Pennsylvania Route 100 is a 59.4-mile (95.6 km) long state highway in the U.S. state of Pennsylvania that runs from U.S. Route 202 near West Chester north to PA 309 in Pleasant Corners. The route runs between the western suburbs of Philadelphia and the Lehigh Valley region of the state, serving Chester, Montgomery, Berks, and Lehigh counties. PA 100 intersects several important highways, including US 30 in Exton, the Pennsylvania Turnpike (Interstate 76, near Lionville, US 422 near Pottstown, US 222 in Trexlertown, and I-78/US 22 in Fogelsville. Several sections of PA 100 are multi-lane divided highway with some interchanges, including between US 202 and the Pennsylvania Turnpike in Chester County between south of Pottstown and New Berlinville, and between Trexlertown and Fogelsville.
Pennsylvania Route 52 is a 11.8-mile-long (19.0 km) state highway located in southeast Pennsylvania. The southern terminus of the route is at the Pennsylvania-Delaware state line near Kennett Square, where the road continues as Delaware Route 52. The northern terminus is at U.S. Route 322 Business in West Chester. Near the Kennett Township community of Longwood, it has about a 1-mile (1.6 km) wrong-way concurrency with US 1. PA 52 passes through suburban and rural areas along its route.
U.S. Route 422 (US 422) is a 271-mile-long (436 km) spur route of US 22 split into two segments in the U.S. states of Ohio and Pennsylvania. The western segment of US 422 runs from downtown Cleveland, Ohio, east to Ebensburg, Pennsylvania. The eastern segment, located entirely within Pennsylvania, runs from Hershey east to King of Prussia, near Philadelphia. US 422 Business serves as a business route into each of four towns along the way.
U.S. Route 30 (US 30) is a U.S. Highway that runs east–west across the southern part of Pennsylvania, passing through Pittsburgh and Philadelphia on its way from the West Virginia state line east to the Benjamin Franklin Bridge over the Delaware River into New Jersey.
The Baltimore Pike was an auto trail connecting Baltimore, Maryland, with Philadelphia, Pennsylvania.
Pennsylvania Route 3 is a 24.3-mile (39.1 km) state highway located in the southeastern portion of Pennsylvania. The route runs from U.S. Route 322 Business in West Chester east to PA 611 in Philadelphia.
Pennsylvania Route 72 is a 37.8-mile-long (60.8 km) north–south state route located in southeast Pennsylvania. The southern terminus of the route is at U.S. Route 222 /PA 272 in Lancaster. The northern terminus is at PA 443 north of Lickdale in Union Township. PA 72 serves as a major road connecting Lancaster and Lebanon counties, serving East Petersburg, Manheim, Cornwall, Lebanon, and Jonestown. The route intersects several major roads including US 30 and PA 283 north of Lancaster, the Pennsylvania Turnpike south of Cornwall, US 322 along a concurrency on a freeway bypassing Cornwall, US 422 in Lebanon, US 22 near Jonestown, and I-81 via Fisher Avenue in Lickdale.
Pennsylvania Route 23 is an 81.14-mile-long (130.58 km) state highway in southeastern Pennsylvania. The route begins at PA 441 in Marietta and heads east to U.S. Route 1 at City Avenue on the border of Lower Merion Township and Philadelphia. PA 23 begins at Marietta in Lancaster County and continues east to Lancaster, where it passes through the city on a one-way pair of streets and intersects US 222 and US 30.
U.S. Route 222 Business is a 12.17-mile (19.59 km) business route of US 222 in Reading, Pennsylvania. The southern terminus is at US 222 in Cumru Township. Its northern terminus is at US 222 in Ontelaunee Township. The route begins at the US 222 freeway and heads through the southwestern suburbs of Reading as Lancaster Avenue, intersecting Pennsylvania Route 724 in Shillington. US 222 Bus. continues into Reading on Lancaster Avenue and intersects the northern termini of PA 625 and PA 10 before reaching an interchange with the US 422 freeway.
U.S. Route 422 Business is a 7.29-mile-long (11.73 km) business route of US 422 located in the Reading, Pennsylvania area. The route is one of four auxiliary routes of US 422 in Pennsylvania. Its western terminus is at an interchange with US 222 and US 422 in Wyomissing. Its eastern terminus is at an interchange with US 422 in Reiffton. US 422 Bus. heads east from US 222/US 422 along Penn Avenue, passing through Wyomissing and West Reading. The route has an interchange with the US 422 freeway before it crosses the Schuylkill River into Reading. US 422 Bus. passes through downtown Reading on the one-way pair of Franklin Street eastbound and Washington Street westbound, intersecting the southern terminus of Pennsylvania Route 183 and crossing US 222 Bus. The business route heads into the eastern part of the city southeast on Perkiomen Avenue before following the one-way pair of Perkiomen Avenue eastbound and Mineral Spring Road westbound into Mount Penn. US 422 Bus. continues along Perkiomen Avenue to St. Lawrence, where it intersects the western terminus of PA 562 and turns southeast. The route passes through Reiffton before it merges into eastbound US 422.
Pennsylvania Route 113 is a 46.9-mile-long (75.5 km) state route in eastern Pennsylvania. The southern terminus of the route is at U.S. Route 30 Business in Downingtown. Its northern terminus is at PA 611 in Tinicum Township. The route is signed as north–south although its exact alignment follows a northeast-southwest routing. The route serves Chester, Montgomery, and Bucks counties, passing through Lionville, Phoenixville, Trappe, Skippack, Harleysville, Souderton, and Silverdale along the way.
U.S. Route 1 (US 1) is a major north–south U.S. Route, extending from Key West, Florida, in the south to Fort Kent, Maine, at the Canada–United States border in the north. In the U.S. state of Pennsylvania, US 1 runs for 81 miles (130 km) from the Maryland state line near Nottingham northeast to the New Jersey state line at the Delaware River in Morrisville, through the southeastern portion of the state. The route runs southwest to northeast and serves as a major arterial road through the city of Philadelphia and for many of the suburbs in the Delaware Valley metropolitan area. South of Philadelphia, the road mostly follows the alignment of the Baltimore Pike. Within Philadelphia, it mostly follows Roosevelt Boulevard. North of Philadelphia, US 1 parallels the route of the Lincoln Highway. Several portions of US 1 in Pennsylvania are freeways, including from near the Maryland state line to Kennett Square, the bypass of Media, the concurrency with Interstate 76 and the Roosevelt Expressway in Philadelphia, and between Bensalem Township and the New Jersey state line.
U.S. Route 322 is a spur of US 22, running from Cleveland, Ohio, east to Atlantic City, New Jersey. In the U.S. state of Pennsylvania, the route runs from the Ohio state line in West Shenango Township southeast to the Commodore Barry Bridge over the Delaware River in Chester, at which point the route crosses into New Jersey. The route passes near or through several cities, including Meadville, DuBois, State College, and Harrisburg. US 322 in Pennsylvania is named the 28th Division Highway in honor of the 28th Infantry Division.
Pennsylvania Route 842 is a state highway in Chester County, Pennsylvania. The route runs from PA 841 in West Marlborough Township to U.S. Route 322 Business in downtown West Chester. PA 842 runs through rural areas with some development between PA 841 and West Chester as a two-lane undivided road. Along this stretch, the route forms a concurrency with PA 82 in Unionville, where it intersects the western terminus of PA 162. In West Chester, PA 842 is routed along one-way streets. PA 842 was first designated by 1928 between PA 82 in Unionville and US 122/PA 5/PA 62 in West Chester. The route was extended west to PA 841 in 1937.
U.S. Route 30 Business is a 19-mile (31 km) business route of US 30 in Chester County, Pennsylvania. The route follows the former alignment of US 30 between Sadsbury Township and East Whiteland Township, passing through Coatesville, Downingtown, and Exton. US 30 follows a freeway bypass between these two points. The present alignment of US 30 Bus. was originally part of a turnpike called the Philadelphia and Lancaster Turnpike that was completed in 1794. The state took over the turnpike at the beginning of the 20th century. In 1913, present-day US 30 Bus. was incorporated into the Lincoln Highway, an auto trail that ran from San Francisco east to New York City. The Lincoln Highway through Pennsylvania became Pennsylvania Route 1 (PA 1) in 1924. US 30 was designated concurrent with PA 1 west of Philadelphia in 1926, with the PA 1 designation removed two years later. US 30 was widened into a multilane road through Chester County in the 1930s. In the 1960s, US 30 was moved to a freeway bypass around Coatesville and Downingtown, with US 30 Bus. designated onto the former alignment of US 30. In 1995, US 30 Bus. was extended east when US 30 was extended to bypass Exton.
U.S. Route 13 (US 13) is a United States Numbered Highway running from Fayetteville, North Carolina, north to Morrisville, Pennsylvania. The route runs for 49.359 miles (79.436 km) through the Delaware Valley in the U.S. state of Pennsylvania. The route enters the state from Delaware in Marcus Hook, Delaware County. It continues northeast through Delaware County, passing through the city of Chester before heading through suburban areas along Chester Pike to Darby. US 13 enters the city of Philadelphia on Baltimore Avenue and runs through West Philadelphia to University City, where it turns north along several city streets before heading east across the Schuylkill River along Girard Avenue. The route turns north and heads to North Philadelphia, where it runs northeast along Hunting Park Avenue. US 13 becomes concurrent with US 1 on Roosevelt Boulevard, continuing into Northeast Philadelphia. US 13 splits southeast on a one-way pair of streets before heading northeast out of the city on Frankford Avenue. The route continues into Bucks County as Bristol Pike, heading northeast to Bristol, where it turns into a divided highway. US 13 becomes a freeway in Tullytown and continues north to its terminus at US 1 in Falls Township, near Morrisville. US 13 roughly parallels Interstate 95 (I-95) through its course in Pennsylvania.
U.S. Route 202 is a US Highway running from New Castle, Delaware, northeast to Bangor, Maine. The route runs through the southeastern part of the U.S. state of Pennsylvania, passing through the western and northern suburbs of Philadelphia in the Delaware Valley metropolitan area. US 202 serves largely as a toll-free bypass around the city, avoiding the busy traffic and congestion on Interstate 95 (I-95). It is signed north–south and follows a general southwest–northeast direction through the state, serving West Chester, King of Prussia, Bridgeport, Norristown, Montgomeryville, Doylestown, and New Hope. US 202 enters Pennsylvania from Delaware and heads north as a divided highway, where it becomes concurrent with US 322 at an intersection with US 1 in Painters Crossing. The two routes run north and become a freeway that bypasses West Chester to the east, with US 322 splitting from US 202. US 202 continues north and east along the freeway to King of Prussia, where it reverts to an at-grade divided highway following an interchange with I-76. The route becomes a one-way pair as it passes through Bridgeport and Norristown before both directions rejoin and the road continues northeast. US 202 follows an expressway-grade parkway between Montgomeryville and Doylestown prior to bypassing Doylestown to the south along a freeway. The route continues northeast as an at-grade road to New Hope, where it turns into a freeway again before it crosses the Delaware River on the New Hope–Lambertville Toll Bridge into New Jersey.
U.S. Route 220 is a U.S. Highway that is a spur route of US 20. It runs from Rockingham, North Carolina, north to South Waverly, Pennsylvania. In the state of Pennsylvania, the route runs 248 miles (399 km) from the Maryland border in Cumberland Valley Township, Bedford County northeast to an interchange with Interstate 86 (I-86)/New York State Route 17 in South Waverly, Bradford County a short distance south of the New York border. Through the state, US 220 passes through the cities and towns of Bedford, Altoona, State College, Lock Haven, Williamsport, and Towanda. US 220 is concurrent with the entire completed Pennsylvania segment of I-99 between I-70/I-76 in Bedford and I-80 near Bellefonte. US 220 is also a freeway around Bedford, along the I-80 concurrency between Bellefonte and Mill Hall, between Mill Hall and Jersey Shore, from the western end of Williamsport to near Halls, and near the New York border. The remainder of US 220 in Pennsylvania is mostly a two-lane surface road.
A total of at least five special routes of U.S. Route 322 currently exist.
Several special routes of U.S. Route 30 exist. In order from west to east they are as follows.
US 322 in East Bradford Township 
PA 162 in West Chester 
PA 842 in West Chester
PA 3 in West Chester
PA 52 in West Chester
