State Route 58 is a major east-west state highway in the U.S. state of California that runs across the Coast Ranges, the southern San Joaquin Valley, the Tehachapi Mountains, which border the southern Sierra Nevada, and the Mojave Desert. It runs between U.S. Route 101 near Santa Margarita and Interstate 15 in Barstow. It has junctions with Interstate 5 near Buttonwillow, State Route 99 in Bakersfield, State Route 202 in Tehachapi, State Route 14 near Mojave, and U.S. Route 395 at Kramer Junction. SR 58 also provides access to Edwards Air Force Base. At various points it is known as the Calf Canyon Highway, Carrisa Highway, Bakersfield-McKittrick Highway, Rosa Parks Highway, Rosedale Highway, Barstow-Bakersfield Highway, Bakersfield Tehachapi Highway, Kern County Korean War Veterans Memorial Highway, and Mojave-Barstow Highway.
State Route 140 is a state highway in the U.S. state of California, 102 miles (164 km) in length. It begins in the San Joaquin Valley at Interstate 5 near Gustine, and runs east into Sierra Nevada, terminating in Yosemite National Park.
State Route 120 is a state highway in the U.S. state of California, running west to east across the central part of the state. It runs from Interstate 5 in Lathrop in the San Joaquin Valley through Yosemite National Park, to its end at U.S. Route 6 in Mono County, in eastern California. While the route is signed as a contiguous route through Yosemite National Park, the portion in park boundaries is federally maintained, and is not included in the state route logs. The portion at Tioga Pass is the highest paved through road in the California State Route system. This part is not maintained in the winter and is usually closed during the winter season.
State Route 49 is a north–south state highway in the U.S. state of California that passes through many historic mining communities of the 1849 California gold rush. Highway 49 is numbered after the "49ers", the waves of immigrants who swept into the area looking for gold, and it is known as the Golden Chain Highway. This roadway begins at Oakhurst, Madera County, in the Sierra Nevada, where it diverges from State Route 41. It continues in a generally northwest direction, weaving through the communities of Goldside and Ahwahnee, before crossing into Mariposa County. State Route 49 then continues northward through the counties of Tuolumne, Calaveras, Amador, El Dorado, Placer, Nevada, Yuba, Sierra, and Plumas, where it reaches its northern terminus at State Route 70, in Vinton.
State Route 299 is an east–west state highway in the state of California that runs across the northern part of the state. At 305.777 miles (492.100 km), it is the third longest California state highway. Route 299 begins at US 101 at the northern edge of Arcata and continues in an easterly direction through to the Nevada state line. Between Arcata and Redding, Route 299 intersects with State Route 96, and is briefly co-signed with State Route 3. In Redding, it intersects with State Route 273, State Route 44, and Interstate 5. East of Redding, it intersects with State Route 89, and a section is co-signed with State Route 139 before reaching Alturas. It is then co-signed with U.S. Route 395 northeast of Alturas, and then runs east toward the border with Nevada. A ghost town, Vya, Nevada, can be reached via this route, which after the border becomes a dirt road, which was formerly Nevada State Route 8A. The segment of SR 299 between Arcata and Redding is the Trinity Scenic Byway, a National Forest Scenic Byway.
State Route 12 is a state highway in the U.S. state of California that travels in an east–west direction from State Route 116 in Sebastopol in Sonoma County to State Route 49 just north of San Andreas in Calaveras County. The route connects the Sonoma and Napa valleys with the Sacramento–San Joaquin River Delta and the Sierra Foothills. It is constructed to freeway standards from the Fulton Road/South Wright Road stoplight in Santa Rosa, to its partial interchange with Farmers Lane.
State Route 33 is a north–south state highway in the U.S. state of California. It runs north from U.S. Route 101 in Ventura through the Transverse Ranges and the western side of the San Joaquin Valley to Interstate 5 at a point east of Tracy. SR 33 replaced part of U.S. Route 399 in 1964 during the "great renumbering" of routes. In the unincorporated sections of Kern County it is known as the West Side Highway. In addition, the California Legislature designated the entire Kern County portion as the Petroleum Highway in 2004. The southernmost portion in Ventura is a freeway known as the Ojai Freeway, while it is known as the Maricopa Highway from Ojai to Maricopa.
State Route 20 is a state highway in the northern-central region of the state of California, running east–west north of Sacramento from the North Coast to the Sierra Nevada. Its west end is at SR 1 in Fort Bragg, from where it heads east past Clear Lake, Colusa, Yuba City, Marysville and Nevada City to I-80 near Emigrant Gap, where eastbound traffic can continue on other routes to Lake Tahoe or Nevada.
State Route 88, also known as the Carson Pass Highway, is a state highway in the U.S. state of California. It travels in an east–west direction from Stockton in the San Joaquin Valley, crossing the Sierra Nevada at Carson Pass, and ending at the Nevada state line, whereupon it becomes Nevada State Route 88, eventually terminating at U.S. Route 395.
State Route 89 is a state highway in the U.S. state of California that travels in the north–south direction, serving as a major thoroughfare for many mountain communities in the Sierra Nevada and the Cascade Range. It starts from U.S. Route 395 near Topaz Lake, winding its way up to the 8,314-foot (2,534 m) Monitor Pass, down to the Carson River, and up again over the 7,740-foot (2,359 m) Luther Pass. From that point on, the route generally loses elevation on its way past Lake Tahoe, through Tahoe and Plumas National Forests until Lake Almanor. For roughly nine miles the route is then a part of State Route 36. The route then ascends to the 5,753-foot (1,754 m) Morgan Summit. After it enters Lassen Volcanic National Park it continues to gain elevation until it reaches its highest point in an unnamed pass in the middle of Lassen Peak and Bumpass Mountain. The road then descends and heads northwest, finally terminating at Interstate 5 at the foot of Mount Shasta at around 3,600 feet (1,100 m).
State Route 108 is a state highway in the U.S. state of California that runs from the Central Valley and across the Sierra Nevada via the Sonora Pass. It generally runs northeast from downtown Modesto near the SR 99/SR 132 interchange, to U.S. Route 395 near the Nevada state line. The route was once recommended to continue south of Modesto to Interstate 5, although today that portion exists as a county road. Parts of SR 108 are closed annually during the winter due to inclement weather along the summit.
State Route 121 is a state highway in the U.S. state of California. It runs through the Wine Country region of Sonoma and Napa counties. Its southern terminus is at State Route 37 at Sears Point, and its northern terminus is at State Route 128 near Lake Berryessa. SR 121 passes through the Carneros region of the southern Sonoma Valley and Napa Valley.
State Route 190 is a state highway in the U.S. state of California that is split into two parts by the Sierra Nevada. The western portion begins at Tipton at a junction with State Route 99 and heads east towards Porterville before ending at Quaking Aspen in the Sequoia National Forest. The eastern portion begins at US 395 at Olancha, heads east through Death Valley National Park, and ends at State Route 127 at Death Valley Junction. The 43.0-mile (69.2 km) portion over the Sierra Nevada remains unconstructed, and the California Department of Transportation (Caltrans) has no plans to build it through the wilderness areas. SR 190 is a National Scenic Byway known as the Death Valley Scenic Byway.
State Route 136 is a state highway in the U.S. state of California, running along the northern edge of Owens Lake in Inyo County from U.S. Route 395 in Lone Pine to State Route 190.
State Route 266 is a state highway in the U.S. state of California. The route traverses Fish Lake Valley, which is part in California and part in Nevada. The route connects two Nevada state routes that traverse the Nevada portion of the valley, NV 264 and NV 266. The only connection from SR 266 to the rest of California's road network is via SR 168 in the community of Oasis. Prior to 1986 the southern and northern halves of modern SR 266 had separate numerical designations. The southern portion of the highway, along with modern SR 168, dates to the auto trail era, forming part of the Midland Trail.
State Route 168 is an east-west state highway in the U.S. state of California that is separated into two distinct segments by the Sierra Nevada mountains. The western segment runs from State Routes 41 and 180 in Fresno east to Huntington Lake along the western slope of the Sierra. The eastern segment connects Lake Sabrina in the Eastern Sierra to State Route 266 in the community of Oasis, just to the west of the Nevada border. The eastern segment of SR 168 also forms a concurrency with U.S. Route 395 between Bishop and Big Pine.
State Route 178 is a state highway in the U.S. state of California that exists in two constructed segments. The gap in between segments is connected by various local roads and State Route 190 through Death Valley National Park. The western segment runs from State Route 99 in Bakersfield and over the Walker Pass in the Sierra Nevada to the turnoff for the Trona Pinnacles National Natural Landmark. The eastern segment runs from the southeasterly part of Death Valley to Nevada State Route 372 at the Nevada state line.
State Route 174 is a state highway in the U.S. state of California. The two-lane 13-mile (21 km) highway in the western Sierra Nevada, added to the state highway system in 1933, connects Interstate 80 in Colfax with SR 20/SR 49 in Grass Valley, crossing the Bear River next to a 1924 concrete arch bridge. The majority of the route is eligible for the State Scenic Highway System, but local residents have blocked its designation due to property right concerns.
U.S. Route 6 (US 6) is a transcontinental United States Numbered Highway, stretching from Bishop, California, in the west to Provincetown, Massachusetts, in the east. The California portion of US 6 lies in the eastern portion of the state from Bishop in the Owens Valley north to the Nevada state line in Mineral County. Prior to a 1964 Highway renumbering project US 6 extended to the Pacific Ocean in Long Beach, California, as part of the historic auto trail named the Grand Army of the Republic Highway.
U.S. Route 95 (US 95) is a United States Numbered Highway, stretching from the Mexican border in San Luis, Arizona to the Canadian border near Eastport, Idaho. The California portion of US 95 traverses through the far eastern edges of both Riverside and San Bernardino counties. US 95 serves Blythe and Needles and junctions with SR 62 at Vidal Junction.
I-15 at Baker 
SR 373 at Nevada state line south of Amargosa Valley, NV 
