Adiponectin receptor 2

ADIPOR2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3WXW
Identifiers
Aliases	ADIPOR2 , adiponectin receptor 2, ACDCR2, PAQR2
External IDs	OMIM: 607946; MGI: 93830; HomoloGene: 56119; GeneCards: ADIPOR2; OMA:ADIPOR2 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12p13.33 Start 1,688,574 bp [1] End 1,788,674 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6 F1|6 56.78 cM Start 119,330,111 bp [2] End 119,394,665 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus callosum C1 segment right adrenal cortex right lung left adrenal gland left adrenal cortex substantia nigra liver epithelium of colon hippocampus proper Top expressed in lactiferous gland brown adipose tissue transitional epithelium of urinary bladder vestibular membrane of cochlear duct epithelium of small intestine epithelium of stomach pyloric antrum left lobe of liver white adipose tissue tunica adventitia of aorta More reference expression data BioGPS n/a
Gene ontology Molecular function adipokinetic hormone receptor activity adiponectin binding metal ion binding identical protein binding protein heterodimerization activity signaling receptor activity Cellular component integral component of membrane membrane intrinsic component of plasma membrane plasma membrane Biological process positive regulation of glucose import glucose homeostasis response to nutrient lipid metabolism female pregnancy adiponectin-activated signaling pathway fatty acid metabolic process vascular wound healing heart development negative regulation of cell growth fatty acid oxidation hormone-mediated signaling pathway regulation of fatty acid biosynthetic process positive regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79602 68465 Ensembl ENSG00000006831 ENSG00000285070 ENSMUSG00000030168 UniProt Q86V24 Q8BQS5 RefSeq (mRNA) NM_024551 NM_001375363 NM_001375364 NM_001375365 NM_197985 NM_001355692 RefSeq (protein) NP_078827 NP_001362292 NP_001362293 NP_001362294 NP_932102 NP_001342621 Location (UCSC) Chr 12: 1.69 – 1.79 Mb Chr 6: 119.33 – 119.39 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Adiponectin receptor 2 (AdipoR2) is a protein which in humans is encoded by the ADIPOR2 gene. ^[5] It is a member of the progestin and adipoQ receptor (PAQR) family, and is also known as PAQR2. ^[6]

Structure

Similar to G protein-coupled receptors (GPCRs), AdipoR2 also possesses 7 transmembrane domains. However, AdipoR2 is orientated oppositely to GPCRs in the membrane (i.e., cytoplasmic N-terminus, extracellular C-terminus) and does not associate with G proteins. ^[5]

Function

The adiponectin receptors, AdipoR1 and AdipoR2, serve as receptors for globular and full-length adiponectin and mediate increased AMPK and PPAR-α ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin. ^[5] In 2016, the University of Tokyo announced that it would launch an investigation into claims of fabrication of AdipoR1 and AdipoR2 identification data, as accused by an anonymous person/group called Ordinary_researchers. ^[7]

Ligands

Agonists

Peptide

• Adiponectin
• ADP-355 ^[8]
• ADP-399 ^[8]

Non-peptide

• AdipoRon ^[9]
• Deoxyschizandrin ^[10]
• Parthenolide ^[10]
• Syringing ^[10]
• Taxifoliol ^[10]

Antagonists

Peptide

• ADP-400 ^[8]

See also

• Adiponectin receptor
• Adiponectin receptor 1

References

1. ENSG00000285070 GRCh38: Ensembl release 89: ENSG00000006831, ENSG00000285070 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030168 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T (June 2003). "Cloning of adiponectin receptors that mediate antidiabetic metabolic effects". Nature. 423 (6941): 762–9. Bibcode:2003Natur.423..762Y. doi:10.1038/nature01705. PMID   12802337. S2CID   52860797.
6. Tang YT, Hu T, Arterburn M, Boyle B, Bright JM, Emtage PC, Funk WD (September 2005). "PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif". Journal of Molecular Evolution. 61 (3): 372–80. Bibcode:2005JMolE..61..372T. doi:10.1007/s00239-004-0375-2. PMID   16044242. S2CID   31473802.
7. University of Tokyo to investigate data manipulation charges against six prominent research groups ScienceInsider, Dennis Normile, Sep 20, 2016
8. Otvos L, Knappe D, Hoffmann R, Kovalszky I, Olah J, Hewitson TD, Stawikowska R, Stawikowski M, Cudic P, Lin F, Wade JD, Surmacz E, Lovas S (2014). "Development of second generation peptides modulating cellular adiponectin receptor responses". Frontiers in Chemistry. 2: 93. Bibcode:2014FrCh....2...93O. doi: 10.3389/fchem.2014.00093 . PMC   4201147 . PMID   25368867.
9. Okada-Iwabu M, Yamauchi T, Iwabu M, Honma T, Hamagami K, Matsuda K, Yamaguchi M, Tanabe H, Kimura-Someya T, Shirouzu M, Ogata H, Tokuyama K, Ueki K, Nagano T, Tanaka A, Yokoyama S, Kadowaki T (November 2013). "A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity". Nature. 503 (7477): 493–9. Bibcode:2013Natur.503..493O. doi:10.1038/nature12656. PMID   24172895. S2CID   4447039.
10. Sun Y, Zang Z, Zhong L, Wu M, Su Q, Gao X, Zan W, Lin D, Zhao Y, Zhang Z (2013). "Identification of adiponectin receptor agonist utilizing a fluorescence polarization based high throughput assay". PLOS ONE. 8 (5): e63354. Bibcode:2013PLoSO...863354S. doi: 10.1371/journal.pone.0063354 . PMC   3653934 . PMID   23691032.

External links

• Human ADIPOR2 genome location and ADIPOR2 gene details page in the UCSC Genome Browser .