2-hydroxyethylphosphonate dioxygenase

2-hydroxyethylphosphonate dioxygenase
Identifiers
EC no.	1.13.11.72
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

2-hydroxyethylphosphonate dioxygenase (EC 1.13.11.72, HEPD, phpD (gene)) is an enzyme with systematic name 2-hydroxyethylphosphonate:O₂ 1,2-oxidoreductase (hydroxymethylphosphonate forming). ^{[1] [2]} This enzyme catalyses the following chemical reaction

2-hydroxyethylphosphonic acid

 

O₂

 

 

 

 

(hydroxymethyl)phosphonic acid

+

 

formic acid

2-hydroxyethylphosphonate dioxygenase contains non-heme-Fe(II) and is involved in the biosynthesis of phosphinothricin. ^{[3] [4]}

References

1. Whitteck JT, Malova P, Peck SC, Cicchillo RM, Hammerschmidt F, van der Donk WA (March 2011). "On the stereochemistry of 2-hydroxyethylphosphonate dioxygenase". Journal of the American Chemical Society. 133 (12): 4236–9. Bibcode:2011JAChS.133.4236W. doi:10.1021/ja1113326. PMC   3069692 . PMID   21381767.
2. Peck SC, Cooke HA, Cicchillo RM, Malova P, Hammerschmidt F, Nair SK, van der Donk WA (August 2011). "Mechanism and substrate recognition of 2-hydroxyethylphosphonate dioxygenase". Biochemistry. 50 (30): 6598–605. doi:10.1021/bi200804r. PMC   3143709 . PMID   21711001.
3. Enzyme 1.13.11.72 at KEGG Pathway Database.
4. Cicchillo RM, Zhang H, Blodgett JA, Whitteck JT, Li G, Nair SK, van der Donk WA, Metcalf WW (June 2009). "An unusual carbon-carbon bond cleavage reaction during phosphinothricin biosynthesis". Nature. 459 (7248): 871–4. Bibcode:2009Natur.459..871C. doi:10.1038/nature07972. PMC   2874955 . PMID   19516340.

External links

• 2-hydroxyethylphosphonate+dioxygenase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)