Carbonic anhydrase 13

CA13
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3CZV, 3D0N, 3DA2, 4HU1, 4KNM, 4KNN, 4QIZ, 4QJP, 4QJX, 4QSJ
Identifiers
Aliases	CA13 , CAXIII, carbonic anhydrase 13
External IDs	OMIM: 611436; MGI: 1931322; HomoloGene: 75207; GeneCards: CA13; OMA:CA13 - orthologs
Gene location (Human) Chr. Chromosome 8 (human) [1] Band 8q21.2 Start 85,220,587 bp [1] End 85,284,073 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 A1 Start 14,706,787 bp [2] End 14,728,062 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa palpebral conjunctiva pancreatic epithelial cell mucosa of ileum nasal epithelium amniotic fluid endothelial cell gingival epithelium skin of arm duodenum Top expressed in meninges esophagus membranous bone lip jejunum mandible vestibular sensory epithelium vestibular membrane of cochlear duct gastric mucosa epithelium of stomach More reference expression data BioGPS n/a
Gene ontology Molecular function zinc ion binding lyase activity metal ion binding carbonate dehydratase activity carbonic anhydrase Cellular component myelin sheath cytosol intracellular membrane-bounded organelle Biological process bicarbonate transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 377677 71934 Ensembl ENSG00000185015 ENSMUSG00000027555 UniProt Q8N1Q1 Q9D6N1 RefSeq (mRNA) NM_198584 NM_024495 RefSeq (protein) NP_940986 NP_078771 Location (UCSC) Chr 8: 85.22 – 85.28 Mb Chr 3: 14.71 – 14.73 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Carbonic anhydrase 13 is a protein that in humans is encoded by the CA13 gene. ^[5]

Function

Carbonic anhydrases (CAs) are a family of zinc metalloenzymes that catalyze the interconversion between carbon dioxide and water and the dissociated ions of carbonic acid (i.e. bicarbonate and hydrogen ions). ^{[6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000185015 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027555 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Carbonic anhydrase 13" . Retrieved 2019-12-31.
6. Badger MR, Price GD (1994). "The role of carbonic anhydrase in photosynthesis". Annu. Rev. Plant Physiol. Plant Mol. Biol. 45: 369–392. doi:10.1146/annurev.pp.45.060194.002101.
7. Lindskog S (1997). "Structure and mechanism of carbonic anhydrase". Pharmacology & Therapeutics. 74 (1): 1–20. doi:10.1016/S0163-7258(96)00198-2. PMID   9336012.

Further reading

• Lehtonen J, Shen B, Vihinen M, Casini A, Scozzafava A, Supuran CT, et al. (January 2004). "Characterization of CA XIII, a novel member of the carbonic anhydrase isozyme family". The Journal of Biological Chemistry. 279 (4): 2719–27. doi: 10.1074/jbc.M308984200 . PMID   14600151.
• Kummola L, Hämäläinen JM, Kivelä J, Kivelä AJ, Saarnio J, Karttunen T, Parkkila S (April 2005). "Expression of a novel carbonic anhydrase, CA XIII, in normal and neoplastic colorectal mucosa". BMC Cancer. 5: 41. doi: 10.1186/1471-2407-5-41 . PMC   1097719 . PMID   15836783.
• Hilvo M, Innocenti A, Monti SM, De Simone G, Supuran CT, Parkkila S (2008). "Recent advances in research on the most novel carbonic anhydrases, CA XIII and XV". Current Pharmaceutical Design. 14 (7): 672–8. doi:10.2174/138161208783877811. PMID   18336313.

External links

• Overview of all the structural information available in the PDB for UniProt : Q8N1Q1 (Human Carbonic anhydrase 13) at the PDBe-KB .

This article incorporates text from the United States National Library of Medicine, which is in the public domain.