SOX12

Last updated
SOX12
Identifiers
Aliases SOX12 , SOX22, SRY-box 12, SRY-box transcription factor 12
External IDs OMIM: 601947 MGI: 98360 HomoloGene: 5057 GeneCards: SOX12
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006943

NM_011438

RefSeq (protein)

NP_008874

NP_035568

Location (UCSC) Chr 20: 0.33 – 0.33 Mb Chr 2: 152.24 – 152.24 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

SOX12 is a protein that in humans is encoded by the SOX12 gene. [5] [6] Sox12 belongs to the SoxC group of Sox family of transcription factors, together with Sox4 and Sox11. Sox12-null knockout mice appear normal, unlike Sox4 or Sox11 knockout mice. This probably comes from functional redundancy with Sox4 and Sox11. [7] Sox12 is a weaker activator than both Sox4 and Sox11 in mouse. [8]

Members of the SOX family of transcription factors are characterized by the presence of a DNA-binding high mobility group (HMG) domain, homologous to the HMG box of sex-determining region Y (SRY). Forming a subgroup of the HMG domain superfamily, SOX proteins have been implicated in cell fate decisions in a diverse range of developmental processes. SOX transcription factors have diverse tissue-specific expression patterns during early development and have been proposed to act as target-specific transcription factors and/or as chromatin structure regulatory elements. The protein encoded by this gene was identified as a SOX family member based on conserved domains and its expression in various tissues suggests a role in both differentiation and maintenance of several cell types. [6]

Related Research Articles

SOX genes encode a family of transcription factors that bind to the minor groove in DNA, and belong to a super-family of genes characterized by a homologous sequence called the HMG-box. This HMG box is a DNA binding domain that is highly conserved throughout eukaryotic species. Homologues have been identified in insects, nematodes, amphibians, reptiles, birds and a range of mammals. However, HMG boxes can be very diverse in nature, with only a few amino acids being conserved between species.

NRF1 Protein-coding gene in the species Homo sapiens

Nuclear respiratory factor 1, also known as Nrf1, Nrf-1, NRF1 and NRF-1, encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternate transcriptional splice variants, which encode the same protein, have been characterized. Additional variants encoding different protein isoforms have been described but they have not been fully characterized. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor -like 1" which has an official symbol of NFE2L1.

NFYB Protein-coding gene in the species Homo sapiens

Nuclear transcription factor Y subunit beta is a protein that in humans is encoded by the NFYB gene.

SOX9 Transcription factor gene of the SOX family

Transcription factor SOX-9 is a protein that in humans is encoded by the SOX9 gene.

SOX10 Transcription factor gene of the SOX family

Transcription factor SOX-10 is a protein that in humans is encoded by the SOX10 gene.

SOX4 Protein-coding gene in the species Homo sapiens

Transcription factor SOX-4 is a protein that in humans is encoded by the SOX4 gene.

SOX3 Protein-coding gene in the species Homo sapiens

Transcription factor SOX-3 is a protein that in humans is encoded by the SOX3 gene. This gene encodes a member of the SOX family of transcription factors involved in the regulation of embryonic brain development and in determination of cell fate. The encoded protein acts as a transcriptional activator.

SOX5 Protein-coding gene in Homo sapiens

Transcription factor SOX-5 is a protein that in humans is encoded by the SOX5 gene.

SOX13 Protein-coding gene in the species Homo sapiens

Transcription factor SOX-13 is a protein that in humans is encoded by the SOX13 gene.

SOX6 Protein-coding gene in the species Homo sapiens

Transcription factor SOX-6 is a protein that in humans is encoded by the SOX6 gene.

TCF7 Protein-coding gene in the species Homo sapiens

Transcription factor 7 is the gene that in humans encodes for the TCF1 protein.

SOX18

Transcription factor SOX-18 is a protein that in humans is encoded by the SOX18 gene.

SIX5 Protein-coding gene in the species Homo sapiens

Homeobox protein SIX5 is a protein that in humans is encoded by the SIX5 gene.

SOX11 Protein-coding gene in the species Homo sapiens

Transcription factor SOX-11 is a protein that in humans is encoded by the SOX11 gene.

SOX8

Transcription factor SOX-8 is a protein that in humans is encoded by the SOX8 gene.

SOX15

Protein SOX-15 is a protein that in humans is encoded by the SOX15 gene.

MEOX1 Protein-coding gene in the species Homo sapiens

Homeobox protein MOX-1 is a protein that in humans is encoded by the MEOX1 gene.

SOX21

Transcription factor SOX-21 is a protein that in humans is encoded by the SOX21 gene. It is a member of the Sox gene family of transcription factors.

SRY -box 30 is a protein that in humans is encoded by the SOX30 gene.

SOX7 Protein-coding gene in the species Homo sapiens

SRY-box 7 is a protein that in humans is encoded by the SOX7 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000177732 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000051817 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Jay P, Sahly I, Goze C, Taviaux S, Poulat F, Couly G, Abitbol M, Berta P (Aug 1997). "SOX22 is a new member of the SOX gene family, mainly expressed in human nervous tissue". Hum Mol Genet. 6 (7): 1069–77. doi: 10.1093/hmg/6.7.1069 . PMID   9215677.
  6. 1 2 "Entrez Gene: SOX12 SRY (sex determining region Y)-box 12".
  7. Hoser M, Potzner MR, Koch JM, Bösl MR, Wegner M, Sock E (August 2008). "Sox12 Deletion in the Mouse Reveals Nonreciprocal Redundancy with the Related Sox4 and Sox11 Transcription Factors". Mol. Cell. Biol. 28 (15): 4675–87. doi:10.1128/MCB.00338-08. PMC   2493363 . PMID   18505825.
  8. Dy P, Penzo-Méndez A, Wang H, Pedraza CE, Macklin WB, Lefebvre V (May 2008). "The three SoxC proteins—Sox4, Sox11 and Sox12—exhibit overlapping expression patterns and molecular properties". Nucleic Acids Res. 36 (9): 3101–17. doi:10.1093/nar/gkn162. PMC   2396431 . PMID   18403418.

Further reading