Buffalopox virus | |
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Virus classification ![]() | |
(unranked): | Virus |
Realm: | Varidnaviria |
Kingdom: | Bamfordvirae |
Phylum: | Nucleocytoviricota |
Class: | Pokkesviricetes |
Order: | Chitovirales |
Family: | Poxviridae |
Genus: | Orthopoxvirus |
Species: | |
Virus: | Buffalopox virus |
Buffalopox is caused by buffalopox virus (BPXV); it is a Poxviridae for which the natural host is buffalo. It mainly infects buffalo but has been known to infect cows and humans. It is classified in the Orthopoxvirus (OPV) genus and the subfamily Chordopoxvirinae . The appearance of buffalopox follows a pattern and is described as emerging and re-emerging, it commonly occurs in sporadic and epidemic forms in domestic and commercial farm settings. [1]
The first recorded incidence of buffalopox occurred in India in 1934. [2] Since then many outbreaks have occurred in many parts of the world including Pakistan, Egypt, Nepal, and Bangladesh. While the disease was characterized in 1934, the agent causing the disease was not identified until 1977 when researchers, Singh and Singh, were able to isolate and characterize the virus. [3] In buffaloes the disease is mainly reported in the young and old. BPXV can be spread by sand flies and midges, [4] and transmission studies showed that in addition to infecting buffaloes and cows the virus can also infect guinea pigs and suckling mice. Between 2006 and 2008, there were four outbreaks in domestic buffaloes in India. [1] The buffaloes presented with lesions on the udder, teats, limbs, around the ear, and hindquarters which was indicative of a generalized infection. In this case, there was a reduction of milk yield of about 30-35% which was followed by mastitis that was a consequence of a secondary bacterial infection. The milk attendants developed lesions on their chest, lower abdomen, fingers, hands, forearms, legs, scapular region, feet, and forehead and also presented with a fever, lymphadenopathy, and general malaise. There is also some evidence of milk attendants spreading the virus between buffalo and from buffalo to cows. [5]
In the mild form, lesions occur localized on the udder, teats, and inguinal region, over the parotid, and the base and inner surface of the ear and eyes. In the severe form, the lesions are generalized. The severe form is now rare, and the disease is mainly mild. The result is high morbidity and productivity loss. When the virus infects milk animals it causes mastitis which reduces milk yield and the working capacity of draft animals. The mastitis occurs in approximately fifty percent of the infected animals; in severe cases, the reduction in milk production can be permanent. The incubation time in animals is about 2–4 days and in humans it is 3–19 days. [1]
Structurally BPXV looks like other OPVs and especially Vaccinia Virus (VACV). Studies have shown that the virus particle is brick shaped and measures 280-330 nm by 200-250 nm in size. Before maturation the particle appears oval or spherical and may or may not have a central core. Research has shown that, depending on the specific strain of the virus it can yield between 19 and 26 polypeptides, some of which are glycoproteins. [1]
Humans in close contact with buffaloes are susceptible to buffalopox; with the cessation of the smallpox vaccine in 1980, humans do not develop an antibody titer against the Poxviridae, and as a result have become even more susceptible to viruses like buffalopox. In humans the virus causes lesions that are mainly confined to the hands, forehead, face, buttocks, and legs, and occasionally lymphadenopathy. Human-to-human transmission has not been reported. Milking of infected animals is one of the major modes of spread, thus the main people in danger of contracting the disease are veterinarians, milk attendants, and other people who are in close proximity of the infected animals. There have also been recent reports of nosocomial infections in burn patients and paramedical staff. [6]
Cowpox is an infectious disease caused by the cowpox virus (CPXV). It presents with large blisters in the skin, a fever and swollen glands, historically typically following contact with an infected cow, though in the last several decades more often from infected cats. The hands and face are most frequently affected and the spots are generally very painful.
Mpox is an infectious viral disease that can occur in humans and some other animals. Symptoms include fever, swollen lymph nodes, and a rash that forms blisters and then crusts over. The time from exposure to onset of symptoms ranges from five to twenty-one days. The duration of symptoms is typically two to four weeks. There may be mild symptoms, and it may occur without any symptoms being apparent. The classic presentation of fever and muscle pains, followed by swollen glands, with lesions all at the same stage, has not been found to be common to all outbreaks. Cases may be severe, especially in children, pregnant women or people with suppressed immune systems.
Orf is a farmyard pox, a type of zoonosis. It causes small pustules in the skin of primarily sheep and goats, but can also occur on the hands of humans. A pale halo forms around a red centre. It may persist for several weeks before crusting and then either resolves or leaves a hard lump. There is usually only one lesion, but there may be many, and they are not painful. Sometimes there are swollen lymph glands.
An udder is an organ formed of two or four mammary glands on the females of dairy animals and ruminants such as cattle, goats, and sheep. An udder is equivalent to the breast in primates and elephantine pachyderms. The udder is a single mass hanging beneath the animal, consisting of pairs of mammary glands with protruding teats. In cattle and camels, there are normally two pairs, in sheep, goats and deer, there is one pair, and in some animals, there are many pairs. In animals with udders, the mammary glands develop on the milk line near the groin, and mammary glands that develop on the chest are generally referred to as breasts.
Milking is the act of removing milk from the mammary glands of cattle, water buffalo, humans, goats, sheep, and, more rarely, camels, horses and donkeys. Milking may be done by hand or by machine, and requires the animal to be currently or recently pregnant. The milker may refer either to the animal that produces the milk or the person who milks said animal.
A somatic cell count (SCC) is a cell count of somatic cells in a fluid specimen, usually milk. In dairying, the SCC is an indicator of the quality of milk—specifically, its low likeliness to contain harmful bacteria, and thus its high food safety. White blood cells (leukocytes) constitute the majority of somatic cells in question. The number of somatic cells increases in response to pathogenic bacteria like Staphylococcus aureus, a cause of mastitis. The SCC is quantified as cells per milliliter. General agreement rests on a reference range of less than 100,000 cells/mL for uninfected cows and greater than 250,000 for cows infected with significant pathogen levels. Several tests like the PortaSCC milk test and The California mastitis test provide a cow-side measure of somatic cell count. The somatic cell count in the milk also increases after calving when colostrum is produced.
Orthopoxvirus is a genus of viruses in the family Poxviridae and subfamily Chordopoxvirinae. Vertebrates, including mammals and humans, and arthropods serve as natural hosts. There are 12 species in this genus. Diseases associated with this genus include smallpox, cowpox, horsepox, camelpox, and monkeypox. The most widely known member of the genus is Variola virus, which causes smallpox. It was eradicated globally by 1977, through the use of Vaccinia virus as a vaccine. The most recently described species is the Alaskapox virus, first isolated in 2015.
Brucella melitensis is a Gram-negative coccobacillus bacterium from the Brucellaceae family. The bacterium causes ovine brucellosis, along with Brucella ovis. It affects primarily sheep and goats, but cases have also been observed in cattle, yaks, water buffalo, Bactrian and dromedary camels, alpacas, dogs, horses and pigs. Humans can become infected if they have contact with an infected animal or its byproducts. Animals acquire B. melitensis by venereal transmission and contact with the placenta, fetus, fetal fluids, and vaginal discharges from infected animals. The organism is found in blood, urine, milk, and semen. It is zoonotic, unlike B. ovis, causing Malta fever or localized brucellosis in humans.
Camelpox is a disease of camels caused by the camelpox virus (CMPV) of the family Poxviridae, subfamily Chordopoxvirinae, and the genus Orthopoxvirus. It causes skin lesions and a generalized infection. Approximately 25% of young camels that become infected will die from the disease, while infection in older camels is generally more mild. Although rare, the infection may spread to the hands of those that work closely with camels.
Sheeppox is a highly contagious disease of sheep caused by a poxvirus different from the benign orf. This virus is in the family Poxviridae and genus Capripoxvirus. Sheeppox virus (SPV) is the most severe of all the animal pox diseases and can result in some of the most significant economic consequences due to poor wool and leather quality.
Lumpy skin disease (LSD) is an infectious disease in cattle caused by a virus of the family Poxviridae, also known as Neethling virus. The disease is characterized by large fever, enlarged superficial lymph nodes and multiple nodules on the skin and mucous membranes. Infected cattle also may develop edematous swelling in their limbs and exhibit lameness. The virus has important economic implications since affected animals tend to have permanent damage to their skin, lowering the commercial value of their hide. Additionally, the disease often results in chronic debility, reduced milk production, poor growth, infertility, abortion, and sometimes death.
Bovine papillomaviruses (BPV) are a paraphyletic group of DNA viruses of the subfamily Firstpapillomavirinae of Papillomaviridae that are common in cattle. All BPVs have a circular double-stranded DNA genome. Infection causes warts of the skin and alimentary tract, and more rarely cancers of the alimentary tract and urinary bladder. They are also thought to cause the skin tumour equine sarcoid in horses and donkeys.
The United States raw milk debate concerns issues of food safety and claimed health benefits of raw milk, and whether authorities responsible for regulating food safety should prohibit sale of raw milk for consumption.
Variola caprina is a contagious viral disease caused by Goatpox virus, a pox virus that affects goats. The virus usually spreads via the respiratory system, and sometimes spreads through abraded skin. It is most likely to occur in crowded stock. Sources of the virus include cutaneous lesions, saliva, nasal secretions and faeces. There are two types of the disease: the papulo-vesicular form and the nodular form. The incubation period is usually 8–13 days, but it may be as short as four days.
Foot-and-mouth disease (FMD) or hoof-and-mouth disease (HMD) is an infectious and sometimes fatal viral disease that affects cloven-hoofed animals, including domestic and wild bovids. The virus causes a high fever lasting two to six days, followed by blisters inside the mouth and near the hoof that may rupture and cause lameness.
Streptococcus canis is a group G beta-hemolytic species of Streptococcus. It was first isolated in dogs, giving the bacterium its name. These bacteria are characteristically different from Streptococcus dysgalactiae, which is a human-specific group G species that has a different phenotypic chemical composition. S. canis is important to the skin and mucosal health of cats and dogs, but under certain circumstances, these bacteria can cause opportunistic infections. These infections were known to afflict dogs and cats prior to the formal description of the species in Devriese et al., 1986. However, additional studies revealed cases of infection in other mammal species, including cattle and even humans. Instances of mortality from S. canis in humans are very low with only a few reported cases, while actual instances of infection may be underreported due to mischaracterizations of the bacteria as S. dysgalactiae. This species, in general, is highly susceptible to antibiotics, and plans to develop a vaccine to prevent human infections are currently being considered.
Bovine mastitis is the persistent, inflammatory reaction of the udder tissue due to physical trauma or microorganisms infections. Mastitis, a potentially fatal mammary gland infection, is the most common disease in dairy cattle in the United States and worldwide. It is also the most costly disease to the dairy industry. Milk from cows suffering from mastitis has an increased somatic cell count. Prevention and control of mastitis requires consistency in sanitizing the cow barn facilities, proper milking procedure and segregation of infected animals. Treatment of the disease is carried out by penicillin injection in combination with sulphar drug
The monkeypox virus, also called the mpox virus, is a species of double-stranded DNA virus that causes mpox in humans and other mammals. the monkeypox virus is a zoonotic virus belonging to the orthopoxvirus genus, making it closely related to the variola (VARV), cowpox (CPX), and vaccinia (VACV) viruses. MPV is oval-shaped with a lipoprotein outer membrane. The genome is approximately 190 kb.
Pseudocowpox is a disease caused by the Paravaccinia virus or Pseudocowpox virus, a virus of the family Poxviridae and the genus Parapoxvirus. Humans can contract the virus from contact with livestock infected with Bovine papular stomatitis and the disease is common among ranchers, milkers, and veterinarians. Infection in humans will present with fever, fatigue, and lesion on the skin.
A dry cow refers to a dairy cow that is in a stage of their lactation cycle where milk production ceases prior to calving. This part of their lactation cycle is referred to as the cows dry period and typically last between 40 and 65 days. Dry cows are typically divided into two groups: far-off and close-up. Once the cow has entered this stage, producers will seal the cows teat while following a veterinarian recommended, dry cow therapy for their herd. This dry period is a critical part of their lactation cycle and is important for the cows health, the newborn calf and future milk production, as it allows the cow time to rest, eat and prepare for birth. During this time, the cow will produce colostrum for the newly born calf.