Ribosome biogenesis protein BOP1 is a protein that in humans is encoded by the BOP1 gene. [5] [6] It is a WD40 repeat-containing nucleolar protein involved in rRNA processing, thereby controlling the cell cycle. [7] It is required for the maturation of the 25S and 5.8S ribosomal RNAs. It may serve as an essential factor in ribosome formation that coordinates processing of the spacer regions in pre-rRNA.
The Pes1-Bop1 complex has several components: BOP1, GRWD1, PES1, ORC6L, and RPL3 and is involved in ribosome biogenesis and altered chromosome segregation. The overexpression of BOP1 increases the percentage of multipolar spindles in human cells. Deregulation of the BOP1 pathway may contribute to colorectal tumourigenesis in humans. [8] Elevated levels of Bop1 induces Bop1/WDR12 and Bop1/Pes1 subcomplexes and the assembly and integrity of the PeBoW complex is highly sensitive to changes in Bop1 protein levels. [9]
Nop7p-Erb1p-Ytm1p, found in yeast, is potentially the homologous complex of Pes1-Bop1-WDR12 as it is involved in the control of ribosome biogenesis and S phase entry. The integrity of the PeBoW complex is required for ribosome biogenesis and cell proliferation in mammalian cells. [10] In Giardia, the species specific cytoskeleton protein, beta-giardin, interacts with Bop1. [7]
| BOP1NT | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | BOP1NT | ||||||||
| Pfam | PF08145 | ||||||||
| InterPro | IPR012953 | ||||||||
| |||||||||
BOP1 contains a conserved N-terminal domain, BOP1NT.
Erb1 also known as the eukaryotic ribosome biogenesis protein 1 is a yeast protein required for maturation of the 25S and 5.8S ribosomal RNAs. It is a component of 66S pre-ribosomal particles and is homologous to the human protein BOP1.
Pescadillo homolog is a protein that in humans is encoded by the PES1 gene.
Nucleolar protein 56 is a protein that in humans is encoded by the NOP56 gene.
60S ribosomal protein L18a is a protein that in humans is encoded by the RPL18A gene.
The RPS2 gene is the gene which, in humans, encodes the 40S ribosomal protein S2.
Nucleolar RNA helicase 2 is an enzyme that in humans is encoded by the DDX21 gene.
KRR1 small subunit processome component homolog is a protein that in humans is encoded by the KRR1 gene.
60S ribosomal protein L12 is a protein that in humans is encoded by the RPL12 gene.
40S ribosomal protein S5 is a ribosomal subunit of the Eukaryotic ribosome (80S) complex. In humans it is encoded by the RPS5 gene.
40S ribosomal protein S10 is a protein that in humans is encoded by the RPS10 gene.
60S ribosomal protein L35a is a protein that in humans is encoded by the RPL35A gene.
40S ribosomal protein S20 is a protein that in humans is encoded by the RPS20 gene.
ATP-dependent RNA helicase DDX39 is an enzyme that in humans is encoded by the DDX39 gene.
40S ribosomal protein S8 is a protein that in humans is encoded by the RPS8 gene.
39S ribosomal protein L12, mitochondrial is a protein that in humans is encoded by the MRPL12 gene.
Ribosome biogenesis protein WDR12 is a protein that in humans is encoded by the WDR12 gene on chromosome 2. It is ubiquitously expressed in many tissues and cell types. WDR12 participates in ribosome biogenesis and cell proliferation as a component of the PeBoW complex. This protein is associated with cardiovascular diseases such as coronary artery disease and myocardial infarction. The PCSK9 gene also contains one of 27 loci associated with increased risk of coronary artery disease.
39S ribosomal protein L41, mitochondrial is a protein that in humans is encoded by the MRPL41 gene.
Nucleolar protein 6 is a protein that in humans is encoded by the NOL6 gene.
Probable ribosome biogenesis protein RLP24 is a protein that in humans is encoded by the RSL24D1 gene.
28S ribosomal protein S25, mitochondrial is a protein that in humans is encoded by the MRPS25 gene.
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