Hepeviridae

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Hepeviridae
Hepatitis E virus.jpg
TEM micrograph of hepatitis E virions
Virus classification OOjs UI icon edit-ltr.svg
(unranked): Virus
Realm: Riboviria
Kingdom: Orthornavirae
Phylum: Kitrinoviricota
Class: Alsuviricetes
Order: Hepelivirales
Family:Hepeviridae
Genera

Hepeviridae is a family of viruses. [1] Human, pig, wild boar, sheep, cow, camel, monkey, some rodents, bats and chickens serve as natural hosts. There are two genera in the family. Diseases associated with this family include: hepatitis; high mortality rate during pregnancy; and avian hepatitis E virus is the cause of hepatitis-splenomegaly (HS) syndrome among chickens. [1] [2]

Contents

Taxonomy

The following genera are assigned to the family: [1]

A third genus has been proposed — Insecthepevirus. [3] This proposed genus contains one species — Sogatella furcifera hepe-like virus.

A species — Crustacea hepe-like virus 1, has been isolated from a prawn ( Macrobrachium rosenbergii ). [4]

Structure

Viruses in the family Hepeviridae are non-enveloped, with icosahedral and spherical geometries, and T=1 symmetry. The diameter is around 32-34 nm. Genomes are linear and non-segmented, around 7.2kb in length. The genome has three open reading frames. [1] [2]

GenusStructureSymmetryCapsidGenomic arrangementGenomic segmentation
Orthohepevirusicosahedral, sphericalT=1Non-envelopedLinearMonopartite
Piscihepevirusicosahedral, sphericalT=1Non-envelopedLinearMonopartite

Evolution

This has been studied by examining the ORF1 and the capsid proteins. [5] The ORF1 protein appears to be related to members of the Alphatetraviridae - a member of the "Alpha-like" super-group of viruses - while the capsid protein is related to that of the chicken astrovirus capsid - a member of the "Picorna-like" supergroup. This suggests that a recombination event at some point in the past between at least two distinct viruses gave rise to the ancestor of this family. This recombination event occurred at the junction of the structural and non structural proteins.[ citation needed ]

Life cycle

Entry into the host cell is achieved by attachment of the virus to host receptors, which mediates clathrin-mediated endocytosis. Replication follows the positive stranded RNA virus replication model. Positive stranded rna virus transcription is the method of transcription. Translation takes place by leaky scanning. Human, pig, wild boar, monkey, cow, sheep, camel some rodents, bat and chicken serve as the natural host. Transmission routes are zoonosis and fomite. [1] [2]

GenusHost detailsTissue tropismEntry detailsRelease detailsReplication siteAssembly siteTransmission
OrthohepevirusHuman, pig, wild boar, monkey, some rodents, chickenAttachmentIntestine, hepatocytesCytoplasmCytoplasmzoonosis, fomite
Piscihepeviruscutthroat trout ( Oncorhynchus clarkii )AttachmentIntestine, hepatocytesCytoplasmCytoplasmorofaecal

Related Research Articles

<span class="mw-page-title-main">RNA virus</span> Subclass of viruses

An RNA virus is a virus—other than a retrovirus—that has ribonucleic acid (RNA) as its genetic material. The nucleic acid is usually single-stranded RNA (ssRNA) but it may be double-stranded (dsRNA). Notable human diseases caused by RNA viruses include the common cold, influenza, SARS, MERS, COVID-19, Dengue Virus, hepatitis C, hepatitis E, West Nile fever, Ebola virus disease, rabies, polio, mumps, and measles.

<i>Flaviviridae</i> Family of viruses

Flaviviridae is a family of enveloped positive-strand RNA viruses which mainly infect mammals and birds. They are primarily spread through arthropod vectors. The family gets its name from the yellow fever virus; flavus is Latin for "yellow", and yellow fever in turn was named because of its propensity to cause jaundice in victims. There are 89 species in the family divided among four genera. Diseases associated with the group include: hepatitis (hepaciviruses), hemorrhagic syndromes, fatal mucosal disease (pestiviruses), hemorrhagic fever, encephalitis, and the birth defect microcephaly (flaviviruses).

<i>Parvoviridae</i> Family of viruses

Parvoviruses are a family of animal viruses that constitute the family Parvoviridae. They have linear, single-stranded DNA (ssDNA) genomes that typically contain two genes encoding for a replication initiator protein, called NS1, and the protein the viral capsid is made of. The coding portion of the genome is flanked by telomeres at each end that form into hairpin loops that are important during replication. Parvovirus virions are small compared to most viruses, at 23–28 nanometers in diameter, and contain the genome enclosed in an icosahedral capsid that has a rugged surface.

<i>Hepadnaviridae</i> Family of viruses

Hepadnaviridae is a family of viruses. Humans, apes, and birds serve as natural hosts. There are currently 18 species in this family, divided among 5 genera. Its best-known member is hepatitis B virus. Diseases associated with this family include: liver infections, such as hepatitis, hepatocellular carcinomas, and cirrhosis. It is the sole accepted family in the order Blubervirales.

<span class="mw-page-title-main">Rubella virus</span> Species of virus

Rubella virus (RuV) is the pathogenic agent of the disease rubella, transmitted only between humans via the respiratory route, and is the main cause of congenital rubella syndrome when infection occurs during the first weeks of pregnancy.

<span class="mw-page-title-main">Satellite (biology)</span> Subviral agent which depends on a helper virus for its replication

A satellite is a subviral agent that depends on the coinfection of a host cell with a helper virus for its replication. Satellites can be divided into two major classes: satellite viruses and satellite nucleic acids. Satellite viruses, which are most commonly associated with plants, are also found in mammals, arthropods, and bacteria. They encode structural proteins to enclose their genetic material, which are therefore distinct from the structural proteins of their helper viruses. Satellite nucleic acids, in contrast, do not encode their own structural proteins, but instead are encapsulated by proteins encoded by their helper viruses. The genomes of satellites range upward from 359 nucleotides in length for satellite tobacco ringspot virus RNA (STobRV).

<i>Geminiviridae</i> Family of viruses

Geminiviridae is a family of plant viruses that encode their genetic information on a circular genome of single-stranded (ss) DNA. There are 520 species in this family, assigned to 14 genera. Diseases associated with this family include: bright yellow mosaic, yellow mosaic, yellow mottle, leaf curling, stunting, streaks, reduced yields. They have single-stranded circular DNA genomes encoding genes that diverge in both directions from a virion strand origin of replication. According to the Baltimore classification they are considered class II viruses. It is the largest known family of single stranded DNA viruses.

Pseudoviridae is a family of viruses, which includes three genera.

Baltimore classification is a system used to classify viruses based on their manner of messenger RNA (mRNA) synthesis. By organizing viruses based on their manner of mRNA production, it is possible to study viruses that behave similarly as a distinct group. Seven Baltimore groups are described that take into consideration whether the viral genome is made of deoxyribonucleic acid (DNA) or ribonucleic acid (RNA), whether the genome is single- or double-stranded, and whether the sense of a single-stranded RNA genome is positive or negative.

<i>Dependoparvovirus</i> Genus of viruses

Dependoparvovirus is a genus in the subfamily Parvovirinae of the virus family Parvoviridae; they are Group II viruses according to the Baltimore classification. Some dependoparvoviruses are also known as adeno-associated viruses because they cannot replicate productively in their host cell without the cell being coinfected by a helper virus such as an adenovirus, a herpesvirus, or a vaccinia virus.

<i>Marnaviridae</i> Family of viruses

Marnaviridae is a family of positive-stranded RNA viruses in the order Picornavirales that infect various photosynthetic marine protists. Members of the family have non-enveloped, icosahedral capsids. Replication occurs in the cytoplasm and causes lysis of the host cell. The first species of this family that was isolated is Heterosigma akashiwo RNA virus (HaRNAV) in the genus Marnavirus, which infects the toxic bloom-forming Raphidophyte alga, Heterosigma akashiwo. As of 2021, there are twenty species across seven genera in this family, as well as many other related virus sequences discovered through metagenomic sequencing that are currently unclassified.

Endornaviridae is a family of viruses. Plants, fungi, and oomycetes serve as natural hosts. There are 31 species in this family, assigned to 2 genera. Members of Alphaendornavirus infect plants, fungi and the oomycete Phytophthora sp., members of Betaendornavirus infect ascomycete fungi.

<i>Picobirnavirus</i> Genus of viruses

Picobirnavirus is a genus of double-stranded RNA viruses. It is the only genus in the family Picobirnaviridae. Although amniotes, especially mammals, were thought to serve as hosts, it has been recently suggested that these viruses might infect bacteria and possibly some other invertebrates. If they do infect bacteria, then they are Bacteriophages. There are three species in this genus. Associated symptoms include gastroenteritis in animals and humans, though the disease association is unclear.

<i>Lagovirus</i> Genus of viruses

Lagovirus is a genus of viruses, in the family Caliciviridae. Lagomorphs serve as natural hosts. There are two species in this genus. Diseases associated with this genus include: necrotizing hepatitis leading to fatal hemorrhages.

Bocaparvovirus is a genus of viruses in the subfamily Parvovirinae of the virus family Parvoviridae. Humans, cattle, and dogs serve as natural hosts. There are 28 species in this genus. Diseases associated with this genus include, in humans, acute respiratory illness, and in cattle, diarrhea and mild respiratory symptoms.

<i>Bromovirus</i> Genus of viruses

Bromovirus is a genus of viruses, in the family Bromoviridae. Plants serve as natural hosts. There are six species in this genus.

<i>Respirovirus</i> Genus of viruses

Respirovirus is a genus of viruses in the order Mononegavirales, in the family Paramyxoviridae. Rodents and human serve as natural hosts. There are seven species in this genus. Diseases associated with this genus include: croup and other acute febrile respiratory tract infections.

<span class="mw-page-title-main">Quadriviridae</span> Family of viruses

Quadriviridae is a family of double-stranded RNA viruses with a single genus Quadrivirus. The fungi Rosellinia necatrix serves as a natural host. The name of the group derives from the quadripartite genome of its members where in Latin quad means four. There is only one species in this family: Rosellinia necatrix quadrivirus 1.

<i>Orthornavirae</i> Kingdom of viruses

Orthornavirae is a kingdom of viruses that have genomes made of ribonucleic acid (RNA), including genes which encode an RNA-dependent RNA polymerase (RdRp). The RdRp is used to transcribe the viral RNA genome into messenger RNA (mRNA) and to replicate the genome. Viruses in this kingdom share a number of characteristics which promote rapid evolution, including high rates of genetic mutation, recombination, and reassortment.

<i>Macronovirus</i> Genus of virus

Macronovirus is the only genus of the family Sarthroviridae and only contains the species Macrobrachium satellite virus 1

References

  1. 1 2 3 4 5 "ICTV Online (10th) Report Hepeviridae".
  2. 1 2 3 "Viral Zone". ExPASy. Retrieved 15 June 2015.
  3. Wu, Nan; Zhang, Peipei; Liu, Wenwen; Wang, Xifeng (2018). "Sogatella furcifera hepe-like virus: First member of a novel Hepeviridae clade identified in an insect". Virus Research. 250: 81–86. doi:10.1016/j.virusres.2018.03.018. PMID   29605729.
  4. Dong X, Hu T, Liu Q, Li C, Sun Y, Wang Y, Shi W, Zhao Q, Huang J (2020). "A novel Hepe-Like virus from farmed giant freshwater prawn Macrobrachium rosenbergii". Viruses. 12 (3): 323. doi: 10.3390/v12030323 . PMC   7150978 . PMID   32192159.
  5. Kelly, Andrew G; Netzler, Natalie E; White, Peter A (2016). "Ancient recombination events and the origins of hepatitis E virus". BMC Evolutionary Biology. 16 (1): 210. doi: 10.1186/s12862-016-0785-y . PMC   5062859 . PMID   27733122.