Osh Agabi

Last updated
Osh. Agabi
Born
Oshiorenoya Eghierua Agabi

1979 (age 44–45)
Lagos, Nigeria
NationalityNigerian - Swiss - American
Alma mater University of Lagos
Umeå University
ETH Zurich
Imperial College London
Occupation(s)Research, Bioengineering and Entrepreneurship
Years active2015- Present
Known for Bioengineering
Notable workKonikore
TitleFounder and CEO at Koniku

Oshiorenoya Eghierua Agabi, simply referred to as Osh. (born 1979), is a Nigerian-Swiss-American physicist, computational neuroscientist, bioengineer, and entrepreneur. [1]

Contents

Osh. is the CEO of Koniku Inc., a Silicon Valley-based synthetic biotechnology company he founded in 2015. [2] [3] Koniku Inc. designs and builds “smell cyborgs” or “smell processors” known as the Konikore. Kanikore detects, analyzes, and outputs digital data concerning a wide range of smells. The underlying technology is a hybrid of bioengineered neurons and cells and FPGA technology. [4] [5]

Born and raised in Lagos, Nigeria, Osh. exhibited a keen interest in science from a young age. Osh. did his PhD studies in physics and computational neuroscience at the ETH Zürich in Switzerland. He also did a PhD in bioengineering with a focus on neuroengineering at Imperial College London in London. At the Koniku company, Osh.'s work is on the interaction between biology and technology. Konikore is reported to have gained interest from major companies including P&G, AB inBev, Exxon Mobil, Airbus, BASF, and Thermo Fisher Scientific, among others. [6] [7]

Biography

Osh. was born in 1979, and grew up in Lawanson, a suburb of Surulere in Lagos, Nigeria. In 1997, Osh. attended his undergraduate studies at the University of Lagos, Nigeria, where he obtained a Bachelor of Sciences in Physics in 2001. Subsequently, he enrolled at Umeå University, Sweden, to pursue a post-graduate degree. Osh. graduated with a master's degree in physics in 2005. Osh. further enrolled at the ETH Zürich, Switzerland, to pursue PhD studies in physics and neuroscience; he left the ETH Zurich in 2010. He moved to Imperial College London in the UK the following year to work in the Department of Bioengineering until circa 2015, when he left Imperial College on a leave of absence to start Koniku Inc. in California. [8] [9]

Career

Neuronics AG

In 2002, after graduating from the University of Lagos, Osh. was employed among the pioneers of Neuronics AG in Switzerland. Neuronics was an early pick-and-place robot company, founded by Hanruedi Fruh. [10] The company spun out of the University of Zurich AI Lab, led by Rolf Pfeifer. At Neuronics, Osh. started working as a developer and was raised to program leader in 2005. He was responsible for programming robots with a statistical learning framework for the robot grippers to classify objects based on a heterogeneous sensor array. Osh served until the company was acquired in 2008. [11] [12]

Academic career

At the University of Lagos, Osh's final year thesis was using PVDF (Polyvinylidene Fluoride or Polyvinylidene Difluoridee), a piezoelectric material to power body-worn or mobile electronic devices for energy. A subfield of energy harvesting. [13] His final year thesis at Umea University was performed at the Physical Electronics Laboratory at the ETH Zurich Honggerberg Campus. The Physical Electronics Laboratory by Henry Baltes. Osh. was the first to apply the liquid state machines first proposed by Wolfgang Maass and Thomas Natschläger to biological neurons on CMO-based microelectrode arrays. [14] The work has since been expanded by other researchers. During his joint PhD at the Swiss Federal Laboratories for Materials Science and Technology, Neuronics, and Institute of Neuroinformatics, Osh. led a team that successfully recreated the reflex arc on custom glass-based microelectrode arrays. [14] The microelectrode array was an early demonstration of extensive surface functionalization of microelectrode arrays to support contractile muscle cells actively stimulated by spinal motor neurons with successful read out by dorsal root ganglion cells on the chip. [15]

At Imperial College London, Osh. co-designed and built low cost (~$100K–$250K) two photon microscopes for brain imaging in the mouse visual cortex up to layer VI. [16] He also worked on thalamocortical slices for monitoring signal transmission from the retina to the LGN and visual cortex in slices. Osh. also helped develop a system for recording electrical signals, fluorescence imaging, and optical imaging from the mouse brain, i.e., automated patch clamping in the mouse brain using AI. [17] At Imperial College London, Osh. was a visiting scholar at MRC (London Institute of Medical Sciences, Hammersmith). He used two photon microscopes to understand neurodegenerative disorders in transgenic mice by evaluating PSD-95 puncta density in the cortex. [18]

Koniku

In 2015, Osh. founded Koniku Inc., a synthetic biotechnology company, based in California, US. Kaniku was founded with the vision of building wetware chips that integrate biological neurons with silicon. The company strategy appears to aim to build wetware neuron chips that process smell first but get progressively into Artificial General Intelligence chips. The name of the company, Koniku, translates as “immortal” in Nigeria’s Yoruba language. [19] Koniku claims the goal is digitizing all real-world smell data, regardless of source, making the data machine readable. [20] The goal the company claims, its goal is to open up its data backend via Koniku Technology Integrator Ecosystem (KTIE) to other companies, developers, and the general public to build new products and applications. [21] [22] The smell processing of Koniku has applications in disease diagnostics; for example, Koniku aims to convert every home bathroom into a healthcare data center. The smell processor can directly stream all smell data to the cloud. [2] [8]

Konikore

Koniku's flagship product, the Konikore, is a sensory system that can detect and identify specific chemicals, including explosives and biological agents. [23] [24] Konikore's so-called “smell processor” consists of 3 units: the reader unit, which is essentially electronics and optical components; a biochip, which looks like an optic microfluidics device and is a consumable; and an onboard server, which allows remote addressing of each unit. [25]

The biochip device looks like a cell-based array and has the footprint of a modem. It’s reported to house genetically altered neurons in a multi-well cell array style with physical demarcations. [26] Some data indicates this is a full optical system relying on cell fluorescence rather than the more popular electrical readout from the cells as it has been reported in the past. [23] It seems the optical system has the advantage of modularity; however, this advantage is unclear as the company has not made that information clear publicly. [27] They seem to have filed patents for 3-dimensional electrical readouts as well. [28]

Konikore was described as a smell cyborg and was unveiled during the 2017 TEDGlobal conference in Tanzania. The company said that it is capable of detecting and interpreting 4,096 different smells at the same time. [26] [29] Since its launch, the company seems to have deployed its technology at the San Francisco airport in California and other locations, especially in the Gulf States. [30] [31] The company also publicly unveiled the Konikore mounted on a quadruped robot at the 2024 Websummit conference in Doha, Qatar. [32] [33]

Social contributions with Koniku

Since 2017, Koniku has had a partnership with Airbus, leveraging Airbus’ expertise in sensor integration and knowledge of ground and on-board security operations within the aviation and defense departments. [34]

In 2019, Koniku Company was awarded second place in the Misk Global Forum Awards, which are organized by the Misk Foundation in Saudi Arabia. [35] Subsequently, Koniku entered into discussions with oil companies in Saudi Arabia to integrate Konikore into detecting benzene, toluene, ethylene, and xylene. [36]

In 2021, Koniku made a deal with Anheuser-Busch InBev to deploy the Konikore in measuring how a beverage's aromatic notes are perceived and experienced by the nose, to enhance flavor. [37]

During the COVID-19 pandemic, Konikore underwent clinical trials with Treximo, and the University of Southern Nevada aims to secure emergency use authorization as a rapid COVID-19 detection test. [38] [39]

Personal Life

Osh. is based in California, U.S. with his wife & 3 kids. He is reported to be an avid tent camper. He has extensive family links in the United States, Switzerland, United Kingdom, Ireland and Nigeria. [40]

Criticism

In 2020, Koniku Inc. had over 21 patents. The critics stated that the company was too focused on patents and less on scientific publishing. [28] A point the company said it will address more in the future. Osh. fired back at these critics, saying that science has devolved into paper-pushing at the expense of real innovation. [2]

Recognitions

Related Research Articles

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References

  1. ↑ "Nigeria-born Koniku's Founder Oshiorenoya Agabi Is Changing Computing With His Microprocessors". Tekedia. 2017-06-15. Retrieved 2024-08-14.
  2. 1 2 3 Nachiappan, Arthi (2024-08-14). "Koniku Inc scents victory in the quest for the ultimate nose". www.thetimes.com. Retrieved 2024-08-14.
  3. ↑ "Página 4 - LUN, martes, 17 de enero de 2023".
  4. ↑ "Nigerian invents a device that detects disease through breath". 2020-02-26. Retrieved 2024-08-14.
  5. ↑ "Koniku Kore Fuses Live Neurons with a Silicon Chip to Sniff Out Bombs". Digital Trends. 2017-08-29. Retrieved 2024-08-14.
  6. ↑ Onukwue, Alexander (2020-03-24). "Breathing Machine: How Koniku could change disease detection". TechCabal. Retrieved 2024-08-14.
  7. ↑ Lewis, Nell (2020-11-03). "Could a bomb-sniffing device transform airport security?". CNN. Retrieved 2024-08-14.
  8. 1 2 Busari, Stephanie (2017-08-28). "Nigerian creates a device that can detect explosives and cancer cells". CNN. Retrieved 2024-08-14.
  9. ↑ "Where Man Meets Machine - A Nigerian Techie Is Building A Computer Out Of Actual Brains!". WeeTracker. 2019-03-06. Retrieved 2024-08-14.
  10. ↑ Früh, Hansruedi; Keller, Philipp; Perucchi, Tino (2007), Lungarella, Max; Iida, Fumiya; Bongard, Josh; Pfeifer, Rolf (eds.), "Intelligent Mobile Manipulators in Industrial Applications:Experiences and Challenges", 50 Years of Artificial Intelligence: Essays Dedicated to the 50th Anniversary of Artificial Intelligence, Berlin, Heidelberg: Springer, pp. 370–385, doi:10.1007/978-3-540-77296-5_33, ISBN   978-3-540-77296-5 , retrieved 2024-08-17
  11. ↑ Trifork. "Osh Agabi at GOTO Copenhagen 2018". gotocph.com. Retrieved 2024-08-17.
  12. ↑ "The Birth of Wetware". proto.life. 2018-05-31. Retrieved 2024-08-17.
  13. ↑ "Nigerian neuroscientist builds computer that can smell explosives". www.domain-b.com. Retrieved 2024-08-18.
  14. 1 2 Jacopo, Lamanna; Federico, Esposti; Signorini, M.G. (2008-01-01). "A new, robust and multi-purpose approach to Burst Detection based on mono-dimensional MEA spiking activity series". BIOPRO.
  15. ↑ Agabi, Oshiorenoya; Weigel, Stefan; Früh, Hansruedi; Stoop, Ruedi; Bruinink, Arie (2008). "In vitro model for the peripheral nervous system". MEA Meeting 2008. Proceedings. July 8–11, 2008, Reutlingen, Germany 6th International Meeting on Substrate-integrated Microelectrode Arrays: 219–220.
  16. ↑ Oshiorenoya, Agabi E.; Marchand, Paul; Mutlu, Murat; Klotz, Laura; Schultz, Simon R. (2013-11-01). "Calcium imaging in temporal focus". 2013 6th International IEEE/EMBS Conference on Neural Engineering (NER). IEEE. pp. 1525–1528. doi:10.1109/ner.2013.6696236. ISBN   978-1-4673-1969-0.
  17. ↑ Hafizović, Sadik (2006). Neural interface and atomic-force microscope in CMOS technology (Doctoral Thesis thesis). ETH Zurich.
  18. ↑ Figueira, Helen (2015-05-01). "Student start-up tackles debilitating diseases". LMS Laboratory of Medical Sciences. Retrieved 2024-08-18.
  19. ↑ Elites, The (2017-08-29). "Meet Oshiorenoya Agabi, The Nigerian Engineer Who Makes Drones That Smell Bombs". The Elites Nigeria. Retrieved 2024-08-17.
  20. ↑ "High-Tech Smell Sensors Aim to Sniff Out Disease, Explosives—and Even Moods". 2022-07-16. Retrieved 2024-08-14.
  21. ↑ "Airbus successfully tests automated aviation security technology with U.S. Authorities | Airbus". us.airbus.com. 2021-10-14. Retrieved 2024-08-15.
  22. ↑ "Koniku and Airbus Expand Partnership to Re-imagine Aviation Security". Silicon UK. 2022-07-20. Retrieved 2024-08-15.
  23. 1 2 Christou, Luke (2021-02-04). "Could a new robot replace sniffer dogs at airport security?". Airport Technology. Retrieved 2024-08-17.
  24. ↑ Sternlicht, Alexandra. "Can Covid-19 Be Smelled?". Forbes. Retrieved 2024-08-14.
  25. ↑ "TEDGlobal: The computer that can smell explosives". BBC News. 2017-08-28. Retrieved 2024-08-14.
  26. 1 2 Writer, Staff (2017-09-08). "Koniku Kore - The Computer Chip That Can Detect Smells". Bold Business. Retrieved 2024-08-15.
  27. ↑ "Is a Giant Purple Nipple the Digital Nose of the Future?". Bloomberg.com. 2021-08-17. Retrieved 2024-08-14.
  28. 1 2 Salau, Seyi John (2020-02-28). "'Leveraging Konikore technology to bridge doctor-patient ratio'". Businessday NG. Retrieved 2024-08-17.
  29. ↑ BellaNaija.com (2017-08-28). "#TEDGlobal2017 Kicks off in Tanzania! Here are the Highlights of Day 1 – A New Map". BellaNaija. Retrieved 2024-08-15.
  30. ↑ "Transforming Airport Security with Koniku". www.whipsaw.com. Retrieved 2024-08-17.
  31. ↑ "Paws for thought with Finnish airport operator". www.blueskynews.aero. Retrieved 2024-08-17.
  32. ↑ "Covid-Sniffing Robots Offer Testing Alternative". Bloomberg.com. 2020-10-01. Retrieved 2024-08-14.
  33. ↑ Guerrini, Federico. "Neuron-Based Chips Will Soon Become Commonplace, This Startup Founder Says". Forbes. Retrieved 2024-08-14.
  34. ↑ "Koniku and Airbus Expand Partnership to Re-imagine Aviation Security | Transport Security International Magazine". www.tsi-mag.com. 2022-08-02. Retrieved 2024-08-19.
  35. ↑ "6 Saudi teams scale heights as Canadians win Entrepreneurship World Cup". Arab News. 2019-11-15. Retrieved 2024-08-15.
  36. ↑ "Silicon Valley's Osh Agabi lifts the lid on Koniku's disease-detection tech". Arab News. 2021-10-19. Retrieved 2024-08-15.
  37. ↑ "About the 'smell camera' that will taste your beer . . ". Appellation Beer. 2021-08-23. Retrieved 2024-08-15.
  38. ↑ Vaimal, Rahul (2020-11-03). "This small device could transform airport security forever - GCC Business News" . Retrieved 2024-08-15.
  39. ↑ "COVID-19-sniffing robots offer testing alternative to swabs - Taipei Times". www.taipeitimes.com. 2020-10-04. Retrieved 2024-08-15.
  40. ↑ QLNews (2024-02-28). "Web Summit Qatar shines through with innovations, insights and calls for action". Qatar Living. Retrieved 2024-08-20.
  41. ↑ https://blogs.anderson.ucla.edu/anderson/2015/04/ucla-anderson-students-on-winning-team-koniku-takes-top-prize-of-10000-at-mit-global-startup-worksho.html
  42. ↑ Scott, Steve (2016-11-14). "Reflections on the Hello Tomorrow Summit #CatalystGrant". Digital Science. Retrieved 2024-08-17.
  43. ↑ "Silicon Valley's Osh Agabi lifts the lid on Koniku's disease-detection tech". Arab News. 2021-10-19. Retrieved 2024-08-14.
  44. ↑ "Koniku Wins Global Innovation Olympian in World 2050 Challenge – THISDAYLIVE". www.thisdaylive.com. Retrieved 2024-08-15.
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