HOXA4

HOXA4
Identifiers
Aliases	HOXA4 , HOX1, HOX1D, homeobox A4
External IDs	OMIM: 142953 MGI: 96176 HomoloGene: 37583 GeneCards: HOXA4
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7p15.2 Start 27,128,507 bp [1] End 27,130,780 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6 B3|6 25.4 cM Start 52,166,651 bp [2] End 52,168,733 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastric mucosa fallopian tube left uterine tube right uterine tube gastrocnemius muscle right lung fundus skeletal muscle tissue upper lobe of left lung kidney Top expressed in seminiferous tubule spermatocyte spermatid brown adipose tissue thyroid gland somite tracheobronchial tree abdominal wall sternocleidomastoid muscle thoracic diaphragm More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity sequence-specific DNA binding DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific Cellular component nucleus nuclear body Biological process multicellular organism development anatomical structure morphogenesis regulation of transcription, DNA-templated transcription, DNA-templated regulation of transcription by RNA polymerase II skeletal system development anterior/posterior pattern specification positive regulation of transcription by RNA polymerase II embryonic skeletal system morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3201 15401 Ensembl ENSG00000197576 ENSMUSG00000000942 UniProt Q00056 P06798 RefSeq (mRNA) NM_002141 NM_008265 RefSeq (protein) NP_002132 NP_032291 Location (UCSC) Chr 7: 27.13 – 27.13 Mb Chr 6: 52.17 – 52.17 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Homeobox A4, also known as HOXA4, is a protein which in humans is encoded by the HOXA4 gene. ^{[5] [6]}

Function

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. ^[7] Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. ^[5]

See also

• Homeobox

References

1. GRCh38: Ensembl release 89: ENSG00000197576 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000000942 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: HOXA4 homeobox A4".
6. McAlpine PJ, Shows TB (July 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID   1973146.
7. Scott MP (November 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID   1358459. S2CID   13370372.

Further reading

• Scott MP (1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID   1358459. S2CID   13370372.
• Buettner R, Yim SO, Hong YS, et al. (1991). "Alteration of homeobox gene expression by N-ras transformation of PA-1 human teratocarcinoma cells". Mol. Cell. Biol. 11 (7): 3573–83. doi:10.1128/mcb.11.7.3573. PMC   361102 . PMID   1675427.
• McAlpine PJ, Shows TB (1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID   1973146.
• Peverali FA, D'Esposito M, Acampora D, et al. (1991). "Expression of HOX homeogenes in human neuroblastoma cell culture lines". Differentiation. 45 (1): 61–9. doi:10.1111/j.1432-0436.1990.tb00458.x. PMID   1981366.
• Ferguson-Smith AC, Fienberg A, Ruddle FH (1989). "Isolation, chromosomal localization, and nucleotide sequence of the human HOX 1.4 homeobox". Genomics. 5 (2): 250–8. doi:10.1016/0888-7543(89)90054-2. PMID   2571574.
• Boncinelli E, Acampora D, Pannese M, et al. (1990). "Organization of human class I homeobox genes". Genome. 31 (2): 745–56. doi:10.1139/g89-133. PMID   2576652.
• Verlinsky Y, Morozov G, Gindilis V, et al. (1995). "Homeobox gene expression in human oocytes and preembryos". Mol. Reprod. Dev. 41 (2): 127–32. doi:10.1002/mrd.1080410202. PMID   7654365. S2CID   43123886.
• Apiou F, Flagiello D, Cillo C, et al. (1996). "Fine mapping of human HOX gene clusters". Cytogenet. Cell Genet. 73 (1–2): 114–5. doi:10.1159/000134320. PMID   8646877.
• Kuliev A, Kukharenko V, Morozov G, et al. (1996). "Expression of homebox-containing genes in human preimplantation development and in embryos with chromosomal aneuploidies". J. Assist. Reprod. Genet. 13 (2): 177–81. doi:10.1007/BF02072541. PMID   8688592. S2CID   28126784.
• Duluc I, Lorentz O, Fritsch C, et al. (1997). "Changing intestinal connective tissue interactions alters homeobox gene expression in epithelial cells". J. Cell Sci. 110 (11): 1317–24. doi:10.1242/jcs.110.11.1317. PMID   9202392.
• Stelnicki EJ, Kömüves LG, Kwong AO, et al. (1998). "HOX homeobox genes exhibit spatial and temporal changes in expression during human skin development". J. Invest. Dermatol. 110 (2): 110–5. doi: 10.1046/j.1523-1747.1998.00092.x . PMID   9457903.
• Verlinsky Y, Morozov G, Verlinsky O, et al. (1998). "Isolation of cDNA libraries from individual human preimplantation embryos". Mol. Hum. Reprod. 4 (6): 571–5. doi: 10.1093/molehr/4.6.571 . PMID   9665340.
• Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi: 10.1101/gr.8.11.1097 . PMID   9847074.
• Kosaki K, Kosaki R, Suzuki T, et al. (2002). "Complete mutation analysis panel of the 39 human HOX genes". Teratology. 65 (2): 50–62. doi:10.1002/tera.10009. PMID   11857506.
• Larramendy ML, Niini T, Elonen E, et al. (2003). "Overexpression of translocation-associated fusion genes of FGFRI, MYC, NPMI, and DEK, but absence of the translocations in acute myeloid leukemia. A microarray analysis". Haematologica. 87 (6): 569–77. PMID   12031912.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Méchine-Neuville A, Lefebvre O, Bellocq JP, et al. (2003). "[Increased expression of HOXA9 gene in Hirschsprung disease]". Gastroenterol. Clin. Biol. 26 (12): 1110–7. PMID   12520199.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi: 10.1038/nature01782 . PMID   12853948.
• Strathdee G, Sim A, Parker A, et al. (2007). "Promoter hypermethylation silences expression of the HoxA4 gene and correlates with IgVh mutational status in CLL". Leukemia. 20 (7): 1326–9. doi: 10.1038/sj.leu.2404254 . PMID   16688227.

External links

• HOXA4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.