| 2008 Game Log |
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| # | Date | Time | Opponent | Score | Win | Loss | Save | Attendance | Record |
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| 1 | March 31 | 3:05 pm | Rays | 6 – 2 | Shields (1–0) | Guthrie (0–1) | | 46,807 | 0–1 |
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| # | Date | Time | Opponent | Score | Win | Loss | Save | Attendance | Record |
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| 2 | April 2 | 7:05 pm | Rays | 9 – 6 | Walker (1–0) | Reyes (0–1) | Sherrill (1) | 10,505 | 1-1 | | – | April 3 | 7:05 pm | Rays | Postponed (rain)Rescheduled for September 23 | | 3 | April 4 | 7:05 pm | Mariners | 7 – 4 | Trachsel (1–0) | Washburn (0–1) | Sherrill (2) | 14,429 | 2–1 | | 4 | April 5 | 7:05 pm | Mariners | 6 – 4 | Albers (1–0) | Batista (0–1) | Sherrill (3) | 24,824 | 3–1 | | 5 | April 6 | 1:35 pm | Mariners | 3 – 2 | Sarfate (1–0) | Lowe (0–1) | | 19,215 | 4–1 | | 6 | April 7 | 3:05 pm | Mariners | 5 – 4 | Sarfate (2–0) | O'Flaherty (0–1) | Sherrill (4) | 10,774 | 5–1 | | 7 | April 8 | 2:05 pm | @ Rangers | 8 – 1 | Burres (1–0) | Jennings (0–2) | | 48,808 | 6–1 | | – | April 9 | 8:05 pm | @ Rangers | Postponed (rain)Rescheduled for April 10 | | 8 | April 10 | 5:05 pm | @ Rangers | 3 – 1 | Millwood (1–2) | Trachsel (1-1) | Wilson (2) | – | 6–2 | | 9 | April 10 | 8:05 pm | @ Rangers | 5 – 4 | Wright (1–0) | Bradford (0–1) | Wilson (3) | 15,560 | 6–3 | | 10 | April 11 | 7:10 pm | @ Rays | 10 – 5 | Reyes (1-1) | Sarfate (2–1) | | 12,146 | 6–4 | | 11 | April 12 | 7:10 pm | @ Rays | 3 – 2 | Bradford (1-1) | Wheeler (0–1) | Sherrill (5) | 19,295 | 7–4 | | 12 | April 13 | 1:40 pm | @ Rays | 6 – 2 | Niemann (1–0) | Burres (1-1) | | 16,748 | 7–5 | | 13 | April 14 | 7:05 pm | Blue Jays | 4 – 3 | Albers (2–0) | McGowan (0–1) | Sherrill (6) | 11,510 | 8–5 | | 14 | April 15 | 7:05 pm | Blue Jays | 11 – 3 | Marcum (2–0) | Trachsel (1–2) | | 15,017 | 8–6 | | 15 | April 16 | 7:05 pm | White Sox | 3 – 1 | Contreras (1-1) | Loewen (0–1) | Jenks (6) | 12,080 | 8–7 | | 16 | April 17 | 7:05 pm | White Sox | 6 – 5 (10) | Sherrill (1–0) | Logan (1-1) | | 13,676 | 9–7 | | 17 | April 18 | 7:05 pm | Yankees | 8 – 2 | Cabrera (1–0) | Hughes (0–3) | | 40,653 | 10–7 | | 18 | April 19 | 7:05 pm | Yankees | 6 – 0 | Burres (2–1) | Kennedy (0–2) | Johnson (1) | 41,776 | 11–7 | | 19 | April 20 | 1:35 pm | Yankees | 7 – 1 | Pettitte (3–1) | Trachsel (1–3) | | 37,501 | 11–8 | | 20 | April 22 | 10:10 pm | @ Mariners | 4 – 2 | Rhodes (1–0) | Guthrie (0–2) | Putz (2) | 17,780 | 11–9 | | 21 | April 23 | 10:10 pm | @ Mariners | 3 – 2 | Cabrera (2–0) | Rowland-Smith (0–1) | Sherrill (7) | 16,823 | 12–9 | | 22 | April 24 | 10:10 pm | @ Mariners | 8 – 7 | Bradford (2–1) | Green (1-1) | Sherrill (8) | 16,727 | 13–9 | | – | April 25 | 8:11 pm | @ White Sox | Postponed (rain)Rescheduled for April 26 | | 23 | April 26 | 1:05 pm | @ White Sox | 5 – 1 | Burres (3–1) | Danks (2-2) | Sherrill (9) | 23,043 | 14–9 | | 24 | April 26 | 7:05 pm | @ White Sox | 6 – 5 | Jenks (2–0) | Bierd (0–1) | | 34,757 | 14–10 | | 25 | April 27 | 2:05 pm | @ White Sox | 6 – 1 | Contreras (2-2) | Guthrie (0–3) | | 29,756 | 14–11 | | -- | April 28 | 2:05 pm | @ White Sox | Suspended (rain)To be completed on August 25 | | 26 | April 29 | 7:05 pm | Rays | 7 – 4 | Olson (1–0) | Hammel (2-2) | Sherrill (10) | 11,588 | 15–11 | | 27 | April 30 | 7:05 pm | Rays | 8 – 1 | Sonnanstine (4–1) | Albers (2–1) | | 11,944 | 15–12 |
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| # | Date | Time | Opponent | Score | Win | Loss | Save | Attendance | Record |
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| 28 | May 1 | 12:35 pm | Rays | 4 – 2 | Garza (1–0) | Burres (3–2) | Percival (6) | 16,456 | 15–13 | | 29 | May 2 | 10:05 pm | @ Angels | 4 – 3 | Guthrie (1–3) | Weaver (2–4) | Sherrill (11) | 41,515 | 16–13 | | 30 | May 3 | 3:45 pm | @ Angels | 3 – 1 | Garland (4–3) | Cabrera (2–1) | Rodríguez (12) | 37,601 | 16–14 | | 31 | May 4 | 3:35 pm | @ Angels | 6 – 5 | Saunders (6–0) | Trachsel (1–4) | Rodríguez (13) | 39,273 | 16–15 | | 32 | May 5 | 10:05 pm | @ Athletics | 2 – 1 | Devine (3–0) | Johnson (0–1) | | 10,128 | 16-16 | | 33 | May 6 | 10:05 pm | @ Athletics | 4 – 2 | Duchscherer (3–1) | Burres (3-3) | Casilla (1) | 11,492 | 16–17 | | 34 | May 7 | 3:35 pm | @ Athletics | 6 – 5 | Braden (1–0) | Cormier (0–1) | | 15,235 | 16–18 | | 35 | May 8 | 8:10 pm | @ Royals | 4 – 1 | Cabrera (3–1) | Hochevar (2-2) | | 11,781 | 17–18 | | 36 | May 9 | 8:10 pm | @ Royals | 7 – 4 | Trachsel (2–4) | Meche (2–4) | Sherrill (12) | 21,873 | 18-18 | | 37 | May 10 | 7:10 pm | @ Royals | 6 – 5 | Olson (2–0) | Tomko (1–4) | Sherrill (13) | 15,808 | 19–18 | | 38 | May 11 | 2:10 pm | @ Royals | 4 – 0 | Bannister (4-4) | Burres (3–4) | | 18,635 | 19-19 | | 39 | May 13 | 7:05 pm | Red Sox | 5 – 4 | Guthrie (2–3) | Beckett (4–3) | Sherrill (14) | 38,768 | 20–19 | | 40 | May 14 | 3:05 pm | Red Sox | 6 – 3 | Cabrera (4–1) | Hansen (0–2) | Sherrill (15) | 28,939 | 21–19 | | 41 | May 16 | 7:05 pm | Nationals | 5 – 3 | Olson (3–0) | Hill (0–1) | Sherrill (16) | 29,266 | 22–19 | | 42 | May 17 | 7:05 pm | Nationals | 6 – 5 | Burres (4-4) | Pérez (1–4) | Sherrill (17) | 32,662 | 23–19 | | 43 | May 18 | 1:35 pm | Nationals | 2 – 1 | Lannan (4-4) | Guthrie (2–4) | Rauch (10) | 33,745 | 23–20 | | 44 | May 20 | 7:05 pm | @ Yankees | 12 – 2 | Cabrera (5–1) | Mussina (6–4) | | 51,617 | 24–20 | | 45 | May 21 | 7:05 pm | @ Yankees | 8 – 0 | Rasner (3–0) | Olson (3–1) | | 50,682 | 24–21 | | 46 | May 22 | 7:05 pm | @ Yankees | 2 – 1 | Rivera (2–1) | Johnson (0–2) | | 49,452 | 24–22 | | 47 | May 23 | 7:10 pm | @ Rays | 2 – 0 | Garza (3–1) | Guthrie (2–5) | Percival (14) | 13,635 | 24–23 | | 48 | May 24 | 6:10 pm | @ Rays | 11 – 4 | Jackson (3-3) | Trachsel (2–5) | | 30,445 | 24-24 | | 49 | May 25 | 1:40 pm | @ Rays | 5 – 4 | Percival (1–0) | Sherrill (1-1) | | 17,762 | 24–25 | | 50 | May 26 | 1:35 pm | Yankees | 6 – 1 | Olson (4–1) | Rasner (3–1) | | 34,928 | 25-25 | | 51 | May 27 | 7:05 pm | Yankees | 10 – 9 | Albers (3–1) | Hawkins (1-1) | | 24,030 | 26–25 | | 52 | May 28 | 7:05 pm | Yankees | 4 – 2 | Pettitte (5-5) | Guthrie (2–6) | Rivera (13) | 24,791 | 26-26 | | 53 | May 30 | 7:05 pm | Red Sox | 5 – 2 (13) | Timlin (3-3) | Bradford (2-2) | Papelbon (15) | 46,199 | 26–27 | | 54 | May 31 | 7:05 pm | Red Sox | 6 – 3 | Aardsma (2–1) | Cormier (0–2) | Papelbon (16) | 48,281 | 26–28 |
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| # | Date | Time | Opponent | Score | Win | Loss | Save | Attendance | Record |
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| 55 | June 1 | 1:35 pm | Red Sox | 9 – 4 | Colón (3–0) | Burres (4–5) | | 45,031 | 26–29 | | 56 | June 2 | 7:05 pm | Red Sox | 6 – 3 | Johnson (1–2) | Okajima (1-1) | Sherrill (18) | 25,711 | 27–29 | | 57 | June 3 | 8:10 pm | @ Twins | 5 – 3 | Liz (1–0) | Slowey (2–5) | Sherrill (19) | 18,802 | 28–29 | | 58 | June 4 | 8:10 pm | @ Twins | 7 – 5 | Bonser (3–6) | Cabrera (5–2) | Nathan (16) | 22,057 | 28–30 | | 59 | June 5 | 1:10 pm | @ Twins | 3 – 2 | Olson (5–1) | Baker (2–1) | Sherrill (20) | 19,621 | 29–30 | | 60 | June 6 | 7:07 pm | @ Blue Jays | 6 – 5 | Sarfate (3–1) | Benítez (0–1) | Sherrill (21) | 23,649 | 30-30 | | 61 | June 7 | 1:07 pm | @ Blue Jays | 9 – 5 | Guthrie (3–6) | Burnett (5–6) | | 25,122 | 31–30 | | 62 | June 8 | 1:07 pm | @ Blue Jays | 5 – 4 | Halladay (8–5) | Albers (3–2) | Ryan (13) | 25,365 | 31-31 | | 63 | June 10 | 7:05 pm | @ Red Sox | 10 – 6 | Sarfate (4–1) | Okajima (1–2) | | 37,858 | 32–31 | | 64 | June 11 | 7:05 pm | @ Red Sox | 6 – 3 | Colón (4–1) | Olson (5–2) | Papelbon (19) | 38,130 | 32-32 | | 65 | June 12 | 7:05 pm | @ Red Sox | 9 – 2 | Lester (5–3) | Guthrie (3–7) | | 38,139 | 32–33 | | 66 | June 13 | 7:05 pm | Pirates | 9 – 6 | Burres (5-5) | Osoria (3–2) | Sherrill (22) | 47,305 | 33-33 | | 67 | June 14 | 7:05 pm | Pirates | 8 – 7 | Sherrill (2–1) | Capps (0–2) | | 32,432 | 34–33 | | 68 | June 15 | 1:35 pm | Pirates | 5 – 4 | Capps (1–2) | Sherrill (2-2) | | 31,107 | 34-34 | | 69 | June 17 | 7:05 pm | Astros | 6 – 5 | Johnson (2-2) | Brocail (2-2) | Sherrill (23) | 21,535 | 35–34 | | 70 | June 18 | 7:05 pm | Astros | 2 – 1 | Bradford (3–2) | Valverde (4–2) | | 21,112 | 36-34 | | 71 | June 19 | 7:05 pm | Astros | 7 – 5 | Burres (6–5) | Chacón (2–3) | Sherrill (24) | 31,480 | 37–34 | | 72 | June 20 | 8:05 pm | @ Brewers | 8 – 5 | Cormier (1–2) | Suppan (4–5) | Sherrill (25) | 36,526 | 38–34 | | 73 | June 21 | 7:05 pm | @ Brewers | 3 – 2 | McClung (5–3) | Cabrera (5–3) | Torres (11) | 42,521 | 38–35 | | 74 | June 22 | 2:05 pm | @ Brewers | 7 – 3 | Parra (7–2) | Olson (5–3) | Torres (12) | 43,517 | 38–36 | | 75 | June 24 | 8:05 pm | @ Cubs | 7 – 5 | Guthrie (4–7) | Marshall (0–1) | Sherrill (26) | 41,537 | 39–36 | | 76 | June 25 | 8:05 pm | @ Cubs | 7 – 4 | Lilly (8–5) | Albers (3-3) | Wood (20) | 40,754 | 39–37 | | 77 | June 26 | 2:20 pm | @ Cubs | 11 – 4 | Liz (2–0) | Marquis (6–4) | | 41,670 | 40–37 | | 78 | June 27 | 7:35 pm | @ Nationals | 4 – 2 | Hanrahan (4–2) | Cabrera (5–4) | Rauch (16) | 35,830 | 40–38 | | 79 | June 28 | 7:10 pm | @ Nationals | 9 – 1 | Olson (6–3) | Lannan (4–9) | Cormier (1) | 39,479 | 41–38 | | 80 | June 29 | 1:35 pm | @ Nationals | 3 – 2 (12) | Hanrahan (5–2) | Sherrill (2–3) | | 39,824 | 41–39 | | 81 | June 30 | 7:05 pm | Royals | 6 – 5 (11) | Mahay (4–0) | Bradford (3-3) | Soria (22) | 15,289 | 41–40 |
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| # | Date | Time | Opponent | Score | Win | Loss | Save | Attendance | Record |
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| 82 | July 1 | 7:05 pm | Royals | 7 – 5 | Liz (3–0) | Hochevar (5–6) | Sherrill (27) | 19,756 | 42–40 | | 83 | July 2 | 7:05 pm | Royals | 5 – 2 | Cabrera (6–4) | Meche (6–9) | | 17,909 | 43–40 | | 84 | July 3 | 7:05 pm | Royals | 10 – 7 | Peralta (1–2) | Loewen (0–2) | Soria (23) | 16,782 | 43–41 | | 85 | July 4 | 4:35 pm | Rangers | 10 – 4 | Guthrie (5–7) | Padilla (10–5) | | 21,363 | 44–41 | | 86 | July 5 | 7:05 pm | Rangers | 5 – 3 | Feldman (3-3) | Cormier (1–3) | Wilson (20) | 19,006 | 44–42 | | 87 | July 6 | 1:35 pm | Rangers | 11 – 10 | Millwood (6–4) | Liz (3–1) | Wilson (21) | 22,276 | 44–43 | | 88 | July 8 | 7:07 pm | @ Blue Jays | 7 – 6 | Ryan (2–3) | Johnson (2–3) | | 23,276 | 44-44 | | 89 | July 9 | 7:07 pm | @ Blue Jays | 9 – 8 | Burnett (9–8) | Olson (6–4) | Ryan (17) | 22,365 | 44–45 | | 90 | July 10 | 7:07 pm | @ Blue Jays | 6 – 5 | Camp (2–1) | Sherrill (2–4) | | 22,279 | 44–46 | | 91 | July 11 | 7:05 pm | @ Red Sox | 7 – 3 | Burres (7–5) | Buchholz (2–4) | Sherrill (28) | 37,779 | 45–46 | | 92 | July 12 | 7:05 pm | @ Red Sox | 12 – 1 | Wakefield (6-6) | Liz (3–2) | | 37,539 | 45–47 | | 93 | July 13 | 1:35 pm | @ Red Sox | 2 – 1 | Matsuzaka (10–1) | Cabrera (6–5) | Papelbon (28) | 37,344 | 45–48 | | All-Star Break | | 94 | July 17 | 7:05 pm | Tigers | 6 – 5 | Rogers (7–6) | Olson (6–5) | Jones (18) | 23,224 | 45–49 | | 95 | July 18 | 7:05 pm | Tigers | 7 – 4 | Guthrie (6–7) | Galarraga (7–4) | Sherrill (29) | 29,111 | 46–49 | | 96 | July 19 | 7:05 pm | Tigers | 11 – 10 (10) | Sherrill (3–4) | Dolsi (1–4) | | 31,525 | 47–49 | | 97 | July 20 | 1:35 pm | Tigers | 5 – 1 | Verlander (8–9) | Burres (7–6) | | 23,278 | 47–50 | | 98 | July 21 | 7:05 pm | Blue Jays | 8 – 3 | Liz (4–2) | Litsch (8–7) | | 12,772 | 48–50 | | 99 | July 22 | 7:05 pm | Blue Jays | 10 – 8 | Carlson (2–1) | Cabrera (0–1) | Ryan (19) | 15,184 | 48–51 | | 100 | July 23 | 7:05 pm | Blue Jays | 5 – 1 | Burnett (11–9) | Guthrie (6–8) | | | 48–52 | | 101 | July 24 | 12:35 pm | Blue Jays | 7 – 1 | Halladay (12–7) | Cabrera (6-6) | | 23,329 | 48–53 | | 102 | July 25 | 7:05 pm | Angels | 6 – 5 | Saunders (13–5) | Burres (7-7) | Rodríguez (43) | 27,999 | 48–54 | | 103 | July 26 | 7:05 pm | Angels | 11 – 6 | Garland (9–6) | Liz (4–3) | | 21,819 | 48–55 | | 104 | July 27 | 1:35 pm | Angels | 5 – 2 | Olson (7–5) | Santana (11–5) | Sherrill (30) | 23,365 | 49–55 | | 105 | July 28 | 7:05 pm | @ Yankees | 13 – 4 | Guthrie (7–8) | Mussina (13–7) | | 54,120 | 50–55 | | 106 | July 29 | 7:05 pm | @ Yankees | 7 – 6 | Cabrera (7–6) | Rasner (5–8) | | 54,241 | 51–55 | | 107 | July 30 | 1:05 pm | @ Yankees | 13 – 3 | Chamberlain (4–3) | Sarfate (4–2) | | 54,296 | 51–56 |
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| # | Date | Time | Opponent | Score | Win | Loss | Save | Attendance | Record |
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| 108 | August 1 | 10:10 pm | @ Mariners | 10 – 5 | Olson (8–5) | Washburn (5–10) | | 28,114 | 52–56 | | 109 | August 2 | 10:10 pm | @ Mariners | 3 – 1 | Guthrie (8-8) | Hernández (7-7) | | 30,502 | 53–56 | | 110 | August 3 | 4:10 pm | @ Mariners | 8 – 4 | Putz (3–4) | Cabrera (7-7) | | 33,334 | 53–57 | | 111 | August 4 | 10:05 pm | @ Angels | 6 – 5 | Rodríguez (1–2) | Sherrill (3–5) | | 41,902 | 53–58 | | 112 | August 5 | 10:05 pm | @ Angels | 3 – 0 | Waters (1–0) | Garland (10–7) | Sherrill (31) | 44,027 | 54–58 | | 113 | August 6 | 3:35 pm | @ Angels | 9 – 4 | Santana (13–5) | Olson (8–6) | | 40,130 | 54–59 | | 114 | August 8 | 7:05 pm | Rangers | 9 – 1 | Guthrie (9–8) | Mendoza (3–5) | | 33,351 | 55–59 | | 115 | August 9 | 7:05 pm | Rangers | 9 – 0 | Cabrera (8–7) | Padilla (12–6) | | 30,914 | 56–59 | | 116 | August 10 | 1:35 pm | Rangers | 15 – 7 | Harrison (4–2) | Bierd (0–2) | | 26,878 | 56–60 | | 117 | August 11 | 7:05 pm | @ Indians | 13 – 8 | Mujica (1-1) | Cherry (0–1) | | 23,408 | 56–61 | | 118 | August 12 | 7:05 pm | @ Indians | 7 – 5 | Pérez (2-2) | Johnson (2–4) | Lewis (2) | 21,143 | 56–62 | | 119 | August 13 | 7:05 pm | @ Indians | 6 – 1 | Guthrie (10–8) | Reyes (3–2) | | 21,299 | 57–62 | | 120 | August 14 | 7:05 pm | @ Indians | 11 – 6 | Cabrera (1-1) | Pérez (2–3) | | 22,140 | 58–62 | | 121 | August 15 | 7:05 pm | @ Tigers | 11 – 2 | Cormier (2–3) | Robertson (7–9) | | 40,546 | 59–62 | | 122 | August 16 | 7:05 pm | @ Tigers | 5 – 3 | Verlander (9–13) | Sarfate (4–3) | Rodney (4) | 41,727 | 59–63 | | 123 | August 17 | 1:05 pm | @ Tigers | 16 – 8 | Cabrera (2–1) | Fossum (2–1) | | 40,586 | 60–63 | | 124 | August 18 | 7:05 pm | Red Sox | 6 – 3 | Lester (12–4) | Guthrie (10–9) | Papelbon (33) | 40,429 | 60–64 | | 125 | August 19 | 7:05 pm | Red Sox | 7 – 2 | Matsuzaka (15–2) | Cabrera (8-8) | | 48,515 | 60–65 | | 126 | August 20 | 7:05 pm | Red Sox | 11 – 6 | Waters (2–0) | Buchholz (2–9) | | 33,364 | 61–65 | | 127 | August 22 | 7:05 pm | Yankees | 9 – 4 | Veras (4–2) | Walker (1-1) | Rivera (29) | 45,543 | 61–66 | | 128 | August 23 | 7:05 pm | Yankees | 5 – 3 | Pavano (1–0) | Guthrie (10-10) | Rivera (30) | 48,817 | 61–67 | | 129 | August 24 | 1:35 pm | Yankees | 8 – 7 | E. Ramírez (4–1) | Walker (1–2) | Rivera (31) | | 61–68 | | 130 | August 25 | 6:05 pm | White Sox | 4 – 3 (14) | Castillo (1–0) | H. Ramírez (0–1) | Cherry (1) | 17,367 | 62–68 | | 131 | August 25 | 7:05 pm | White Sox | 4 – 3 | Richard (2-2) | Waters (2–1) | Jenks (26) | 20,707 | 62–69 | | 132 | August 26 | 7:05 pm | White Sox | 8 – 3 | Floyd (14–6) | Burres (7–8) | | 15,398 | 62–70 | | 133 | August 27 | 7:05 pm | White Sox | 11 – 3 | Liz (5–3) | Danks (10–7) | | 15,736 | 63–70 | | 134 | August 29 | 7:10 pm | @ Rays | 14 – 3 | Kazmir (10–6) | Guthrie (10–11) | | 21,439 | 63–71 | | 135 | August 30 | 7:10 pm | @ Rays | 10 – 9 | Wheeler (3–5) | Cherry (0–2) | | 34,805 | 63–72 | | 136 | August 31 | 1:40 pm | @ Rays | 10 – 4 | Shields (12–8) | Burres (7–9) | | 32,379 | 63–73 |
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| # | Date | Time | Opponent | Score | Win | Loss | Save | Attendance | Record |
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| 137 | September 1 | 7:05 pm | @ Red Sox | 7 – 4 | Byrd (10–11) | Olson (8–7) | Papelbon (35) | 37,565 | 63–74 | | 138 | September 2 | 7:05 pm | @ Red Sox | 14 – 2 | Lester (13–5) | Liz (5–4) | | 37,710 | 63–75 | | 139 | September 3 | 1:35 pm | @ Red Sox | 5 – 4 | Masterson (5–4) | Miller (0–1) | | 37,373 | 63–76 | | 140 | September 5 | 7:05 pm | Athletics | 11 – 2 | Braden (5–3) | Waters (2-2) | | 14,984 | 63–77 | | – | September 6 | 1:35 pm | Athletics | Cancelled (rain)Was not made up | | 141 | September 6 | 7:05 pm | Athletics | 5 – 1 | G. Smith (7–14) | Cabrera (8–9) | | 21,553 | 63–78 | | 142 | September 8 | 7:05 pm | Indians | 14 – 3 | Olson (9–7) | Carmona (8–6) | | 11,181 | 64–78 | | 143 | September 9 | 7:05 pm | Indians | 6 – 1 | Sowers (3–8) | Liz (5-5) | | 14,900 | 64–79 | | 144 | September 10 | 7:05 pm | Indians | 7 – 1 | Lewis (7–1) | Waters (2–3) | | 12,438 | 64–80 | | 145 | September 11 | 7:05 pm | Indians | 6 – 3 | Cormier (3-3) | Jackson (0–3) | Miller (1) | 12,526 | 65–80 | | – | September 12 | 7:05 pm | Twins | Postponed (rain)Rescheduled for September 13 | | 146 | September 13 | 1:05 pm | Twins | 12 – 2 | Baker (9–4) | Cabrera (8–10) | | 21,712 | 65–81 | | 147 | September 13 | 7:05 pm | Twins | 12 – 6 | Korecky (2–0) | Olson (9–8) | | 21,712 | 65–82 | | 148 | September 14 | 1:35 pm | Twins | 7 – 3 | Liz (6–5) | Blackburn (10–9) | | 18,559 | 66–82 | | 149 | September 16 | 7:07 pm | @ Blue Jays | 2 – 0 | Waters (3-3) | Marcum (9–7) | | 25,746 | 67–82 | | 150 | September 17 | 7:07 pm | @ Blue Jays | 8 – 7 | Carlson (7–1) | Mickolio (0–1) | Ryan (30) | 24,546 | 67–83 | | 151 | September 18 | 7:07 pm | @ Blue Jays | 3 – 2 | Litsch (12–8) | Olson (9-9) | Ryan (31) | 29,063 | 67–84 | | 152 | September 19 | 7:05 pm | @ Yankees | 3 – 2 | Pavano (4–1) | Liz (6-6) | M. Rivera (37) | 54,136 | 67–85 | | 153 | September 20 | 1:05 pm | @ Yankees | 1 – 0 | M. Rivera (6–5) | Miller (0–2) | | 54,662 | 67–86 | | 154 | September 21 | 8:05 pm | @ Yankees | 7 – 3 | Pettitte (14-14) | Waters (3–4) | | 54,610 | 67–87 | | 155 | September 22 | 5:05 pm | Rays | 4 – 2 | Balfour (6–2) | Cherry (0–3) | Wheeler (12) | 12,489 | 67–88 | | 156 | September 23 | 1:05 pm | Rays | 5 – 2 | Shields (14–8) | Olson (9–10) | Wheeler (13) | 15,215 | 67–89 | | 157 | September 23 | 7:05 pm | Rays | 7 – 5 | Niemann (2–1) | Walker (1–3) | Howell (3) | 15,215 | 67–90 | | 158 | September 24 | 7:05 pm | Rays | 11 – 6 | Jackson (13–11) | Burres (7–10) | Miller (2) | 13,632 | 67–91 | | 159 | September 26 | 7:05 pm | Blue Jays | 3 – 0 | Richmond (1–3) | Waters (3–5) | | 17,716 | 67–92 | | 160 | September 27 | 7:05 pm | Blue Jays | 2 – 1 (7) | Bass (4-4) | Parrish (1-1) | | 18,378 | 68–92 | | 161 | September 28 | 1:35 pm | Blue Jays | 10 – 1 | Litsch (13–9) | Guthrie (10–12) | | 19,554 | 68–93 |
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