Alphaherpesvirinae

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Alphaherpesvirinae
Varicella (Chickenpox) Virus PHIL 1878 lores.jpg
Electron micrograph of a Human alphaherpesvirus 3 virion
Virus classification Red Pencil Icon.png
(unranked): Virus
Realm: Duplodnaviria
Kingdom: Heunggongvirae
Phylum: Peploviricota
Class: Herviviricetes
Order: Herpesvirales
Family: Herpesviridae
Subfamily:Alphaherpesvirinae
Genera

See text

Alphaherpesvirinae is a subfamily of viruses in the family Herpesviridae , primarily distinguished by reproducing more quickly than other subfamilies in the Herpesviridae. In animal virology the most important herpesviruses belong to the Alphaherpesvirinae. Pseudorabies virus is the causative agent of Aujeszky's disease in pigs and Bovine herpesvirus 1 is the causative agent of bovine infectious rhinotracheitis and pustular vulvovaginitis. [1] [2] Mammals serve as natural hosts. There are currently 45 species in this subfamily, divided among 5 genera with one species unassigned to a genus. Diseases associated with this subfamily include: HHV-1 and HHV-2: skin vesicles or mucosal ulcers, rarely encephalitis and meningitis, HHV-3: chickenpox (varicella) and shingles, GaHV-2: Marek's disease. [3] [4]

Contents

Genera

Alphaherpesvirinae consists of the following five genera: [4]

The species Chelonid alphaherpesvirus 6 is currently unassigned to a genus. [4]

Structure

Viruses in Alphaherpesvirinae are enveloped, with icosahedral, spherical to pleomorphic, and round geometries, and T=16 symmetry. The diameter is around 150-200 nm. Genomes are linear and non-segmented, around 120 to 180 kb in length. [3]

GenusStructureSymmetryCapsidGenomic arrangementGenomic segmentation
IltovirusSpherical pleomorphicT=16EnvelopedLinearMonopartite
MardivirusSpherical pleomorphicT=16EnvelopedLinearMonopartite
SimplexvirusSpherical pleomorphicT=16EnvelopedLinearMonopartite
ScutavirusSpherical pleomorphicT=16EnvelopedLinearMonopartite
VaricellovirusSpherical pleomorphicT=16EnvelopedLinearMonopartite

Life cycle

Viral replication is nuclear, and is lysogenic. Entry into the host cell is achieved by attachment of the viral gB, gC, gD and gH proteins to host receptors, which mediates endocytosis. Replication follows the dsDNA bidirectional replication model. DNA-templated transcription, with some alternative splicing mechanism is the method of transcription. Translation takes place by leaky scanning. The virus exits the host cell by nuclear egress, budding, and microtubular outwards viral transport. Mammals serve as the natural host. Transmission routes are sexual, contact, body fluids, lesions, and respiratory. [3]

GenusHost detailsTissue tropismEntry detailsRelease detailsReplication siteAssembly siteTransmission
IltovirusBirds: galliform: psittacineNoneCell receptor endocytosisBuddingNucleusNucleusOral-fecal; aerosol
MardivirusChickens; turkeys; quailNoneCell receptor endocytosisBuddingNucleusNucleusAerosol
SimplexvirusHumans; mammalsEpithelial mucosaCell receptor endocytosisBuddingNucleusNucleusSaliva
ScutavirusSea turtlesNoneCell receptor endocytosisBuddingNucleusNucleusAerosol
VaricellovirusMammalsEpithelial mucosaGlycoproteinsBuddingNucleusNucleusAerosol

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Cytomegalovirus (CMV) is a genus of viruses in the order Herpesvirales, in the family Herpesviridae, in the subfamily Betaherpesvirinae. Humans and other primates serve as natural hosts. The 11 species in this genus include human betaherpesvirus 5, which is the species that infects humans. Diseases associated with HHV-5 include mononucleosis and pneumonia. In the medical literature, most mentions of CMV without further specification refer implicitly to human CMV. Human CMV is the most studied of all cytomegaloviruses.

<i>Paramyxoviridae</i> Family of viruses

Paramyxoviridae is a family of negative-strand RNA viruses in the order Mononegavirales. Vertebrates serve as natural hosts. Diseases associated with this family include measles, mumps, and respiratory tract infections. The family has four subfamilies, 17 genera, and 78 species, three genera of which are unassigned to a subfamily.

Roseolovirus is a genus of viruses in the order Herpesvirales, in the family Herpesviridae, in the subfamily Betaherpesvirinae. There are currently six species in this genus. Diseases associated with this genus include: HHV-6: sixth disease ; HHV-7: symptoms analog to the 'sixth disease'.

Rhadinovirus is a genus of viruses in the order Herpesvirales, in the family Herpesviridae, in the subfamily Gammaherpesvirinae. Humans and other mammals serve as natural hosts. There are 12 species in this genus. Diseases associated with this genus include: Kaposi's sarcoma, primary effusion lymphoma and multicentric Castleman's disease, caused by Human gammaherpesvirus 8 (HHV-8), also known as Kaposi's sarcoma-associated herpesvirus (KSHV). The term rhadino comes from the Latin fragile, referring to the tendency of the viral genome to break apart when it is isolated.

Mardivirus is a genus of viruses in the order Herpesvirales, in the family Herpesviridae, in the subfamily Alphaherpesvirinae. Chickens, turkeys, and quail serve as natural hosts. There are six species in this genus. Diseases associated with this genus include: Marek's disease, which causes asymmetric paralysis of one or more limbs, neurological symptoms, and development of multiple lymphomas that manifest as solid tumors. Gallid herpesvirus 2 is the only one of these viruses known to be pathogenic and due to the antigenic similarity between the three viruses the other two have been used to vaccinate against Marek's disease. These viruses have double stranded DNA genomes with no RNA intermediate.

<i>Herpesviridae</i> Family of DNA viruses

Herpesviridae is a large family of DNA viruses that cause infections and certain diseases in animals, including humans. The members of this family are also known as herpesviruses. The family name is derived from the Greek word ἕρπειν, referring to spreading cutaneous lesions, usually involving blisters, seen in flares of herpes simplex 1, herpes simplex 2 and herpes zoster (shingles). In 1971, the International Committee on the Taxonomy of Viruses (ICTV) established Herpesvirus as a genus with 23 viruses among four groups. As of 2020, 115 species are recognized, all but one of which are in one of the three subfamilies. Herpesviruses can cause both latent and lytic infections.

<i>Cypovirus</i> Genus of viruses

Cypovirus, short for cytoplasmic polyhedrosis virus, is a genus of double-stranded RNA viruses in the family Reoviridae and subfamily Spinareovirinae. Cypoviruses have only been isolated from insects. Diseases associated with this genus include chronic diarrhoea and pale blue iridescence in the guts of larvae. Sixteen species are placed in this genus.

<span class="mw-page-title-main">Duck plague</span> Disease caused by Anatid alphaherpesvirus 1

Duck plague is a worldwide disease caused by Anatid alphaherpesvirus 1 (AnHV-1) of the family Herpesviridae that causes acute disease with high mortality rates in flocks of ducks, geese, and swans. It is spread both vertically and horizontally—through contaminated water and direct contact. Migratory waterfowl are a major factor in the spread of this disease as they are often asymptomatic carriers of disease. The incubation period is three to seven days. Birds as young as one week old can be infected. DEV is not zoonotic.

<i>Gammaherpesvirinae</i> Subfamily of viruses

Gammaherpesvirinae is a subfamily of viruses in the order Herpesvirales and in the family Herpesviridae. Viruses in Gammaherpesvirinae are distinguished by reproducing at a more variable rate than other subfamilies of Herpesviridae. Mammals serve as natural hosts. There are 43 species in this subfamily, divided among 7 genera with three species unassigned to a genus. Diseases associated with this subfamily include: HHV-4: infectious mononucleosis. HHV-8: Kaposi's sarcoma.

Betaherpesvirinae is a subfamily of viruses in the order Herpesvirales and in the family Herpesviridae. Mammals serve as natural hosts. There are 26 species in this subfamily, divided among 5 genera. Diseases associated with this subfamily include: human cytomegalovirus (HHV-5): congenital CMV infection; HHV-6: 'sixth disease' ; HHV-7: symptoms analogous to the 'sixth disease'.

Varicellovirus (var′i-sel′ō-vi′rŭs) is a genus of viruses belonging to subfamily Alphaherpesvirinae, a member of family Herpesviridae. Humans and other mammals serve as natural hosts. There are 19 species in this genus. Diseases associated with this genus include: HHV-3—chickenpox (varicella) and shingles; BoHV-1—infectious bovine rhinotracheitis/infectious pustular vulvovaginitis (IPV); and SuHV-1 —Aujesky's disease.

<i>Iltovirus</i> Genus of viruses

Iltovirus is a genus of viruses in the order Herpesvirales, in the family Herpesviridae, in the subfamily Alphaherpesvirinae. Birds, galliform birds, psittacine birds, chickens, turkeys, and quail serve as natural hosts. There are only two species in this genus. Diseases associated with this genus include: acute respiratory diseases: gaHV-1: infectious laryngotracheitis; psHV-1: Pacheco's disease.

<i>Lymphocryptovirus</i> Genus of viruses

Lymphocryptovirus is a genus of viruses in the order Herpesvirales, in the family Herpesviridae, in the subfamily Gammaherpesvirinae. This genus includes the human-infecting Human gammaherpesvirus 4, as well as viruses that infect both Old World monkeys and New World monkeys. Other names for the Lymphocryptovirus genus include Lymphocryptoviridae and gamma-1 herpesviruses. There are nine species in this genus. Diseases associated with this genus include: mononucleosis, Burkitt's lymphoma, and nasopharyngeal carcinoma.

<i>Simplexvirus</i> Genus of viruses

Simplexvirus is a genus of viruses in the order Herpesvirales, in the family Herpesviridae, in the subfamily Alphaherpesvirinae. Humans and mammals serve as natural hosts. Diseases associated with this genus include skin vesicles or mucosal ulcers, rarely encephalitis, and meningitis.

<i>Herpesvirales</i> Order of viruses

The Herpesvirales is an order of dsDNA viruses with animal hosts, characterised by a common morphology consisting of an icosahedral capsid enclosed in a glycoprotein-containing lipid envelope. Common infections in humans caused by members of this order include cold sores, genital herpes, chickenpox, shingles, and glandular fever. Herpesvirales is the sole order in the class Herviviricetes, which is the sole class in the phylum Peploviricota.

Muromegalovirus is a genus of viruses in the order Herpesvirales, in the family Herpesviridae, in the subfamily Betaherpesvirinae. Rodents serve as natural hosts. There are three species in this genus. Diseases associated with this genus include: infected peritoneal macrophages, dendritic cells (DC) and hepatocytes, inducing significant pathology in both the spleen and the liver. Murid viruses Murid betaherpesvirus 1 (MuHV-1) and Murid betaherpesvirus 2 (MuHV-2), previously defined as mouse cytomegalovirus (MCMV) and rat cytomegalovirus (RCMV), belong to this genus.

Macavirus is a genus of viruses in the order Herpesvirales, in the family Herpesviridae, in the subfamily Gammaherpesvirinae. Mammals serve as natural hosts. There are nine species in this genus. Diseases associated with this genus include: inapparent infection in their reservoir hosts, but fatal lymphoproliferative disease when they infect MCF-susceptible hosts, including cattle, deer, bison, water buffalo and pigs.

Percavirus is a genus of viruses in the order Herpesvirales, in the family Herpesviridae, in the subfamily Gammaherpesvirinae. Mammals serve as natural hosts. There are six species in this genus. Diseases associated with this genus include: conjunctivitis, immunosuppression in foals, pneumonia, respiratory disease.

Scutavirus is a genus of viruses in the order Herpesvirales, in the family Herpesviridae, in the subfamily Alphaherpesvirinae. Turtles and tortoises serve as natural hosts. Diseases associated with this genus include fibropapillomatosis.

Caprine alphaherpesvirus 1 (CpHV-1) is a species of virus known to infect goats worldwide. It has been shown to produce systemic and respiratory symptoms in kids and to cause abortions in adult goats.

References

  1. Mettenleiter; et al. (2008). "Molecular Biology of Animal Herpesviruses". Animal Viruses: Molecular Biology. Caister Academic Press. ISBN   978-1-904455-22-6.
  2. Sandri-Goldin RM., ed. (2006). Alpha Herpesviruses: Molecular and Cellular Biology. Caister Academic Press. ISBN   978-1-904455-09-7.
  3. 1 2 3 "Viral Zone". ExPASy. Retrieved 12 June 2015.
  4. 1 2 3 "Virus Taxonomy: 2020 Release". International Committee on Taxonomy of Viruses (ICTV). March 2021. Retrieved 10 May 2021.