Zona pellucida-like domain

Last updated
Zona pellucida-like domain
Identifiers
SymbolZona_pellucida
Pfam PF00100
InterPro IPR001507
SMART SM00241
PROSITE PDOC00577
Membranome 146
Available protein structures:
Pfam   structures / ECOD  
PDB RCSB PDB; PDBe; PDBj
PDBsum structure summary

The zona pellucida-like domain (ZP domain / ZP-like domain / ZP module) [1] [2] is a large protein region of about 260 amino acids. It has been recognised in a variety of receptor-like eukaryotic glycoproteins. [1] All of these molecules are mosaic proteins with a large extracellular region composed of various domains, often followed by either a transmembrane domain and a short cytoplasmic region or by a GPI-anchor. [2]

Functional and crystallographic studies revealed that the "ZP domain" region common to all these proteins is a protein polymerization module that consists of two distinct but structurally related immunoglobulin-like domains, ZP-N and ZP-C, separated by an interdomain linker (ITD). [3] [4] [5] [6] [7] [8] [9] The ZP module is located in the C-terminal portion of the extracellular region and – with the exception of non-polymeric family member ENG [10] – contains 8 or 10 conserved Cys residues involved in disulfide bonds. [4] [5] [8] The ZP-C domain contains a EHP/IHP motif that controls polymerization. [11]

The first 3D structure of a homopolymeric ZP module protein filament, native human uromodulin (UMOD), was determined by cryo-EM. [12] [13]

Additional copies of isolated ZP-N domains are found in the N-terminal region of egg coat protein subunits involved in fertilization in both vertebrates and invertebrates, with the human zona pellucida components ZP1, ZP2 and ZP4 being the best understood. [4] [14] The mollusc "vitelline envelope receptor for egg lysin" (VERL, Q8WR62 ) is found in the vitelline envelope of mollusc eggs and consists of 22 VERL repeats followed by a ZP module. Structural work from 2017 demonstrated that VERL repeats are also ZP-N domains. [15]

Examples

Humans genes encoding proteins containing this domain include:

References

  1. 1 2 Bork P, Sander C (1992). "A large domain common to sperm receptors (Zp2 and Zp3) and TGF-beta type III receptor". FEBS Lett. 300 (3): 237–40. Bibcode:1992FEBSL.300..237B. doi: 10.1016/0014-5793(92)80853-9 . PMID   1313375. S2CID   38778076.
  2. 1 2 Jovine L, Darie CC, Litscher ES, Wassarman PM (2005). "Zona pellucida domain proteins". Annu. Rev. Biochem. 74: 83–114. doi:10.1146/annurev.biochem.74.082803.133039. PMID   15952882.
  3. ↑ Jovine L, Qi H, Williams Z, Litscher E, Wassarman PM (2002). "The ZP domain is a conserved module for polymerization of extracellular proteins". Nat. Cell Biol. 4 (6): 457–61. doi:10.1038/ncb802. PMID   12021773. S2CID   11575790.
  4. 1 2 3 Monné M, Han L, Schwend T, Burendahl S, Jovine L (2008). "Crystal structure of the ZP-N domain of ZP3 reveals the core fold of animal egg coats". Nature. 456 (7222): 653–7. Bibcode:2008Natur.456..653M. doi:10.1038/nature07599. hdl: 11563/8930 . PMID   19052627. S2CID   4430083. PDB: 3D4C, 3D4G, 3EF7 ​
  5. 1 2 Han L, Monné M, Okumura, H, Schwend, T, Cherry, AL, Flot, D, Matsuda, T, Jovine, L (2010). "Insights into egg coat assembly and egg-sperm interaction from the X-ray structure of full-length ZP3". Cell. 143 (3): 404–15. doi: 10.1016/j.cell.2010.09.041 . hdl: 11563/8931 . PMID   20970175. S2CID   18583237. PDB: 3NK3, 3NK4 ​
  6. ↑ Lin SJ, Hu Y, Zhu J, Woodruff TK, Jardetzky TS (2011). "Structure of betaglycan zona pellucida (ZP)-C domain provides insights into ZP-mediated protein polymerization and TGF-beta binding". Proc Natl Acad Sci U S A. 108 (13): 5232–6. Bibcode:2011PNAS..108.5232L. doi: 10.1073/pnas.1010689108 . PMC   3069177 . PMID   21402931. PDB: 3QW9 ​
  7. ↑ Diestel U, Resch M, Meinhardt K, Weiler S, Hellmann TV, Mueller TD, Nickel J, Eichler J, Muller YA (2013). "Identification of a Novel TGF-β-Binding Site in the Zona Pellucida C-terminal (ZP-C) Domain of TGF-β-Receptor-3 (TGFR-3)". PLOS ONE. 8 (6): e67214. Bibcode:2013PLoSO...867214D. doi: 10.1371/journal.pone.0067214 . PMC   3695229 . PMID   23826237. PDB: 4AJV ​
  8. 1 2 Bokhove M, Nishimura K, Brunati M, Han L, de Sanctis D, Rampoldi L, Jovine L (2016). "A structured interdomain linker directs self-polymerization of human uromodulin". Proc. Natl. Acad. Sci. U.S.A. 113 (6): 1552–1557. Bibcode:2016PNAS..113.1552B. doi: 10.1073/pnas.1519803113 . PMC   4760807 . PMID   26811476. PDB: 4WRN, 5BUP ​
  9. ↑ Bokhove M, Jovine L (2018). "Structure of Zona Pellucida Module Proteins". Curr. Top. Dev. Biol. Current Topics in Developmental Biology. 130: 413–442. doi:10.1016/bs.ctdb.2018.02.007. ISBN   978-0-12-809802-8. PMID   29853186.
  10. ↑ Saito T, Bokhove M, Croci R, Zamora-Caballero S, Han L, Letarte M, de Sanctis D, Jovine L (2017). "Structural Basis of the Human Endoglin-BMP9 Interaction: Insights into BMP Signaling and HHT1". Cell Reports. 19 (9): 1917–1928. doi:10.1016/j.celrep.2017.05.011. PMC   5464963 . PMID   28564608. PDB: 5HZV ​
  11. ↑ Jovine L, Qi H, Williams Z, Litscher ES, Wassarman PM (2004). "A duplicated motif controls assembly of zona pellucida domain proteins". Proc. Natl. Acad. Sci. U.S.A. 101 (16): 5922–7. Bibcode:2004PNAS..101.5922J. doi: 10.1073/pnas.0401600101 . PMC   395899 . PMID   15079052.
  12. ↑ Stsiapanava A, Xu C, Brunati M, Zamora-Caballero S, Schaeffer C, Bokhove M, Han L, Hebert H, Carroni M, Yasumasu S, Rampoldi L, Wu B, Jovine L (2020). "Cryo-EM structure of native human uromodulin, a zona pellucida module polymer". EMBO J. 39 (24): e106807. bioRxiv   10.1101/2020.05.28.119206 . doi: 10.15252/embj.2020106807 . PMC   7737619 . PMID   33196145. PDB: 6TQK, 6TQL ​
  13. ↑ Stsiapanava A, Xu C, Nishio S, Han L, Yamakawa N, Carroni M, Tunyasuvunakool K, Jumper J, de Sanctis D, Wu B, Jovine L (2022). "Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH". Nat. Struct. Mol. Biol. 29 (3): 190–193. doi: 10.1038/s41594-022-00729-3 . PMC   8930769 . PMID   35273390. PDB: 7PFP, 7Q3N ​
  14. ↑ Callebaut I, Mornon JP, Monget P (2007). "Isolated ZP-N domains constitute the N-terminal extensions of Zona Pellucida proteins". Bioinformatics. 23 (15): 1871–1874. doi: 10.1093/bioinformatics/btm265 . PMID   17510169.
  15. ↑ Raj I, Sadat Al Hosseini H, Dioguardi E, Nishimura K, Han L, Villa A, de Sanctis D, Jovine L (2017). "Structural Basis of Egg Coat-Sperm Recognition at Fertilization". Cell. 169 (7): 1315–1326. doi:10.1016/j.cell.2017.05.033. PMC   5480393 . PMID   28622512. PDB: 5II4, 5II5, 5II6, 5MR2, 5IIC, 5IIA, 5IIB, 5MR3 ​
This article incorporates text from the public domain Pfam and InterPro: IPR001507


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