Daniel Trachsel

Daniel Trachsel
Alma mater	Burgdorf University of Applied Sciences
Years active	1993–present
Organization	ReseaChem
Notable work	Psychedelische Chemie Aspekte psychoaktiver Moleküle (2000); Phenethylamine: von der Struktur zur Funktion (2013)
Website	https://nachtschatten.ch/autoren/trachsel/

Daniel Trachsel is a Swiss chemist who studies psychedelics and entactogens. ^{[1] [2]} He has developed and published on a large number of novel psychedelic and entactogen compounds, including their psychoactive effects. ^{[1] [2] [3]} This has been in a manner similar to that of the psychedelic chemist Alexander Shulgin, which has caused Trachsel to sometimes be referred to as the "German Shulgin". ^{[1] [2]} However, unlike Shulgin, Trachsel has distanced himself from any personal self-experiments. ^[1]

Compounds

Compounds that were first known to have been synthesized by Trachsel and colleagues include:

• 2C-CP
• 2C-T-3
• 2C-T-16
• 2C-T-21.5
• 2C-T-25
• 2C-T-27
• 2C-T-28
• 2C-T-30
• 2C-T-31
• 2C-T-32
• 2C-T-33
• 2C-TFE
• 2C-V
• 2C-YN
• 3C-DFE
• DFMDA
• Trifluoromescaline

Selected publications

Books

• Trachsel, D.; Richard, N. (2000). Psychedelische Chemie Aspekte psychoaktiver Moleküle [Psychedelic Chemistry: Aspects of Psychoactive Molecules] (in German) (1 ed.). Nachtschatten-Verlag. ISBN   978-3-907080-53-5. OCLC   247657972 . Retrieved 31 January 2025. [Note: There are also several subsequent editions (2nd (2002) through 5th (2016)).] ^[4]
• Trachsel, D.; Lehmann, D.; Enzensperger, C. (2013). Phenethylamine: von der Struktur zur Funktion [Phenethylamines: From Structure to Function]. Nachtschatten-Science (in German) (1 ed.). Solothurn: Nachtschatten-Verlag. ISBN   978-3-03788-700-4. OCLC   858805226 . Retrieved 31 January 2025.

Papers

• Trachsel, Daniel (2002). "Synthese von neuen (Phenylalkyl)aminen zur Untersuchung von Struktur-Aktivitätsbeziehungen, Mitteilung 1, Mescalin Derivate" [Synthesis of new (phenylalkyl)amines for the investigation of structure-activity relationships, Communication 1, Mescaline derivatives](PDF). Helvetica Chimica Acta. 85 (9): 3019–3026. doi:10.1002/1522-2675(200209)85:9<3019::AID-HLCA3019>3.0.CO;2-4.
• Trachsel, Daniel (2003). "Synthese von neuen (Phenylalkyl)aminen zur Untersuchung von Struktur–Aktivitätsbeziehungen. Mitteilung 2: 4-Thio-substituierte [2-(2,5-Dimethoxyphenyl)ethyl]amine (=2,5-Dimethoxybenzolethanamine)" [Synthesis of new (phenylalkyl)amines for the investigation of structure–activity relationships. Communication 2: 4-thio-substituted [2-(2,5-dimethoxyphenyl)ethyl]amines (=2,5-dimethoxybenzenethanamines)]. Helvetica Chimica Acta. 86 (7): 2610–2619. doi:10.1002/hlca.200390210. ISSN   0018-019X.
• Trachsel, Daniel (2003). "Synthesis of Novel (Phenylalkyl)amines for the Investigation of Structure–Activity Relationships, Part 3: 4-Ethynyl-2,5-dimethoxyphenethylamine (=4-Ethynyl-2,5-dimethoxybenzeneethanamine; 2C-YN)". Helvetica Chimica Acta. 86 (8): 2754–2759. doi:10.1002/hlca.200390224. ISSN   0018-019X.
• Trachsel D, Hadorn M, Baumberger F (March 2006). "Synthesis of fluoro analogues of 3,4-(methylenedioxy)amphetamine (MDA) and its derivatives". Chem Biodivers. 3 (3): 326–336. doi:10.1002/cbdv.200690035. PMID   17193269.
• Trachsel D, Nichols DE, Kidd S, Hadorn M, Baumberger F (May 2009). "4-aryl-substituted 2,5-dimethoxyphenethylamines: synthesis and serotonin 5-HT(2A) receptor affinities". Chem Biodivers. 6 (5): 692–704. doi:10.1002/cbdv.200800235. PMID   19479848.
• Trachsel D (2012). "Fluorine in psychedelic phenethylamines". Drug Test Anal. 4 (7–8): 577–590. doi:10.1002/dta.413. PMID   22374819.
• Luethi D, Trachsel D, Hoener MC, Liechti ME (May 2018). "Monoamine receptor interaction profiles of 4-thio-substituted phenethylamines (2C-T drugs)" (PDF). Neuropharmacology. 134 (Pt A): 141–148. doi:10.1016/j.neuropharm.2017.07.012. PMID   28720478.
• Kolaczynska KE, Luethi D, Trachsel D, Hoener MC, Liechti ME (2021). "Receptor Interaction Profiles of 4-Alkoxy-3,5-Dimethoxy-Phenethylamines (Mescaline Derivatives) and Related Amphetamines" (PDF). Front Pharmacol. 12: 794254. doi: 10.3389/fphar.2021.794254 . PMC   8865417 . PMID   35222010.
• Halberstadt AL, Luethi D, Hoener MC, Trachsel D, Brandt SD, Liechti ME (January 2023). "Use of the head-twitch response to investigate the structure-activity relationships of 4-thio-substituted 2,5-dimethoxyphenylalkylamines" (PDF). Psychopharmacology (Berl). 240 (1): 115–126. doi:10.1007/s00213-022-06279-2. PMC   9816194 . PMID   36477925.

See also

• David E. Nichols
• Jason Wallach

References

1. Passie T, Brandt SD (2018). "Self-Experiments with Psychoactive Substances: A Historical Perspective" (PDF). Handb Exp Pharmacol. 252: 69–110. doi:10.1007/164_2018_177. PMID   30478735. One follower of Shulgin's research can be seen in the Swiss chemist Daniel Trachsel, who published various contributions on many new psychoactive substances and their effects (Trachsel 2011, 2012; Trachsel et al. 2013). Experimental results about their psychoactive effects are included, but the author distanced himself from any [self-experiments (SEs)] (Trachsel 2011, p. 12).
2. Hamilton Morris (27 November 2021). "PODCAST 34: A Four Hour Interview with Dr. David E Nichols". The Hamilton Morris Podcast (Podcast). Patreon. Retrieved 30 January 2025.
3. Halberstadt AL, Chatha M, Klein AK, Wallach J, Brandt SD (May 2020). "Correlation between the potency of hallucinogens in the mouse head-twitch response assay and their behavioral and subjective effects in other species". Neuropharmacology. 167: 107933. doi:10.1016/j.neuropharm.2019.107933. PMC   9191653 . PMID   31917152. The human potency data used in the analysis (Table 4) were collected from several sources, including clinical trials, results published by Dr. Alexander Shulgin and Dr. Daniel Trachsel, as well as from websites such as erowid.com and psychonautwiki.org.
4. "Psychedelische Chemie [Psychedelic Chemistry] Formats and Editions". WorldCat.org. WorldCat. Retrieved 31 January 2025.