Eczema herpeticum

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Eczema herpeticum
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Eczema herpeticum is a rare but severe and contagious disseminated infection that generally occurs at sites of skin damage produced by, for example, atopic dermatitis, burns, long-term usage of topical steroids or eczema. [1] It is also known as Kaposi varicelliform eruption, Pustulosis varioliformis acute and Kaposi–Juliusberg dermatitis.

Contents

Some sources reserve the term "eczema herpeticum" when the cause is due to human herpes simplex virus, [2] and the term "Kaposi varicelliform eruption" to describe the general presentation without specifying the virus. [3]

This condition is most commonly caused by herpes simplex virus type 1 or 2, but may also be caused by coxsackievirus A16, or vaccinia virus. [1] It appears as numerous umbilicated vesicles superimposed on healing atopic dermatitis. it is often accompanied by fever and lymphadenopathy. Eczema herpeticum can be life-threatening in babies.

Presentation

In addition to the skin, this infection affects multiple organs, including the eyes, brain, lung, and liver, and can be fatal.[ citation needed ]

Treatment

It can be treated with systemic antiviral drugs, such as aciclovir or valganciclovir. [4] Foscarnet may also be used for immunocompromised host with Herpes simplex and acyclovir-resistant Herpes simplex.[ citation needed ]

Epidemiology

Even though the disease may develop at any age it is mostly present in childhood. [5] Those who are affected typically have pre-existing cutaneous condition like atopic dermatitis. [5]

History

Eczema herpeticum was first described by Hungarian dermatologist Moriz Kaposi in 1887. [6] Fritz Juliusberg coined the term Pustulosis varioliformis acute in 1898. Eczema herpeticum is caused by Herpes simplex virus HSV1, the virus that causes cold sores; it can also be caused by other related viruses.

See also

Related Research Articles

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Id reactions are types of acute dermatitis developing after days or weeks at skin locations distant from the initial inflammatory or infectious site. They can be localised or generalised. This is also known as an autoeczematous response and there must be an identifiable initial inflammatory or infectious skin problem which leads to the generalised eczema. Often intensely itchy, the red papules and pustules can also be associated with blisters and scales and are always remote from the primary lesion. It is most commonly a blistering rash with itchy vesicles on the sides of fingers and feet as a reaction to fungal infection on the feet, athlete's foot. Stasis dermatitis, allergic contact dermatitis, acute irritant contact eczema and infective dermatitis have been documented as possible triggers, but the exact cause and mechanism is not fully understood. Several other types of id reactions exist including erythema nodosum, erythema multiforme, Sweet's syndrome and urticaria.

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References

  1. 1 2 Olson J, Robles DT, Kirby P, Colven R (2008). "Kaposi varicelliform eruption (eczema herpeticum)". Dermatology Online Journal. 14 (2): 18. doi:10.5070/D39DR4C02Z. PMID   18700121.
  2. "eczema herpeticum" at Dorland's Medical Dictionary
  3. "Kaposi varicelliform eruption" at Dorland's Medical Dictionary
  4. Brook I, Frazier EH, Yeager JK (April 1998). "Microbiology of infected eczema herpeticum". Journal of the American Academy of Dermatology. 38 (4): 627–9. doi:10.1016/S0190-9622(98)70130-6. PMID   9555806.
  5. 1 2 Liaw, Fang-Yih; Huang, Ching-Fu; Hsueh, Ju-Ting; Chiang, Chien-Ping (December 2012). "Eczema herpeticum". Canadian Family Physician. 58 (12): 1358–1361. ISSN   0008-350X. PMC   3520662 . PMID   23242894.
  6. Reitamo, Sakari; Luger, Thomas A; Steinhoff, Martin (2008). Textbook of atopic dermatitis. Informa Healthcare. p. 70. ISBN   978-1841842462.