| C6orf201 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | C6orf201 , dJ1013A10.5, chromosome 6 open reading frame 201, protein MGC87625 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | MGI: 1914011 HomoloGene: 23555 GeneCards: C6orf201 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Chromosome 6 open reading frame 201, C6orf201, is a protein that in humans is encoded by the C6orf201 gene. [5] In humans this gene encodes for a nuclear protein that is primarily expressed in the testis. [6] [7]
In humans, the gene is 51,558 base pairs long. The transcript that produces the longest protein of 140 amino acids is translated from unprocessed mRNA that has six exons and is 1664 nucleotides in length. [8] [9]
Chromosome 6 open reading frame 201 (C6orf201) is also referred to as: dJ1013A10.5, MGC87625, RP5-1013A10.5, and LOC404220. [10]
C6orf201 is located on chromosome 6 at 6p25.2 position and is encoded on the plus strand. [11] C6orf201 is located near the FAM217A gene and the ECI2 gene. [12]
C6orf201 is highly conserved in primates, is moderately conserved in other mammals, and there is also conservation in a few reptiles. [13] There is enough conservation in mycoplasma gallinarum to suggest that there may have been a horizontal gene transfer event sometime during the evolutionary history of C6orf201. There are no paralogs or gene duplication events for C6orf201.
C6orf201 belongs to DUF4523 (Pfam15023), a functionally uncharacterized family of proteins that is found in mammals. [14]
Less common names of the C6orf201 protein are: protein MGC87625, hypothetical protein LOC404220, OTTHUMP00000213693, and OTTHUMP00000213725. [10]
In humans the longest protein variant is 140 amino acids long, [15] has a molecular weight of 16.2 kDa, [16] and an isoelectric point of 10.88. [16] C6orf201 is predicted to be a nuclear protein. [7]
C6orf201 has multiple predicted PKC and CKII phosphorylation sites in humans. [17] The protein also has a nuclear localization signal. [7] C6orf201 has a conserved alpha helix and a conserved beta strand in the protein. [16]
C6orf201 interacts with SRPK1, [18] TMEM106B, [19] and APP. [20]
C6orf201 is primarily expressed in the testis of humans and is also expressed in the testis of adult mice and rats. [6] GEO microarray data also supports expression of C6orf201 in the testis of humans and mouse. [21] [22]
A toxicology study revealed that C6orf201 was one of the top 20 deregulated genes in monkeys that had been exposed to welding fumes for an extended period of time. [23] Another study investigated gene expression after the use of a methylation inhibitor, C6orf201 being one of many genes investigated. [24]
FAM135B is a human gene coding for a protein of unknown function. It is well conserved in primates, rodents, zebra fish. It has one paralog, FAM135A.
Cilia And Flagella Associated Protein 206 (CFAP206) is a gene that in humans encodes a protein “DUF3508”. This protein has a function that is not currently very well understood. Other known aliases are “dJ382I10.1, UPF0704 Protein C6orf165.” In humans, the gene coding sequence is 56,501 base pairs long, with an mRNA of 2,215 base pairs, and a protein sequence of 622 amino acids. The C6orf165 gene is conserved in chimpanzee, rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, mosquito, frog, and more C6orf165 is rarely expressed in humans, with relatively high expression in brain, lungs (trachea) and testis. The molecular weight of UPF0704 is 71,193 Da and the PI is 6.38
Family with sequence similarity 167, member A is a protein in humans that is encoded by the FAM167A gene located on chromosome 8. FAM167A and its paralogs are protein encoding genes containing the conserved domain DUF3259, a protein of unknown function. FAM167A has many orthologs in which the domain of unknown function is highly conserved.
C3orf70 also known as Chromosome 3 Open Reading Frame 70, is a 250aa protein in humans that is encoded by the C3orf70 gene. The protein encoded is predicted to be a nuclear protein; however, its exact function is currently unknown. C3orf70 can be identified with known aliases: Chromosome 3 Open Reading Frame 70, AK091454, UPF0524, and LOC285382.
Chromosome Seven Open Reading Frame 31 (C7orf31) is a protein that in humans is encoded by the C7orf31 gene on chromosome seven.
C12orf40, also known as Chromosome 12 Open Reading Frame 40, HEL-206, and Epididymis Luminal Protein 206 is a protein that in humans is encoded by the C12orf40 gene.
UPF0739 protein C1orf74 is a protein that in humans is encoded by the C1orf74 gene.
C8orf48 is a protein that in humans is encoded by the C8orf48 gene. C8orf48 is a nuclear protein specifically predicted to be located in the nuclear lamina. C8orf48 has been found to interact with proteins that are involved in the regulation of various cellular responses like gene expression, protein secretion, cell proliferation, and inflammatory responses. This protein has been linked to breast cancer and papillary thyroid carcinoma.
Chromosome 11 open reading frame 86, also known as C11orf86, is a protein-coding gene in humans. It encodes for a protein known as uncharacterized protein C11orf86, which is predicted to be a nuclear protein. The function of this protein is currently unknown.
Chromosome 12 Open Reading Frame 42 (C12orf42) is a protein-encoding gene in Homo sapiens.
Chromosome 6 open reading frame 62 (C6orf62), also known as X-trans-activated protein 12 (XTP12), is a gene that encodes a protein of the same name. The encoded protein is predicted to have a subcellular location within the cytosol.
Chromosome 1 open reading frame 112, is a protein that in humans is encoded by the C1orf112 gene, and is located at position 1q24.2. C1orf112 encodes for seventeen variants of mRNA, fifteen of which are functional proteins. C1orf112 has a determined precursor molecular weight of 96.6 kDa and an isoelectric point of 5.62. C1orf112 has been experimentally determined to localize to the mitochondria, although it does not contain a mitochondrial targeting sequence.
Chromosome 19 open reading frame 44 is a protein that in humans is encoded by the C19orf44 gene. C19orf44 is an uncharacterized protein with an unknown function in humans. C19orf44 is non-limiting implying that the protein exists in other species besides human. The protein contains one domain of unknown function (DUF) that is highly conserved throughout its orthologs. This protein is most highly expressed in the testis and ovary, but also has significant expression in the thyroid and parathyroid. Other names for this protein include: LOC84167.
Family with sequence similarity 222 member A or Aggregatin is a protein of unknown function. In humans it is encoded by the gene FAM222A. Aggregatin's cellular function is not well understood, however it has been implicated in Alzheimer's Disease.
C12orf24 is a gene in humans that encodes a protein known as FAM216A. This gene is primarily expressed in the testis and brain, but has constitutive expression in 25 other tissues. FAM216A is an intracellular protein that has been predicted to reside within the nucleus of cells. The exact function of C12orf24 is unknown. FAM216A is highly expressed in Sertoli cells of the testis as well as different stage spermatids.
C6orf136 is a protein in humans encoded by the C6orf136 gene. The gene is conserved in mammals, mollusks, as well some porifera. While the function of the gene is currently unknown, C6orf136 has been shown to be hypermethylated in response to FOXM1 expression in Head Neck Squamous Cell Carcinoma (HNSCC) tissue cells. Additionally, elevated expression of C6orf136 has been associated with improved survival rates in patients with bladder cancer. C6orf136 has three known isoforms.
Chromosome 11 open reading frame 53 is a protein that in humans is encoded by the C11orf53 gene. Reduction in C11orf53 gene expression is associated with increased odds of occurrence of colorectal cancer. Specifically sequence variation (rs3802842) close to the C11orf53 gene locus that lowers the expression of C11orf53 has been observed in the colonic mucosal cells immediately adjacent to colon cancer tumors. C11orf53 downregulation aids in cells' ability to survive in acidic conditions, which are typical of the tumor microenvironment. CRISPR-Cas9 inactivation of C11orf53 in an acute myeloid leukemia cell line made the cells resistant to the BCL2 inhibitor Venetoclax, further supporting a role in cancer predisposition.
C4orf19 is a protein which in humans is encoded by the C4orf19 gene.
Chromosome 12 open reading frame 71 (c12orf71) is a protein which in humans is encoded by c12orf71 gene. The protein is also known by the alias LOC728858.
Chromosome 5 Open Reading Frame 47, or C5ORF47, is a protein which, in humans, is encoded by the C5ORF47 gene. It also goes by the alias LOC133491. The human C5ORF47 gene is primarily expressed in the testis.
