CTDNEP1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | CTDNEP1 , DULLARD, HSA011916, NET56, CTD nuclear envelope phosphatase 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 610684; MGI: 1914431; HomoloGene: 9100; GeneCards: CTDNEP1; OMA:CTDNEP1 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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In cell biology, CTDNEP1 (CTD nuclear envelope phosphatase 1) is a protein coding gene involved in neural development. It is a member of DXDX(T/V) phosphatase family and is a potential regulator of neural tube development in Xenopus . The gene promotes neural development by inhibiting bone morphogenetic proteins (BMPs). The encoded protein is relatively small and only contains 244 amino acids.
CTDnep1, which stands for CTD nuclear envelope phosphatase 1. It is a protein coding gene, which include phosphatase activity and protein serine/threonine phosphatase activity. CTDnep1 encodes a protein serine/threonine phosphatase and dephosphorylates LPIN1 and LPIN2. LPIN1 and LPIN2 catalyze the reaction of the conversion of phosphatidic acid to diacylglycerol. The reaction can affect and change the lipid concentration of the endoplasmic reticulum and the nucleus.
Neural development happens in the dorsal ectoderm. In the genus Xenopus, over expression of CTDNEP1 undergoes apoptosis in early development. CTDNEP1 helps promote Ubiquitin by proteosomal degradation. CTDNEP1 mRNA is derived from maternal genes and is localized within the animal neural hemisphere. Functioning negatively for the regulation of Bone Morphogenetic Proteins (BMPs), CTDNEP1 conserves the C-terminal region of NLI-IF, in which is fairly dominant in cellular functions. CTDNEP1 is essential for inhibiting BMP receptor activation during Xenopus neuralization.
Human CTDNEP1 has shown that the protein has two membrane spanning regions. One end is the N-terminal end, which helps localize the protein to the nuclear envelope. CTDNEP1 dephosphorylates the mammalian phosphatidic acid phosphatase, lipin. CTDNEP1 participates in a unique phosphatase cascade regulating nuclear membrane biogenesis, and that this cascade is conserved from yeast to mammals. There is belief that CTDNEP1 may have other targets that is not only associated with the nuclear envelope. In recent studies, CTDNEP1 interacts with BMP type 1 to inhibit dependent phosphorylation. This can conclude that it is a potential source for regulating the level of BMP signaling and can affect germ cell specification.
CTD nuclear envelope phosphatase 1 is a protein in humans that is encoded by the CTDNEP1 gene. [4]
Bone morphogenetic protein 4 is a protein that in humans is encoded by BMP4 gene. BMP4 is found on chromosome 14q22-q23.
The bone morphogenetic protein receptor, type IA also known as BMPR1A is a protein which in humans is encoded by the BMPR1A gene. BMPR1A has also been designated as CD292.
BMP and activin membrane-bound inhibitor homolog , also known as BAMBI, is a protein which in humans is encoded by the BAMBI gene.
In cell biology, Dullard protein is a protein coding gene involved in neural development. It is a member of DXDX(T/V) phosphatase family and is a potential regulator of neural tube development in Xenopus. The gene promotes neural development by inhibiting Bone Morphogenetic Proteins (BMPs). Dullard is also known as CTDnep1, which stands for CTD nuclear envelope phosphatase 1. This gene is relatively small and only contains 244 amino acids.
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform is an enzyme that in humans is encoded by the PPP2R2B gene.
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit is an enzyme that in humans is encoded by the PPP1CC gene.
Serine/threonine-protein phosphatase 5 is an enzyme that in humans is encoded by the PPP5C gene.
Protein phosphatase 1A is an enzyme that in humans is encoded by the PPM1A gene.
Lipid phosphate phosphohydrolase 1 also known as phosphatidic acid phosphatase 2a is an enzyme that in humans is encoded by the PPAP2A gene.
Serine/threonine-protein phosphatase 4 catalytic subunit is an enzyme that in humans is encoded by the PPP4C gene.
Lipin-1 is a protein that in humans is encoded by the LPIN1 gene.
Lipid phosphate phosphohydrolase 3 (LPP3), also known as phospholipid phosphatase 3 (PLPP3) and phosphatidic acid phosphatase type 2B, is an enzyme that in humans is encoded by the PPAP2B gene on chromosome 1. It is ubiquitously expressed in many tissues and cell types. LPP3 is a cell-surface glycoprotein that hydrolyzes extracellular lysophosphatidic acid (LPA) and short-chain phosphatidic acid. Its function allows it to regulate vascular and embryonic development by inhibiting LPA signaling, which is associated with a wide range of human diseases, including cardiovascular disease and cancer, as well as developmental defects. The PPAP2B gene also contains one of 27 loci associated with increased risk of coronary artery disease.
Dual specificity protein phosphatase 4 is an enzyme that in humans is encoded by the DUSP4 gene.
Serine/threonine-protein phosphatase with EF-hands 1 is an enzyme that in humans is encoded by the PPEF1 gene.
Protein phosphatase 1G is an enzyme that in humans is encoded by the PPM1G gene.
BMP-2-inducible protein kinase is an enzyme in humans encoded by the BMP2K gene.
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 is an enzyme that in humans is encoded by the CTDSP1 gene.
MORN1 containing repeat 1, also known as Morn1, is a protein that in humans is encoded by the MORN1 gene.
EVI5L is a protein that in humans is encoded by the EVI5L gene. EVI5L is a member of the Ras superfamily of monomeric guanine nucleotide-binding (G) proteins, and functions as a GTPase-activating protein (GAP) with a broad specificity. Measurement of in vitro Rab-GAP activity has shown that EVI5L has significant Rab2A- and Rab10-GAP activity.
C14orf93 is a protein that is encoded in humans by the C14orf93 gene. It is a globular protein with a conserved C-terminus that is localized to the nucleus. While expressed relatively highly in all tissues except nervous tissue, it is expressed particularly highly in T cells and other immune tissues.