Adiponectin receptor 1

ADIPOR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3WXV
Identifiers
Aliases	ADIPOR1 , adiponectin receptor 1, ACDCR1, CGI45, PAQR1, TESBP1A, CGI-45
External IDs	OMIM: 607945; MGI: 1919924; HomoloGene: 69199; GeneCards: ADIPOR1; OMA:ADIPOR1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q32.1 Start 202,940,826 bp [1] End 202,958,572 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 E4 Start 134,343,116 bp [2] End 134,361,089 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood monocyte skin of leg bone marrow skin of abdomen islet of Langerhans olfactory zone of nasal mucosa right lung minor salivary glands upper lobe of left lung Top expressed in blood granulocyte stroma of bone marrow knee joint fetal liver hematopoietic progenitor cell neural layer of retina triceps brachii muscle atrium medial head of gastrocnemius muscle ankle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function adipokinetic hormone receptor activity adiponectin binding metal ion binding identical protein binding protein heterodimerization activity protein kinase binding signaling receptor activity Cellular component integral component of membrane membrane intrinsic component of plasma membrane plasma membrane Biological process glucose homeostasis lipid metabolism leptin-mediated signaling pathway adiponectin-activated signaling pathway fatty acid metabolic process regulation of lipid metabolic process regulation of glucose metabolic process negative regulation of cell growth fatty acid oxidation hormone-mediated signaling pathway positive regulation of insulin receptor signaling pathway positive regulation of receptor signaling pathway via JAK-STAT negative regulation of epithelial to mesenchymal transition negative regulation of receptor signaling pathway via JAK-STAT negative regulation of epithelial cell migration negative regulation of NIK/NF-kappaB signaling G protein-coupled receptor signaling pathway regulation of fatty acid biosynthetic process positive regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51094 72674 Ensembl ENSG00000159346 ENSMUSG00000026457 UniProt Q96A54 Q91VH1 RefSeq (mRNA) NM_001290553 NM_001290557 NM_001290629 NM_015999 NM_028320 NM_001306069 RefSeq (protein) NP_001277482 NP_001277486 NP_001277558 NP_057083 NP_001292998 NP_082596 Location (UCSC) Chr 1: 202.94 – 202.96 Mb Chr 1: 134.34 – 134.36 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Adiponectin receptor 1 (AdipoR1) is a protein which in humans is encoded by the ADIPOR1 gene. ^[5] It is a member of the progestin and adipoQ receptor (PAQR) family, and is also known as PAQR1. ^[6]

Structure

Similar to G protein-coupled receptors (GPCRs), AdipoR1 also possesses 7 transmembrane domains. However, AdipoR1 is orientated oppositely to GPCRs in the membrane (i.e., cytoplasmic N-terminus, extracellular C-terminus) and does not associate with G proteins. ^[5]

Function

The adiponectin receptors, AdipoR1 and AdipoR2, serve as receptors for globular and full-length adiponectin and mediate increased AMPK and PPAR-α ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin. ^{[5] [7]} In 2016, the University of Tokyo announced that it would launch an investigation into claims of fabrication of AdipoR1 and AdipoR2 identification data, as accused by an anonymous person/group called Ordinary_researchers. ^[8]

Ligands

Agonists

Peptide

• Adiponectin
• ADP-355 ^[9]
• ADP-399 ^[9]

Non-peptide

• AdipoRon ^[10]
• (−)-Arctigenin ^[11]
• Arctiin ^[11]
• Gramine ^[11]
• Matairesinol ^[11]

Antagonists

Peptide

• ADP-400 ^[9]

See also

• Adiponectin receptor
• Adiponectin receptor 2

References

1. GRCh38: Ensembl release 89: ENSG00000159346 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026457 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, et al. (June 2003). "Cloning of adiponectin receptors that mediate antidiabetic metabolic effects". Nature. 423 (6941): 762–9. Bibcode:2003Natur.423..762Y. doi:10.1038/nature01705. PMID   12802337. S2CID   52860797.
6. Tang YT, Hu T, Arterburn M, Boyle B, Bright JM, Emtage PC, et al. (September 2005). "PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif". Journal of Molecular Evolution. 61 (3): 372–80. Bibcode:2005JMolE..61..372T. doi:10.1007/s00239-004-0375-2. PMID   16044242. S2CID   31473802.
7. "Entrez Gene: ADIPOR1 adiponectin receptor 1".
8. University of Tokyo to investigate data manipulation charges against six prominent research groups ScienceInsider, Dennis Normile, Sep 20, 2016
9. Otvos L, Knappe D, Hoffmann R, Kovalszky I, Olah J, Hewitson TD, et al. (2014). "Development of second generation peptides modulating cellular adiponectin receptor responses". Frontiers in Chemistry. 2: 93. Bibcode:2014FrCh....2...93O. doi: 10.3389/fchem.2014.00093 . PMC   4201147 . PMID   25368867.
10. Okada-Iwabu M, Yamauchi T, Iwabu M, Honma T, Hamagami K, Matsuda K, et al. (November 2013). "A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity". Nature. 503 (7477): 493–9. Bibcode:2013Natur.503..493O. doi:10.1038/nature12656. PMID   24172895. S2CID   4447039.
11. Sun Y, Zang Z, Zhong L, Wu M, Su Q, Gao X, et al. (2013). "Identification of adiponectin receptor agonist utilizing a fluorescence polarization based high throughput assay". PLOS ONE. 8 (5): e63354. Bibcode:2013PLoSO...863354S. doi: 10.1371/journal.pone.0063354 . PMC   3653934 . PMID   23691032.

External links

• Human ADIPOR1 genome location and ADIPOR1 gene details page in the UCSC Genome Browser .

Further reading

• Crimmins NA, Martin LJ (September 2007). "Polymorphisms in adiponectin receptor genes ADIPOR1 and ADIPOR2 and insulin resistance". Obesity Reviews. 8 (5): 419–23. doi:10.1111/j.1467-789X.2007.00348.x. PMID   17716299. S2CID   825474.
• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (May 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Research. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC   310876 . PMID   10810093.
• Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, et al. (June 2003). "Cloning of adiponectin receptors that mediate antidiabetic metabolic effects". Nature. 423 (6941): 762–9. Bibcode:2003Natur.423..762Y. doi:10.1038/nature01705. PMID   12802337. S2CID   52860797.
• Kharroubi I, Rasschaert J, Eizirik DL, Cnop M (December 2003). "Expression of adiponectin receptors in pancreatic beta cells". Biochemical and Biophysical Research Communications. 312 (4): 1118–22. doi:10.1016/j.bbrc.2003.11.042. PMID   14651988.
• Civitarese AE, Jenkinson CP, Richardson D, Bajaj M, Cusi K, Kashyap S, et al. (May 2004). "Adiponectin receptors gene expression and insulin sensitivity in non-diabetic Mexican Americans with or without a family history of Type 2 diabetes". Diabetologia. 47 (5): 816–20. doi: 10.1007/s00125-004-1359-x . PMID   15105989.
• Wang H, Zhang H, Jia Y, Zhang Z, Craig R, Wang X, et al. (August 2004). "Adiponectin receptor 1 gene (ADIPOR1) as a candidate for type 2 diabetes and insulin resistance". Diabetes. 53 (8): 2132–6. doi: 10.2337/diabetes.53.8.2132 . PMID   15277397.
• Staiger H, Kaltenbach S, Staiger K, Stefan N, Fritsche A, Guirguis A, et al. (September 2004). "Expression of adiponectin receptor mRNA in human skeletal muscle cells is related to in vivo parameters of glucose and lipid metabolism". Diabetes. 53 (9): 2195–201. doi: 10.2337/diabetes.53.9.2195 . PMID   15331527.
• Berner HS, Lyngstadaas SP, Spahr A, Monjo M, Thommesen L, Drevon CA, et al. (October 2004). "Adiponectin and its receptors are expressed in bone-forming cells". Bone. 35 (4): 842–9. doi:10.1016/j.bone.2004.06.008. PMID   15454091.
• Punyadeera C, Zorenc AH, Koopman R, McAinch AJ, Smit E, Manders R, et al. (March 2005). "The effects of exercise and adipose tissue lipolysis on plasma adiponectin concentration and adiponectin receptor expression in human skeletal muscle". European Journal of Endocrinology. 152 (3): 427–36. doi: 10.1530/eje.1.01872 . hdl: 10536/DRO/DU:30008881 . PMID   15757860.
• Hara K, Horikoshi M, Kitazato H, Yamauchi T, Ito C, Noda M, et al. (July 2005). "Absence of an association between the polymorphisms in the genes encoding adiponectin receptors and type 2 diabetes". Diabetologia. 48 (7): 1307–14. doi: 10.1007/s00125-005-1806-3 . PMID   15918014.
• Damcott CM, Ott SH, Pollin TI, Reinhart LJ, Wang J, O'connell JR, et al. (July 2005). "Genetic variation in adiponectin receptor 1 and adiponectin receptor 2 is associated with type 2 diabetes in the Old Order Amish". Diabetes. 54 (7): 2245–50. doi: 10.2337/diabetes.54.7.2245 . PMID   15983228.
• Neumeier M, Weigert J, Schäffler A, Weiss T, Kirchner S, Laberer S, et al. (September 2005). "Regulation of adiponectin receptor 1 in human hepatocytes by agonists of nuclear receptors". Biochemical and Biophysical Research Communications. 334 (3): 924–9. doi:10.1016/j.bbrc.2005.06.187. PMID   16023994.
• Zhang J, Holt H, Wang C, Hadid OH, Byrne CD (August 2005). "Expression of AdipoR1 in vivo in skeletal muscle is independently associated with measures of truncal obesity in middle-aged caucasian men". Diabetes Care. 28 (8): 2058–60. doi: 10.2337/diacare.28.8.2058 . PMID   16043761.
• Tang YT, Hu T, Arterburn M, Boyle B, Bright JM, Emtage PC, et al. (September 2005). "PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif". Journal of Molecular Evolution. 61 (3): 372–80. Bibcode:2005JMolE..61..372T. doi:10.1007/s00239-004-0375-2. PMID   16044242. S2CID   31473802.
• Jonsson JR, Moschen AR, Hickman IJ, Richardson MM, Kaser S, Clouston AD, et al. (December 2005). "Adiponectin and its receptors in patients with chronic hepatitis C". Journal of Hepatology. 43 (6): 929–36. doi:10.1016/j.jhep.2005.05.030. PMID   16139921.