POM121

Last updated
POM121
Identifiers
Aliases POM121 , P145, POM121A, POM121 transmembrane nucleoporin
External IDs OMIM: 615753 MGI: 2137624 HomoloGene: 70878 GeneCards: POM121
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001257190
NM_172020
NM_001367610

NM_148932

RefSeq (protein)

NP_001244119
NP_742017
NP_001354539

NP_683734

Location (UCSC) Chr 7: 72.88 – 72.95 Mb Chr 5: 135.4 – 135.42 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Nuclear envelope pore membrane protein POM 121 is a protein that in humans is encoded by the POM121 gene. [5] [6] [7] Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined. [8]

Contents

Function

The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. This gene encodes a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is an integral membrane protein that localizes to the central spoke ring complex and participates in anchoring the nuclear pore complex to the nuclear envelope. [8]

Antibodies against this protein can be used to identify the nuclear envelope in immunofluorescence experiments. [9]

Related Research Articles

<span class="mw-page-title-main">Nuclear pore</span>

A nuclear pore is a part of a large complex of proteins, known as a nuclear pore complex that spans the nuclear envelope, which is the double membrane surrounding the eukaryotic cell nucleus. There are approximately 1,000 nuclear pore complexes (NPCs) in the nuclear envelope of a vertebrate cell, but this number varies depending on cell type and the stage in the life cycle. The human nuclear pore complex (hNPC) is a 110 megadalton (MDa) structure. The proteins that make up the nuclear pore complex are known as nucleoporins; each NPC contains at least 456 individual protein molecules and is composed of 34 distinct nucleoporin proteins. About half of the nucleoporins typically contain solenoid protein domains—either an alpha solenoid or a beta-propeller fold, or in some cases both as separate structural domains. The other half show structural characteristics typical of "natively unfolded" or intrinsically disordered proteins, i.e. they are highly flexible proteins that lack ordered tertiary structure. These disordered proteins are the FG nucleoporins, so called because their amino-acid sequence contains many phenylalanine–glycine repeats.

<span class="mw-page-title-main">Nucleoporin 210kDa</span> Protein-coding gene in the species Homo sapiens

Nuclear pore glycoprotein-210 (gp210) is an essential trafficking regulator in the eukaryotic nuclear pore complex. Gp-210 anchors the pore complex to the nuclear membrane. and protein tagging reveals its primarily located on the luminal side of double layer membrane at the pore. A single polypeptide motif of gp210 is responsible for sorting to nuclear membrane, and indicate the carboxyl tail of the protein is oriented toward the cytoplasmic side of the membrane.

<span class="mw-page-title-main">Nuclear pore glycoprotein p62</span> Protein-coding gene in the species Homo sapiens

Nuclear pore glycoprotein p62 is a protein complex associated with the nuclear envelope. The p62 protein remains associated with the nuclear pore complex-lamina fraction. p62 is synthesized as a soluble cytoplasmic precursor of 61 kDa followed by modification that involve addition of N-acetylglucosamine residues, followed by association with other complex proteins. In humans it is encoded by the NUP62 gene.

<span class="mw-page-title-main">Nuclear envelope</span> Nuclear membrane surrounding the nucleus in eukaryotic cells

The nuclear envelope, also known as the nuclear membrane, is made up of two lipid bilayer membranes that in eukaryotic cells surround the nucleus, which encloses the genetic material.

<span class="mw-page-title-main">Nucleoporin</span> Family of proteins that form the nuclear pore complex

Nucleoporins are a family of proteins which are the constituent building blocks of the nuclear pore complex (NPC). The nuclear pore complex is a massive structure embedded in the nuclear envelope at sites where the inner and outer nuclear membranes fuse, forming a gateway that regulates the flow of macromolecules between the cell nucleus and the cytoplasm. Nuclear pores enable the passive and facilitated transport of molecules across the nuclear envelope. Nucleoporins, a family of around 30 proteins, are the main components of the nuclear pore complex in eukaryotic cells. Nucleoporin 62 is the most abundant member of this family. Nucleoporins are able to transport molecules across the nuclear envelope at a very high rate. A single NPC is able to transport 60,000 protein molecules across the nuclear envelope every minute.

<span class="mw-page-title-main">Nucleoporin 153</span> Protein-coding gene in the species Homo sapiens

Nucleoporin 153 (Nup153) is a protein which in humans is encoded by the NUP153 gene. It is an essential component of the basket of nuclear pore complexes (NPCs) in vertebrates, and required for the anchoring of NPCs. It also acts as the docking site of an importing karyopherin. On the cytoplasmic side of the NPC, Nup358 fulfills an analogous role.

<span class="mw-page-title-main">Nucleoporin 88</span> Protein-coding gene in the species Homo sapiens

Nucleoporin 88 (Nup88) is a protein that in humans is encoded by the NUP88 gene.

<span class="mw-page-title-main">Nucleoporin 50</span> Protein-coding gene in the species Homo sapiens

Nucleoporin 50 (Nup50) is a protein that in humans is encoded by the NUP50 gene.

<span class="mw-page-title-main">NXT1</span> Protein-coding gene in the species Homo sapiens

NTF2-related export protein 1 is a protein that in humans is encoded by the NXT1 gene.

<span class="mw-page-title-main">Nucleoporin 54</span> Protein-coding gene in the species Homo sapiens

Nucleoporin 54 (Nup54) is a protein that in humans is encoded by the NUP54 gene.

<span class="mw-page-title-main">Nuclear pore complex protein Nup133</span> Protein-coding gene in the species Homo sapiens

Nuclear pore complex protein Nup133, or Nucleoporin Nup133, is a protein that in humans is encoded by the NUP133 gene.

<span class="mw-page-title-main">NUPL2</span> Protein-coding gene in the species Homo sapiens

Nucleoporin-like 2 is a protein that in humans is encoded by the NUPL2 gene.

<span class="mw-page-title-main">Nucleoporin 160</span> Protein-coding gene in the species Homo sapiens

Nucleoporin 160 (Nup160) is a protein that in humans is encoded by the NUP160 gene.

<span class="mw-page-title-main">Nucleoporin 155</span> Protein-coding gene in the species Homo sapiens

Nucleoporin 155 (Nup155) is a protein that in humans is encoded by the NUP155 gene.

<span class="mw-page-title-main">NDC1</span> Protein-coding gene in the species Homo sapiens

Nucleoporin NDC1 is a protein that in humans is encoded by the TMEM48 gene. It anchors aladin to the nuclear pore complex.

<span class="mw-page-title-main">Nucleoporin 43</span> Protein-coding gene in the species Homo sapiens

Nucleoporin 43 (Nup43) is a protein that in humans is encoded by the NUP43 gene.

<span class="mw-page-title-main">Nucleoporin 93</span> Protein-coding gene in the species Homo sapiens

Nucleoporin 93 (Nup93) is a protein that in humans is encoded by the NUP93 gene.

<span class="mw-page-title-main">NUPL1</span> Protein-coding gene in the species Homo sapiens

Nucleoporin p58/p45 is a protein that in humans is encoded by the NUPL1 gene.

<span class="mw-page-title-main">Nucleoporin 35</span> Protein-coding gene in the species Homo sapiens

Nucleoporin 35 (Nup35) is a protein that in humans is encoded by the NUP35 gene.

<span class="mw-page-title-main">Nucleoporin 205</span> Protein-coding gene in the species Homo sapiens

Nucleoporin 205 (Nup205) is a protein that in humans is encoded by the NUP205 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000196313 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000053293 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Hallberg E, Wozniak RW, Blobel G (Aug 1993). "An integral membrane protein of the pore membrane domain of the nuclear envelope contains a nucleoporin-like region". J Cell Biol. 122 (3): 513–21. doi:10.1083/jcb.122.3.513. PMC   2119659 . PMID   8335683.
  6. Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi: 10.1093/dnares/5.3.169 . PMID   9734811.
  7. Funakoshi T, Maeshima K, Yahata K, Sugano S, Imamoto F, Imamoto N (Oct 2007). "Two distinct human POM121 genes: requirement for the formation of nuclear pore complexes". FEBS Lett. 581 (25): 4910–6. doi: 10.1016/j.febslet.2007.09.021 . PMID   17900573. S2CID   12819086.
  8. 1 2 "Entrez Gene: POM121 POM121 membrane glycoprotein (homo sapiens)".
  9. Kihlmark M, Imreh G, Hallberg E (October 2001). "Sequential degradation of proteins from the nuclear envelope during apoptosis". J. Cell Sci. 114 (Pt 20): 3643–53. doi:10.1242/jcs.114.20.3643. PMID   11707516.

Further reading