HOXA3

Last updated
HOXA3
Identifiers
Aliases HOXA3 , HOX1, HOX1E, homeobox A3
External IDs OMIM: 142954 MGI: 96175 HomoloGene: 40725 GeneCards: HOXA3
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_030661
NM_153631
NM_153632

NM_010452

RefSeq (protein)

NP_109377
NP_705895

NP_034582

Location (UCSC) Chr 7: 27.11 – 27.15 Mb Chr 6: 52.15 – 52.19 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Homeobox protein Hox-A3 is a protein that in humans is encoded by the HOXA3 gene. [5] [6] [7]

Contents

Function

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Three transcript variants encoding two different isoforms have been found for this gene. [7]

During normal fetal development, HoxA3 is expressed in mesenchymal neural crest cells and endodermal cells found in the third pharyngeal pouch. [8] Expression of HoxA3 in these cells affects the proper formation of the thymus, thyroid, and parathyroid organs. [9] [10] While the gene does not seem to affect the proliferation or migration of the pharyngeal neural crest cells, it does appear to trigger cellular differentiation events required to form these organs. [9] Knockout of HoxA3 leads to failure in forming the thymus (athymia) and parathyroid gland (aparthyroidism). [10] Mutant HoxA3 also causes a reduction in thyroid size. While the follicular and parafollicular cells still differentiate, their numbers are reduced and they are not evenly distributed throughout the gland. [9] Mutant HoxA3 models show similar phenotypes as those seen in DiGeorge's Syndrome, and it is possible that the two are linked. [9]

Regulation

The HOXA3 gene is repressed by the microRNA miR-10a. [11]

See also

Related Research Articles

<span class="mw-page-title-main">HOXB6</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-B6 is a protein that in humans is encoded by the HOXB6 gene.

<span class="mw-page-title-main">HOXD10</span> Protein-coding gene in humans

Homeobox D10, also known as HOXD10, is a protein which in humans is encoded by the HOXD10 gene.

<span class="mw-page-title-main">HOXA5</span> Protein-coding gene in humans

Homeobox protein Hox-A5 is a protein that in humans is encoded by the HOXA5 gene.

<span class="mw-page-title-main">HOXB4</span> Protein-coding gene in humans

Homeobox protein Hox-B4 is a protein that in humans is encoded by the HOXB4 gene.

<span class="mw-page-title-main">HOXC8</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-C8 is a protein that in humans is encoded by the HOXC8 gene.

<span class="mw-page-title-main">HOXA7</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-A7 is a protein that in humans is encoded by the HOXA7 gene.

<span class="mw-page-title-main">HOXA13</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-A13 is a protein that in humans is encoded by the HOXA13 gene.

<span class="mw-page-title-main">HOXB2</span> Protein-coding gene in humans

Homeobox protein Hox-B2 is a protein that in humans is encoded by the HOXB2 gene.

<span class="mw-page-title-main">HOXB9</span> Protein-coding gene in humans

Homeobox protein Hox-B9 is a protein that in humans is encoded by the HOXB9 gene.

<span class="mw-page-title-main">HOXD3</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-D3 is a protein that in humans is encoded by the HOXD3 gene.

<span class="mw-page-title-main">HOXB3</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-B3 is a protein that in humans is encoded by the HOXB3 gene.

<span class="mw-page-title-main">HOXC4</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-C4 is a protein that in humans is encoded by the HOXC4 gene.

<span class="mw-page-title-main">HOXD9</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-D9 is a protein that in humans is encoded by the HOXD9 gene.

<span class="mw-page-title-main">HOXA4</span> Protein-coding gene in the species Homo sapiens

Homeobox A4, also known as HOXA4, is a protein which in humans is encoded by the HOXA4 gene.

<span class="mw-page-title-main">HOXB8</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-B8 is a protein that in humans is encoded by the HOXB8 gene.

<span class="mw-page-title-main">HOXC9</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-C9 is a protein that in humans is encoded by the HOXC9 gene.

<span class="mw-page-title-main">HOXD1</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-D1 is a protein that in humans is encoded by the HOXD1 gene.

<span class="mw-page-title-main">HOXC5</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-C5 is a protein that in humans is encoded by the HOXC5 gene.

<span class="mw-page-title-main">HOXC11</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-C11 is a protein that in humans is encoded by the HOXC11 gene.

<span class="mw-page-title-main">HOXA6</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-A6 is a protein that in humans is encoded by the HOXA6 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000105997 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000079560 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. McAlpine PJ, Shows TB (July 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID   1973146.
  6. Scott MP (November 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID   1358459. S2CID   13370372.
  7. 1 2 "Entrez Gene: HOXA3 homeobox A3".
  8. Hunt P, Gulisano M, Cook M, Sham MH, Faiella A, Wilkinson D, Boncinelli E, Krumlauf R (October 1991). "A distinct Hox code for the branchial region of the vertebrate head". Nature. 353 (6347): 861–4. Bibcode:1991Natur.353..861H. doi:10.1038/353861a0. PMID   1682814. S2CID   4312466.
  9. 1 2 3 4 Manley NR, Capecchi MR (July 1995). "The role of Hoxa-3 in mouse thymus and thyroid development". Development. 121 (7): 1989–2003. doi:10.1242/dev.121.7.1989. PMID   7635047.
  10. 1 2 Chojnowski JL, Masuda K, Trau HA, Thomas K, Capecchi M, Manley NR (October 2014). "Multiple roles for HOXA3 in regulating thymus and parathyroid differentiation and morphogenesis in mouse". Development. 141 (19): 3697–708. doi:10.1242/dev.110833. PMC   4197593 . PMID   25249461.
  11. Han L, Witmer PD, Casey E, Valle D, Sukumar S (August 2007). "DNA methylation regulates MicroRNA expression". Cancer Biology & Therapy. 6 (8): 1284–8. doi: 10.4161/cbt.6.8.4486 . PMID   17660710.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.