  49. 1 2 3 Thayer KA, Heindel JJ, Bucher JR, Gallo MA (Jun 2012). "Role of environmental chemicals in diabetes and obesity: a National Toxicology Program workshop review". Environmental Health Perspectives. 120 (6): 779–89. doi:10.1289/ehp.1104597. PMC   3385443 . PMID   22296744.
  50. Zeratsky K (Jul 2010). "What are the health concerns about BPA?". Mayo Clinic Women's Healthsource. 14 (7): 8. PMID   20517192.
  51. Vom Saal FS, Nagel SC, Coe BL, Angle BM, Taylor JA (May 2012). "The estrogenic endocrine disrupting chemical bisphenol A (BPA) and obesity". Molecular and Cellular Endocrinology. 354 (1–2): 74–84. doi:10.1016/j.mce.2012.01.001. PMC   3306519 . PMID   22249005.
  52. "Inorganic Arsenic" (PDF). TEACH Chemical Summary. United States Environmental Protection Agency. 2007-08-01. p. 20.
  53. Del Razo LM, García-Vargas GG, Valenzuela OL, Castellanos EH, Sánchez-Peña LC, Currier JM, et al. (2011). "Exposure to arsenic in drinking water is associated with increased prevalence of diabetes: a cross-sectional study in the Zimapán and Lagunera regions in Mexico". Environmental Health. 10 (1): 73. Bibcode:2011EnvHe..10...73D. doi: 10.1186/1476-069X-10-73 . PMC   3169452 . PMID   21864395.
  54. Lind L, Lind PM (Jun 2012). "Can persistent organic pollutants and plastic-associated chemicals cause cardiovascular disease?". Journal of Internal Medicine. 271 (6): 537–53. doi: 10.1111/j.1365-2796.2012.02536.x . PMID   22372998.
  55. Pratt LA, Brody DJ, Gu Q (Oct 2011). "Antidepressant use in persons aged 12 and over: United States, 2005-2008". NCHS Data Brief (76): 1–8. PMID   22617183.
  56. Chen X, Margolis KJ, Gershon MD, Schwartz GJ, Sze JY (2012). "Reduced serotonin reuptake transporter (SERT) function causes insulin resistance and hepatic steatosis independent of food intake". PLOS ONE. 7 (3): e32511. Bibcode:2012PLoSO...732511C. doi: 10.1371/journal.pone.0032511 . PMC   3297606 . PMID   22412882.
  57. Shankar A, Xiao J, Ducatman A (2011). "Perfluoroalkyl chemicals and elevated serum uric acid in US adults". Clinical Epidemiology. 3: 251–8. doi: 10.2147/CLEP.S21677 . PMC   3191115 . PMID   22003309.
  58. White SS, Fenton SE, Hines EP (Oct 2011). "Endocrine disrupting properties of perfluorooctanoic acid". The Journal of Steroid Biochemistry and Molecular Biology. 127 (1–2): 16–26. doi:10.1016/j.jsbmb.2011.03.011. PMC   3335904 . PMID   21397692.
  59. Hines EP, White SS, Stanko JP, Gibbs-Flournoy EA, Lau C, Fenton SE (May 2009). "Phenotypic dichotomy following developmental exposure to perfluorooctanoic acid (PFOA) in female CD-1 mice: Low doses induce elevated serum leptin and insulin, and overweight in mid-life". Molecular and Cellular Endocrinology. 304 (1–2): 97–105. doi:10.1016/j.mce.2009.02.021. PMID   19433254. S2CID   24249833.
  60. Macchi C (May 9, 2022). "Obesogens in Foods". Biomolecules. 12 (5): 680. doi: 10.3390/biom12050680 . PMC   9138445 . PMID   35625608.
  61. Kelly M (August 2013). The environmental fate of the phytoestrogens genistein and daidzein (Ph.D. thesis). University of Minnesota. hdl:11299/175207.
  62. Kladnicka I, Bludovska M, Plavinova I, Muller L, Mullerova D (May 2022). "Obesogens in Foods". Biomolecules. 12 (5): 680. doi: 10.3390/biom12050680 . PMC   9138445 . PMID   35625608.

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