2,6-Dimethylmescaline

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2,6-Dimethylmescaline
2,6-Dimethylmescaline.svg
Clinical data
Other namesDMe-M; Dimethylmescaline; 2,6-Dimethyl-3,4,5-trimethoxyphenethylamine; 3,4,5-Trimethoxy-2,6-dimethylphenethylamine
Drug class Serotonin receptor modulator
ATC code
  • None
Identifiers
  • 2-(3,4,5-trimethoxy-2,6-dimethylphenyl)ethan-1-amine
Chemical and physical data
Formula C13H21NO3
Molar mass 239.315 g·mol−1
3D model (JSmol)
  • NCCc1c(C)c(OC)c(c(c1C)OC)OC
  • InChI=1S/C13H21NO3/c1-8-10(6-7-14)9(2)12(16-4)13(17-5)11(8)15-3/h6-7,14H2,1-5H3
  • Key:VUZBXFVHLMPADZ-UHFFFAOYSA-N

2,6-Dimethylmescaline, or simply dimethylmescaline (DMe-M), also known as 2,6-dimethyl-3,4,5-trimethoxyphenethylamine, is a serotonin receptor modulator of the phenethylamine and scaline families related to mescaline. [1] It is the 2,6-dimethyl derivative of mescaline. [1] The drug shows affinity for the serotonin 5-HT1A, 5-HT2A, and 5-HT2C receptors (Ki = 45 nM, 879 nM, and 1,002 nM, respectively). [1] These affinities were 66-fold, 5.2-fold, and 7.7-fold higher than those of mescaline, respectively. [1] The drug is not known to have been tested in animals or humans. [1] 2,6-Dimethylmescaline was first described in the scientific literature by Daniel Trachsel and colleagues in 2013. [1] The source of the information cited by Trachsel and colleagues was personal communication with David E. Nichols in 2010. [1]

Contents

See also

References

  1. 1 2 3 4 5 6 7 Trachsel D, Lehmann D, Enzensperger C (2013). Phenethylamine: von der Struktur zur Funktion [Phenethylamines: From Structure to Function]. Nachtschatten-Science (in German) (1 ed.). Solothurn: Nachtschatten-Verlag. pp. 935–936. ISBN   978-3-03788-700-4. OCLC   858805226. Archived from the original on 21 August 2025.
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