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Names | |
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IUPAC name (1R,2S,4S,5′S,6S,7S,8R,9S,12S,13S,16S,18S)-5′,7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icosane-6,2′-piperidine]-16-ol | |
Other names
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Identifiers | |
3D model (JSmol) | |
91747 | |
ChEBI | |
ChEMBL | |
ChemSpider | |
ECHA InfoCard | 100.000.947 |
EC Number |
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KEGG | |
PubChem CID | |
UNII | |
CompTox Dashboard (EPA) | |
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Properties | |
C27H45NO2 | |
Molar mass | 415.662 g·mol−1 |
Hazards | |
GHS labelling: | |
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Danger | |
H301, H302, H331 | |
P261, P264, P270, P271, P301+P310, P301+P312, P304+P340, P311, P321, P330, P403+P233, P405, P501 | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). |
Tomatidine is a natural compound found in leaves of tomatoes and green tomatoes. [1] Chemically, it is the aglycone of tomatine. It has been shown to have potential health benefits in animal models. [2] For instance, tomatidine inhibited skeletal muscle atrophy in a mouse model of skeletal unloading-induced atrophy [3] and to prevent or reverse sarcopenia (loss of muscle mass and strength due to biological aging) by inhibiting the activation of genes by ATF4. [4]
Dietary supplementation with ~0.04% tomatidine for 10 weeks reduced plasma cholesterol and atherosclerosis in ApoE-deficient mice without evidence of toxicity. [5]
It is investigated as compound to increase longevity and it increased lifespan and healthspan of C. elegans . [6] It is also investigated in osteoporosis. [7] [8]
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