Caulimoviridae

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Caulimoviridae
Virus classification OOjs UI icon edit-ltr.svg
(unranked): Virus
Realm: Riboviria
Kingdom: Pararnavirae
Phylum: Artverviricota
Class: Revtraviricetes
Order: Ortervirales
Family:Caulimoviridae

Caulimoviridae is a family of viruses infecting plants. [1] The family contains 11 genera. [2] [3] Viruses belonging to the family Caulimoviridae are termed double-stranded DNA (dsDNA) reverse-transcribing viruses (or pararetroviruses) i.e. viruses that contain a reverse transcription stage in their replication cycle. This family contains all plant viruses with a dsDNA genome that have a reverse transcribing phase in their lifecycle.

Contents

Taxonomy

The following genera are recognized: [3]

Virus particle structure

All viruses of this family are non-enveloped. Virus particles are either bacilliform or isometric. The type of nucleocapsid incorporated into the virus structure determines the size of the viral particles. Bacilliform particles are approximately 35–50 nm in diameter and up to 900 nm in length. Isometric particles are on average 45–50 nm in diameter and show icosahedral symmetry.

Genome structure and replication

Genomic map of CaMV, a well-studied member of this family. ORFs: 1--Movement Protein, 2--Aphid transmission factor, 3--Virion-associated protein, 4--gag-Capsid, 5--pro/pol-A3 Protease and RT/RNase H, 6--Transactivator/viroplasmin. MP, CP, PRO, POL are common among this family. Arrangement varies. CauliflowerMosaicRNA35S.png
Genomic map of CaMV, a well-studied member of this family. ORFs: 1—Movement Protein, 2—Aphid transmission factor, 3—Virion-associated protein, 4—gag-Capsid, 5—pro/pol-A3 Protease and RT/RNase H, 6—Transactivator/viroplasmin. MP, CP, PRO, POL are common among this family. Arrangement varies.

Structure

The genomes of viruses from this family contain monopartite, non-covalently closed circular dsDNA of 7.2–9.3 kbp with discontinuities in both genome strands at specific places [1] . These genomes contain one open reading frame (ORF), as observed in petuviruses, to eight ORFs such as in the soymoviruses.

Proteins encoded by the viral genomes always include reverse transcriptase (RT), a ribonuclease H (RnaseH), aspartic proteases (AP), capsids (CP), 30K movement proteins (MP) and viral associated proteins (VAP) [1] . Some ORF code for proteins of unknown function.

The AP, RT and RnaseH are coded in the same ORF and produce a polyprotein. The RT protein unify the five family in the order Ortervirales : Belpaoviridae, Caulimoviridae, Metaviridae , Pseudoviridae and Retroviridae [4] . However, unlike the other four families, the Caulimoviridae genomes do not encode an integrase protein. Thus their integration is not mandatory in their replication life cycle [1] .

Replication

The virion enter in the host cell and will reach the nucleus. The capsid protein are disassembled and the circular dsDNA enter the nucleus via the nuclear pore. The viral DNA forms supercoiled mini-chromosome structures upon entering the host nucleus, where it is transcribed by the host polymerase II into polyadenylated RNA which is terminally redundant (due to transcription occurring twice for some parts of the DNA). Newly transcribed RNA are exported into the cytoplasm where it is either translated into viral proteins, or retrotranscribed into new copies of the dsDNA viral genome by the viral reverse transcriptase. New dsDNA genomes are encapsidated in the cytoplasm and released.

Integration

The presence of endogenous viral elements (EVEs) in plant genomes is widespread. [5] [6] [7] and most known plant EVEs originate from viruses with DNA genomes in the family Caulimoviridae. Integration is thought to occur through non-homologous end-joining (illegitimate recombination) during DNA repair mechanisms. Most plant EVEs are non infectious. However, infectious Caulimoviridae EVEs have been reported in the genome of petunia [8] ( Petunia vein clearing virus ), banana [9] (Banana streak OL virus, Banana streak GF virus, Banana streak IM virus) and Nicotiana edwardsonii [10] ( Tobacco vein clearing virus ).

References

  1. 1 2 3 4 Teycheney, PY; Geering, ADW; Dasgupta, I; Hull, R; Kreuze, JF; Lockhart, B; Muller, E; Olszewski, N; Pappu, H; Pooggin, MM; Richert-Pöggeler, KR; Schoelz, JE; Seal, S; Stavolone, L; Umber, M; ICTV Report Consortium (October 2020). "ICTV Virus Taxonomy Profile: Caulimoviridae". The Journal of General Virology. 101 (10): 1025–1026. doi: 10.1099/jgv.0.001497 . PMC   7660458 . PMID   32940596.
  2. ↑ "ICTV Report Caulimoviridae".
  3. 1 2 "Virus Taxonomy: 2020 Release". International Committee on Taxonomy of Viruses (ICTV). March 2021. Retrieved 21 May 2021.
  4. ↑ Krupovic, Mart; Blomberg, Jonas; Coffin, John M.; Dasgupta, Indranil; Fan, Hung; Geering, Andrew D.; Gifford, Robert; Harrach, Balázs; Hull, Roger; Johnson, Welkin; Kreuze, Jan F.; Lindemann, Dirk; Llorens, Carlos; Lockhart, Ben; Mayer, Jens (15 June 2018). Sandri-Goldin, Rozanne M. (ed.). "Ortervirales: New Virus Order Unifying Five Families of Reverse-Transcribing Viruses". Journal of Virology. 92 (12). doi:10.1128/JVI.00515-18. ISSN   0022-538X. PMC   5974489 .
  5. ↑ Recent advances in plant virology. Caranta, Carole. Norfolk, UK: Caister Academic Press. 2011. ISBN   9781904455752. OCLC   644654169.{{cite book}}: CS1 maint: others (link)
  6. ↑ Geering, Andrew D. W.; Maumus, Florian; Copetti, Dario; Choisne, Nathalie; Zwickl, Derrick J.; Zytnicki, Matthias; McTaggart, Alistair R.; Scalabrin, Simone; Vezzulli, Silvia (10 November 2014). "Endogenous florendoviruses are major components of plant genomes and hallmarks of virus evolution". Nature Communications. 5 (1): 5269. Bibcode:2014NatCo...5.5269G. doi:10.1038/ncomms6269. ISSN   2041-1723. PMC   4241990 . PMID   25381880.
  7. ↑ Diop, Seydina Issa; Geering, Andrew D. W.; Alfama-Depauw, Françoise; Loaec, Mikaël; Teycheney, Pierre-Yves; Maumus, Florian (12 January 2018). "Tracheophyte genomes keep track of the deep evolution of the Caulimoviridae". Scientific Reports. 8 (1): 572. Bibcode:2018NatSR...8..572D. doi:10.1038/s41598-017-16399-x. ISSN   2045-2322. PMC   5766536 . PMID   29330451.
  8. ↑ Richert-Pöggeler, Katja R.; Noreen, Faiza; Schwarzacher, Trude; Harper, Glyn; Hohn, Thomas (15 September 2003). "Induction of infectious petunia vein clearing (pararetro) virus from endogenous provirus in petunia". The EMBO Journal. 22 (18): 4836–4845. doi:10.1093/emboj/cdg443. ISSN   0261-4189. PMC   212712 . PMID   12970195.
  9. ↑ Gayral, Philippe; Noa-Carrazana, Juan-Carlos; Lescot, Magali; Lheureux, Fabrice; Lockhart, Benham E. L.; Matsumoto, Takashi; Piffanelli, Pietro; Iskra-Caruana, Marie-Line (1 July 2008). "A Single Banana Streak Virus Integration Event in the Banana Genome as the Origin of Infectious Endogenous Pararetrovirus". Journal of Virology. 82 (13): 6697–6710. doi:10.1128/JVI.00212-08. ISSN   0022-538X. PMC   2447048 . PMID   18417582.
  10. ↑ Lockhart, B. E.; Menke, J.; Dahal, G.; Olszewski, N. E. (2000). "Characterization and genomic analysis of tobacco vein clearing virus, a plant pararetrovirus that is transmitted vertically and related to sequences integrated in the host genome". Journal of General Virology. 81 (6): 1579–1585. doi: 10.1099/0022-1317-81-6-1579 . PMID   10811941.
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