Reza Dana

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Reza Dana
Dr.Reza Dana, MD MSc MPH.png
Dana in 2019
Education St. Paul's School
Johns Hopkins University (BA, MD, MPH)
Illinois Eye and Ear Infirmary (residency)
Wills Eye Hospital
Massachusetts Eye and Ear
Harvard University (MSc)
Alma mater St. Paul's School
Johns Hopkins University
Illinois Eye and Ear Infirmary
Wills Eye Hospital
Harvard Medical School
Occupation(s)Claes H. Dohlman Chair of Ophthalmology, W. Clement Stone Clinical Research Scholar Harvard Medical School
Known for Dry Eye Disease
Corneal Transplantation Research
Medical career
Field Medical research,
Immunology
Ophthalmology
Institutions Massachusetts Eye and Ear
Massachusetts General Hospital
Brigham and Women's Hospital
Harvard Medical School
Harvard University

Reza Dana is the Claes H. Dohlman Professor of Ophthalmology, senior scientist and W. Clement Stone Clinical Research Scholar at Massachusetts Eye and Ear, Harvard Medical School, and director of the Harvard-Vision Clinical Scientist Development Program. [1]

Contents

Dana is an internationally recognized expert in the field of corneal disorders and ocular inflammation. He is best known for his work on the molecular and cellular mechanisms of ocular inflammation with translational applications to autoimmunity, transplantation, dry eye disease, and angiogenesis. [2] He is a member of editorial boards of 10 journals, including as editor-in-chief of Cornea. [3] [4]

Education and training

Dana attended the Tehran International School during his early years and graduated summa cum laude from St. Paul's School, New Hampshire. [5] He pursued his baccalaureate degree at Johns Hopkins University School of Arts and Sciences, where he was invited to join the Phi Beta Kappa. Dr. Dana attended medical school at Johns Hopkins School of Medicine, and also obtained a master's degree in Public Health from Johns Hopkins Bloomberg School of Public Health. [6] He received his Ophthalmology residency training at the Illinois Eye and Ear Infirmary, and clinical cornea and external diseases fellowship at Wills Eye Hospital in Philadelphia. He received advanced fellowship training in Immunology and Uveitis at the Massachusetts Eye and Ear and pursued laboratory research training in Ocular and Transplantation Immunology Laboratory at the Schepens Eye Research Institute, Harvard Medical School under the mentorship of the late J. Wayne Streilein. [6]

Research and career

Dana joined as an instructor in the department of ophthalmology at Harvard Medical School in 1995 and has been a faculty member here ever since. In 2006, he was named the director of Cornea Service at Massachusetts Eye and Ear, and in 2007, he was appointed the Claes H. Dohlman Chair in Ophthalmology and vice chairman for academic programs. He is also an honorary professor of ophthalmology at Shanghai Medical College, Fudan University. [7]

Dana's research focus is in the area of immuno-inflammatory disorders of the cornea and ocular surface. He has published over 370 peer-reviewed publications and over 150 reviews, edited several books and serves as the senior editor for Elsevier's Encyclopedia of the Eye. [8] [9] His work has been cited more than 25000 times and carries an h-index of 82. [10] His is widely recognized for (i) identifying, phenotyping and functionally characterizing resident bone marrow-derived antigen-presenting cells (APC) of the cornea, [11] (ii) identifying novel mechanisms of corneal APC trafficking, [12] (iii) defining novel functional interactions between lymphatic endothelia and APC, [13] (iv) identifying selective topical cytokine and chemokine targeting to promote transplant survival by suppressing effector T cells, [14] [15] [16] [17] (v) defining novel mechanisms employed by the corneal epithelium to maintain angiogenic privilege including the VEGFR-3 sink [18] and PD-L1 mechanisms, [19] (vi) developing strategies to promote corneal endothelial cell survival in transplantation, including gene therapy. [20] [21]

Awards and honors

Dr.Joan Miller introducing Dana at the Friedenwald Award reception at Association for Research in Vision and Ophthalmology Annual Meeting 2018 in Honolulu. Dana ARVO Friedenwald.jpg
Dr.Joan Miller introducing Dana at the Friedenwald Award reception at Association for Research in Vision and Ophthalmology Annual Meeting 2018 in Honolulu.
Dana receiving the Ellis Island Medal of Honor in 2019 Reza-dana-ellis.png
Dana receiving the Ellis Island Medal of Honor in 2019

Teaching and Mentoring

Dana is the vice chair of academic programs at the Department of Ophthalmology, Massachusetts Eye and Ear and a faculty for the Graduate Program in Immunology, Harvard Medical School. [2] He is the recipient of the Harvard Medical School Clifford Barger Excellence in Mentoring Award, the top mentoring award bestowed at Harvard Medical School. [30] He has mentored over 120 postdoctoral research fellows from 33 countries, 80 clinical fellows and residents, medical students, and graduate students enrolled in Harvard Medical School. He is the director of the NIH-funded Harvard-Vision Clinical Scientist Development Program since 2004. [43]

Related Research Articles

<span class="mw-page-title-main">Keratoconus</span> Medical condition involving the eye

Keratoconus (KC) is a disorder of the eye that results in progressive thinning of the cornea. This may result in blurry vision, double vision, nearsightedness, irregular astigmatism, and light sensitivity leading to poor quality-of-life. Usually both eyes are affected. In more severe cases a scarring or a circle may be seen within the cornea.

<span class="mw-page-title-main">Cornea</span> Transparent front layer of the eye

The cornea is the transparent front part of the eye that covers the iris, pupil, and anterior chamber. Along with the anterior chamber and lens, the cornea refracts light, accounting for approximately two-thirds of the eye's total optical power. In humans, the refractive power of the cornea is approximately 43 dioptres. The cornea can be reshaped by surgical procedures such as LASIK.

<span class="mw-page-title-main">Pterygium (eye)</span> Pinkish, triangular tissue growth on the cornea of the eye

A pterygium of the eye is a pinkish, roughly triangular tissue growth of the conjunctiva onto the cornea of the eye. It typically starts on the cornea near the nose. It may slowly grow but rarely grows so large that it covers the pupil and impairs vision. Often both eyes are involved.

<span class="mw-page-title-main">Corneal transplantation</span> Surgical procedure of repairing corneal tissue to treat corneal blindness

Corneal transplantation, also known as corneal grafting, is a surgical procedure where a damaged or diseased cornea is replaced by donated corneal tissue. When the entire cornea is replaced it is known as penetrating keratoplasty and when only part of the cornea is replaced it is known as lamellar keratoplasty. Keratoplasty simply means surgery to the cornea. The graft is taken from a recently deceased individual with no known diseases or other factors that may affect the chance of survival of the donated tissue or the health of the recipient.

<span class="mw-page-title-main">Corneal neovascularization</span> Medical condition

Corneal neovascularization (CNV) is the in-growth of new blood vessels from the pericorneal plexus into avascular corneal tissue as a result of oxygen deprivation. Maintaining avascularity of the corneal stroma is an important aspect of corneal pathophysiology as it is required for corneal transparency and optimal vision. A decrease in corneal transparency causes visual acuity deterioration. Corneal tissue is avascular in nature and the presence of vascularization, which can be deep or superficial, is always pathologically related.

<span class="mw-page-title-main">Pedram Hamrah</span> German-American ophthalmologist

Pedram Hamrah is a German-American ophthalmologist and immunologist. He obtained his M.D. from the University of Cologne, Germany.

<span class="mw-page-title-main">Keratoprosthesis</span> Surgical procedure where a diseased cornea is replaced with an artificial one

Keratoprosthesis is a surgical procedure where a diseased cornea is replaced with an artificial cornea. Traditionally, keratoprosthesis is recommended after a person has had a failure of one or more donor corneal transplants. More recently, a less invasive, non-penetrating artificial cornea has been developed which can be used in more routine cases of corneal blindness. While conventional cornea transplant uses donor tissue for transplant, an artificial cornea is used in the keratoprosthesis procedure. The surgery is performed to restore vision in patients with severely damaged cornea due to congenital birth defects, infections, injuries and burns.

J. Wayne Streilein was a scientist whose main area of research was the ocular immune system. He is known particularly for studying the mechanisms that keep the cornea avascular despite the inflammatory and other stimuli that usually promote small blood vessel ingrowth; these peculiar corneal mechanisms provide the basis for what is known as the "corneal antiangiogenic privilege".

<span class="mw-page-title-main">Boston keratoprosthesis</span> Prosthetic cornea

Boston keratoprosthesis is a collar button design keratoprosthesis or artificial cornea. It is composed of a front plate with a stem, which houses the optical portion of the device, a back plate and a titanium locking c-ring. It is available in type I and type II formats. The type I design is used much more frequently than the type II which is reserved for severe end stage dry eye conditions and is similar to the type I except it has a 2 mm anterior nub designed to penetrate through a tarsorrhaphy. The type I format will be discussed here as it is more commonly used.

<span class="mw-page-title-main">Gholam A. Peyman</span> Iranian-American ophthalmologist and retina surgeon known for inventing LASIK eye surgery

Gholam A. Peyman is an Iranian American ophthalmologist, retina surgeon, and inventor. He is best known for his invention of LASIK eye surgery, a vision correction procedure designed to allow people to see clearly without glasses. He was awarded the first US patent for the procedure in 1989.

Mooren's ulcer is a rare idiopathic ocular disorder that may lead to blindness due to progressive destruction of the peripheral cornea. Although the etiology of Mooren's ulcer is poorly understood, recent evidence suggests that the pathogenesis of this disease appears to be the result of an autoimmune process directed against molecules expressed in the corneal stroma.

<span class="mw-page-title-main">Farhad Hafezi</span> Swiss eye surgeon and researcher (born 1967)

Farhad Hafezi is a prominent Swiss eye surgeon and researcher. Hafezi first gained recognition as a leading retina researcher in 1994, having been the first to discover a gene responsible for light-induced retinal degeneration. However, he changed his research focus to the cornea in 2003, and it is this work, particularly on corneal collagen cross-linking (CXL), which he helped pioneer, and advanced laser refractive surgery that he is internationally known for today. Hafezi's current clinical and laboratory research is focused on gaining a better understanding of the cornea. His research group at the University of Zurich has three main research foci:

The Legacy Devers Eye Institute in Portland, Oregon, is one of the few private, non-profit centers for ophthalmological care, research, and training in the United States. The institute is affiliated with Legacy Health, a network of seven hospitals in Portland and Southwest Washington. Legacy Devers includes the Thelma and Gilbert Schnitzer Comprehensive Glaucoma Center.

David Myer Maurice was a British ophthalmologist, noted for his contributions to the development of the specular microscope used for examination of the cornea.

ProfessorKeryn Anne Williams is an Australian medical scientist who works in the field of ophthalmology. She was a Principal Research Fellow in the School of Medicine at Flinders University. Her research interests include clinical and experimental corneal transplantation, ocular inflammation, ocular immunology and eye banking.

<span class="mw-page-title-main">V. S. Sangwan</span> Indian ophthalmologist

Virender Singh Sangwan is an Indian ophthalmologist and the Dr. Paul Dubord Chair professor and director of the L. V. Prasad Eye Institute, Hyderabad. Known for his research on limbal stem cells, Sangwan is the founder secretary and an adviser of the Uveitis Society of India. The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards for his contributions to Medical Sciences in 2006.

<span class="mw-page-title-main">Corneal opacity</span> Medical condition

Corneal opacification is a term used when the human cornea loses its transparency. The term corneal opacity is used particularly for the loss of transparency of cornea due to scarring. Transparency of the cornea is dependent on the uniform diameter and the regular spacing and arrangement of the collagen fibrils within the stroma. Alterations in the spacing of collagen fibrils in a variety of conditions including corneal edema, scars, and macular corneal dystrophy is clinically manifested as corneal opacity. The term corneal blindness is commonly used to describe blindness due to corneal opacity.

Herbert Edward Kaufman is an American ophthalmologist who discovered idoxuridine, the first clinically useful antiviral agent; co-developed with William Bourne the clinical specular microscope to view the live corneal endothelium, co-developed timolol with Thomas Zimmerman, a new class of medications to treat glaucoma; corneal storage media for eye banks; natamycin, the first commercially available medication to treat fungal infections of the eye; co-developed with Tony Gasset the use of bandage contact lenses; and was involved in the first laser vision photorefractive keratectomy of the eye with Marguarite McDonald.

Exposure keratopathy is medical condition affecting the cornea of eyes. It can lead to corneal ulceration and permanent loss of vision due to corneal opacity.

Anastasios John Kanellopoulos is a Greek-American eye surgeon specializing in corneal transplantation, cornea crosslinking for keratoconus, complicated cataract surgery and complicated glaucoma. Widely known for research and clinical contributions in micro-incision cataract, customized laser refractive surgery and corneal cross-linking propagation and most innovations, reducing corneal transplants for advanced keratoconus.

References

  1. ↑ "Research Profile: Reza Dana, M.D., M.Sc., MPH | Mass. Eye and Ear". www.masseyeandear.org. Retrieved 2020-10-20.
  2. 1 2 Research Profile: Reza Dana, MD, MSc, MPH
  3. ↑ Dana, Reza (2020). "Letter From the New Editor-in-Chief". Cornea. 39 (1): 1. doi:10.1097/ICO.0000000000002231. ISSN   1536-4798. PMID   31764283. S2CID   208275145.
  4. ↑ "Reza Dana, MD, MSc, MPH, FARVO". eye.hms.harvard.edu. Retrieved 2020-10-20.
  5. ↑ Memarian, Jahandad (September 14, 2017). "Reza Dana: Success Begins Outside Your Comfort Zone". HuffPost . Retrieved 2020-10-20.
  6. 1 2 3 Streilein, J. Wayne (2004-03-01). "Introducing Reza Dana, the 2003 Recipient of the Cogan Award". Investigative Ophthalmology & Visual Science. 45 (3): 721. doi:10.1167/iovs.03-0509. ISSN   1552-5783.
  7. ↑ "Dana CV" (PDF). Archived from the original (PDF) on 2019-11-08. Retrieved 2019-11-10.
  8. ↑ Dana, Reza. "Pubmed Bibliography". National Library of Medicine.
  9. ↑ Dana, Reza (2010). Encyclopedia of the Eye. Elsevier. ISBN   978-0-12-374198-1.
  10. ↑ "Google Scholar".
  11. ↑ Hamrah, Pedram; Huq, Syed O.; Liu, Ying; Zhang, Qiang; Dana, M. Reza (2003). "Corneal immunity is mediated by heterogeneous population of antigen-presenting cells". Journal of Leukocyte Biology. 74 (2): 172–178. doi:10.1189/jlb.1102544. ISSN   0741-5400. PMID   12885933. S2CID   15964172.
  12. ↑ Liu, Ying; Hamrah, Pedram; Zhang, Qiang; Taylor, Andrew W.; Dana, M. Reza (2002-01-21). "Draining Lymph Nodes of Corneal Transplant Hosts Exhibit Evidence for Donor Major Histocompatibility Complex (MHC) Class II–positive Dendritic Cells Derived from MHC Class II–negative Grafts". The Journal of Experimental Medicine. 195 (2): 259–268. doi:10.1084/jem.20010838. ISSN   0022-1007. PMC   2193609 . PMID   11805152.
  13. ↑ Chen, Lu; Hamrah, Pedram; Cursiefen, Claus; Zhang, Qiang; Pytowski, Bronislaw; Streilein, J. Wayne; Dana, M. Reza (2004). "Vascular endothelial growth factor receptor-3 mediates induction of corneal alloimmunity". Nature Medicine. 10 (8): 813–815. doi:10.1038/nm1078. ISSN   1078-8956. PMID   15235599. S2CID   1449221.
  14. ↑ Huq, Syed; Liu, Ying; Benichou, Gilles; Dana, M. Reza (2004-10-01). "Relevance of the Direct Pathway of Sensitization in Corneal Transplantation Is Dictated by the Graft Bed Microenvironment". The Journal of Immunology. 173 (7): 4464–4469. doi:10.4049/jimmunol.173.7.4464. ISSN   0022-1767. PMID   15383577.
  15. ↑ Hattori, Takaaki; Saban, Daniel R.; Emami‐naeini, Parisa; Chauhan, Sunil K.; Funaki, Toshinari; Ueno, Hiroki; Dana, Reza (2012). "Donor-derived, tolerogenic dendritic cells suppress immune rejection in the indirect allosensitization-dominant setting of corneal transplantation". Journal of Leukocyte Biology. 91 (4): 621–627. doi:10.1189/jlb.1011500. ISSN   1938-3673. PMC   3317274 . PMID   22291211.
  16. ↑ Dohlman, Thomas; Omoto, Masahiro; Hua, Jing; Stevenson, William; Lee, Sang-Mok; Chauhan, Sunil; Dana, Reza (2015). "VEGF-trap Aflibercept Significantly Improves Long-term Graft Survival in High-risk Corneal Transplantation". Transplantation. 99 (4): 678–686. doi: 10.1097/TP.0000000000000512 . ISSN   0041-1337. PMID   25606789. S2CID   26944722.
  17. ↑ Amouzegar, Afsaneh; Chauhan, Sunil K.; Dana, Reza (2016-05-15). "Alloimmunity and Tolerance in Corneal Transplantation". The Journal of Immunology. 196 (10): 3983–3991. doi:10.4049/jimmunol.1600251. ISSN   0022-1767. PMC   4874505 . PMID   27183635.
  18. ↑ Cursiefen, Claus; Chen, Lu; Saint-Geniez, Magali; Hamrah, Pedram; Jin, Yiping; Rashid, Saadia; Pytowski, Bronislaw; Persaud, Kris; Wu, Yan; Streilein, J. Wayne; Dana, Reza (2006-07-25). "Nonvascular VEGF receptor 3 expression by corneal epithelium maintains avascularity and vision". Proceedings of the National Academy of Sciences of the United States of America. 103 (30): 11405–11410. Bibcode:2006PNAS..10311405C. doi: 10.1073/pnas.0506112103 . ISSN   0027-8424. PMC   1544098 . PMID   16849433.
  19. ↑ Shen, Linling; Jin, Yiping; Freeman, Gordon J.; Sharpe, Arlene H.; Dana, M. Reza (2007-09-15). "The function of donor versus recipient programmed death-ligand 1 in corneal allograft survival". Journal of Immunology. 179 (6): 3672–3679. doi: 10.4049/jimmunol.179.6.3672 . ISSN   0022-1767. PMID   17785803.
  20. ↑ Fuchsluger, T. A.; Jurkunas, U.; Kazlauskas, A.; Dana, R. (2011). "Anti-apoptotic gene therapy prolongs survival of corneal endothelial cells during storage". Gene Therapy. 18 (8): 778–787. doi:10.1038/gt.2011.20. ISSN   1476-5462. PMC   3587653 . PMID   21412281.
  21. ↑ Fuchsluger, Thomas A.; Jurkunas, Ula; Kazlauskas, Andrius; Dana, Reza (2011). "Corneal endothelial cells are protected from apoptosis by gene therapy". Human Gene Therapy. 22 (5): 549–558. doi:10.1089/hum.2010.079. ISSN   1557-7422. PMC   3081440 . PMID   21158568.
  22. ↑ "Heed Fellows || The Heed Foundation". www.heed.org. Retrieved 2020-10-20.
  23. 1 2 3 "Honors and Distinctions - Schepens Eye Research Institute of Mass. Eye and Ear". www.schepens.harvard.edu. Archived from the original on 2019-11-10. Retrieved 2019-11-10.
  24. ↑ "Reza Dana | Harvard Catalyst Profiles | Harvard Catalyst". connects.catalyst.harvard.edu. Retrieved 2020-10-20.
  25. ↑ "Alcon Research Institute Past Grant Recipients | MyAlcon.com". www.myalcon.com. Archived from the original on 2019-11-10. Retrieved 2019-11-10.
  26. ↑ "Ever Association". www.everassociation.org. Retrieved 2020-10-20.
  27. ↑ "LSUHSC School of Medicine". www.medschool.lsuhsc.edu. Retrieved 2020-10-20.
  28. ↑ "The Association for Research in Vision and Ophthalmology- 2013 ARVO Fellows". www.arvo.org. Retrieved 2020-10-20.
  29. ↑ "Ocular Microbiology and Immunology Group, Inc". Ocular Microbiology and Immunology Group, Inc. Retrieved 2020-10-20.
  30. 1 2 "A. Clifford Barger Excellence in Mentoring Award Recipients". The Office for Diversity Inclusion and Community Partnership at Harvard Medical School. Retrieved 2020-10-20.
  31. ↑ "Reza Dana, MD, MSc, MPH, Receives Kersley Medal". eye.hms.harvard.edu. Retrieved 2020-10-20.
  32. ↑ "Roger F. Meyer Lectureship in Cornea | Ophthalmology | Michigan Medicine". Ophthalmology. 2017-08-28. Retrieved 2020-10-20.
  33. ↑ "Reza Dana Elected to Academia Ophthalmologica Internationalis". eye.hms.harvard.edu. Retrieved 2020-10-20.
  34. ↑ "Honorary Lectures + ICO Medal Winners | Eye Doctors ©2019". entertainment.ie. Retrieved 2019-11-10.
  35. ↑ "Dr. Reza Dana to Receive 2016 Endre A. Balazs Prize". eye.hms.harvard.edu. 2016-04-28. Retrieved 2020-10-20.
  36. ↑ "The 121st Annual Meeting of the Japanese Ophthalmological Society". convention.jtbcom.co.jp. Retrieved 2020-10-20.
  37. ↑ "Reza Dana receives Senior Achievement Award from AAO". eye.hms.harvard.edu. Retrieved 2020-10-20.
  38. ↑ Jurkunas, Ula. "30th Biennial Cornea Conference". Grantome.
  39. ↑ "Dr. Reza Dana to receive Friedenwald Award from the Association for Research in Vision and Ophthalmology". eye.hms.harvard.edu. 2017-06-02. Retrieved 2019-11-10.
  40. ↑ "Reza Dana, MD, MSc, MPH, Awarded Research to Prevent Blindness Stein Innovation Award". eye.hms.harvard.edu. 2018-06-25. Retrieved 2020-10-20.
  41. ↑ "2019 Ellis Island Medal of Honor Recipients". eihonors.org. Archived from the original on 2019-07-15. Retrieved 2020-10-20.
  42. ↑ "Reza Dana". The Ophthalmologist. Retrieved 2020-10-20.
  43. ↑ "Reza Dana, MD, MSc, MPH". Harvard Medical School. Retrieved 2020-10-20.
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