OTX1

Last updated
OTX1
Identifiers
Aliases OTX1 , orthodenticle homeobox 1
External IDs OMIM: 600036 MGI: 97450 HomoloGene: 7875 GeneCards: OTX1
Gene location (Human)
Ideogram human chromosome 2.svg
Chr. Chromosome 2 (human) [1]
Human chromosome 2 ideogram.svg
HSR 1996 II 3.5e.svg
Red rectangle 2x18.png
Band 2p15Start63,050,057 bp [1]
End63,057,836 bp [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001199770
NM_014562

NM_011023

RefSeq (protein)

NP_001186699
NP_055377

NP_035153

Location (UCSC) Chr 2: 63.05 – 63.06 Mb Chr 11: 21.99 – 22 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Homeobox protein OTX1 is a protein that in humans is encoded by the OTX1 gene. [5] [6]

Contents

Function

This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. The Otx gene is active in the region of the first gill arch, which is related to the upper and lower jaw and two of the bones of the ear. [7] A similar protein in mice is required for proper brain and sensory organ development and can cause epilepsy. [6]

Related Research Articles

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HOXC9 protein-coding gene in the species Homo sapiens

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000115507 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000005917 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kastury K, Druck T, Huebner K, Barletta C, Acampora D, Simeone A, Faiella A, Boncinelli E (July 1994). "Chromosome locations of human EMX and OTX genes". Genomics. 22 (1): 41–5. doi:10.1006/geno.1994.1343. PMID   7959790.
  6. 1 2 "Entrez Gene: OTX1 orthodenticle homeobox 1".
  7. Shubin, Neil "Your Inner Fish" 2009

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.