AGPAT3

AGPAT3
Identifiers
Aliases	AGPAT3 , LPAAT-GAMMA1, LPAAT3, 1-acylglycerol-3-phosphate O-acyltransferase 3, 1-AGPAT 3
External IDs	OMIM: 614794; MGI: 1336186; HomoloGene: 10591; GeneCards: AGPAT3; OMA:AGPAT3 - orthologs
Gene location (Human) Chr. Chromosome 21 (human) [1] Band 21q22.3 Start 43,865,223 bp [1] End 43,987,592 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10 C1|10 39.72 cM Start 78,105,012 bp [2] End 78,188,323 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in external globus pallidus Brodmann area 23 middle temporal gyrus entorhinal cortex postcentral gyrus parotid gland jejunal mucosa subthalamic nucleus endothelial cell gastrocnemius muscle Top expressed in saccule seminiferous tubule otic placode spermatid brown adipose tissue lip proximal tubule superior frontal gyrus retinal pigment epithelium cerebellar cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity acyltransferase activity lysophosphatidic acid acyltransferase activity 1-acylglycerol-3-phosphate O-acyltransferase activity Cellular component integral component of membrane plasma membrane nuclear envelope endoplasmic reticulum endoplasmic reticulum membrane membrane nucleus Golgi membrane Biological process phosphatidic acid biosynthetic process CDP-diacylglycerol biosynthetic process metabolism phospholipid biosynthetic process lipid metabolism phospholipid metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56894 28169 Ensembl ENSG00000160216 ENSMUSG00000001211 UniProt Q9NRZ7 Q9D517 RefSeq (mRNA) NM_001037553 NM_020132 NM_001369878 NM_001369880 NM_001369881 NM_053014 RefSeq (protein) NP_001032642 NP_064517 NP_001356807 NP_001356809 NP_001356810 NP_443747 NP_001391799 NP_001391800 NP_001391801 NP_001391802 NP_001391803 NP_001391804 NP_001391805 NP_001391806 NP_001391807 NP_001391808 NP_001391809 NP_001391810 NP_001391811 Location (UCSC) Chr 21: 43.87 – 43.99 Mb Chr 10: 78.11 – 78.19 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

1-acyl-sn-glycerol-3-phosphate acyltransferase gamma is an enzyme that in humans is encoded by the AGPAT3 gene. ^[5]

The protein encoded by this gene is an acyltransferase (specifically, 1-acylglycerol-3-phosphate O-acyltransferase) that converts lysophosphatidic acid (1-acyl-sn-glycerol 3-phosphate) into phosphatidic acid, which is the second step in the de novo phospholipid biosynthetic pathway. The encoded protein may be an integral membrane protein. Two transcript variants encoding the same protein have been found for this gene. ^[5]

See also

• Stereospecific numbering, for sn-

References

1. GRCh38: Ensembl release 89: ENSG00000160216 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000001211 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3".

External links

• Human AGPAT3 genome location and AGPAT3 gene details page in the UCSC Genome Browser .

Further reading

• Leung DW (2001). "The structure and functions of human lysophosphatidic acid acyltransferases". Front. Biosci. 6: D944–53. doi: 10.2741/Leung . PMID   11487472.
• Wistow G, Bernstein SL, Ray S, et al. (2002). "Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium". Mol. Vis. 8: 185–95. PMID   12107412.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Lu B, Jiang YJ, Zhou Y, et al. (2005). "Cloning and characterization of murine 1-acyl-sn-glycerol 3-phosphate acyltransferases and their regulation by PPARα in murine heart". Biochem. J. 385 (Pt 2): 469–77. doi:10.1042/BJ20041348. PMC   1134718 . PMID   15367102.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Agarwal AK, Barnes RI, Garg A (2006). "Functional characterization of human 1-acylglycerol-3-phosphate acyltransferase isoform 8: cloning, tissue distribution, gene structure, and enzymatic activity". Arch. Biochem. Biophys. 449 (1–2): 64–76. doi:10.1016/j.abb.2006.03.014. PMID   16620771.
• Hu YH, Warnatz HJ, Vanhecke D, et al. (2006). "Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins". BMC Genomics. 7: 155. doi: 10.1186/1471-2164-7-155 . PMC   1526728 . PMID   16780588.