| 2021 MUSC Health Women's Open | |
|---|---|
| Date | 12–18 April |
| Edition | 49th |
| Category | WTA 250 |
| Draw | 32S / 16D |
| Prize money | US$235,238 |
| Surface | Green clay |
| Location | Charleston, South Carolina, United States |
| Venue | Family Circle Tennis Center |
| Champions | |
| Singles | |
| | |
| Doubles | |
| | |
The second 2021 Charleston Open (branded as the MUSC Health Women's Open for commercial reasons) was a tournament on the 2021 WTA Tour. It was played on outdoor green clay courts in Daniel Island. It was held one day after the 48th edition ended and was a replacement tournament for other tournaments that were not held because of travel restrictions, and organised by Charleston Tennis with a single-year licence in 2021, held at Family Circle Tennis Center from April 12 to 18, 2021. [1]
| Country | Player | Rank1 | Seed |
|---|---|---|---|
| Ons Jabeur | 28 | 1 | |
| Magda Linette | 51 | 2 | |
| Shelby Rogers | 52 | 3 | |
| Alizé Cornet | 59 | 4 | |
| Misaki Doi | 77 | 5 | |
| Ajla Tomljanović | 78 | 6 | |
| Lauren Davis | 79 | 7 | |
| Madison Brengle | 81 | 8 |
The following players received wildcards into the main draw:
The following player received entry as a special exempt:
The following players received entry from the qualifying draw:
| Country | Player | Country | Player | Rank1 | Seed |
|---|---|---|---|---|---|
| Ellen Perez | Storm Sanders | 117 | 1 | ||
| Kaitlyn Christian | Sabrina Santamaria | 123 | 2 | ||
| Arina Rodionova | Rosalie van der Hoek | 167 | 4 |
The following pair received a wildcard into the doubles main draw:
The following pair received entry into the doubles main draw using a protected ranking:
The following pair received entry into the doubles main draw as an alternate: