Β-Naphthoflavone

β-Naphthoflavone

Names
IUPAC name Benzo[5,6]flavone
Systematic IUPAC name 3-Phenyl-1H-naphtho[2,1-b]pyran-1-one
Other names 5,6-Benzoflavone, BNF
Identifiers
CAS Number	6051-87-2  Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:77013  N
ChEMBL	ChEMBL26260  Y
ChemSpider	2271  Y
DrugBank	DB06732  Y
ECHA InfoCard	100.025.417
PubChem CID	2361
UNII	1BT0256Y8O  Y
CompTox Dashboard (EPA)	DTXSID8030423
InChI InChI=1S/C19H12O2/c20-16-12-18(14-7-2-1-3-8-14)21-17-11-10-13-6-4-5-9-15(13)19(16)17/h1-12H Y Key: OUGIDAPQYNCXRA-UHFFFAOYSA-N Y InChI=1/C19H12O2/c20-16-12-18(14-7-2-1-3-8-14)21-17-11-10-13-6-4-5-9-15(13)19(16)17/h1-12H Key: OUGIDAPQYNCXRA-UHFFFAOYAM
SMILES O=C\1c3c(O/C(=C/1)c2ccccc2)ccc4c3cccc4
Properties
Chemical formula	C19H12O2
Molar mass	272.303 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N  verify  (what is  YN ?) Infobox references

β-Naphthoflavone, also known as 5,6-benzoflavone, is a potent agonist of the aryl hydrocarbon receptor and as such is an inducer of such detoxification enzymes as cytochromes P450 (CYPs) and uridine 5'-diphospho-glucuronosyltransferases (UGTs). ^[1] β-Naphthoflavone is a putative chemopreventive agent. ^[2]

See also

• α-Naphthoflavone

References

1. Chlouchi A, Girard C, Bonet A, Viollon-Abadie C, Heyd B, Mantion G, Martin H, Richert L (2007). "Effect of chrysin and natural coumarins on UGT1A1 and 1A6 activities in rat and human hepatocytes in primary culture". Planta Med. 73 (8): 742–7. doi:10.1055/s-2007-981548. PMID   17599282. S2CID   260281088.
2. Izzotti A, Bagnasco M, Cartiglia C, Longobardi M, Camoirano A, Tampa E, Lubet RA, De Flora S (2005). "Modulation of multigene expression and proteome profiles by chemopreventive agents". Mutat Res. 591 (1–2): 212–23. doi:10.1016/j.mrfmmm.2005.03.032. PMID   16083920.