Tuomas Knowles

Last updated
Tuomas Knowles
NationalityBritish, Finnish
Alma mater ETH Zurich, University of Cambridge, University of Geneva
Known forProtein biophysics
Awards Corday–Morgan Prize from the Royal Society of Chemistry, Raymond and Beverly Sackler International Prize in Biophysics, Harrison-Meldola Memorial Prize from the Royal Society of Chemistry, Rita and John Cornforth Award, Royal Society of Chemistry, 2019
Scientific career
Fields Biophysics, Chemistry, Physical Chemistry [1]
Institutions University of Cambridge
Doctoral advisor Sir Mark Welland
Other academic advisors Sir Chris Dobson

Tuomas Knowles is a British scientist and Professor of Physical Chemistry and Biophysics at the Department of Chemistry [2] and at the Cavendish Laboratory at the University of Cambridge. [3] He is the co-director of the Cambridge Centre for Misfolding Diseases [4] and a Fellow of St John's College, Cambridge. [5] [ circular reference ] Prof. Knowles is a co-founder of four biotechnology companies: Fluidic Analytics, Wren Therapeutics, Xampla and Transition Bio. He was also the Cambridge Enterprise Academic Entrepreneur of the year in 2019. [6]

Contents

Education

Tuomas Knowles studied Biology at the University of Geneva and Physics at the Swiss Federal Institute of Technology in Zurich and at the University of Cambridge. He holds a Ph.D. in Physics from the University of Cambridge and a master's degree in Physics from the Swiss Federal Institute of Technology Zurich. He was a visiting scholar at Harvard University [7] and Weston Visiting Professor at the Weizmann Institute of Science in Israel.

Research

The research of Tuomas Knowles focuses on understanding protein behavior in health and disease. Knowles is known for his work on protein aggregation and for describing the kinetics of this process and the underlying molecular mechanisms. He discovered the first integrated rate law for amyloid formation [8] which has allowed the mechanisms of this process to be elucidated by researchers worldwide and together with collaborators he has made software available to the research community for kinetic analysis of protein aggregation. He has published over 300 papers, has an H-index of 70 and has been named Highly Cited Researcher by the Web of Science. [9]

Awards and honors

Related Research Articles

<span class="mw-page-title-main">Alan Fersht</span> British chemist (born 1943)

Sir Alan Roy Fersht is a British chemist at the MRC Laboratory of Molecular Biology, Cambridge, and an Emeritus Professor in the Department of Chemistry at the University of Cambridge. He was Master of Gonville and Caius College, Cambridge from 2012 to 2018. He works on protein folding, and is sometimes described as a founder of protein engineering.

<span class="mw-page-title-main">Richard Henderson (biologist)</span> British biologist

Richard Henderson is a British molecular biologist and biophysicist and pioneer in the field of electron microscopy of biological molecules. Henderson shared the Nobel Prize in Chemistry in 2017 with Jacques Dubochet and Joachim Frank."Thanks to his work, we can look at individual atoms of living nature, thanks to cryo-electron microscopes we can see details without destroying samples, and for this he won the Nobel Prize in Chemistry."

<span class="mw-page-title-main">Daan Frenkel</span> Dutch physicist (born 1948)

Daan Frenkel is a Dutch computational physicist in the Department of Chemistry at the University of Cambridge.

Jeffery W. Kelly is an American businessman and chemist who is on the faculty of the Scripps Research Institute in La Jolla, California.

<span class="mw-page-title-main">Athene Donald</span> British physicist

Dame Athene Margaret Donald is a British physicist. She is Professor Emerita of Experimental Physics at the University of Cambridge, and Master of Churchill College, Cambridge.

<span class="mw-page-title-main">Michael L. Klein</span> American chemist (born 1940)

Michael Lawrence KleinNAS is Laura H. Carnell Professor of Science and director of the Institute for Computational Molecular Science in the college of science and technology at Temple University in Philadelphia, US. He was previously the Hepburn Professor of Physical Science in the Center for Molecular Modeling at the University of Pennsylvania.

<span class="mw-page-title-main">Chris Dobson</span> British chemist (1949–2019)

Sir Christopher Martin Dobson was a British chemist, who was the John Humphrey Plummer Professor of Chemical and Structural Biology in the Department of Chemistry at the University of Cambridge, and Master of St John's College, Cambridge.

The Harrison-Meldola Memorial Prizes are annual prizes awarded by Royal Society of Chemistry to chemists in Britain who are 34 years of age or below. The prize is given to scientist who demonstrate the most meritorious and promising original investigations in chemistry and published results of those investigations. There are 3 prizes given every year, each winning £5000 and a medal. Candidates are not permitted to nominate themselves.

<span class="mw-page-title-main">Martin Gruebele</span>

Martin Gruebele is a German-born American physical chemist and biophysicist who is currently James R. Eiszner Professor of Chemistry, Professor of Physics, Professor of Biophysics and Computational Biology at the University of Illinois Urbana-Champaign, where he is the principal investigator of the Gruebele Group.

Sheena Elizabeth Radford FRS FMedSci is a British biophysicist, and Astbury Professor of Biophysics in the Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology at the University of Leeds. Radford is the Associate Editor of the Journal of Molecular Biology.

<span class="mw-page-title-main">James Naismith (chemist)</span> British structural biologist

James Henderson Naismith is Professor of Structural Biology at the University of Oxford, former Director of the Research Complex at Harwell and Director of the Rosalind Franklin Institute. He previously served as Bishop Wardlaw Professor of Chemical Biology at the University of St Andrews. He was a member of Council of the Royal Society (2021-2022). He is currently the Vice-Chair of Council of the European X-ray Free Electron Laser and Vice-President (non-clinical) of The Academy of Medical Sciences. It has been announced that he will be the Head of the MPLS division at Oxford in the autumn of 2023.

<span class="mw-page-title-main">David Ron</span> British scientist

David Ron FRS is a British biochemist.

<span class="mw-page-title-main">Jane Clarke (scientist)</span> English biochemist and academic

Jane Clarke is an English biochemist and academic. Since October 2017, she has served as President of Wolfson College, Cambridge. She is also Professor of Molecular Biophysics, a Wellcome Trust Senior Research Fellow in the Department of Chemistry at the University of Cambridge. She was previously a Fellow of Trinity Hall, Cambridge. In 2023, she was elected to the National Academy of Sciences.

Sir David Klenerman is a British biophysical chemist and a professor of biophysical chemistry at the Department of Chemistry at the University of Cambridge and a Fellow of Christ's College, Cambridge.

<span class="mw-page-title-main">Nigel Scrutton</span>

Nigel Shaun Scrutton is a British biochemist and biotechnology innovator known for his work on enzyme catalysis, biophysics and synthetic biology. He is Director of the UK Future Biomanufacturing Research Hub, Director of the Fine and Speciality Chemicals Synthetic Biology Research Centre (SYNBIOCHEM), and Co-founder, Director and Chief Scientific Officer of the 'fuels-from-biology' company C3 Biotechnologies Ltd. He is Professor of Enzymology and Biophysical Chemistry in the Department of Chemistry at the University of Manchester. He is former Director of the Manchester Institute of Biotechnology (MIB).

<span class="mw-page-title-main">Ian William Murison Smith</span>

Ian William Murison Smith was a chemist who served as a research fellow and lecturer in the Department of Chemistry, University of Cambridge from 1963 to 1985 and Professor of Chemistry at the University of Birmingham from 1985 to 2002.

<span class="mw-page-title-main">William Eaton (scientist)</span> American biophysicist

William Allen Eaton is a biophysical chemist who is a NIH Distinguished Investigator, Chief of the Section on Biophysical Chemistry, and Chief of the Laboratory of Chemical Physics at the National Institute of Diabetes and Digestive and Kidney Diseases, one of the 20 Institutes of the United States National Institutes of Health.

<span class="mw-page-title-main">Michele Vendruscolo</span> Italian British physicist

Michele Vendruscolo is an Italian British physicist working in the UK, noted for his theoretical and experimental work on protein folding, misfolding and aggregation.

Jean Baum is an American chemist. She is the distinguished professor of chemistry and chemical biology at Rutgers University, where she is also vice dean for research and graduate education in the school of arts and sciences, and also vice chair of the department of chemistry and chemical biology. Her research investigates protein–protein interaction and protein aggregation using nuclear magnetic resonance spectroscopy (NMR) and other biochemical and biophysical techniques. She serves as treasurer for the Protein Society.

Jerelle A. Joseph is a computational chemist and academic from Dominica, who is also an advocate for representation and diversity in science. She is the founder of CariScholar, a network connecting students and academics from Caribbean countries.

References

  1. "Tuomas Knowles". scholar.google.co.uk.
  2. "Tuomas Knowles — Knowles Lab". www-knowles.ch.cam.ac.uk. 9 June 2016.
  3. "Professor Tuomas Knowles — Department of Physics". www.phy.cam.ac.uk. 10 May 2019.
  4. "Index | Centre for Misfolding Diseases". www.cmd.ch.cam.ac.uk.
  5. St John's College, Cambridge
  6. "IfM News and Features". www.ifm.eng.cam.ac.uk.
  7. "Tuomas Knowles". weitzlab.seas.harvard.edu.
  8. Knowles TP, Waudby CA, Devlin GL, Cohen SI, Aguzzi A, Vendruscolo M, et al. (December 2009). "An analytical solution to the kinetics of breakable filament assembly". Science. 326 (5959): 1533–7. Bibcode:2009Sci...326.1533K. doi:10.1126/science.1178250. PMID   20007899. S2CID   6267152.
  9. "Five Professors named as 2019 Highly Cited Researchers | Yusuf Hamied Department of Chemistry". www.ch.cam.ac.uk.
  10. "Prizes and awards 2017". Royal Society of Chemistry. 9 May 2017.
  11. "Past Laureates of the Raymond and Beverly Sackler International Prize in Biophysics". Tel Aviv University. September 5, 2012.
  12. "Previous winners". Royal Society of Chemistry.