Reza Dana

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Reza Dana
Dr.Reza Dana, MD MSc MPH.png
Dana in 2019
Education St. Paul's School
Johns Hopkins University (BA, MD, MPH)
Illinois Eye and Ear Infirmary (Residency)
Wills Eye Hospital
Massachusetts Eye and Ear
Harvard University (MSc)
Alma mater St. Paul's School
Johns Hopkins University
Harvard University
Occupation(s)Claes H. Dohlman Chair in Ophthalmology, Harvard Medical School
Known for Corneal Transplantation
Ocular Trauma
Dry Eye Disease
Medical career
Field Medical research,
Immunology
Ophthalmology
Institutions Massachusetts Eye and Ear
Massachusetts General Hospital
Brigham and Women's Hospital
Harvard Medical School
Harvard University

Reza Dana is the Claes H. Dohlman Chair in Ophthalmology, Senior Scientist and W. Clement Stone Clinical Research Scholar, Director of Cornea at Massachusetts Eye and Ear, Vice Chair for Academic Programs at the Department of Ophthalmology, Harvard Medical School, and Director of the Harvard-Vision Clinical Scientist Development Program. [1]

Contents

Dana is an internationally recognized expert in the field of corneal disorders and ocular inflammation. He is best known for his work on the mechanisms of ocular inflammation with translational applications to transplantation, autoimmunity, and angiogenesis. [2] He is a member of editorial boards of 10 journals, including as editor-in-chief of Cornea. [3] [4]

Education and training

Dana attended the Tehran International School during his early years and graduated summa cum laude from St. Paul's School, New Hampshire. [5] He pursued his baccalaureate degree at Johns Hopkins University School of Arts and Sciences, where he was invited to join the Phi Beta Kappa. Dr. Dana attended medical school at Johns Hopkins School of Medicine, and also obtained a master's degree in Public Health from Johns Hopkins Bloomberg School of Public Health. [6] He received his Ophthalmology residency training at the Illinois Eye and Ear Infirmary, and clinical cornea and external diseases fellowship at Wills Eye Hospital in Philadelphia. He received advanced fellowship training in Immunology and Uveitis at the Massachusetts Eye and Ear and pursued laboratory research training in Ocular and Transplantation Immunology Laboratory at the Schepens Eye Research Institute, Harvard Medical School under the mentorship of the late J. Wayne Streilein. [6]

Research and career

Dana joined the ophthalmology faculty at the Harvard Medical School as an Instructor in 1995 and has been a faculty member there ever since. In 2006, he was named the director of the Cornea Service at Massachusetts Eye and Ear, and in 2007, he was appointed the Claes H. Dohlman Chair in Ophthalmology and Vice Chairman for Academic Programs.

Dana's research focus is in the area of immuno-inflammatory disorders of the cornea and ocular surface. He has published over 400 peer-reviewed publications and over 150 reviews, and edited several books. [7] [8] His work has been cited more than 53000 times and carries an h-index of 110 as per Google Scholar. [9] His is widely recognized for (i) identifying, phenotyping and functionally characterizing resident bone marrow-derived antigen-presenting cells (APC) of the cornea, [10] (ii) identifying novel mechanisms of corneal APC trafficking, [11] (iii) defining novel functional interactions between lymphatic endothelia and APC, [12] (iv) identifying selective topical cytokine and chemokine targeting to promote transplant survival by suppressing effector T cells, [13] [14] [15] [16] (v) defining novel mechanisms employed by the corneal epithelium to maintain angiogenic privilege including the VEGFR-3 sink [17] and PD-L1 mechanisms, [18] (vi) developing strategies to promote corneal endothelial cell survival in transplantation, including gene therapy. [19] [20] (vi) demonstrating the function of memory Th17 cells in pathogenesis of ocular surface autoimmunity. [21] [22] [23] (vii) evaluating the role of regulatory T cells in corneal graft tolerance. [24] [25] [26] (viii) insights into the contribution of diabetes to alterations in corneal graft immunity. [27] (ix) developing novel biomaterials for therapeutics delivery to the eye. [28] [29]

Lectures, awards and honors

Dr.Joan Miller introducing Dr. Dana at the Friedenwald Award reception at Association for Research in Vision and Ophthalmology Annual Meeting 2018 in Honolulu. Dana ARVO Friedenwald.jpg
Dr.Joan Miller introducing Dr. Dana at the Friedenwald Award reception at Association for Research in Vision and Ophthalmology Annual Meeting 2018 in Honolulu.
Dr. Dana receiving the Ellis Island Medal of Honor in 2019 Reza-dana-ellis.png
Dr. Dana receiving the Ellis Island Medal of Honor in 2019

Teaching and Mentoring

Dana is the Vice Chair for Academic Programs at the Department of Ophthalmology, Massachusetts Eye and Ear and a faculty for the Graduate Program in Immunology, Harvard Medical School. [2] He is the recipient of the Harvard Medical School Clifford Barger Excellence in Mentoring Award, the top mentoring award bestowed at Harvard Medical School. [38] He has mentored over 150 postdoctoral research fellows from 36 countries, 250 clinical fellows and residents, medical students, and graduate students. He has been the director of the National Institutes of Health-funded Harvard-Vision Clinical Scientist Development Program since 2004. [58]

References

  1. ↑ "Research Profile: Reza Dana, M.D., M.Sc., MPH | Mass. Eye and Ear". www.masseyeandear.org. Retrieved 2020-10-20.
  2. 1 2 Research Profile: Reza Dana, MD, MSc, MPH
  3. ↑ Dana, Reza (2020). "Letter From the New Editor-in-Chief". Cornea. 39 (1): 1. doi:10.1097/ICO.0000000000002231. ISSN   1536-4798. PMID   31764283. S2CID   208275145.
  4. ↑ "Reza Dana, MD, MSc, MPH, FARVO". eye.hms.harvard.edu. Retrieved 2020-10-20.
  5. ↑ Memarian, Jahandad (September 14, 2017). "Reza Dana: Success Begins Outside Your Comfort Zone". HuffPost . Retrieved 2020-10-20.
  6. 1 2 3 Streilein, J. Wayne (2004-03-01). "Introducing Reza Dana, the 2003 Recipient of the Cogan Award". Investigative Ophthalmology & Visual Science. 45 (3): 721. doi:10.1167/iovs.03-0509. ISSN   1552-5783.
  7. ↑ Dana, Reza. "Pubmed Bibliography". National Library of Medicine.
  8. ↑ Dana, Reza (2010). Encyclopedia of the Eye. Elsevier. ISBN   978-0-12-374198-1.
  9. ↑ "Google Scholar".
  10. ↑ Hamrah, Pedram; Huq, Syed O.; Liu, Ying; Zhang, Qiang; Dana, M. Reza (2003). "Corneal immunity is mediated by heterogeneous population of antigen-presenting cells". Journal of Leukocyte Biology. 74 (2): 172–178. doi:10.1189/jlb.1102544. ISSN   0741-5400. PMID   12885933. S2CID   15964172.
  11. ↑ Liu, Ying; Hamrah, Pedram; Zhang, Qiang; Taylor, Andrew W.; Dana, M. Reza (2002-01-21). "Draining Lymph Nodes of Corneal Transplant Hosts Exhibit Evidence for Donor Major Histocompatibility Complex (MHC) Class II–positive Dendritic Cells Derived from MHC Class II–negative Grafts". The Journal of Experimental Medicine. 195 (2): 259–268. doi:10.1084/jem.20010838. ISSN   0022-1007. PMC   2193609 . PMID   11805152.
  12. ↑ Chen, Lu; Hamrah, Pedram; Cursiefen, Claus; Zhang, Qiang; Pytowski, Bronislaw; Streilein, J. Wayne; Dana, M. Reza (2004). "Vascular endothelial growth factor receptor-3 mediates induction of corneal alloimmunity". Nature Medicine. 10 (8): 813–815. doi:10.1038/nm1078. ISSN   1078-8956. PMID   15235599. S2CID   1449221.
  13. ↑ Huq, Syed; Liu, Ying; Benichou, Gilles; Dana, M. Reza (2004-10-01). "Relevance of the Direct Pathway of Sensitization in Corneal Transplantation Is Dictated by the Graft Bed Microenvironment". The Journal of Immunology. 173 (7): 4464–4469. doi:10.4049/jimmunol.173.7.4464. ISSN   0022-1767. PMID   15383577.
  14. ↑ Hattori, Takaaki; Saban, Daniel R.; Emami-naeini, Parisa; Chauhan, Sunil K.; Funaki, Toshinari; Ueno, Hiroki; Dana, Reza (2012). "Donor-derived, tolerogenic dendritic cells suppress immune rejection in the indirect allosensitization-dominant setting of corneal transplantation". Journal of Leukocyte Biology. 91 (4): 621–627. doi:10.1189/jlb.1011500. ISSN   1938-3673. PMC   3317274 . PMID   22291211.
  15. ↑ Dohlman, Thomas; Omoto, Masahiro; Hua, Jing; Stevenson, William; Lee, Sang-Mok; Chauhan, Sunil; Dana, Reza (2015). "VEGF-trap Aflibercept Significantly Improves Long-term Graft Survival in High-risk Corneal Transplantation". Transplantation. 99 (4): 678–686. doi: 10.1097/TP.0000000000000512 . ISSN   0041-1337. PMID   25606789. S2CID   26944722.
  16. ↑ Amouzegar, Afsaneh; Chauhan, Sunil K.; Dana, Reza (2016-05-15). "Alloimmunity and Tolerance in Corneal Transplantation". The Journal of Immunology. 196 (10): 3983–3991. doi:10.4049/jimmunol.1600251. ISSN   0022-1767. PMC   4874505 . PMID   27183635.
  17. ↑ Cursiefen, Claus; Chen, Lu; Saint-Geniez, Magali; Hamrah, Pedram; Jin, Yiping; Rashid, Saadia; Pytowski, Bronislaw; Persaud, Kris; Wu, Yan; Streilein, J. Wayne; Dana, Reza (2006-07-25). "Nonvascular VEGF receptor 3 expression by corneal epithelium maintains avascularity and vision". Proceedings of the National Academy of Sciences of the United States of America. 103 (30): 11405–11410. Bibcode:2006PNAS..10311405C. doi: 10.1073/pnas.0506112103 . ISSN   0027-8424. PMC   1544098 . PMID   16849433.
  18. ↑ Shen, Linling; Jin, Yiping; Freeman, Gordon J.; Sharpe, Arlene H.; Dana, M. Reza (2007-09-15). "The function of donor versus recipient programmed death-ligand 1 in corneal allograft survival". Journal of Immunology. 179 (6): 3672–3679. doi: 10.4049/jimmunol.179.6.3672 . ISSN   0022-1767. PMID   17785803.
  19. ↑ Fuchsluger, T. A.; Jurkunas, U.; Kazlauskas, A.; Dana, R. (2011). "Anti-apoptotic gene therapy prolongs survival of corneal endothelial cells during storage". Gene Therapy. 18 (8): 778–787. doi:10.1038/gt.2011.20. ISSN   1476-5462. PMC   3587653 . PMID   21412281.
  20. ↑ Fuchsluger, Thomas A.; Jurkunas, Ula; Kazlauskas, Andrius; Dana, Reza (2011). "Corneal endothelial cells are protected from apoptosis by gene therapy". Human Gene Therapy. 22 (5): 549–558. doi:10.1089/hum.2010.079. ISSN   1557-7422. PMC   3081440 . PMID   21158568.
  21. ↑ Chen, Y.; Chauhan, S. K.; Lee, H. Soo; Saban, D. R.; Dana, R. (January 2014). "Chronic dry eye disease is principally mediated by effector memory Th17 cells". Mucosal Immunology. 7 (1): 38–45. doi:10.1038/mi.2013.20. ISSN   1935-3456. PMC   3732510 . PMID   23571503.
  22. ↑ Chen, Yihe; Chauhan, Sunil K.; Tan, Xuhua; Dana, Reza (February 2017). "Interleukin-7 and -15 maintain pathogenic memory Th17 cells in autoimmunity". Journal of Autoimmunity. 77: 96–103. doi:10.1016/j.jaut.2016.11.003. ISSN   1095-9157. PMC   5276802 . PMID   27899224.
  23. ↑ Chen, Yihe; Shao, Chunyi; Fan, Nai-Wen; Nakao, Takeshi; Amouzegar, Afsaneh; Chauhan, Sunil K.; Dana, Reza (January 2021). "The functions of IL-23 and IL-2 on driving autoimmune effector T-helper 17 cells into the memory pool in dry eye disease". Mucosal Immunology. 14 (1): 177–186. doi:10.1038/s41385-020-0289-3. ISSN   1935-3456. PMC   7581618 . PMID   32327706.
  24. ↑ Shao, Chunyi; Chen, Yihe; Nakao, Takeshi; Amouzegar, Afsaneh; Yin, Jia; Tahvildari, Maryam; Lužnik, Zala; Chauhan, Sunil K.; Dana, Reza (January 2019). "Local Delivery of Regulatory T Cells Promotes Corneal Allograft Survival". Transplantation. 103 (1): 182–190. doi:10.1097/TP.0000000000002442. ISSN   1534-6080. PMC   6309927 . PMID   30247445.
  25. ↑ Coco, Giulia; Foulsham, William; Nakao, Takeshi; Yin, Jia; Amouzegar, Afsaneh; Taketani, Yukako; Chauhan, Sunil K.; Dana, Reza (February 2020). "Regulatory T cells promote corneal endothelial cell survival following transplantation via interleukin-10". American Journal of Transplantation. 20 (2): 389–398. doi:10.1111/ajt.15631. ISSN   1600-6143. PMC   6984989 . PMID   31587452.
  26. ↑ Inomata, Takenori; Hua, Jing; Di Zazzo, Antonio; Dana, Reza (2016-12-23). "Impaired Function of Peripherally Induced Regulatory T Cells in Hosts at High Risk of Graft Rejection". Scientific Reports. 6 (1): 39924. Bibcode:2016NatSR...639924I. doi:10.1038/srep39924. ISSN   2045-2322. PMC   5180229 . PMID   28008995.
  27. ↑ Blanco, Tomás; Musayeva, Aytan; Singh, Rohan Bir; Nakagawa, Hayate; Lee, Seokjoo; Alemi, Hamid; Gonzalez-Nolasco, Bruno; Ortiz, Gustavo; Wang, Shudan; Kahale, Francesca; Dohlman, Thomas H.; Chen, Yihe; Dana, Reza (2023-09-01). "The impact of donor diabetes on corneal transplant immunity". American Journal of Transplantation. 23 (9): 1345–1358. doi:10.1016/j.ajt.2023.05.027. ISSN   1600-6135. PMC   10527508 . PMID   37245642.
  28. ↑ Shirzaei Sani, Ehsan; Kheirkhah, Ahmad; Rana, Devyesh; Sun, Zhongmou; Foulsham, William; Sheikhi, Amir; Khademhosseini, Ali; Dana, Reza; Annabi, Nasim (2019-03-20). "Sutureless repair of corneal injuries using naturally derived bioadhesive hydrogels". Science Advances. 5 (3): eaav1281. Bibcode:2019SciA....5.1281S. doi:10.1126/sciadv.aav1281. PMC   6426459 . PMID   30906864.
  29. ↑ Jumelle, Clotilde; Yung, Ann; Sani, Ehsan Shirzaei; Taketani, Yukako; Gantin, Fanny; Bourel, Louisa; Wang, Shudan; Yüksel, Erdem; Seneca, Senne; Annabi, Nasim; Dana, Reza (2022-01-01). "Development and characterization of a hydrogel-based adhesive patch for sealing open-globe injuries". Acta Biomaterialia. 137: 53–63. doi:10.1016/j.actbio.2021.10.021. ISSN   1742-7061. PMC   8678346 . PMID   34673229.
  30. ↑ "Heed Fellows || The Heed Foundation". www.heed.org. Retrieved 2020-10-20.
  31. 1 2 3 "Honors and Distinctions - Schepens Eye Research Institute of Mass. Eye and Ear". www.schepens.harvard.edu. Archived from the original on 2019-11-10. Retrieved 2019-11-10.
  32. ↑ "Reza Dana | Harvard Catalyst Profiles | Harvard Catalyst". connects.catalyst.harvard.edu. Retrieved 2020-10-20.
  33. ↑ "Alcon Research Institute Past Grant Recipients | MyAlcon.com". www.myalcon.com. Archived from the original on 2019-11-10. Retrieved 2019-11-10.
  34. ↑ "Ever Association". www.everassociation.org. Retrieved 2020-10-20.
  35. ↑ "LSUHSC School of Medicine". www.medschool.lsuhsc.edu. Retrieved 2020-10-20.
  36. ↑ "The Association for Research in Vision and Ophthalmology- 2013 ARVO Fellows". www.arvo.org. Retrieved 2020-10-20.
  37. ↑ "Ocular Microbiology and Immunology Group, Inc". Ocular Microbiology and Immunology Group, Inc. Retrieved 2020-10-20.
  38. 1 2 "A. Clifford Barger Excellence in Mentoring Award Recipients". The Office for Diversity Inclusion and Community Partnership at Harvard Medical School. Retrieved 2020-10-20.
  39. ↑ "Reza Dana, MD, MSc, MPH, Receives Kersley Medal". eye.hms.harvard.edu. Retrieved 2020-10-20.
  40. ↑ "Roger F. Meyer Lectureship in Cornea | Ophthalmology | Michigan Medicine". Ophthalmology. 2017-08-28. Retrieved 2020-10-20.
  41. ↑ "Reza Dana Elected to Academia Ophthalmologica Internationalis". eye.hms.harvard.edu. Retrieved 2020-10-20.
  42. ↑ "Honorary Lectures + ICO Medal Winners | Eye Doctors ©2019". entertainment.ie. Retrieved 2019-11-10.
  43. ↑ "Dr. Reza Dana to Receive 2016 Endre A. Balazs Prize". eye.hms.harvard.edu. 2016-04-28. Retrieved 2020-10-20.
  44. ↑ "The 121st Annual Meeting of the Japanese Ophthalmological Society". convention.jtbcom.co.jp. Retrieved 2020-10-20.
  45. ↑ "Reza Dana receives Senior Achievement Award from AAO". eye.hms.harvard.edu. Retrieved 2020-10-20.
  46. ↑ Jurkunas, Ula. "30th Biennial Cornea Conference". Grantome.
  47. ↑ "Dr. Reza Dana to receive Friedenwald Award from the Association for Research in Vision and Ophthalmology". eye.hms.harvard.edu. 2017-06-02. Retrieved 2019-11-10.
  48. ↑ "Reza Dana, MD, MSc, MPH, Awarded Research to Prevent Blindness Stein Innovation Award". eye.hms.harvard.edu. 2018-06-25. Retrieved 2020-10-20.
  49. ↑ "2019 Ellis Island Medal of Honor Recipients". eihonors.org. Archived from the original on 2019-07-15. Retrieved 2020-10-20.
  50. ↑ "Reza Dana". The Ophthalmologist. Retrieved 2020-10-20.
  51. ↑ "Past meetings". Bowmans. Retrieved 2025-01-07.
  52. ↑ "American Uveitis Society - Spring 2024 Meeting". uveitissociety.org. Retrieved 2025-01-07.
  53. ↑ "Highlights from the 2024 Annual Meeting and Alumni Reunion". eye.hms.harvard.edu. Retrieved 2025-01-07.
  54. ↑ "Anderson Lectureship at DMEI in OKC". DMEI | Dean McGee Eye Institute. Retrieved 2025-01-07.
  55. ↑ "Main Stage". annualmeeting.ascrs.org. Retrieved 2025-01-07.
  56. ↑ "Reza Dana, MD, MSc, MPH, to Give ASCRS Richard L. Lindstrom, MD, Lecture". eye.hms.harvard.edu. Retrieved 2025-05-19.
  57. ↑ "The 1st Joseph Markoff, PhD, MD Endowed Lecture: Reza Dana, MD, MSc, MPH - Wills Eye Hospital CME - Continuing Education (CE)". willseye.cloud-cme.com. Retrieved 2025-05-19.
  58. ↑ "Reza Dana, MD, MSc, MPH". Harvard Medical School. Retrieved 2020-10-20.
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